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Journal Articles

Quantitative Estimation of the In Vivo Equivalent Factor VIII Activity of NXT007, an Emicizumab-Based, Next-Generation, Activated Factor VIII-Mimetic Bispecific Antibody, from Nonclinical Data

Koichiro Yoneyama, Tetsuhiro Soeda, Kazuki Yamaguchi, Takuya Miwa, Takaaki Ishida, Tomohisa Saito

Blood (2022) 140 (Supplement 1): 11295–11296.

https://doi.org/10.1182/blood-2022-155918

Published: 2022

Journal Articles

A Healthy Volunteer-Derived, Factor VIII-Neutralized, Acquired Hemophilia a-Mimetic Plasma Produces Similar Pharmacodynamic Responses of Emicizumab to Those in Patients with Congenital Hemophilia a with or without Inhibitors

Koichiro Yoneyama, Kazuo Tokuda, Tetsuhiro Soeda, Tomohisa Saito, Midori Shima

Blood (2021) 138 (Supplement 1): 3190.

https://doi.org/10.1182/blood-2021-144549

Published: 2021

Journal Articles

Pharmacology and Pharmacokinetics of NXT007; Emicizumab-Based Engineered Fixa/Fx Bispecific Antibody with Improved Properties

Kazuki Yamaguchi, Tetsuhiro Soeda, PhD, Motohiko Sato, Norihito Shibahara, PhD, Hikaru Koga, Mina Ichiki, Eri Joyashiki, Yuri Teranishi, Kei Nishimura, Hirotake Shiraiwa, Hidetomo Kitamura, PhD DVM, Tomoyuki Igawa, PhD, Hiroko Konishi, Takehisa Kitazawa, DVM

Blood (2020) 136 (Supplement 1): 19.

https://doi.org/10.1182/blood-2020-138958

Published: 2020

Journal Articles

A Modified Thrombin Generation Analysis to Measure the Plasma Coagulation Potency in the Presence of Anti-FIXa/FX Bispecific Antibody, Emicizumab

Kenichi Ogiwara, MD PhD, Keiji Nogami, MDPhD, Tomoko Matsumoto, PhD, Mariko Noguchi-Sasaki, PhD, Tetsuhiro Soeda, PhD, Naoki Matsumoto, PhD, Michinori Hirata, PhD, Midori Shima, MD PhD

Blood (2018) 132 (Supplement 1): 1200.

https://doi.org/10.1182/blood-2018-99-118504

Published: 2018

Journal Articles

A Novel Clot Waveform Analysis to Measure the Plasma Coagulation Potency in the Presence of Anti-Fixa/Fx Bispecific Antibody, Emicizumab

Keiji Nogami, MD PhD, Tomoko Matsumoto, PhD, Yuka Tabuchi, Tetsuhiro Soeda, PhD, Nobuo Arai, Takehisa Kitazawa, Hidenari Takaoka, Kunihiro Hattori, PhD, Midori Shima, MD PhD

Blood (2016) 128 (22): 1388.

https://doi.org/10.1182/blood.V128.22.1388.1388

Published: 2016

Journal Articles

Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A

Atsushi Muto, Kazutaka Yoshihashi, Minako Takeda, Takehisa Kitazawa, Tetsuhiro Soeda, Tomoyuki Igawa, Zenjiro Sampei, Taichi Kuramochi, Akihisa Sakamoto, Kenta Haraya, Kenji Adachi, Yoshiki Kawabe, Keiji Nogami, Midori Shima, Kunihiro Hattori

Blood (2014) 124 (20): 3165–3171.

https://doi.org/10.1182/blood-2014-07-585737

Published: 2014

Includes: Supplemental data

Journal Articles

Hemostatic Effect of a Novel Bispecific Antibody (ACE910) Against Activated Factor IX and Factor X in an Acquired Hemophilia A Model

Atsushi Muto, Takehisa Kitazawa, DVM, Kazutaka Yoshihasi, DVM, PhD, Minako Takeda, DVM, Tetsuhiro Soeda, PhD, Tomoyuki Igawa, PhD, Zenjiro Sampei, Yuichiro Sakamoto, Yukiko Okuyama-Nishida, PhD, Hiroyuki Saito, Yoshiki Kawabe, PhD, Midori Shima, MD, PhD, Akira Yoshioka, MD, PhD, Kunihiro Hattori, PhD

Blood (2012) 120 (21): 42.

https://doi.org/10.1182/blood.V120.21.42.42

Published: 2012

Journal Articles

Generation of a Novel Bispecific Antibody (ACE910) Against Activated Factor IX and Factor X Mimicking the Function of Factor VIII Cofactor Activity

Tomoyuki Igawa, PhD, Zenjiro Sampei, Tetsuhiro Soeda, PhD, Yukiko Okuyama-Nishida, PhD, Chifumi Moriyama, Tetsuya Wakabayashi, Eriko Tanaka, Atsushi Muto, Tetsuo Kojima, PhD, Takehisa Kitazawa, DVM, Kazutaka Yoshihashi, DVM, PhD, Aya Harada, Miho Funaki, Kenta Haraya, Tachibana Tatsuhiko, PhD, Sachiyo Suzuki, Keiko Esaki, Yoshiaki Nabuchi, PhD, Kunihiro Hattori, PhD

