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Renier J. Brentjens, MD PhD
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Journal Articles

A Phase I Study of CD19-Targeted 19(T2)28z1xx CAR T Cells in Adult Patients with Relapsed or Refractory B-Cell Malignancies

Jae H. Park, MD, Isabelle Riviere, PhD, Devanjan S. Sikder, Vladimir P. Bermudez, Brigitte Senechal, Xiuyan Wang, PhD, Thomas H. Auchincloss, Claudia Diamonte, RN, Elizabeth Halton, NP-BC AOCNP, M. Lia Palomba, MD, Renier J. Brentjens, MD PhD, Michel Sadelain, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 43–44.
https://doi.org/10.1182/blood-2020-143088
Published: 2020
Journal Articles

Easix and Modified-Easix Are Early Predictors of Severe Cytokine Release Syndrome and Neurotoxicity in Patients Treated with Chimeric Antigen Receptor T Cells

Martina Pennisi, Miriam Sanchez-Escamilla, MD, Jessica Flynn, BS, Molly A. Maloy, MS, Mari Lynne Silverberg, Yakup Batlevi, PhD, Roni Shouval, Connie Lee Batlevi, MD PhD, Renier J. Brentjens, MD PhD, Sean M. Devlin, PhD, Parastoo B. Dahi, MD, Claudia Diamonte, RN, Sergio A Giralt, MD, Elizabeth Halton, NP-BC AOCNP, Tania Jain, MD, Elena Mead, MD, Maria Lia Palomba, MD, Bianca Santomasso, MD PhD, Craig S. Sauter, MD, Michael Scordo, MD, Gunjan L. Shah, MD, Jae H. Park, MD, Miguel-Angel Perales, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1947.
https://doi.org/10.1182/blood-2019-126208
Published: 2019
Journal Articles

Clinical Factors Associated with Improved Survival Following Allogeneic HSCT after CD19 CAR Therapy in Adult Patients with Relapsed B-ALL

Jae H. Park, MD, Jessica Flynn, BS, Mithat Gonen, Yvette Bernal, MS, Claudia Diamonte, RN, Elizabeth Halton, NP-BC AOCNP, Xiuyan Wang, PhD, Isabelle Riviere, PhD, Michel Sadelain, MD PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1348.
https://doi.org/10.1182/blood-2019-129343
Published: 2019
Journal Articles

Optimal Dual-Targeted CAR Construct Simultaneously Targeting Bcma and GPRC5D Prevents Bcma-Escape Driven Relapse in Multiple Myeloma

Carlos Fernandez de Larrea, MD PhD, Mette Staehr, PhD, Andrea Lopez, Yunxin Chen, MBBS, Terence J Purdon, MS, Khong Y. Ng, PhD, Hans Wendel, MD, Renier J. Brentjens, MD PhD, Eric L Smith, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 136.
https://doi.org/10.1182/blood-2019-126145
Published: 2019
Journal Articles

Hematological Count Recovery in Patients Undergoing Treatment with Chimeric Antigen Receptor T Cells (CAR T)

Tania Jain, MD, Andrea Knezevic, MS, Martina Pennisi, Josel D Ruiz, MPH, Sean M. Devlin, PhD, Molly A. Maloy, MS, Elizabeth Halton, NP-BC AOCNP, Claudia Diamonte, RN, Michael Scordo, MD, Craig S. Sauter, MD, Elena Mead, MD, Bianca Santomasso, MD PhD, M. Lia Palomba, MD, Gunjan L. Shah, MDMS, Connie Lee Batlevi, MD PhD, Eric L Smith, MD PhD, Sergio A. Giralt, MD, Renier J. Brentjens, MD PhD, Jae H. Park, MD, Miguel-Angel Perales, MD, Sham Mailankody, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 4455.
https://doi.org/10.1182/blood-2019-127480
Published: 2019
Journal Articles

Comparing Gradings of Immune Effector Cells Toxicities: Application of Astct Consensus Grading System and Implications for Clinical Management

