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Samir H Barghout, BSPharm, MSc
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Journal Articles

Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism

Rashim Pal Singh, MSc,PhD, Danny V. Jeyaraju, PhD, Veronique Voisin, PhD, Changjiang Xu, Samir H Barghout, BSPharm, MSc, Dilshad H. Khan, Rose Hurren, BSc, Marcela Gronda, MSc, Xiaoming Wang, Yulia Jitkova, PhD, David Sharon, PhD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Joelle Soriano, Eric R. Lechman,, PhD MSC, Neil MacLean, Mark D. Minden, MD PhD, Steven M Chan, MD PhD, John E. Dick, Gary D Bader, Aaron Schimmer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1339.
https://doi.org/10.1182/blood-2018-99-111015
Published: 2018
Journal Articles

A Genome-Wide CRISPR/Cas9 Knockout Screen Identifies BEND3 As a Determinant of Sensitivity to UBA1 Inhibition in Acute Myeloid Leukemia

Samir H Barghout, BSPharm, MSc, Neil MacLean, G. Wei Xu, Geethu Thomas, PhDMSc,BSc, Zachary Blatman, Rose Hurren, BSc, Aaron D Schimmer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1350.
https://doi.org/10.1182/blood-2018-99-110406
Published: 2018
Journal Articles

Patients Who Are Refractory to Ida-FLAG As Initial Induction Chemotherapy for AML Have Persistence of the Dominant Genetic Mutations and a Poor Clinical Outcome

Simon Kavanagh, Emily Heath, Rose Hurren, BSc, Samir H. Barghout, BSPharm, MSc, Sanduni U. Liyanage, Hon. B. Sc, PhD, Thirushi Siriwardena, Jaime Claudio, Tong Zhang, Mahadeo Sukhai, Tracy L. Stockley, Suzanne Kamel-Reid, Amr Rostom, MD, Dina Khalaf, BSc, MSc, MD, Andrzej Lutynski, Anna Rydlewski, MD, Andre C. Schuh, MD FRCPC, Vikas Gupta, MD PhD, Hassan Sibai, MBBS, Dawn Maze, MD FRCPC, MSc, Steven M. Chan, MDPhD, Aaron D. Schimmer, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2596.
https://doi.org/10.1182/blood.V130.Suppl_1.2596.2596
Published: 2017
Journal Articles

TAK-243 Is a Selective UBA1 Inhibitor That Displays Preclinical Activity in Acute Myeloid Leukemia (AML)

Samir H. Barghout, BSPharm, MSc, Parasvi Patel, BSc (Hons), Xiaoming Wang, G. Wei Xu, Simon Kavanagh, Marcela Gronda, MSc, Rose Hurren, BSc, Danny V. Jeyaraju, PhD, Neil MacLean, Marc Hyer, PhD, Allison Berger, PhD, Tary Traore, Michael Sintchak, Michael Milhollen, Mark D. Minden, MD PhD, Razq Hakem, PhD, Aaron D. Schimmer, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 814.
https://doi.org/10.1182/blood.V130.Suppl_1.814.814
Published: 2017
Journal Articles

Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells

Danny V. Jeyaraju, PhD, Veronique Voisin, Changjiang Xu, Samir H. Barghout, BSPharm, MSc, Dilshad H. Khan, Rose Hurren, BSc, Marcela Gronda, MSc, Xiaoming Wang, Yulia Jitkova, PhD, David Sharon, PhD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Joelle Soriano, Eric R. Lechman, PhD, Neil MacLean, Mark D. Minden, MD PhD, Steven M. Chan, MDPhD, John E. Dick, PhD, Gary D Bader, Aaron D. Schimmer, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 881.
https://doi.org/10.1182/blood.V130.Suppl_1.881.881
Published: 2017