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Journal Articles

Inhibition of Hyper-Activated Lysosomes Restores Youthful Properties and Functions in Old Hematopoietic Stem Cells

Tasleem Arif, Jiajing Qiu, Saghi Ghaffari

Blood (2022) 140 (Supplement 1): 985.

https://doi.org/10.1182/blood-2022-169540

Published: 2022

Journal Articles

Mild Anemia As a Single Independent Predictor of Mortality in Patients with COVID-19

Douglas Tremblay, MD, Joseph Rapp, Naomi Alpert, William Lieberman-Cribbin, John Mascarenhas, MD, Emanuela Taioli, MD PhD, Saghi Ghaffari, MDPhD

Blood (2020) 136 (Supplement 1): 41–42.

https://doi.org/10.1182/blood-2020-141786

Published: 2020

Journal Articles

Elevated P21 (CDKN1a) Mediates Apoptosis of Beta-Thalassemic Erythroid Cells in Mice but Its Ablation Doesn't Improve Erythroid Maturation

Miao Lin, Vijay Menon, PhD, Raymond Liang, PhD, Tasleem Arif, PhD, Laura Breda, PhD, Stefano Rivella, PhD, Saghi Ghaffari, MDPhD

Blood (2020) 136 (Supplement 1): 19.

https://doi.org/10.1182/blood-2020-143384

Published: 2020

Journal Articles

Activated but Not Quiescent Hematopoietic Stem Cells Rely Readily on Glycolysis As Their Main Source of Energy

Tasleem Arif, PhD, Raymond Liang, PhD, Maio Lin, Msc, Svetlana Kalmikova, Msc, Artem Kasianov, PhD, Vijay Menon, PhD, Dmitri Papatsenko, PhD, Saghi Ghaffari, PhD MD

Blood (2019) 134 (Supplement_1): 271.

https://doi.org/10.1182/blood-2019-129099

Published: 2019

Journal Articles

Identification of Potent Quiescent Human Hematopoietic Stem Cells Using Mitochondrial Profile

Jiajing Qiu, PhD, Jana Gjini, Miao Lin, Msc, Tasleem Arif, PhD, Saghi Ghaffari, PhD MD

Blood (2019) 134 (Supplement_1): 5602.

https://doi.org/10.1182/blood-2019-129913

Published: 2019

Journal Articles

Lysosomal Activation Is Required for Priming of Quiescent Hematopoietic Stem Cells

Tasleem Arif, PhD, Raymond Liang, PhD, Maio Lin, Msc, Svetlana Kalmikova, Msc, Artem Kasianov, PhD, Dmitri Papatsenko, PhD, Saghi Ghaffari, PhD MD

Blood (2019) 134 (Supplement_1): 722.

https://doi.org/10.1182/blood-2019-131934

Published: 2019

Journal Articles

Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities

Marie-Dominique Filippi, Saghi Ghaffari

Blood (2019) 133 (18): 1943–1952.

https://doi.org/10.1182/blood-2018-10-808873

Published: 2019

Journal Articles

Mitochondrial Regulation Is Essential for Erythroid Nuclear Clearance

Raymond Liang, PhD, Vijay Menon, PhD, Miao Lin, Msc, Roberta Nowak, Velia M. Fowler, PhD, Geoffrey Girnun, Saghi Ghaffari, MDPhD

Blood (2018) 132 (Supplement 1): 843.

https://doi.org/10.1182/blood-2018-99-120063

Published: 2018

Journal Articles

Regulation of Hematopoietic Stem Cell Mitochondrial Metabolism

Saghi Ghaffari, MD PhD

Blood (2016) 128 (22): SCI-33.

https://doi.org/10.1182/blood.V128.22.SCI-33.SCI-33

Published: 2016

Journal Articles

Loss of Foxo3 Reduces Erythroblast Apoptosis and Enhances RBC Production in Beta-Thalassemic Mice

Raymond Liang, B.S., Genís Campreciós, PhD, Carolina L. Bigarella, PhD, Saghi Ghaffari, MD PhD

