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Journal Articles

Venetoclax and Azacitidine for Newly Diagnosed Non-Elderly Adult Patients with Acute Myeloid Leukemia and Adverse Risk Features

Jonathan A. Gutman, MD, Amanda Winters, MDPhD, Maria L Amaya, MD PhD, Christine M. McMahon, MD, Jeffrey Schowinsky, MD, Diana Abbott, PhD, Andrew Hammes, MS, Shanshan Pei, PhD, Brett M. Stevens, PhD, Craig T. Jordan, PhD, Clayton Smith, MD, Daniel A. Pollyea
Journal: Blood
Blood (2020) 136 (Supplement 1): 9.
https://doi.org/10.1182/blood-2020-136120
Published: 2020
Journal Articles

Developmental Plasticity of Acute Myeloid Leukemia Mediates Resistance to Venetoclax-Based Therapy

Shanshan Pei, PhD, Daniel A Pollyea, MD, Annika Gustafson, Mohammad Minhajuddin, PhD, Brett M. Stevens, PhD, Haobin Ye, PhD, Anagha Inguva, BSc, Maria L Amaya, MD PhD, Anna Krug, BS, Courtney L Jones, PhD, Biniam Adane, PhD, Amanda Winters, MD PhD, Nabilah Khan, Jessica Ponder, PhD, Jeffrey Schowinsky, Andrew Hammes, MS, Diana Abbott, PhD, Jason R Myers, MS, John M Ashton, PhD, Jonathan A Gutman, MD, Enkhtsetseg Purev, MD PhD, Haley E. Ramsey, PhDMSc, Michael R. Savona, MD, Stephen W. Fesik, PhD, Clayton Smith, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 185.
https://doi.org/10.1182/blood-2019-131390
Published: 2019
Journal Articles

Venetoclax and Azacitidine for Older Newly Diagnosed Patients with Acute Myeloid Leukemia: A Single-Institution Pilot Study Using Measurable Residual Disease to Guide Therapy

Amanda Winters, MD PhD, Jonathan A Gutman, MD, Enkhtsetseg Purev, MD PhD, Brett M. Stevens, PhD, Shanshan Pei, PhD, Jeffrey Schowinsky, Diana Abbott, PhD, Andrew Hammes, MS, Molly Nakic, Lindsey Lyle, Keri Halsema, Dwight Macero, PA-C, Alex Hirose, Chelsey Boggs, Angie Falco, Natalie Monson, Shirstine Rahkola, Sarah Wright, Tyler D'Ovidio, Clayton Smith, MD, Craig T Jordan, PhD, Daniel A Pollyea, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2638.
https://doi.org/10.1182/blood-2019-122120
Published: 2019
Journal Articles

Inhibition of Fatty Acid Metabolism Re-Sensitizes Resistant Leukemia Stem Cells to Venetoclax with Azacitidine

Courtney L Jones, PhD, Brett M. Stevens, PhD, Rachel Culp-Hill, BS, Angelo Dalessandro, PhD, Anna Krug, BS, Madeline Goosman, Shanshan Pei, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1272.
https://doi.org/10.1182/blood-2019-125773
Published: 2019
Journal Articles

STAT3 Plays a Critical Role in Mitochondrial Function and Survival of Primary AML Cells

Maria L Amaya, MD PhD, Anagha Inguva, BSc, Courtney L Jones, PhD, Anna Krug, BS, Shanshan Pei, PhD, Phillip Reigan, PhD, Craig T Jordan, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1275.
https://doi.org/10.1182/blood-2019-127669
Published: 2019
Journal Articles

Leukemia Stem Cells in Relapsed AML Patients Are Uniquely Dependent on Nicotinamide Metabolism

Courtney L Jones, PhD, Brett M Stevens, PhD, Rachel Culp-Hill, BS, Travis Nemkov, Angelo D'Alessandro, PhD, Shanshan Pei, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 429.
https://doi.org/10.1182/blood-2018-99-111366
Published: 2018
Journal Articles

