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Journal Articles

A Spacer Sequence Inserted between the A1 and A2 Domains of Factor VIII Overcomes the Requirement for Proteolytic Cleavage at Arg 372 in the Generation of Cofactor Activity

Manjunath Goolyam Basavaraj, PhD, Sriram Krishnaswamy, PhD

Blood (2020) 136 (Supplement 1): 21.

https://doi.org/10.1182/blood-2020-142522

Published: 2020

Journal Articles

A Novel Variant of Factor VIII Yields Cofactor Activity without Proteolysis between the A1 and A2 Domains

Manjunath Goolyam Basavaraj, PhD, Sriram Krishnaswamy, PhD

Blood (2018) 132 (Supplement 1): 3771.

https://doi.org/10.1182/blood-2018-99-116267

Published: 2018

Journal Articles

JNJ-64179375 Inhibits Exosite I-Mediated Thrombin Activity While Preserving Exosite II and Active Site Function in Vitro

Matthew Bunce, PhD, Madhu Chintala, PhD, Sriram Krishnaswamy, PhD, Harlan N Bradford, BA

Blood (2018) 132 (Supplement 1): 24.

https://doi.org/10.1182/blood-2018-99-116291

Published: 2018

Journal Articles

A Single Cleavage Reaction in the Proteolytic Activation of Factor V to the Cofactor Is Rate-Limiting in a Step That Is Selectively Dependent on Anion Binding Exosite 2 of Thrombin

Harlan N Bradford, BA, Sriram Krishnaswamy, PhD

Blood (2017) 130 (Supplement 1): 3649.

https://doi.org/10.1182/blood.V130.Suppl_1.3649.3649

Published: 2017

Journal Articles

Structural Basis for the Procofactor to Cofactor Transition in Human Factor V

Shekhar Kumar, PhD, Wei Deng, PhD, Steven Stayrook, PhD, Renhao Li, PhD, Rodney M. Camire, PhD, Sriram Krishnaswamy, PhD

Blood (2016) 128 (22): 253.

https://doi.org/10.1182/blood.V128.22.253.253

Published: 2016

Journal Articles

Prothrombin Membrane Binding and Gla-Dependent Function Are Not Required for Effective Hemostasis In Vivo

Lindsey A. Greene, MD, Nabil K. Thalji, BS, Harlan Bradford, BA, Sriram Krishnaswamy, PhD MD, Rodney M. Camire, PhD

Blood (2015) 126 (23): 124.

https://doi.org/10.1182/blood.V126.23.124.124

Published: 2015

Journal Articles

The NET Effect: Platelet Factor 4 and DNA-Histone Interactions in Sepsis

Kandace Gollomp, MD, Johnston Ian, Diarra Fatoumata, Guohua Zhao, Sriram Krishnaswamy, PhD MD, Mortimer Poncz, MD, M. Anna Kowalska, PhD

Blood (2015) 126 (23): 2197.

https://doi.org/10.1182/blood.V126.23.2197.2197

Published: 2015

Journal Articles

Long-Range Allosteric Linkage Between Exosites Reciprocally Regulates the Zymogenicity of Prothrombin Derivatives

Joseph A. Micucci, PhD, Parvathi Kamath, PhD, Anuja Khan, PhD, Paul E. Bock, PhD, Sriram Krishnaswamy, PhD

Blood (2015) 126 (23): 122.

https://doi.org/10.1182/blood.V126.23.122.122

Published: 2015

Journal Articles

The Affinity of Factor X for the Intrinsic Xase Is Determined By Exosite Interactions Between the Substrate and the Enzyme Complex

Manjunath Goolyam Basavaraj, PhD, Sriram Krishnaswamy, PhD

Blood (2015) 126 (23): 1065.

https://doi.org/10.1182/blood.V126.23.1065.1065

Published: 2015

Journal Articles

The X-Ray Structure of a Variant of Human Factor V Provides Structural Insights into the Procofactor Activation Paradox