Blood (2015) 126 (23): 756.

https://doi.org/10.1182/blood.V126.23.756.756

Published: 2015

Journal Articles

A Systems Approach Identifies Essential FOXO3 Functions in Erythroblast Enucleation Process

Raymond Liang, Genís Campreciós, PhD, Yan Kou, Ms, Kathleen E McGrath, PhD, Roberta Novak, Seana C Catherman, B.S., Pauline Rimmele, PhD, Carolina L. Bigarella, PhD, Emery H Bresnick, PhD, Dmitri Papatsenko, PhD, Avi Ma'ayan, Velia M. Fowler, PhD, James Palis, MD, Saghi Ghaffari, MD PhD

Blood (2014) 124 (21): 445.

https://doi.org/10.1182/blood.V124.21.445.445

Published: 2014

Journal Articles

The RNA-Degrading Exosome Complex Is an Endogenous Suppressor of Erythroid Maturation

Skye C McIver, PhD, Yoon-A Kang, PhD, Andrew W DeVilbiss, BS, Chelsea A O'Driscoll, BS, David T. Yang, MD, Saghi Ghaffari, MD PhD, Emery H Bresnick, PhD

Blood (2014) 124 (21): 2659.

https://doi.org/10.1182/blood.V124.21.2659.2659

Published: 2014

Journal Articles

The exosome complex establishes a barricade to erythroid maturation

Skye C. McIver, Yoon-A Kang, Andrew W. DeVilbiss, Chelsea A. O’Driscoll, Jonathan N. Ouellette, Nathaniel J. Pope, Genis Camprecios, Chan-Jung Chang, David Yang, Eric E. Bouhassira, Saghi Ghaffari, Emery H. Bresnick

Blood (2014) 124 (14): 2285–2297.

https://doi.org/10.1182/blood-2014-04-571083

Published: 2014

Includes: Supplemental data

Journal Articles

RNA Sequencing Of Adult Bone Marrow Erythroid Populations Reveals Significant Transcriptional Deregulation In Foxo3 -/- Mutant Cells

Genís Campreciós, PhD, Xin Zhang, MD, PhD, Yan Kou, Ms, Avi Ma'ayan, PhD, Saghi Ghaffari, MD, PhD

Blood (2013) 122 (21): 3416.

https://doi.org/10.1182/blood.V122.21.3416.3416

Published: 2013

Journal Articles

Loss Of p53 Rescues The Defective Function Of Foxo3 -/- Hematopoietic Stem Cells But Enhances Their Predisposition To Malignancy

Carolina L. Bigarella, PhD, Pauline Rimmele, PhD, Rebeca Dieguez-Gonzalez, PhD, Raymond Liang, Brigitte Izac, MSc, Dmitri Papatsenko, PhD, Saghi Ghaffari, MD, PhD

Blood (2013) 122 (21): 4199.

https://doi.org/10.1182/blood.V122.21.4199.4199

Published: 2013

Journal Articles

Steady State Differences In Metabolic Properties Of Bone Marrow Versus Spleen Erythroid Cells

Genís Campreciós, PhD, Jeffrey Barminko, PhD, Jeffrey Bernitz, BS, Saghi Ghaffari, MD, PhD

Blood (2013) 122 (21): 943.

https://doi.org/10.1182/blood.V122.21.943.943

Published: 2013

Journal Articles

Foxo3-Mediated Redox Regulation Is Required for DNA Damage Response in Hematopoietic Stem Cells.

