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Journal Articles

Deferasirox Associated to Liver Failure and Death in a Sickle Cell Anemia Patient Homozygous for the -1774delG Polymorphism in the ABCC2 Gene Encoding Multidrug Resistance Protein 2 (MRP2)

Caroline Cordeiro Barroso Braga, Bruno Deltreggia Benites, MD, Dulcineia M de Albuquerque, Marisa Claudia Alvarez, Fernando F Costa, PhD MD, Simone C O Gilli, MD PhD, Sara T.O. Saad, MD PhD

Blood (2016) 128 (22): 4822.

https://doi.org/10.1182/blood.V128.22.4822.4822

Published: 2016

Journal Articles

Circulating Lipoprotein Concentrations Correlate with Total but Not Free Heme in Different Sickle Cell Disease Genotypes

Felipe Vendrame, M.Sc., Sara T.O. Saad, MD, PhD, Fernando F Costa, MD, PhD, Kleber Yotsumoto Fertrin, MD, PhD

Blood (2015) 126 (23): 4580.

https://doi.org/10.1182/blood.V126.23.4580.4580

Published: 2015

Journal Articles

Hypersegmented Neutrophil Percentage Using Automated Digital Cell Morphology: A Simple Laboratory Parameter to Monitor Hydroxyurea Therapy in Sickle Cell Disease Patients

Kleber Yotsumoto Fertrin, MD, PhD, Elza Miyuki Kimura, B.Sc., Fernanda Madureira de Oliveira Araujo, B.Sc., Maria de Fatima Pereira Gilberti, MD, Sara T.O. Saad, MD, PhD, Fernando F Costa, MD, PhD

Blood (2015) 126 (23): 2188.

https://doi.org/10.1182/blood.V126.23.2188.2188

Published: 2015

Journal Articles

Nix (BNIP3L) Is Downregulated in High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia and Its Silencing Enhances Decitabine-Mediated Apoptosis

Mariana Lazarini, PhD, João Agostinho Machado-Neto, MSc, Adriana Silva Santos Duarte, PhD, Fernando V Pericole, MD, Karla Priscila Ferro, PhD, Paula de Melo Campos, MD, Fabiola Traina, MD PhD, Sara T.O. Saad, MD, PhD

Blood (2014) 124 (21): 3239.

https://doi.org/10.1182/blood.V124.21.3239.3239

Published: 2014

Journal Articles

Arhgap21 +/- Mice Show Impaired Adhesion, Migration, Homing and Short Term Reconstitution of Hematopoietic Progenitor Cells

Juliana M. Xavier, Ricon Lauremília, PhD, Vieira Karla, PhD, Longhini Ana Leda, PhD, Franchi Gilberto, Jr, Nowill Alexandre, MD PhD, Carolina Bigarella, PhD, Sara T.O Saad, MD, PhD

Blood (2014) 124 (21): 4333.

https://doi.org/10.1182/blood.V124.21.4333.4333

Published: 2014

Journal Articles

Inhibition of Phosphodiesterase 9A (PDE9A) Significantly Reduces Cytokine-Stimulated Adhesion of Neutrophils From Sickle Cell Disease Individuals, in Vitro , but Not Red Cell Adhesion.

Lediana I Miguel, B.Sc., Camila B. Almeida, M.Sc., Carla F Franco-Penteado, Ph.D, Marcos André C Bezerra, Ph.D., Fabiola Traina, M.D., Ph.D., Venina M Dominical, B.Sc., Aderson S Araujo, M.D., Ph.D., Sara T.O. Saad, M.D, Ph.D., Fernando F. Costa, Ph.D., M.D., Nicola Conran, Ph.D.

Blood (2009) 114 (22): 1520.

https://doi.org/10.1182/blood.V114.22.1520.1520

Published: 2009

Journal Articles

Alpha-Catenin, ARHGAP21 and β-Catenin Are Abnormally Expressed in Bone Marrow Cells From Patients with Myelodysplatic Syndromes and Are a Possible Target for Decitabine Treatment.

Karin Spat Barcellos, PhD, in, Molecular, Biology, Sheila Maria Winnischofer, PhD, Mariana Lazarini, Master, Degree, Doctorate, Stude, Adriana Silva Santos Duarte, PhD, Carolina Louzao Bigarella, PhD, Fabiola Traina, MD, PhD, Fernando Ferreira Costa, Ph.D., M.D., Sara T.O Saad, M.D., Ph.D.