Shekhar Kumar, PhD, Steven Stayrook, PhD, Rodney M. Camire, PhD, Sriram Krishnaswamy, PhD

Blood (2015) 126 (23): 121.

https://doi.org/10.1182/blood.V126.23.121.121

Published: 2015

Journal Articles

Platelet Pitp-Alpha Promotes Thrombin Generation and the Dissemination of Tumor Metastasis, but Has Minimal Effect on Vascular Plug Formation

Liang Zhao, PhD, Lurong Lian, Aae Suzuki, Timothy J. Stalker, PhD, Sang H Min, MD, Sriram Krishnaswamy, PhD MD, Amy Durham, VMD, Charles S. Abrams, MD

Blood (2015) 126 (23): 418.

https://doi.org/10.1182/blood.V126.23.418.418

Published: 2015

Journal Articles

Assembly of Prothrombinase on Endothelial Cells: Receptor-Mediated or Phospholipid-Driven?

Mikhail Galkin, PhD, Harlan Bradford, BA, Sriram Krishnaswamy, PhD

Blood (2015) 126 (23): 2267.

https://doi.org/10.1182/blood.V126.23.2267.2267

Published: 2015

Journal Articles

Distinct Mechanism of Anti-Hemophilic FVIII Activation By Nascent FXa in the Tissue Factor-FVIIa Coagulation Initiation Complex Resistant to FXa-Directed Inhibition

Yuichi Kamikubo, PhD, Grazia Loredana Mendolicchio, MD PhD, Antonella Zampolli, PhD, Patrizia Marchese, PhD, Andrew J. Gale, PhD, Sriram Krishnaswamy, PhD, Andras Gruber, MD, Lars Christian Petersen, Wolfram Ruf, MD, Zaverio M Ruggeri, MD

Blood (2014) 124 (21): 2803.

https://doi.org/10.1182/blood.V124.21.2803.2803

Published: 2014

Journal Articles

X-Ray Structure of an Anticoagulant RNA Aptamer Bound to Factor Xa. Structural Basis for Its Ability to Disrupt Interactions Between Xa and Va within Prothrombinase

Shekhar Kumar, PhD, Bruce A. Sullenger, PhD, Steven Stayrook, PhD, Sriram Krishnaswamy, PhD

Blood (2014) 124 (21): 4232.

https://doi.org/10.1182/blood.V124.21.4232.4232

Published: 2014

Journal Articles

A Proposed Role for Platelet Factor 4 in Histone Pathobiology in Sepsis

M. Anna Kowalska, PhD, Guohua Zhao, PhD, Ian Johnston, BS, Elsa Treffeisen, BA, Fatoumata Diarra, Sriram Krishnaswamy, PhD, Mortimer Poncz, MD

Blood (2014) 124 (21): 98.

https://doi.org/10.1182/blood.V124.21.98.98

Published: 2014

Journal Articles

New Structural Insights into High Affinity Membrane Binding By Coagulation Factor V/Va

Shekhar Kumar, PhD, Steven Stayrook, PhD, James A. Huntington, PhD, Rodney M. Camire, PhD, Sriram Krishnaswamy, PhD

Blood (2014) 124 (21): 4216.

https://doi.org/10.1182/blood.V124.21.4216.4216

Published: 2014

Journal Articles

Meizothrombin Is Unexpectedly Zymogen-Like: Its Slow Conversion to Proteinase Dominates Thrombin Production by Prothrombinase

Harlan Bradford, BA, Sriram Krishnaswamy, PhD

Blood (2010) 116 (21): 2215.

https://doi.org/10.1182/blood.V116.21.2215.2215

Published: 2010

Journal Articles

Heparin-Induced Thrombocytopenia Antibodies Inhibit PF4-Dependent Enhancement of Activated Protein C Formation by Binding to Antigenic Complexes Formed with the Chondroitin Sulfate Side-Chain of Thrombomodulin

