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Journal Articles

Eptacog Beta (rFVIIa) Has a Low Incidence of Spontaneous Rebleeding through 24 and 48 Hours in Adult and Adolescent Patients with Hemophilia A or B with Inhibitors

Amy L. Dunn, Yesim Dargaud, Yasmina L. Abajas, Manuel Carcao, Giancarlo Castaman, Adam Giermasz, Cédric Hermans, Magdalena D. Lewandowska, Johnny Mahlangu, Shannon L. Meeks, Wolfgang A. Miesbach, Michael Recht, Vanessa Salinas, Tammuella Chrisentery-Singleton, Hongying Wang, Ian S Mitchell, Guy Young

Blood (2022) 140 (Supplement 1): 8485–8488.

https://doi.org/10.1182/blood-2022-157343

Published: 2022

Journal Articles

Eptacog Beta Efficacy in Children and Adolescents with Hemophilia A or B and Inhibitors: Subset Analysis Suggests Improved Caregiver Capacity to Assess Bleeding Episode Resolution with Subject Age

Blood (2021) 138 (Supplement 1): 3195.

https://doi.org/10.1182/blood-2021-147434

Published: 2021

Journal Articles

Single 225μg/Kg Dose Treatment with Eptacog Beta (Factor VIIa, Recombinant) Results in Rapid Hemostasis in Joint Bleeds for Persons with Hemophilia Α or Β with Inhibitors: A PERSEPT1 Subset Analysis

Janna M. Journeycake, MD, Cedric Hermans, MDMRCP,PhD, Jonathan M. Ducore, MD MPH, Miguel A. Escobar, MD, Guy Young, MD, Michael Wang, MD, Doris Quon, MD PhD, W Allan Alexander, MD, Ian S Mitchell, PhD, Ahmad Al-Sabbagh, MD, Daniel Bonzo, PhD

Blood (2020) 136 (Supplement 1): 2–3.

https://doi.org/10.1182/blood-2020-136443

Published: 2020

Journal Articles

In Vitro Evaluation of Thrombin Generation of Eptacog Beta (Factor VIIa, Recombinant) and Emicizumab in Congenital Hemophilia Α Plasma with and without Inhibitors

Steven W. Pipe, MD, Michael Recht, MD PhD, Michael U. Callaghan, MD, Robert F. Sidonio, Jr., MDMSc, Jerry Grandoni, PhD, Veronique Duretz, Daniel Bonzo, PhD, Jean Luc Plantier, PhD, Sean Evans, PhD RPh, Ian S Mitchell, PhD, Cedric Hermans, MDMRCP,PhD

Blood (2020) 136 (Supplement 1): 41–42.

https://doi.org/10.1182/blood-2020-136430

Published: 2020

Journal Articles

PERSEPT3: A Phase 3 Clinical Trial to Evaluate the Hemostatic Efficacy of Eptacog Beta (Recombinant Human FVIIa) in Perioperative Care in Subjects with Hemophilia Α or B with Inhibitors

Miguel A. Escobar, MD, Doris Quon, MD PhD, Cindy A. Leissinger, MD, James V Luck, Jr., MD, Ahmad Al-Sabbagh, MD, Daniel Bonzo, PhD, Ian S Mitchell, PhD, W Allan Alexander, MD, Cedric Hermans, MDMRCP,PhD

Blood (2020) 136 (Supplement 1): 34–36.

https://doi.org/10.1182/blood-2020-136448

Published: 2020

Journal Articles

Protein Kinase C-Theta Interacts with mTORC2 and Vimentin to Limit Regulatory T-Cell Function

Cameron McDonald-Hyman, BA, Govindarajan Thangavelu, PhD, James Muller, Guoan Zhang, PhD, Sudha Kumari, PhD, Asim Saha, PhD, Brent H. Koehn, PhD, Jason S. Mitchell, PhD, Brian T Fife, PhD, Jonathan S. Serody, MD, Mark J. Osborn, PhD, Keli L. Hippen, PhD, Ameeta Kelekar, PhD, David H. Munn, MD, Amnon Altman, PhD, Thomas A. Neubert, PhD, Michael L. Dustin, PhD, Bruce R. Blazar, MD

Blood (2015) 126 (23): 849.

https://doi.org/10.1182/blood.V126.23.849.849

Published: 2015

Journal Articles

Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1

Le Xuan Truong Nguyen, Yunqin Lee, Lenore Urbani, Paul J. Utz, Anne W. Hamburger, John B. Sunwoo, Beverly S. Mitchell