Martina Pennisi, Tania Jain, MD, Elena Mead, MD, Bianca Santomasso, MD PhD, Mari Lynne Silverberg, Yakup Batlevi, PhD, Roni Shouval, Molly A. Maloy, MS, Sean M. Devlin, PhD, Connie Lee Batlevi, MD PhD, Renier J. Brentjens, MD PhD, Parastoo B. Dahi, MD, Claudia Diamonte, RN, Jessica Flynn, BS, Sergio A Giralt, MD, Elizabeth Halton, NP-BC AOCNP, Maria Lia Palomba, MD, Miriam Sanchez-Escamilla, MD, Craig S. Sauter, MD, Michael Scordo, MD, Gunjan L. Shah, MD, Jae H. Park, MD, Miguel-Angel Perales, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4458.
https://doi.org/10.1182/blood-2019-126022
Published: 2019
Journal Articles

Intestinal Microbiota Composition Prior to CAR T Cell Infusion Correlates with Efficacy and Toxicity

Melody Smith, MD, Eric R. Littmann, BA, John B. Slingerland, BSc, Annelie Clurman, BA, Ann E. Slingerland, BSc, Ying Taur, MD MPH, Jonas Schluter, PhD, Jae H. Park, MD, Roisin O'Cearbhaill, MD, Sham Mailankody, MBBS, Eric L. Smith, MD PhD, Maria Lia Palomba, MD, Oladapo Yeku, MD PhD, Jonathan U. Peled, MD, Elizabeth Halton, NP-BC AOCNP, Claudia Diamonte, RN, Jason Chan, Malloury Hall, BA, Pavan Anant, BS, Peter Kane, BA, Sergio Giralt, MD, Isabelle Riviere, PhD, Renier J. Brentjens, MD PhD, Eric G. Pamer, MD, Marcel R.M. van den Brink, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3492.
https://doi.org/10.1182/blood-2018-99-118628
Published: 2018
Journal Articles

Clinical Responses and Pharmacokinetics of MCARH171, a Human-Derived Bcma Targeted CAR T Cell Therapy in Relapsed/Refractory Multiple Myeloma: Final Results of a Phase I Clinical Trial

Sham Mailankody, MBBS, Arnab Ghosh, MBBS, PhD, Mette Staehr, PhD, Terence J Purdon, MS, Mikhail Roshal, MD PhD, Elizabeth Halton, NP-BC AOCNP, Claudia Diamonte, RN, John Pineda, RN, Pavan Anant, BS, Yvette Bernal, MS, Analisa Wills, Neha Korde, MD, Nikoletta Lendvai, MDPhD, Alexander M. Lesokhin, MD, Hani Hassoun, MD, Malin Hultcrantz, MD PhD, Heather J. Landau, MD, Gunjan L. Shah, MD, Michael Scordo, MD, David J. Chung, MDPhD, Oscar B Lahoud, MD, Pallavi Khattar, MD, Carlos Fernandez de Larrea, MD PhD, Qi Gao, Achim Jungbluth, MDPhD, Jae H. Park, MD, Kevin J. Curran, MD, Craig S. Sauter, MD, Maria Lia Palomba, MD, Brigitte Senechal, PhD, Xiuyan Wang, PhD, Ahmet Dogan, MD PhD, Sergio Giralt, MD, Isabelle Riviere, PhD, Ola Landgren, MD PhD, Renier J. Brentjens, MD PhD, Eric L. Smith, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 959.
https://doi.org/10.1182/blood-2018-99-119717
Published: 2018
Journal Articles

Resource Utilization Early after Chimeric Antigen Receptor (CAR) T Cell Infusion for Hematologic Malignancies

Gunjan L. Shah, MDMS, Jae H. Park, MD, Craig S. Sauter, MD, Elaine Duck, RN MS MA, Elizabeth Halton, NP-BC AOCNP, Maria Lia Palomba, MD, Connie Lee Batlevi, MD, Anas Younes, MD, Mark Blaine Geyer, MD, Eric L. Smith, MD PhD, Sham Mailankody, MBBS, Elena Mead, MD, Bianca Santomasso, MD PhD, Miguel-Angel Perales, MD, Paul Sabbatini, MD, Sergio Giralt, MD, Renier J. Brentjens, MD PhD, Peter Bach, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 616.
https://doi.org/10.1182/blood-2018-99-114093
Published: 2018
Journal Articles