Blood (2012) 120 (21): 1126.

https://doi.org/10.1182/blood.V120.21.1126.1126

Published: 2012

Journal Articles

Mechanisms of Factor VIII Activation by Recombinant Factor VIIa Analog through Tissue Factor-Independent Manner

Kenichi Ogiwara, Keiji Nogami, Tetsuhiro Soeda, Tomoko Matsumoto, Katsumi Nishiya, Midori Shima

Blood (2008) 112 (11): 1028.

https://doi.org/10.1182/blood.V112.11.1028.1028

Published: 2008

Journal Articles

Identification of a Factor IXa-Interactive Site within the C2 Domain of Factor VIIIa and a Crucial Role of These Associations for the Process of Clot Formation

Tetsuhiro Soeda, Keiji Nogami, Kenichi Ogiwara, Masahiro Takeyama, Katsumi Nishiya, Midori Shima

Blood (2008) 112 (11): 1035.

https://doi.org/10.1182/blood.V112.11.1035.1035

Published: 2008

Journal Articles

Tissue Factor-Dependent Activation of Factor VIII by Factor VIIa in the Early Phase of Blood Coagulation

Tetsuhiro Soeda, Keiji Nogami, Tomoko Matsumoto, Kenichi Ogiwara, Katsumi Nishiya, Midori Shima

Blood (2008) 112 (11): 1036.

https://doi.org/10.1182/blood.V112.11.1036.1036

Published: 2008

Journal Articles

Identification of a Protein S-Interactive Site on the Factor VIII A2 Domain.

Masahiro Takeyama, MD, Keiji Nogami, MD, PhD, Tetsuhiro Soeda, Akira Yoshioka, MD, PhD, Midori Shima, MD, PhD

Blood (2007) 110 (11): 2684.

https://doi.org/10.1182/blood.V110.11.2684.2684

Published: 2007

Journal Articles

Role of the Direct Interaction between Factor VIII C2 and Factor IXa Gla Domain in the Factor Xase Complex.

Tetsuhiro Soeda, Keiji Nogami, MD, PhD, Masahiro Takeyama, MD, Kenichi Ogiwara, MD, Kazuhiko Tomokiyo, PhD, Yoichi Sakata, MD, PhD, Akira Yoshioka, MD, PhD, Midori Shima, MD, PhD

Blood (2007) 110 (11): 2687.

https://doi.org/10.1182/blood.V110.11.2687.2687

Published: 2007

Journal Articles

Characterization of an Anti-Factor VIII Monoclonal Antibody with A1 and A3 Epitopes Which Increases Factor VIII Activity.

Masahiro Takeyama, MD, Keiji Nogami, MD,PhD, Tetsuhiro Soeda, phD, Tsukasa Suzuki, phD, Kunihiro Hattori, phD, Kohei Tatsumi, MD, Yuri Fujita, MD, Ichiro Tanaka, MD.PhD, Akira Yoshioka, MD,PhD, Midori Shima, MD,PhD

Blood (2006) 108 (11): 1702.

https://doi.org/10.1182/blood.V108.11.1702.1702

Published: 2006

NARROW

Quantitative Estimation of the In Vivo Equivalent Factor VIII Activity of NXT007, an Emicizumab-Based, Next-Generation, Activated Factor VIII-Mimetic Bispecific Antibody, from Nonclinical Data

A Healthy Volunteer-Derived, Factor VIII-Neutralized, Acquired Hemophilia a-Mimetic Plasma Produces Similar Pharmacodynamic Responses of Emicizumab to Those in Patients with Congenital Hemophilia a with or without Inhibitors

Pharmacology and Pharmacokinetics of NXT007; Emicizumab-Based Engineered Fixa/Fx Bispecific Antibody with Improved Properties

A Modified Thrombin Generation Analysis to Measure the Plasma Coagulation Potency in the Presence of Anti-FIXa/FX Bispecific Antibody, Emicizumab

A Novel Clot Waveform Analysis to Measure the Plasma Coagulation Potency in the Presence of Anti-Fixa/Fx Bispecific Antibody, Emicizumab

Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A

Hemostatic Effect of a Novel Bispecific Antibody (ACE910) Against Activated Factor IX and Factor X in an Acquired Hemophilia A Model

Generation of a Novel Bispecific Antibody (ACE910) Against Activated Factor IX and Factor X Mimicking the Function of Factor VIII Cofactor Activity

Mechanisms of Factor VIII Activation by Recombinant Factor VIIa Analog through Tissue Factor-Independent Manner

Identification of a Factor IXa-Interactive Site within the C2 Domain of Factor VIIIa and a Crucial Role of These Associations for the Process of Clot Formation

Tissue Factor-Dependent Activation of Factor VIII by Factor VIIa in the Early Phase of Blood Coagulation

Identification of a Protein S-Interactive Site on the Factor VIII A2 Domain.

Role of the Direct Interaction between Factor VIII C2 and Factor IXa Gla Domain in the Factor Xase Complex.

Characterization of an Anti-Factor VIII Monoclonal Antibody with A1 and A3 Epitopes Which Increases Factor VIII Activity.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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