Blood (2009) 114 (22): 1778.

https://doi.org/10.1182/blood.V114.22.1778.1778

Published: 2009

Journal Articles

IRS1 and SHP2 Signaling in Myelodysplastic Syndrome and Acute Myeloid Leukemia.

Fabiola Traina, MD, PhD, João Agostinho Machado Neto, BSci, Arthur Antolini, Flavio Araújo Borges, Junior, Mariana Lazarini, Master, Degree, Doctorate, Stude, Patricia M.B. Favaro, PhD, Leticia Fröhlich -Archangelo, PhD, Paulo C.A. Pernanbuco Filho, Adriana Silva Santos Duarte, PhD, Fernando Ferreira Costa, Ph.D., M.D., Sara T.O Saad, M.D., Ph.D.

Blood (2009) 114 (22): 1779.

https://doi.org/10.1182/blood.V114.22.1779.1779

Published: 2009

Journal Articles

MDM2 SNP309 and TP53 SNPArg72Pro Polymorphisms in Myelodysplastic Syndrome.

João Agostinho Machado Neto, BSci, Fabiola Traina, MD, PhD, Paula Melo Campos, BSci, Marilisia Andreoli, BSci, Irene Lorand Metze, Ph.D., Fernando Ferreira Costa, PhD, MD, Sara T.O. Saad, MD, PhD

Blood (2009) 114 (22): 1745.

https://doi.org/10.1182/blood.V114.22.1745.1745

Published: 2009

Journal Articles

Upregulation of the Anti-Apoptotic Protein, Survivin, in Hematopoietic Cells in Sickle Cell Anemia and Effects of Hydroxyurea Therapy.

Carolina Lanaro, B.Sc., Ph.D, Carla Fernanda Franco-Penteado, B.Sc., M.Sc., Ph.D, Mariana R. B. Mello, B.Sc., M.Sc, Kleber Yotsumoto Fertrin, MD, Marcos André C Bezerra, Ph.D., Dulcinéia M. Albuquerque, B.Sc., M.Sc., Ph.D, Nicola Conran, Ph.D., Sara T.O. Saad, MD, PhD, Aderson S. Araujo, M.D., Ph.D., Fernando F. Costa, PhD, MD

Blood (2009) 114 (22): 1532.

https://doi.org/10.1182/blood.V114.22.1532.1532

Published: 2009

Journal Articles

Effect of High Levels of Growth Differentiation Factor 15 (GDF15) On Hepcidin Expression in Monocytes of β-Thalassemia Intermedia Patients.

Kleber Yotsumoto Fertrin, MD, Carolina Lanaro, B.Sc., Ph.D, Carla Fernanda Franco-Penteado, B.Sc., M.Sc., Ph.D, Dulcinéia M Albuquerque, B.Sc., M.Sc.,Ph.D, Mariana R. B. Mello, B.Sc., M.Sc, Marcos André C Bezerra, Ph.D., Betania Lucena Borges Tavares Domingues, B.Sc, Sara T.O Saad, M.D., Ph.D., Aderson S Araujo, M.D., Ph.D., Fernando Ferreira Costa, Ph.D., M.D.

Blood (2009) 114 (22): 4061.

https://doi.org/10.1182/blood.V114.22.4061.4061

Published: 2009

Journal Articles

Inflammatory Mediators Are Increased in Leukocytes of IVS-I-6 (T→C) Homozygous β-Thalassemia Intermedia.

Marcos André C Bezerra, B.Sc., M.Sc., Ph.D., Carla Fernanda Franco-Penteado, B.Sc., M.Sc., Ph.D, Carolina Lanaro, B.Sc., Ph.D, Mariana R. B. Mello, B.Sc., M.Sc, Sheley Gambero, B.Sc., M.Sc, Dulcinéia M Albuquerque, B.Sc., M.Sc., Ph.D, Kleber Yotsumoto Fertrin, MD, Sara T.O Saad, Ph.D., M.D., Aderson S Araujo, M.D., Ph.D., Fernando Ferreira Costa, Ph.D., M.D.