Carolina L. Bigarella, PhD, Pauline Rimmele, PhD, Brigitte Izac, MSc, Valentina d'Escamard, MSc, Saghi Ghaffari, MD, PhD

Blood (2012) 120 (21): 2295.

https://doi.org/10.1182/blood.V120.21.2295.2295

Published: 2012

Journal Articles

Acetylation Is Critical for Foxo3 Protein Stability and Activity in Hematopoietic Stem and Progenitor Cells

Carolina L. Bigarella, PhD, Pauline Rimmele, PhD, Raymond Liang, Yasaman Azodi, Brigitte Izac, MSc, Valentina d'Escamard, MSc, Saghi Ghaffari, MD, PhD

Blood (2012) 120 (21): 1198.

https://doi.org/10.1182/blood.V120.21.1198.1198

Published: 2012

Journal Articles

Resveratrol Induces Erythroid Maturation by Activating FOXO3 and Improves in Vivo Erythropoiesis in Normal and Beta -Thalassemic Mice

Sara Santos Franco, PhD student, Luigia De Falco, PhD, Saghi Ghaffari, MD, PhD, Carlo Brugnara, M.D., David Sinclair, PhD, Achille Iolascon, MD, PhD, Mohandas Narla, DSc, Mariarita Bertoldi, PhD, Christophe Lebouf, PhD, Anne Janin, MD, PhD, Angela Siciliano, Mrs, Pauline Rimmele, PhD, Maria Domenica Cappellini, MD, Shady Michan, PhD, Elisa Zoratti, PhD, Lucia De Franceschi, MD

Blood (2012) 120 (21): 3191.

https://doi.org/10.1182/blood.V120.21.3191.3191

Published: 2012

Journal Articles

Metabolic Cross Talk Between Foxo3 and mTOR Is Essential for Hematopoietic Stem Cell Function

Pauline Rimmele, PhD, Valentina d'Escamard, MSc, Kocabas Fatih, Ph.D, Chengcheng Zhang, Ph.D, Hesham A. Sadek, M.D., Ph.D, Saghi Ghaffari, MD, PhD

Blood (2012) 120 (21): 856.

https://doi.org/10.1182/blood.V120.21.856.856

Published: 2012

NARROW

Inhibition of Hyper-Activated Lysosomes Restores Youthful Properties and Functions in Old Hematopoietic Stem Cells

Mild Anemia As a Single Independent Predictor of Mortality in Patients with COVID-19

Elevated P21 (CDKN1a) Mediates Apoptosis of Beta-Thalassemic Erythroid Cells in Mice but Its Ablation Doesn't Improve Erythroid Maturation

Activated but Not Quiescent Hematopoietic Stem Cells Rely Readily on Glycolysis As Their Main Source of Energy

Identification of Potent Quiescent Human Hematopoietic Stem Cells Using Mitochondrial Profile

Lysosomal Activation Is Required for Priming of Quiescent Hematopoietic Stem Cells

Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities

Mitochondrial Regulation Is Essential for Erythroid Nuclear Clearance

Regulation of Hematopoietic Stem Cell Mitochondrial Metabolism

Loss of Foxo3 Reduces Erythroblast Apoptosis and Enhances RBC Production in Beta-Thalassemic Mice

A Systems Approach Identifies Essential FOXO3 Functions in Erythroblast Enucleation Process

The RNA-Degrading Exosome Complex Is an Endogenous Suppressor of Erythroid Maturation

The exosome complex establishes a barricade to erythroid maturation

RNA Sequencing Of Adult Bone Marrow Erythroid Populations Reveals Significant Transcriptional Deregulation In Foxo3 -/- Mutant Cells

Loss Of p53 Rescues The Defective Function Of Foxo3 -/- Hematopoietic Stem Cells But Enhances Their Predisposition To Malignancy

Steady State Differences In Metabolic Properties Of Bone Marrow Versus Spleen Erythroid Cells

Foxo3-Mediated Redox Regulation Is Required for DNA Damage Response in Hematopoietic Stem Cells.

Acetylation Is Critical for Foxo3 Protein Stability and Activity in Hematopoietic Stem and Progenitor Cells

Resveratrol Induces Erythroid Maturation by Activating FOXO3 and Improves in Vivo Erythropoiesis in Normal and Beta -Thalassemic Mice

Metabolic Cross Talk Between Foxo3 and mTOR Is Essential for Hematopoietic Stem Cell Function

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American Society of Hematology

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American Society of Hematology

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