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Journal Articles

Building Capacity and Assessing Stroke Risk with Transcranial Doppler Ultrasonography in Sub-Saharan Africa: The Reach Experience

Brigida Santos, MD, Maria Nakafeero, Adam Lane, PhD, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Janet Adams, Banu Aygun, MD, Susan E. Stuber, MA, George A. Tomlinson, PhD BSc, MSc, Teresa Latham, MA, Patrick T. McGann, MD MS, Russell E. Ware, MD PhD

Blood (2020) 136 (Supplement 1): 17–18.

https://doi.org/10.1182/blood-2020-142318

Published: 2020

Journal Articles

Hydroxyurea to Reduce Stroke Risk in Tanzanian Children with Sickle Cell Anemia

Emmanuela E. Ambrose, MD, Luke R. Smart, MD, Primrose Songoro, RN, Idd Shabani, MD, Protas Komba, MD, Mwesige Charles, BScHLS, Thad A. Howard, MS, Susan E. Stuber, MA, Adam Lane, PhD, Teresa Latham, MA, Abel Nkono Makubi, PhD MD MSc, Russell E. Ware, MD PhD

Blood (2020) 136 (Supplement 1): 20–21.

https://doi.org/10.1182/blood-2020-135944

Published: 2020

Journal Articles

Optimizing Hydroxyurea Therapy with Reduced Laboratory Monitoring for Children with Sickle Cell Anemia in Sub-Saharan Africa: The Reach Experience

Banu Aygun, MD, George A. Tomlinson, PhD BSc, MSc, Patrick T. McGann, MD MS, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Brigida Santos, MD, Susan E. Stuber, MA, Adam Lane, PhD, Teresa Latham, MA, Russell E. Ware, MD PhD

Blood (2020) 136 (Supplement 1): 17.

https://doi.org/10.1182/blood-2020-134180

Published: 2020

Journal Articles

Rapid and Automated Quantitation of Dense Red Blood Cells: A Robust Biomarker of Therapeutic Response to Early Initiation of Hydroxyurea in Young Children with Sickle Cell Anemia

Alina Sadaf, MD, Charles T. Quinn, MD, Jennifer B Korpik, Amanda Pfeiffer, BS, MA, Mary Reynaud, MA, MT(ASCP), Omar Niss, MD, Punam Malik, MD, Russell E. Ware, MD PhD, Theodosia A. Kalfa, MD PhD, Patrick T. McGann, MD MS

Blood (2020) 136 (Supplement 1): 16–17.

https://doi.org/10.1182/blood-2020-137070

Published: 2020

Journal Articles

Genetic Variants That Influence Fetal Hemoglobin Expression from Hydroxyurea Treatment

Blood (2020) 136 (Supplement 1): 8–9.

https://doi.org/10.1182/blood-2020-143139

Published: 2020

Journal Articles

Genetic Basis of Erythrocyte Alloimmunization Among Children with Sickle Cell Anemia in the Dominican Republic

Kristina Prus, MD, Rosa M. Nieves, MD, Thad A. Howard, MS, Susan E. Stuber, MA, Rafael Mena, MD, Teresa Latham, MA, Russell E. Ware, MD PhD

Blood (2020) 136 (Supplement 1): 28–29.

https://doi.org/10.1182/blood-2020-142015

Published: 2020

Journal Articles

Novel Genetic Loci That Influence Fetal Hemoglobin Expression in Children with Sickle Cell Anemia

Anu Marahatta, PhD, Thad A. Howard, MS, Susan E. Stuber, MA, Kathryn L McElhinney, BS, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Brigida Santos, MD, Chandy C. John, MD MS, Robert Opoka, MMED, Rosa M. Nieves, MD, Rafael Mena, MD, Jasmine Baker, PhD, Teresa Latham, MA, Jonathan M. Flanagan, PhD, Russell E. Ware, MD PhD

Blood (2020) 136 (Supplement 1): 33–34.

