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Journal Articles

Macaque CRISPR/Cas9 Age-Related Clonal Hematopoiesis Model Demonstrates Expansion of TET2-Mutated Clones and Applicability for Testing Mitigation Approaches

Taehoon Shin, Shirley Chen, BS, Stefan Cordes, MD PhD, Yifan Zhou, MS, Byung-Chul Lee, PhD, Aisha Aljanahi, BS, So Gun Hong, PhD, Robert E. Donahue, VMD, Kyung-Rok Yu, PhD, Cynthia E. Dunbar, MD

Blood (2020) 136 (Supplement 1): 27–28.

https://doi.org/10.1182/blood-2020-140770

Published: 2020

Journal Articles

Preclinical Evaluation for Engraftment of Gene-Edited CD34+ Cells with a Sickle Cell Disease Mutation in a Rhesus Transplantation Model

Naoya Uchida, MD, Linhong Li, PhD, Tina Nassehi, Morgan Yapundich, Jackson Gamer, Claire Drysdale, Juan J. Haro-Mora, PhD, Selami Demirci, PhD, Aylin Bonifacino, MS, Allen Krouse, Nathaniel S. Linde, Cornell Allen, MS, Suk See De Ravin, MD, PhD, Robert E. Donahue, VMD, Harry L. Malech, MD, Madhusudan Peshwa, PhD, John F. Tisdale, MD

Blood (2019) 134 (Supplement_1): 609.

https://doi.org/10.1182/blood-2019-122727

Published: 2019

Journal Articles

A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates

Blood (2019) 134 (Supplement_1): 610.

https://doi.org/10.1182/blood-2019-125968

Published: 2019

Journal Articles

Truncated Erythropoietin Receptors Confer an In Vivo Selective Advantage in Gene-Modified Erythroid Cells Expressing Fetal Hemoglobin Due to BCL11A Interference

Naoya Uchida, MD, Claire Drysdale, Morgan Yapundich, Jackson Gamer, Tina Nassehi, Matthew Wielgosz, Francesca Ferrara, PhD, Juan J. Haro-Mora, PhD, Selami Demirci, PhD, Aylin Bonifacino, MS, Allen Krouse, Nathaniel S. Linde, Robert E. Donahue, VMD, Byoung Y. Ryu, PhD, John F. Tisdale, MD

Blood (2019) 134 (Supplement_1): 2063.

https://doi.org/10.1182/blood-2019-122770

Published: 2019

Journal Articles

Durable and Robust Fetal Globin Induction without Anemia in Rhesus Monkeys Following Autologous Hematopoietic Stem Cell Transplant with BCL11A Erythroid Enhancer Editing

Blood (2019) 134 (Supplement_1): 4632.

https://doi.org/10.1182/blood-2019-129394

Published: 2019

Journal Articles

Long-Term, Clonal Tracking Comparing Autologous Transplantation of G-CSF/SCF-Primed Bone Marrow CD34+ Cells with G-CSF/SCF-Mobilized Peripheral Blood CD34+ Cells in Rhesus Macaques

Sanggu Kim, PhD, Robert E. Donahue, VMD, Aylin Bonifacino, MS, Mark Metzger, Cynthia E. Dunbar, MD, Irvin Chen, PhD

Blood (2018) 132 (Supplement 1): 4524.

https://doi.org/10.1182/blood-2018-99-117047

Published: 2018

Journal Articles

Intrabone Delivery of CD34+ Cells Using an Optimized Delivery System Does Not Enhance Engraftment in a Rhesus Macaque Model of Hematopoietic Stem Cell Transplantation

Blood (2018) 132 (Supplement 1): 5677.

https://doi.org/10.1182/blood-2018-99-114730

Published: 2018

Journal Articles

Modeling Human Paroxysmal Nocturnal Hemoglobinuria Via CRISPR/Cas9 HSPC Gene Editing in Non-Human Primate

Taehoon Shin, PhD, Eun Jung Baek, MD, Marcus A.F. Corat, PhD, Shirley Chen, BS, Robert E. Donahue, VMD, Kyung-Rok Yu, PhD, Cynthia E. Dunbar, MD

Blood (2018) 132 (Supplement 1): 1309.

https://doi.org/10.1182/blood-2018-99-111984

Published: 2018

Journal Articles

A Non-Human Primate CRISPR/Cas9 Model of Clonal Hematopoiesis of Indeterminate Potential Demonstrates Expansion of TET2-Disrupted Clones

Kyung-Rok Yu, PhD, Cynthia E Dunbar, MD, Marcus Corat, Shirley Chen, Aisha Aljanahi, Eun Jung Baek, Jean-Yves Metais, Hannah Natanson, Thomas Winkler, MD, Robert E Donahue, VMD

Blood (2017) 130 (Supplement 1): 117.