M. Anna Kowalska, PhD, Lubica Rauova, PhD, Vincent Hayes, BA, Douglas B. Cines, MD, Daniel W. Bougie, PhD, Richard H. Aster, MD, Sriram Krishnaswamy, PhD, Mortimer Poncz, MD

Blood (2010) 116 (21): 721.

https://doi.org/10.1182/blood.V116.21.721.721

Published: 2010

Journal Articles

Imaging of Coagulation Reactions During Thrombus Formation In Vivo with Novel Fluorescent Protein Derivatives

Lacramioara Ivanciu, PhD, Rodney M. Camire, PhD, Sriram Krishnaswamy, PhD

Blood (2010) 116 (21): 817.

https://doi.org/10.1182/blood.V116.21.817.817

Published: 2010

Journal Articles

Driving Thrombin From a Protease-Like State to a Zymogen-Like State and Back.

Parvathi Kamath, Ph.D., Sriram Krishnaswamy, PhD

Blood (2009) 114 (22): 852.

https://doi.org/10.1182/blood.V114.22.852.852

Published: 2009

NARROW

A Spacer Sequence Inserted between the A1 and A2 Domains of Factor VIII Overcomes the Requirement for Proteolytic Cleavage at Arg 372 in the Generation of Cofactor Activity

A Novel Variant of Factor VIII Yields Cofactor Activity without Proteolysis between the A1 and A2 Domains

JNJ-64179375 Inhibits Exosite I-Mediated Thrombin Activity While Preserving Exosite II and Active Site Function in Vitro

A Single Cleavage Reaction in the Proteolytic Activation of Factor V to the Cofactor Is Rate-Limiting in a Step That Is Selectively Dependent on Anion Binding Exosite 2 of Thrombin

Structural Basis for the Procofactor to Cofactor Transition in Human Factor V

Prothrombin Membrane Binding and Gla-Dependent Function Are Not Required for Effective Hemostasis In Vivo

The NET Effect: Platelet Factor 4 and DNA-Histone Interactions in Sepsis

Long-Range Allosteric Linkage Between Exosites Reciprocally Regulates the Zymogenicity of Prothrombin Derivatives

The Affinity of Factor X for the Intrinsic Xase Is Determined By Exosite Interactions Between the Substrate and the Enzyme Complex

The X-Ray Structure of a Variant of Human Factor V Provides Structural Insights into the Procofactor Activation Paradox

Platelet Pitp-Alpha Promotes Thrombin Generation and the Dissemination of Tumor Metastasis, but Has Minimal Effect on Vascular Plug Formation

Assembly of Prothrombinase on Endothelial Cells: Receptor-Mediated or Phospholipid-Driven?

Distinct Mechanism of Anti-Hemophilic FVIII Activation By Nascent FXa in the Tissue Factor-FVIIa Coagulation Initiation Complex Resistant to FXa-Directed Inhibition

X-Ray Structure of an Anticoagulant RNA Aptamer Bound to Factor Xa. Structural Basis for Its Ability to Disrupt Interactions Between Xa and Va within Prothrombinase

A Proposed Role for Platelet Factor 4 in Histone Pathobiology in Sepsis

New Structural Insights into High Affinity Membrane Binding By Coagulation Factor V/Va

Meizothrombin Is Unexpectedly Zymogen-Like: Its Slow Conversion to Proteinase Dominates Thrombin Production by Prothrombinase

Heparin-Induced Thrombocytopenia Antibodies Inhibit PF4-Dependent Enhancement of Activated Protein C Formation by Binding to Antigenic Complexes Formed with the Chondroitin Sulfate Side-Chain of Thrombomodulin

Imaging of Coagulation Reactions During Thrombus Formation In Vivo with Novel Fluorescent Protein Derivatives

Driving Thrombin From a Protease-Like State to a Zymogen-Like State and Back.

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American Society of Hematology

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American Society of Hematology

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