https://doi.org/10.1182/blood-2020-143025

Published: 2020

Journal Articles

Increased Hydroxyurea Prescribing Practices over Ten Years with Improved Clinical Outcomes in Children with Sickle Cell Anemia: A Single Center's Experience

Kristine Anne Karkoska, MD, Kevin E Todd, Jr., MD, Kelly Clapp, NP, Lynette Fenchel, NP, Theodosia A. Kalfa, MD PhD, Punam Malik, MD, Omar Niss, MD, Charles T. Quinn, MD, Russell E. Ware, MD PhD, Patrick T. McGann, MD MS

Blood (2020) 136 (Supplement 1): 34.

https://doi.org/10.1182/blood-2020-138754

Published: 2020

Journal Articles

Concomitant Hydroxyurea and Voxelotor: Results from the HOPE Study

Russell E. Ware, MD PhD, Clark Brown, MD PhD, Mariane de Montalembert, MD PhD, Margaret Tonda, PharmD, Barbara Tong, PhD, Carolyn Hoppe, MD, Joshua Lehrer-Graiwer, MD MPhil, FACC, Miguel R. Abboud, MD

Blood (2019) 134 (Supplement_1): 1003.

https://doi.org/10.1182/blood-2019-130767

Published: 2019

Journal Articles

Profound Alteration of Host Response in Severe Malarial Anemia By Sickle Cell Disease: Reduction of Parasite Sequestration and Inflammation, Upregulation of Angiopoietin-2

Ryan C Henrici, PhD BS, Casey Sautter, MDMS, Robert Opoka, MMED, Ruth Namazzi, MD, Gregory S Park, Dibyadyuti John, PhD, Andrea L Conroy, PhD, Russell E. Ware, MD PhD, Chandy C. John, MDMS

Blood (2019) 134 (Supplement_1): 2283.

https://doi.org/10.1182/blood-2019-129566

Published: 2019

Journal Articles

Stroke Avoidance for Children in República Dominicana (SACRED):a Prospective Trial to Reduce Stroke in Children with Sickle Cell Anemia

Luisanna Sanchez, MD, Rosa M. Nieves, MD, Teresa S. Latham, MA, Adam Lane, PhD, Neelum Jeste, MD, Gabriela S. Urcuyo, MD, Melissa E. Berges, MD, Carla Florencio, MD, Carla Gonzalez, MD, Paola Del Villar, MD, Janet Adams, Susan Stuber, MA, William Schultz, M.H.S., Rafael Mena, MD, Russell E. Ware, MD PhD

Blood (2019) 134 (Supplement_1): 2285.

https://doi.org/10.1182/blood-2019-130214

Published: 2019

Journal Articles

Ndepth: A Randomized Controlled Trial of a Novel Dose-Prediction Equation to Determine Maximum Tolerated Dose for Hydroxyurea Therapy in Pediatric Patients with Sickle Cell Anemia

Alex George, MD PhD, Bogdan Dinu, MD, Norma Estrada, Charles Minard, PhD, Richard L Hurwitz, MD, Donald Mahoney, MD, Amber M Yates, MD, Mary Vaughan, FNP - C, Alaundra Carmouche, FNP - C, Gladstone Airewele, MDMPH, Kirk E Susan, P.A., Titilope Adenike Fasipe, MD PhD, Precious Uwaezuoke, FNP, Russell E. Ware, MD PhD

Blood (2019) 134 (Supplement_1): 2267.

https://doi.org/10.1182/blood-2019-127414

Published: 2019

Journal Articles

Hydroxyurea Therapy to Prevent Incident Stroke Among Children with Sickle Cell Anaemia in Jamaica: The Extend Trial