https://doi.org/10.1182/blood.V130.Suppl_1.117.117

Published: 2017

Journal Articles

Aberrant Clonal Hematopoiesis of the Erythroid and Myeloid Lineages in a Lentivirally Barcoded Rhesus Macaque

Diego A Espinoza, BA, Chuanfeng Wu, MD, Xing Fan, MD, Di Yang, MD, Idalia Montano Yabe, MS, Selami Demirci, PhD, So Gun Hong, PhD, Aylin Bonifacino, MS, Allen Krouse, Mark Metzger, Rong Lu, PhD, Katherine R Calvo, MD PhD, John F Tisdale, MD, Xiaolin Wu, PhD, Suk See De Ravin, MD PhD, Harry L Malech, MD, Robert E Donahue, VMD, Cynthia E Dunbar, MD

Blood (2017) 130 (Supplement 1): 606.

https://doi.org/10.1182/blood.V130.Suppl_1.606.606

Published: 2017

Journal Articles

Skewed HSC Clonal Output of T-Cells in an Aged Rhesus Macaque after CD3e-Immunotoxin Treatment

Sanggu Kim, PhD, Gajendra Suryavanshi, PhD, Aylin Bonifacino, MS, Chuanfeng Wu, MD, Cynthia E Dunbar, MD, Robert E Donahue, VMD, Irvin Chen, PhD

Blood (2017) 130 (Supplement 1): 3758.

https://doi.org/10.1182/blood.V130.Suppl_1.3758.3758

Published: 2017

Journal Articles

Clonal Tracking of the Source of Red Cell and Platelet Production in Rhesus Macaques

Xing Fan, MD, Chuanfeng Wu, MD, Diego Espinoza, Stephanie Sellers, Aylin Bonifacino, MS, Robert E Donahue, VMD, Luca Schifanella, Genoveffa Franchini, Cynthia E Dunbar, MD

Blood (2017) 130 (Supplement 1): 932.

https://doi.org/10.1182/blood.V130.Suppl_1.932.932

Published: 2017

Journal Articles

Suicide Gene (HSVtk) Ablation of Hematopoietic Stem Cells and Their Progeny In the Rhesus Macaque Model: An Approach to Deletion of Dangerous Clones.

Cecilia Barese, MD, PhD, Connor King, Stephanie Sellers, Allen E Krouse, Mark E Metzger, Catia Traversari, MD, Claudio Bordignon, MD, Steven M. Kornblau, MD, Frank Marini, III, PhD, Robert E Donahue, VMD, Cynthia E. Dunbar, MD

Blood (2010) 116 (21): 3759.

https://doi.org/10.1182/blood.V116.21.3759.3759

Published: 2010

Journal Articles

Microarray Analysis of CD34+CXCR4+ and CD34+CXCR4- Cells Reveals Two Distinct Hematopoietic Stem/Progenitor Populations

Robert E Donahue, VMD, Ping Jin, Yu Tian, Robyn S Allen, Aylin Bonifacino, David Stroncek, MD

Blood (2010) 116 (21): 4798.

https://doi.org/10.1182/blood.V116.21.4798.4798

Published: 2010

Journal Articles

Probing the Impact of AMD3100/GCSF Mobilization on the Peripheral Blood T Cell Content Using a Rhesus Macaque Model: Increased Proportions of FoxP3+/CD4+ T Cells Occur After Mobilization and Leukapheresis

Leslie Kean, MD, PhD, Sharon Sen, Mark E Metzger, Aylin Bonifacino, Karnail Singh, Robert E Donahue, VMD

Blood (2010) 116 (21): 350.

https://doi.org/10.1182/blood.V116.21.350.350

Published: 2010

Journal Articles

Long-Term Reconstitution of Transduced Rhesus CD34+ Cells Mobilized by G-CSF and Plerixafor.

Naoya Uchida, MD, PhD, Aylin Bonifacino, Allen E Krouse, Sandra D Price, Ross M Fasano, MD, Gyorgy Csako, MD, Susan F Leitman, MD, Mark E Metzger, Matthew M Hsieh, MD, Joseph J Mattapallil, VMD, PhD, John F Tisdale, MD, Robert E Donahue, VMD

Blood (2010) 116 (21): 1449.

https://doi.org/10.1182/blood.V116.21.1449.1449

Published: 2010

Journal Articles

A Modified HIV1-Based Lentiviral Vector Can Transduce Rhesus Hematopoietic Repopulating Cells as Efficiently as An SIV Vector in An Autologous Transplantation Model.

Naoya Uchida, MD, PhD, Phillip W Hargrove, M.S., Kareem Washington, PhD, Coen J. Lap, MD, Matthew M. Hsieh, MD, Aylin C. Bonifacino, Sandra D. Price, Allen E. Krouse, Mark E. Metzger, Robert E. Donahue, VMD, Derek Persons, MD, PhD, John F. Tisdale, MD

Blood (2009) 114 (22): 692.

https://doi.org/10.1182/blood.V114.22.692.692

Published: 2009

Journal Articles

AMD3100 and Granulocyte Colony Stimulating Factor (G-CSF) Mobilize Different CD34+ Cell Populations Based on Global Gene and Micro RNA Expression.