CAR T Cell Therapy Targeting G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D), a Novel Target for the Immunotherapy of Multiple Myeloma

Eric L. Smith, MD PhD, Kimberly Harrington, Mette Staehr, PhD, Reed Masakayan, MS, Jon Jones, BS, Thomas Long, PhD, Majid Ghoddusi, DVM, PhD, Terence J Purdon, MS, Trevor Do, Xiuyan Wang, PhD, Minh Pham, Jessica M Brown, Elizabeth Peguero, Carlos Fernández De Larrea, MD PhD, Pei Wang, PhD, Hong Liu, MD PhD, Yiyang Xu, PhD, Sarah Garrett, Steven Almo, PhD, Isabelle Riviere, PhD, Cheng Liu, PhD, Blythe Duke Sather, PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 589.
https://doi.org/10.1182/blood-2018-99-110471
Published: 2018
Journal Articles

A Phase I First-in-Human Clinical Trial of CD19-Targeted 19-28z/4-1BBL "Armored" CAR T Cells in Patients with Relapsed or Refractory NHL and CLL Including Richter's Transformation

Jae H. Park, MD, Maria Lia Palomba, MD, Connie Lee Batlevi, MD, Isabelle Riviere, PhD, Xiuyan Wang, PhD, Brigitte Senechal, PhD, Richard R. Furman, MD, Yvette Bernal, MS, Malloury Hall, BA, John Pineda, RN, Claudia Diamonte, RN, Elizabeth Halton, NP-BC AOCNP, Renier J. Brentjens, MD PhD, Michel Sadelain, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 224.
https://doi.org/10.1182/blood-2018-99-117737
Published: 2018
Journal Articles

Prediction of CAR T-Related Toxicities in R/R DLBCL Patients Treated with Axicabtagene Ciloleucel Using Point of Care Cytokine Measurements

Rawan Faramand, MD, Hiroshi Kotani, MD PhD, Dylan Morrissey, Bin Yu, Frederick L. Locke, MD, Michael D. Jain, MDPhD, Julio C. Chavez, MD, Xuefeng Wang, PhD, Asmita Mishra, MD, Christina A Bachmeier, PharmD, Renier J. Brentjens, MD PhD, Sarah Yoo, Jae H. Park, MD, Marco L. Davila, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 95.
https://doi.org/10.1182/blood-2018-99-116539
Published: 2018
Journal Articles

Development and Evaluation of a Human Single Chain Variable Fragment (scFv) Derived Bcma Targeted CAR T Cell Vector Leads to a High Objective Response Rate in Patients with Advanced MM

Eric L Smith, MDPhD, Sham Mailankody, MBBS, Arnab Ghosh, MBBS, PhD, Reed Masakayan, MS, Mette Staehr, PhD, Terence J Purdon, MS, Elizabeth Halton, NP, Claudia Diamonte, RN, Pavan Anant, Yvette Bernal, MS, Xiuyan Wang, PhD, Yongzeng Wang, PhD, Sarah Garrett, Steven Almo, PhD, Pei Wang, PhD, Hong Liu, MD PhD, Yiyang Xu, PhD, Elena Mead, MD, Jae H. Park, MD, Kevin J. Curran, MD, Craig S. Sauter, MD, Sergio A. Giralt, MD, Ola Landgren, MD PhD, Ahmet Dogan, MD PhD, Mikhail Roshal, MDPhD, Cheng Liu, PhD, Isabelle Riviere, PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 742.
https://doi.org/10.1182/blood.V130.Suppl_1.742.742
Published: 2017
Journal Articles

Development of JCARH125: Optimization of a Fully Human Anti-Bcma CAR for Use in the Treatment of Multiple Myeloma