Angela Rankine-Mullings, MBBS, Marvin Ellsworth Reid, MB, BS, PhD, Deanne Soares, MBBS,DM Radiology, Carolyn Taylor-Bryan, MBBS, PhD BSc, DM, Margaret Wisdom-Phipps, RN, RM, Karen Aldred, MSc, Teresa Latham, MA, Jennifer Knight-Madden, MBBS, PhD, Lesley King, MBBS, MRCP, Asha Badaloo, PhD, Adam Lane, PhD, Robert J. Adams, MD MS, Russell E. Ware, MD PhD

Blood (2019) 134 (Supplement_1): 2269.

https://doi.org/10.1182/blood-2019-126781

Published: 2019

Journal Articles

Optimizing Hydroxyurea Dosing in Sickle Cell Anemia: The Uganda MTD Study

Chandy C. John, MDMS, Robert Opoka, MMED, Teresa Latham, MA, Heather Hume, MDFRCPC, Maria Nakafeero, Phillip Kasirye, Christopher Ndugwa, Adam Lane, PhD, Russell E. Ware, MD PhD

Blood (2019) 134 (Supplement_1): 520.

https://doi.org/10.1182/blood-2019-125128

Published: 2019

Journal Articles

Effects of Hydroxyurea Treatment on Malaria Infections in Sub-Saharan Africa

Peter Olupot-Olupot, George A. Tomlinson, PhD BSc, MSc, Teresa S. Latham, MA, Patrick T. McGann, MD, Brigida Santos, Banu Aygun, MD, Susan Stuber, MA, Leon Tshilolo, MD PhD, Adam Lane, PhD, Thomas N. Williams, Russell E. Ware, MD PhD

Blood (2019) 134 (Supplement_1): 522.

https://doi.org/10.1182/blood-2019-129251

Published: 2019

Journal Articles

Hydroxyurea Pharmacokinetic Profiles in Children Treated for Extreme Thrombocytosis after Total Pancreatectomy with Islet Cell Autotransplant Demonstrate Poor Absorption

Alexander A Boucher, MD, Min Dong, PhD, Anu Marahatta, PhD, Adriane Hausfeld, Thad A. Howard, MS, Jaimie D Nathan, MD, Alexander A. Vinks, PharmD, PhD FCP, Patrick T. McGann, MD, Russell E. Ware, MD PhD, Lori Luchtman-Jones, MD

Blood (2019) 134 (Supplement_1): 4893.

https://doi.org/10.1182/blood-2019-127378

Published: 2019

Journal Articles

Pharmacokinetics-Guided Dosing of Hydroxyurea Can Achieve Near-Pancellular Fetal Hemoglobin Expression in Sickle Cell Anemia: F-Cell Analysis As a Benchmark for Disease-Modifying Therapy

Charles T. Quinn, MD, Omar Niss, MD, Amanda Pfeiffer, Jennifer Korpik, Holly Bonar, Mary Reynaud, Russell E. Ware, MD PhD, Patrick T. McGann, MD

Blood (2019) 134 (Supplement_1): 892.

https://doi.org/10.1182/blood-2019-130414

Published: 2019

Journal Articles

Splenomegaly in Children with Sickle Cell Anemia Receiving Hydroxyurea in Sub-Saharan Africa

Leon Tshilolo, MD PhD, George A. Tomlinson, PhD BSc, MSc, Patrick T. McGann, MD, Teresa S. Latham, MA, Peter Olupot-Olupot, Brigida Santos, Banu Aygun, MD, Susan Stuber, MA, Adam Lane, PhD, Thomas N. Williams, Russell E. Ware, MD PhD

Blood (2019) 134 (Supplement_1): 993.

https://doi.org/10.1182/blood-2019-129937

Published: 2019

Journal Articles

Genetic Analysis in the Tanzania Sickle Surveillance Study (TS3): Modifiers of Sickle Cell Disease and Identification of Hemoglobin Variants

Luke R. Smart, MD, Emmanuela E. Ambrose, MD, Mwesige Charles, BScHLS, Arielle G. Hernandez, MPH, Teresa S. Latham, MA, Adolfine Hokororo, MD MMed, MSc, Medard Beyanga, BLS, MSc, Erasmus Kamugisha, MD MSc, PhD, Erius Tebuka, MD MMed, Thad A. Howard, MS, Russell E. Ware, MD PhD