Blood (2009) 114 (22): 4068.

https://doi.org/10.1182/blood.V114.22.4068.4068

Published: 2009

Journal Articles

Hydroxyurea Therapy Is Associated with Decreased Platelet Aggregation Responses and Activation in Sickle Cell Disease.

Renata Proença-Ferreira, M.Sc., Tania F.G.S. Machado, Fabiola Traina, M.D., Ph.D., Sara T.O. Saad, M.D., Ph.D., Fernando Ferreira Costa, Ph.D., M.D., Nicola Conran, Ph.D.

Blood (2009) 114 (22): 2565.

https://doi.org/10.1182/blood.V114.22.2565.2565

Published: 2009

Journal Articles

Increased Adhesive Properties and Reactive Oxygen Species of Red Cells, Platelets and Leukocytes and Neutrophil Chemotaxis in IVS-1-6 (T → C) Homozygous β-Thalassemia Intermedia.

Carla Fernanda Franco-Penteado, B.Sc., M.Sc., Ph.D, Marcos André Cavalcanti Bezerra, B.Sc., M.Sc, Mariana R. B. Mello, B.Sc., M.Sc, Sheley Gambero, B.Sc., M.Sc, Dulcinéia M Albuquerque, B.Sc., M.Sc., Ph.D, Carolina Lanaro, B.Sc., Ph.D, Sara T.O. Saad, MD, PhD, Aderson S. Araújo, M.D., Ph.D., Fernando F. Costa, PhD, MD

Blood (2008) 112 (11): 1873.

https://doi.org/10.1182/blood.V112.11.1873.1873

Published: 2008

Journal Articles

ANKHD1, a New Ankyrin-Repeat Protein, Binds to SIVA and May Modulate ROS Generation, Cell Cycle and Apoptosis Signaling in Cancer Cells

Fabiola Traina, MD, PhD, Patrícia Cristina Rodrigues, M.Sc., Mariana Lazarini, M.Sc., Paulo Roberto Moura Lima, PhD, Fernando F. Costa, MD, PhD, Sara T.O. Saad, MD, PhD

Blood (2008) 112 (11): 5319.

https://doi.org/10.1182/blood.V112.11.5319.5319

Published: 2008

Journal Articles

Simvastatin Reduces the in Vitro Adhesion of Sickle Cell Disease Neutrophils to Endothelial Layers

Andreia A Canalli, B.Sc., Ph.D., Renata P. Ferreira, B.Sc., Sara T.O. Saad, MD, PhD, Nicola Conran, B.Sc, PhD, Fernando F. Costa, M.D., Ph.D.

Blood (2008) 112 (11): 2489.

https://doi.org/10.1182/blood.V112.11.2489.2489

Published: 2008

Journal Articles

Production and Expression of Inflammatory Mediators in Leukocytes of Sickle Cell Anaemia Patients and Effects of Hydroxyurea Therapy on This Production

Carolina Lanaro, B.Sc., Ph.D, Carla Fernanda Franco-Penteado, B.Sc., M.Sc., Ph.D, Dulcinéia M Albuquerque, B.Sc., M.Sc., Ph.D, Sara T.O. Saad, MD, PhD, Nicola Conran, B.Sc., Ph.D, Fernando F. Costa, PhD, MD

Blood (2008) 112 (11): 2490.

https://doi.org/10.1182/blood.V112.11.2490.2490

Published: 2008

Journal Articles

Platelets from Sickle Cell Disease Individuals Demonstrate Increased Adhesive Properties That Are Reversed by Hydroxyurea Therapy in Association with Alterations in Intraplatelet cAMP and α IIb α 3 Integrin Activation

Renata P. Ferreira, B.Sc., Carla F. Franco-Penteado, Ph.D., Sara T.O. Saad, M.D., Ph.D., Fernando F. Costa, M.D., Ph.D., Nicola Conran, Ph.D.

Blood (2008) 112 (11): 2472.

https://doi.org/10.1182/blood.V112.11.2472.2472

Published: 2008

Journal Articles

Induction of Caspase-Independent Apoptosis by Sickle Cell Disease (SCD) Serum in Non-SCD Leukocytes

Camila B. Almeida, M.Sc., Fernanda Gonçalves Pereira, M.Sc., Irene Lorand Metze, MD, Ph.D., Sara T.O. Saad, MD, PhD, Fernando F. Costa, PhD, MD, Nicola Conran, Ph.D.