Relapsed Acute Myeloid Leukemia Is Less Sensitive to Venetoclax + Azacitidine Due to Leukemia Stem Cell Resistance Driven By Fatty Acid Metabolism and Can be Overcome By Pharmacologic Inhibition of CPT1

Daniel A Pollyea, MD, Courtney L Jones, PhD, Brett M Stevens, PhD, Shanshan Pei, PhD, Angelo D'Alessandro, PhD, Rachel Culp-Hill, BS, Diana Abbott, PhD, Andrew Hammes, MS, James Dugan, MD, Jonathan A Gutman, MD, Enkhtsetseg Purev, MD PhD, Clayton Smith, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 432.
https://doi.org/10.1182/blood-2018-99-111507
Published: 2018
Journal Articles

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

Courtney L Jones, PhD, Brett M Stevens, PhD, Angelo D'Alessandro, PhD, Julia Reisz, PhD, Rachel Culp-Hill, BS, Travis Nemkov, Shanshan Pei, PhD, Nabilah Khan, Biniam Adane, PhD, Haobin Ye, PhD, Dominik Reinhold, Clayton Smith, MD, James DeGregori, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1521.
https://doi.org/10.1182/blood-2018-99-111965
Published: 2018
Journal Articles

Mitochondrial Fission 1 Regulates GSK3 and AMPK Signaling to Sustain Leukemia Stem Cell Function in Acute Myelogenous Leukemia

Shanshan Pei, PhD, Mohammad Minhajuddin, PhD, Biniam Adane, BS, Brett M Stevens, PhD, Nabilah Khan, PhD, Angelo D'alessandro, PhD, Travis Nemkov, Kirk C Hansen, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2016) 128 (22): 1703.
https://doi.org/10.1182/blood.V128.22.1703.1703
Published: 2016
Journal Articles

The Role of NADPH Oxidase 2 in Normal and Malignant Hematopoiesis

Biniam Adane, BS, Haobin Ye, PhD, Shanshan Pei, PhD, Nabilah Khan, PhD, Mohammad Minhajuddin, PhD, Brett M Stevens, PhD, Vadym Zaberezhnyy, Daniel A Pollyea, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2016) 128 (22): 1079.
https://doi.org/10.1182/blood.V128.22.1079.1079
Published: 2016
Journal Articles

Regulation of Mitochondrial Morphology Is Important for Leukemia Stem Cell Function

Shanshan Pei, PhD, Mohammad Minhajuddin, PhD, Brett M Stevens, PhD, Biniam Adane, Nabilah Khan, PhD, Angelo D'alessandro, PhD, Travis Nemkov, Kirk C Hansen, PhD, Daniel Pollyea, MD MS, Craig T Jordan, PhD
Journal: Blood
Blood (2015) 126 (23): 842.
https://doi.org/10.1182/blood.V126.23.842.842
Published: 2015
Journal Articles

Cellular Iron Status Is Associated with Better Survival and Increased Chemotherapy Sensitivity in AML

Paul A. Seligman, MD, Shanshan Pei, PhD, Jeffrey R. Parrish, BS, Rhoda B. Schleicher, MS, Prakhar Singal, Craig T Jordan, PhD
Journal: Blood
Blood (2015) 126 (23): 4975.
https://doi.org/10.1182/blood.V126.23.4975.4975
Published: 2015
Journal Articles

Aldehyde Dehydrogenases Play a Role in Acute Myeloid Leukemia and Have Prognostic and Therapeutic Significance

Maura Gasparetto, MD, Shanshan Pei, PhD, Mohammad Minhajuddin, PhD, Daniel A. Pollyea, MD MS, Vasilis Vasiliou, PhD, R. Keith Humphries, MD PhD, Craig T. Jordan, PhD, Clayton A. Smith, MD FRCPC
Journal: Blood
Blood (2014) 124 (21): 2238.
https://doi.org/10.1182/blood.V124.21.2238.2238
Published: 2014