Blood (2015) 125 (16): 2519–2529.

https://doi.org/10.1182/blood-2014-12-616433

Published: 2015

Includes: Supplemental data

Journal Articles

Preclinical Activity of a New Proteasome Inhibitor, MLN9708, in Acute Myelogenous Leukemias Expressing NPM1 Mutated Protein

Jacqueline S Garcia, MD, Min Huang, Bruno C Medeiros, MD, Beverly S. Mitchell, MD

Blood (2014) 124 (21): 993.

https://doi.org/10.1182/blood.V124.21.993.993

Published: 2014

Journal Articles

Interaction of TIF-90 and filamin A in the regulation of rRNA synthesis in leukemic cells

Le Xuan Truong Nguyen, Steven M. Chan, Tri Duc Ngo, Aparna Raval, Kyeong Kyu Kim, Ravindra Majeti, Beverly S. Mitchell

Blood (2014) 124 (4): 579–589.

https://doi.org/10.1182/blood-2013-12-544726

Published: 2014

Includes: Supplemental data

Journal Articles

The ASH Clinical Research Training Institute (CRTI) Positively Impacts The Success Of Early Career Hematologists In Patient-Oriented Clinical Research

Linda J Burns, MD, Charles P Clayton, James N. George, MD, Beverly S. Mitchell, Scott D. Gitlin, MD

Blood (2013) 122 (21): 1679.

https://doi.org/10.1182/blood.V122.21.1679.1679

Published: 2013

Journal Articles

Activation Of Akt Enhances Ribosomal RNA Synthesis In AML Cells Through a Novel Isoform Of TIF-1A and Inhibition Of Filamin A Cleavage

Le Xuan Truong Nguyen, PhD, Min Huang, Steven M. Chan, MD, PhD, Ravi Majeti, MD, PhD, Beverly S. Mitchell

Blood (2013) 122 (21): 1266.

https://doi.org/10.1182/blood.V122.21.1266.1266

Published: 2013

Journal Articles

Are Racial and Ethnic Disparities In Acute Myeloid Leukemia Due To Differences In Treatment?

Manali I. Patel, MD, MPH, Yifei Ma, MS, Beverly S. Mitchell, Kim Rhoads, MS MD MPH

Blood (2013) 122 (21): 726.

https://doi.org/10.1182/blood.V122.21.726.726

Published: 2013

Journal Articles

Reduced rRNA expression and increased rDNA promoter methylation in CD34 + cells of patients with myelodysplastic syndromes

Aparna Raval, Kunju J. Sridhar, Shripa Patel, Brit B. Turnbull, Peter L. Greenberg, Beverly S. Mitchell

Blood (2012) 120 (24): 4812–4818.

https://doi.org/10.1182/blood-2012-04-423111

Published: 2012

Includes: Supplemental data

Journal Articles

Are Disparities in Acute Myelogenous Leukemia Due to Poor Prognostic Factors At Diagnosis? A National Study

Manali I. Patel, MD, MPH, Yifei Ma, MS, Beverly S. Mitchell, Kim Rhoads, MS MD MPH

Blood (2012) 120 (21): 2061.

https://doi.org/10.1182/blood.V120.21.2061.2061

Published: 2012

Journal Articles

Cysteine 288 Regulates NPMc+ Cytoplasmic Localization and Sensitizes Leukemic Cells to Bortezomib-Induced Apoptosis Through a Redox-Sensitive Mechanism

Min Huang, Xinran Li, Beverly S. Mitchell

Blood (2012) 120 (21): 532.

https://doi.org/10.1182/blood.V120.21.532.532

Published: 2012

Journal Articles

Reactivation of Telomerase in Late Generation Tert−/− Mice Results in Reversal of Anemia

Aparna Raval, PhD, Brenda Kusler, BS, Alina Garbuzov, BS, Steven Artandi, MD, PhD, Beverly S. Mitchell

Blood (2012) 120 (21): 1258.

https://doi.org/10.1182/blood.V120.21.1258.1258

Published: 2012

Journal Articles

Defective Hematopoiesis and Erythroid Differentiation Resulting From Telomerase Deficiency

Aparna Raval, PhD, Brenda Kusler, BS, Steven Artandi, MD, PhD, Beverly S. Mitchell, MD

Blood (2011) 118 (21): 2410.

https://doi.org/10.1182/blood.V118.21.2410.2410

Published: 2011

Journal Articles

Ribosomal RNA Expression In CD34+ Hematopoietic Progenitor Cells Inversely Correlates with Ribosomal DNA Methylation In Myelodysplastic Syndromes.