Blood (2008) 112 (11): 2475.

https://doi.org/10.1182/blood.V112.11.2475.2475

Published: 2008

Journal Articles

Expression of High Levels of Human γ-Globin in Adult Mice Carrying a Transgene of the Brazilian Type of Hereditary Persistence of Fetal Hemoglobin.

Anderson F. Cunha, PhD, Ana F. Brugnerotto, Monica B. Melo, PhD, Marcus A.F. Corat, PhD, Ana P. Gimenes, Luiz A.C. Passos, PhD, Emily E. Devlin, PhD, David M. Bodine, PhD, Sara T.O. Saad, MD, PhD, Fernando F. Costa, MD, PhD

Blood (2007) 110 (11): 3831.

https://doi.org/10.1182/blood.V110.11.3831.3831

Published: 2007

NARROW

Deferasirox Associated to Liver Failure and Death in a Sickle Cell Anemia Patient Homozygous for the -1774delG Polymorphism in the ABCC2 Gene Encoding Multidrug Resistance Protein 2 (MRP2)

Circulating Lipoprotein Concentrations Correlate with Total but Not Free Heme in Different Sickle Cell Disease Genotypes

Hypersegmented Neutrophil Percentage Using Automated Digital Cell Morphology: A Simple Laboratory Parameter to Monitor Hydroxyurea Therapy in Sickle Cell Disease Patients

Nix (BNIP3L) Is Downregulated in High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia and Its Silencing Enhances Decitabine-Mediated Apoptosis

Arhgap21 +/- Mice Show Impaired Adhesion, Migration, Homing and Short Term Reconstitution of Hematopoietic Progenitor Cells

Inhibition of Phosphodiesterase 9A (PDE9A) Significantly Reduces Cytokine-Stimulated Adhesion of Neutrophils From Sickle Cell Disease Individuals, in Vitro , but Not Red Cell Adhesion.

Alpha-Catenin, ARHGAP21 and β-Catenin Are Abnormally Expressed in Bone Marrow Cells From Patients with Myelodysplatic Syndromes and Are a Possible Target for Decitabine Treatment.

IRS1 and SHP2 Signaling in Myelodysplastic Syndrome and Acute Myeloid Leukemia.

MDM2 SNP309 and TP53 SNPArg72Pro Polymorphisms in Myelodysplastic Syndrome.

Upregulation of the Anti-Apoptotic Protein, Survivin, in Hematopoietic Cells in Sickle Cell Anemia and Effects of Hydroxyurea Therapy.

Effect of High Levels of Growth Differentiation Factor 15 (GDF15) On Hepcidin Expression in Monocytes of β-Thalassemia Intermedia Patients.

Inflammatory Mediators Are Increased in Leukocytes of IVS-I-6 (T→C) Homozygous β-Thalassemia Intermedia.

Hydroxyurea Therapy Is Associated with Decreased Platelet Aggregation Responses and Activation in Sickle Cell Disease.

Increased Adhesive Properties and Reactive Oxygen Species of Red Cells, Platelets and Leukocytes and Neutrophil Chemotaxis in IVS-1-6 (T → C) Homozygous β-Thalassemia Intermedia.

ANKHD1, a New Ankyrin-Repeat Protein, Binds to SIVA and May Modulate ROS Generation, Cell Cycle and Apoptosis Signaling in Cancer Cells

Simvastatin Reduces the in Vitro Adhesion of Sickle Cell Disease Neutrophils to Endothelial Layers

Production and Expression of Inflammatory Mediators in Leukocytes of Sickle Cell Anaemia Patients and Effects of Hydroxyurea Therapy on This Production

Platelets from Sickle Cell Disease Individuals Demonstrate Increased Adhesive Properties That Are Reversed by Hydroxyurea Therapy in Association with Alterations in Intraplatelet cAMP and α IIb α 3 Integrin Activation

Induction of Caspase-Independent Apoptosis by Sickle Cell Disease (SCD) Serum in Non-SCD Leukocytes

Expression of High Levels of Human γ-Globin in Adult Mice Carrying a Transgene of the Brazilian Type of Hereditary Persistence of Fetal Hemoglobin.

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American Society of Hematology

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