Robert E. Donahue, VMD, Ping Jin, PhD, Aylin C. Bonifacino, Mark E. Metzger, David Stroncek, MD

Blood (2008) 112 (11): 1385.

https://doi.org/10.1182/blood.V112.11.1385.1385

Published: 2008

Journal Articles

Development of An HIV1-Based Lentiviral Vector Able to Transduce Both Human and Rhesus Blood Cells.

Naoya Uchida, MD, Kareem Washington, PhD, Jun Hayakawa, MD, PhD, Matthew Hsieh, MD, Aylin C. Bonifacino, Allen E. Krouse, Mark E. Metzger, Robert E. Donahue, VMD, John F. Tisdale, MD

Blood (2008) 112 (11): 2353.

https://doi.org/10.1182/blood.V112.11.2353.2353

Published: 2008

Journal Articles

In Vitro Culture during Retroviral Transduction Improves Thymic Repopulation and Output after TBI and Autologous PBPC Transplantation in Rhesus Macaques.

Ruth Seggewiss, MD, Karin Lore, PhD, Javier F. Guenaga, Stefania Pittaluga, MD PhD, Mark E. Metzger, Allen Krouse, Robert E. Donahue, VMD, David Ambrozak, Daniel C. Douek, MD PhD, Cynthia E. Dunbar, MD

Blood (2004) 104 (11): 1196.

https://doi.org/10.1182/blood.V104.11.1196.1196

Published: 2004

NARROW

Macaque CRISPR/Cas9 Age-Related Clonal Hematopoiesis Model Demonstrates Expansion of TET2-Mutated Clones and Applicability for Testing Mitigation Approaches

Preclinical Evaluation for Engraftment of Gene-Edited CD34+ Cells with a Sickle Cell Disease Mutation in a Rhesus Transplantation Model

A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates

Truncated Erythropoietin Receptors Confer an In Vivo Selective Advantage in Gene-Modified Erythroid Cells Expressing Fetal Hemoglobin Due to BCL11A Interference

Durable and Robust Fetal Globin Induction without Anemia in Rhesus Monkeys Following Autologous Hematopoietic Stem Cell Transplant with BCL11A Erythroid Enhancer Editing

Long-Term, Clonal Tracking Comparing Autologous Transplantation of G-CSF/SCF-Primed Bone Marrow CD34+ Cells with G-CSF/SCF-Mobilized Peripheral Blood CD34+ Cells in Rhesus Macaques

Intrabone Delivery of CD34+ Cells Using an Optimized Delivery System Does Not Enhance Engraftment in a Rhesus Macaque Model of Hematopoietic Stem Cell Transplantation

Modeling Human Paroxysmal Nocturnal Hemoglobinuria Via CRISPR/Cas9 HSPC Gene Editing in Non-Human Primate

A Non-Human Primate CRISPR/Cas9 Model of Clonal Hematopoiesis of Indeterminate Potential Demonstrates Expansion of TET2-Disrupted Clones

Aberrant Clonal Hematopoiesis of the Erythroid and Myeloid Lineages in a Lentivirally Barcoded Rhesus Macaque

Skewed HSC Clonal Output of T-Cells in an Aged Rhesus Macaque after CD3e-Immunotoxin Treatment

Clonal Tracking of the Source of Red Cell and Platelet Production in Rhesus Macaques

Suicide Gene (HSVtk) Ablation of Hematopoietic Stem Cells and Their Progeny In the Rhesus Macaque Model: An Approach to Deletion of Dangerous Clones.

Microarray Analysis of CD34+CXCR4+ and CD34+CXCR4- Cells Reveals Two Distinct Hematopoietic Stem/Progenitor Populations

Probing the Impact of AMD3100/GCSF Mobilization on the Peripheral Blood T Cell Content Using a Rhesus Macaque Model: Increased Proportions of FoxP3+/CD4+ T Cells Occur After Mobilization and Leukapheresis

Long-Term Reconstitution of Transduced Rhesus CD34+ Cells Mobilized by G-CSF and Plerixafor.

A Modified HIV1-Based Lentiviral Vector Can Transduce Rhesus Hematopoietic Repopulating Cells as Efficiently as An SIV Vector in An Autologous Transplantation Model.

AMD3100 and Granulocyte Colony Stimulating Factor (G-CSF) Mobilize Different CD34+ Cell Populations Based on Global Gene and Micro RNA Expression.

Development of An HIV1-Based Lentiviral Vector Able to Transduce Both Human and Rhesus Blood Cells.

In Vitro Culture during Retroviral Transduction Improves Thymic Repopulation and Output after TBI and Autologous PBPC Transplantation in Rhesus Macaques.

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American Society of Hematology

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American Society of Hematology

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