Blood (2019) 134 (Supplement_1): 988.

https://doi.org/10.1182/blood-2019-128554

Published: 2019

Journal Articles

Realizing Effectiveness across Continents with Hydroxyurea (REACH): A Prospective Multi-National Trial of Hydroxyurea for Sickle Cell Anemia in Sub-Saharan Africa

Leon Tshilolo, MDPhD, George Tomlinson, Thomas N. Williams, Brigida Santos, Peter Olupot-Olupot, Adam Lane, PhD, Banu Aygun, MD, Susan Stuber, MA, Teresa Latham, MA, Patrick T. McGann, MD, Russell E. Ware, MD PhD

Blood (2018) 132 (Supplement 1): 3.

https://doi.org/10.1182/blood-2018-99-113818

Published: 2018

NARROW

Building Capacity and Assessing Stroke Risk with Transcranial Doppler Ultrasonography in Sub-Saharan Africa: The Reach Experience

Hydroxyurea to Reduce Stroke Risk in Tanzanian Children with Sickle Cell Anemia

Optimizing Hydroxyurea Therapy with Reduced Laboratory Monitoring for Children with Sickle Cell Anemia in Sub-Saharan Africa: The Reach Experience

Rapid and Automated Quantitation of Dense Red Blood Cells: A Robust Biomarker of Therapeutic Response to Early Initiation of Hydroxyurea in Young Children with Sickle Cell Anemia

Genetic Variants That Influence Fetal Hemoglobin Expression from Hydroxyurea Treatment

Genetic Basis of Erythrocyte Alloimmunization Among Children with Sickle Cell Anemia in the Dominican Republic

Novel Genetic Loci That Influence Fetal Hemoglobin Expression in Children with Sickle Cell Anemia

Increased Hydroxyurea Prescribing Practices over Ten Years with Improved Clinical Outcomes in Children with Sickle Cell Anemia: A Single Center's Experience

Concomitant Hydroxyurea and Voxelotor: Results from the HOPE Study

Profound Alteration of Host Response in Severe Malarial Anemia By Sickle Cell Disease: Reduction of Parasite Sequestration and Inflammation, Upregulation of Angiopoietin-2

Stroke Avoidance for Children in República Dominicana (SACRED):a Prospective Trial to Reduce Stroke in Children with Sickle Cell Anemia

Ndepth: A Randomized Controlled Trial of a Novel Dose-Prediction Equation to Determine Maximum Tolerated Dose for Hydroxyurea Therapy in Pediatric Patients with Sickle Cell Anemia

Hydroxyurea Therapy to Prevent Incident Stroke Among Children with Sickle Cell Anaemia in Jamaica: The Extend Trial

Optimizing Hydroxyurea Dosing in Sickle Cell Anemia: The Uganda MTD Study

Effects of Hydroxyurea Treatment on Malaria Infections in Sub-Saharan Africa

Hydroxyurea Pharmacokinetic Profiles in Children Treated for Extreme Thrombocytosis after Total Pancreatectomy with Islet Cell Autotransplant Demonstrate Poor Absorption

Pharmacokinetics-Guided Dosing of Hydroxyurea Can Achieve Near-Pancellular Fetal Hemoglobin Expression in Sickle Cell Anemia: F-Cell Analysis As a Benchmark for Disease-Modifying Therapy

Splenomegaly in Children with Sickle Cell Anemia Receiving Hydroxyurea in Sub-Saharan Africa

Genetic Analysis in the Tanzania Sickle Surveillance Study (TS3): Modifiers of Sickle Cell Disease and Identification of Hemoglobin Variants

Realizing Effectiveness across Continents with Hydroxyurea (REACH): A Prospective Multi-National Trial of Hydroxyurea for Sickle Cell Anemia in Sub-Saharan Africa

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