Kim Harrington, BS, Rebecca Wu, BS, Collin Hauskins, BS, Rupesh Amin, PhD, Thomas Long, PhD, Aye Chen, BA, Ayu Rahardjo, BS, Casey Thayer, BS, Garnet Navvaro, BS, Madelyn Myers, MS, Jon Jones, BS, Alex Baturevych, BS, Stan Morkowski, PhD, Ruth Salmon, PhD, Christopher J Bond, PhD, Mette Staehr, PhD, Terence J Purdon, MS, Reed Masakayan, MS, Cheng Liu, PhD, Hong Liu, MD PhD, Yiyang Xu, PhD, Pei Wang, PhD, Margot Pont, PhD, Damian J. Green, MD, Renier J. Brentjens, MD PhD, Eric L Smith, MDPhD, Blythe Duke Sather, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1813.
https://doi.org/10.1182/blood.V130.Suppl_1.1813.1813
Published: 2017
Journal Articles

Risk of Hyponatremia and Associated Clinical Characteristics in Patients with Acute Lymphoblastic Leukemia after CD19 Targeted Chimeric Antigen Receptor (CAR) T-Cells

Brianne N. Dixon, PharmD, Ryan J. Daley, PharmD, BCOP, Troy Z. Horvat, PharmD, BCOP, Larry W Buie, PharmD, BCOP, FASHP, Meier Hsu, MS, Sheron Latcha, MD, Renier J. Brentjens, MD PhD, Jae H. Park, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3584.
https://doi.org/10.1182/blood.V130.Suppl_1.3584.3584
Published: 2017
Journal Articles

Enhancing CAR T Cell Anti-Tumor Efficacy through Secreted Single Chain Variable Fragment (scFv) Immune Checkpoint Blockade

Sarwish Rafiq, PhD, Hollie J. Jackson, PhD, Oladapo Yeku, MD PhD, Terence J Purdon, MS, Dayenne G. van Leeuwen, Kevin J. Curran, MD, Ryan N Ahmed, Grace D Cullen, Su Yan, Pei Wang, PhD, Jingyi Xiang, Cheng Liu, PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 842.
https://doi.org/10.1182/blood.V130.Suppl_1.842.842
Published: 2017
Journal Articles

High Dose Cyclophosphamide and Pre-Treatment Disease Burden Dictate Response and Survival in a Multicenter Clinical Trial Using CD19-Specific CAR T Cells for Relapsed/Refractory B-ALL

Kevin J. Curran, MD, Steven P. Margossian, MD PhD, Nancy A. Kernan, MD, Lewis B. Silverman, MD, Jae H. Park, MD, Craig S. Sauter, MD, Eric L Smith, MDPhD, Farid Boulad, MD, Maria I. Cancio, MD, Christopher Forlenza, Carolyn Jackson, Neerav Shukla, MD, Barbara Spitzer, Susan Prockop, MD, Peter G. Steinherz, MD, Andrew L. Kung, MD PhD, Richard J. O'Reilly, MD, Isabelle Riviere, PhD, Michel Sadelain, MD PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1326.
https://doi.org/10.1182/blood.V130.Suppl_1.1326.1326
Published: 2017
Journal Articles

Implications of Concurrent Ibrutinib Therapy on CAR T-Cell Manufacturing and Phenotype and on Clinical Outcomes Following CD19-Targeted CAR T-Cell Administration in Adults with Relapsed/Refractory CLL

Mark Blaine Geyer, MD, Jae H. Park, MD, Isabelle Riviere, PhD, Brigitte Senechal, PharmD, PhD, Xiuyan Wang, PhD, Terence J. Purdon, Michel W. Sadelain, MD PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2016) 128 (22): 58.
https://doi.org/10.1182/blood.V128.22.58.58
Published: 2016
Journal Articles

The Development of a qPCR Assay for the Evaluation of the Dendritic Cell Chimeric Antigen Receptor Transcriptome

Yan Leyfman, BS, Anthony Daniyan, MD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2016) 128 (22): 5895.
https://doi.org/10.1182/blood.V128.22.5895.5895
Published: 2016
Journal Articles

IL-18 Secreting CAR T Cells Enhance Cell Persistence, Induce Prolonged B Cell Aplasia and Eradicate CD19+ Tumor Cells without Need for Prior Conditioning

Mauro P. Avanzi, MD PhD, Dayenne G. van Leeuwen, Xinghuo Li, Kenneth Cheung, Hyebin Park, Terence J. Purdon, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2016) 128 (22): 816.
https://doi.org/10.1182/blood.V128.22.816.816
Published: 2016