Aparna Raval, PhD, Daniel A Pollyea, MD, Kunju J Shridhar, PhD, Shripa Patel, Peter L. Greenberg, MD, Beverly S. Mitchell, MD

Blood (2010) 116 (21): 1682.

https://doi.org/10.1182/blood.V116.21.1682.1682

Published: 2010

Journal Articles

A Phase I Study of Sequential Azacitidine and Lenalidomide for Elderly Patients with Acute Myeloid Leukemia (AML)

Daniel A Pollyea, MD, Holbrook E Kohrt, MD, Leonel Gallegos, MD, Caroline Berube, MD, Steven Coutre, MD, Jason Gotlib, M.D., M.S., Michaela Liedtke, MD, Beverly S. Mitchell, MD, Bruno C. Medeiros, MD

Blood (2010) 116 (21): 3288.

https://doi.org/10.1182/blood.V116.21.3288.3288

Published: 2010

Journal Articles

A Novel Missense Mutation In An MDS Patient and Effects on TET2 mRNA Expression and Clinical Outcomes

Daniel A Pollyea, MD, Aparna Raval, PhD, Brenda Kusler, Jason R Gotlib, MD, MS, Ash A. Alizadeh, MD, PhD, Beverly S. Mitchell, MD

Blood (2010) 116 (21): 1889.

https://doi.org/10.1182/blood.V116.21.1889.1889

Published: 2010

NARROW

Eptacog Beta (rFVIIa) Has a Low Incidence of Spontaneous Rebleeding through 24 and 48 Hours in Adult and Adolescent Patients with Hemophilia A or B with Inhibitors

Eptacog Beta Efficacy in Children and Adolescents with Hemophilia A or B and Inhibitors: Subset Analysis Suggests Improved Caregiver Capacity to Assess Bleeding Episode Resolution with Subject Age

Single 225μg/Kg Dose Treatment with Eptacog Beta (Factor VIIa, Recombinant) Results in Rapid Hemostasis in Joint Bleeds for Persons with Hemophilia Α or Β with Inhibitors: A PERSEPT1 Subset Analysis

In Vitro Evaluation of Thrombin Generation of Eptacog Beta (Factor VIIa, Recombinant) and Emicizumab in Congenital Hemophilia Α Plasma with and without Inhibitors

PERSEPT3: A Phase 3 Clinical Trial to Evaluate the Hemostatic Efficacy of Eptacog Beta (Recombinant Human FVIIa) in Perioperative Care in Subjects with Hemophilia Α or B with Inhibitors

Protein Kinase C-Theta Interacts with mTORC2 and Vimentin to Limit Regulatory T-Cell Function

Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1

Preclinical Activity of a New Proteasome Inhibitor, MLN9708, in Acute Myelogenous Leukemias Expressing NPM1 Mutated Protein

Interaction of TIF-90 and filamin A in the regulation of rRNA synthesis in leukemic cells

The ASH Clinical Research Training Institute (CRTI) Positively Impacts The Success Of Early Career Hematologists In Patient-Oriented Clinical Research

Activation Of Akt Enhances Ribosomal RNA Synthesis In AML Cells Through a Novel Isoform Of TIF-1A and Inhibition Of Filamin A Cleavage

Are Racial and Ethnic Disparities In Acute Myeloid Leukemia Due To Differences In Treatment?

Reduced rRNA expression and increased rDNA promoter methylation in CD34 + cells of patients with myelodysplastic syndromes

Are Disparities in Acute Myelogenous Leukemia Due to Poor Prognostic Factors At Diagnosis? A National Study

Cysteine 288 Regulates NPMc+ Cytoplasmic Localization and Sensitizes Leukemic Cells to Bortezomib-Induced Apoptosis Through a Redox-Sensitive Mechanism

Reactivation of Telomerase in Late Generation Tert−/− Mice Results in Reversal of Anemia

Defective Hematopoiesis and Erythroid Differentiation Resulting From Telomerase Deficiency

Ribosomal RNA Expression In CD34+ Hematopoietic Progenitor Cells Inversely Correlates with Ribosomal DNA Methylation In Myelodysplastic Syndromes.

A Phase I Study of Sequential Azacitidine and Lenalidomide for Elderly Patients with Acute Myeloid Leukemia (AML)

A Novel Missense Mutation In An MDS Patient and Effects on TET2 mRNA Expression and Clinical Outcomes

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