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Theodore R. Holman
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Journal Articles

Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors

Jesse I. Mobbs, Katrina A. Black, Michelle Tran, Wessel A. C. Burger, Hariprasad Venugopal, Theodore R. Holman, Michael Holinstat, David M. Thal, Alisa Glukhova
Journal: Blood
Blood (2023) 142 (14): 1233–1242.
https://doi.org/10.1182/blood.2023020441
Published: 2023
Includes: Multimedia, Supplemental data
Journal Articles

Novel 12-LOX Inhibitor ML355 Attenuates Platelet Reactivity and Impairs Thrombus Growth, Stability and Vessel Occlusion In Vivo

Reheman Adili, MD, Theodore R Holman, PhD, Michael Holinstat, PhD
Journal: Blood
Blood (2015) 126 (23): 3442.
https://doi.org/10.1182/blood.V126.23.3442.3442
Published: 2015
Journal Articles

12-HETrE, a Novel 12-LOX Oxylipin, Prevents Platelet Activation in a Gα s -like Manner

Jennifer Yeung, MS, Pilar Fernandez-Perez, BS, Joanne Vesci, MLT, Theodore R Holman, PhD, Jin Ren, PhD, Michael Holinstat, PhD
Journal: Blood
Blood (2014) 124 (21): 1436.
https://doi.org/10.1182/blood.V124.21.1436.1436
Published: 2014
Journal Articles

Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation

Jennifer Yeung, Benjamin E. Tourdot, Pilar Fernandez-Perez, Joanne Vesci, Jin Ren, Christopher J. Smyrniotis, Diane K. Luci, Ajit Jadhav, Anton Simeonov, David J. Maloney, Theodore R. Holman, Steven E. McKenzie, Michael Holinstat
Journal: Blood
Blood (2014) 124 (14): 2271–2279.
https://doi.org/10.1182/blood-2014-05-575878
Published: 2014
Includes: Supplemental data
Journal Articles

12-Lipoxygenase Regulates Platelet Reactivity and Thrombosis Through Formation Of Unique Oxylipins

Jennifer Yeung, MS, Pilar Fernandez-Perez, MS, Joanne Vesci, MLT, Theodore R Holman, PhD, Michael Holinstat, PhD
Journal: Blood
Blood (2013) 122 (21): 3515.
https://doi.org/10.1182/blood.V122.21.3515.3515
Published: 2013
Journal Articles

An ω-6 Fatty Acid, Dgla, Prevents Platelet Activation and Thrombosis in Vivo .

Jennifer Yeung, Kenneth Ikei, Joanne Vesci, MLT, Theodore R Holman, PhD, Michael Holinstat, PhD
Journal: Blood
Blood (2012) 120 (21): 2169.
https://doi.org/10.1182/blood.V120.21.2169.2169
Published: 2012
Journal Articles

12-HETrE, An Endogenous Inhibitor of Platelet Activation,

Jennifer Yeung, Kenneth Ikei, Joanne Vesci, MLT, Alex Arnouk, Theodore R Holman, PhD, Michael Holinstat, PhD
Journal: Blood
Blood (2011) 118 (21): 3254.
https://doi.org/10.1182/blood.V118.21.3254.3254
Published: 2011