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Thomas Friess
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Journal Articles

Clinical BET Inhibitor RG6146 Demonstrates Potent and on-Target Activity in Pre-Clinical Models of Hematological Malignancy and Combines with Anti-CD20 and BCL-2 Inhibition to Provide Superior Efficacy

Astrid Rueflibrasse, PhD, Thomas Friess, PhD, Stephanie Lechner, Lisa Wellinger, Jurriaan Brouwer, William E. Pierceall, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2071.
https://doi.org/10.1182/blood.V130.Suppl_1.2071.2071
Published: 2017
Journal Articles

The Triple Combination of the CD20 Antibody Obinutuzumab with the Bcl-2 Inhibitor Venetoclax (GDC-199) and the MDM2 Inhibitor Idasanutlin Results in Superior Efficacy and Long Term Response in Wildtype p53 NHL Tumor Models

Frank Herting, PhD, Thomas Friess, PhD, Pablo Umaña, PhD, Middleton Steven, PhD, Christian Klein, PhD
Journal: Blood
Blood (2016) 128 (22): 4178.
https://doi.org/10.1182/blood.V128.22.4178.4178
Published: 2016
Journal Articles

Combination of the Glycoengineered Type II CD20 Antibody Obinutuzumab (GA101) and the MDM2 Selective Antagonist RG7388 Results in Superior Anti-Tumor Activity

Frank Herting, PhD, Sylvia Herter, PhD, Thomas Friess, PhD, Christian Lehmann, PhD, Marina Bacac, PhD, Markus Dangl, PhD, Christian Klein, PhD
Journal: Blood
Blood (2014) 124 (21): 1780.
https://doi.org/10.1182/blood.V124.21.1780.1780
Published: 2014
Journal Articles

Superior Efficacy of the Novel Type II, Glycoengineered CD20 Antibody GA101 vs . the Type I CD20 Antibodies Rituximab and Ofatumumab

Sylvia Herter, Inja Waldhauer, Tina Otz, Frank Herting, Sabine Lang, Valeria Nicolini, Michaela Römmele, Thomas Friess, Erwin Van Puijenbroek, Marina Bacac, K. Michael Weidner, PhD, Christian Gerdes, Pablo Umana, PhD, Christian Klein, PhD
Journal: Blood
Blood (2010) 116 (21): 3925.
https://doi.org/10.1182/blood.V116.21.3925.3925
Published: 2010
Journal Articles

Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell–mediated B-cell cytotoxicity

Ekkehard Mössner, Peter Brünker, Samuel Moser, Ursula Püntener, Carla Schmidt, Sylvia Herter, Roger Grau, Christian Gerdes, Adam Nopora, Erwin van Puijenbroek, Claudia Ferrara, Peter Sondermann, Christiane Jäger, Pamela Strein, Georg Fertig, Thomas Friess, Christine Schüll, Sabine Bauer, Joseph Dal Porto, Christopher Del Nagro, Karim Dabbagh, Martin J. S. Dyer, Sibrand Poppema, Christian Klein, Pablo Umaña
Journal: Blood
Blood (2010) 115 (22): 4393–4402.
https://doi.org/10.1182/blood-2009-06-225979
Published: 2010
Journal Articles

GA101, a Novel Humanized Type II CD20 Antibody with Glycoengineered Fc and Enhanced Cell Death Induction, Mediates Superior Efficacy in a Variety of NHL Xenograft Models in Comparison to Rituximab.

Thomas Friess, PhD, Christian Gerdes, PhD, Adam Nopora, PhD, Monika Patre, PhD, Susanne Preiss, PhD, Erwin van Puijenbroek, Christine Schuell, PhD, Sabine Bauer, PhD, Pablo Umana, PhD, Christian Klein, PhD
Journal: Blood
Blood (2007) 110 (11): 2338.
https://doi.org/10.1182/blood.V110.11.2338.2338
Published: 2007
Journal Articles

GA101, a Novel Humanized Type II CD20 Antibody with Glycoengineered Fc and Enhanced Cell Death Induction, Exhibits Superior Anti-Tumor Efficacy and Superior Tissue B Cell Depletion In Vivo.

Pablo Umana, PhD, Moessner Ekkehard, PhD, Bruenker Peter, PhD, Klingner Gabriele, Puentener Ursula, PhD, Tobias Suter, PhD, Roger Grau, PhD, Carla Schmidt, PhD, Sylvia Herter, PhD, Christian Gerdes, PhD, Adam Nopora, PhD, Monika Patre, PhD, Samuel Moser, PhD, Peter Sondermann, PhD, Luise Wheat, PhD, Martin J.S. Dyer, PhD, Sibrand Poppema, PhD, Sabine Bauer, PhD, Manfred Kubbies, PhD, Pamela Strein, PhD, Georg Fertig, PhD, Thomas Friess, PhD, Karim Dabbagh, PhD, Joe DalPorto, PhD, Christian Klein, PhD
Journal: Blood
Blood (2007) 110 (11): 2348.
https://doi.org/10.1182/blood.V110.11.2348.2348
Published: 2007
Journal Articles

Novel 3 rd Generation Humanized Type II CD20 Antibody with Glycoengineered Fc and Modified Elbow Hinge for Enhanced ADCC and Superior Apoptosis Induction.

Pablo Umana, PhD, Ekkehard Moessner, Ph.D., Peter Bruenker, Ph.D., Gabriele Unsin, MSc., Ursula Puentener, MSc., Tobias Suter, Ph.D., Roger Grau, Ph.D., Carla Schmidt, Ph.D., Christian Gerdes, Ph.D., Adam Nopora, Ph.D., Monika Patre, Ph.D., Samuel Moser, MSc., Peter Sondermann, Ph.D., Luise Wheat, Ph.D., Martin J.S. Dyer, Ph.D., Sibrand Poppema, Ph.D., Sabine Bauer, Ph.D., Pamela Strein, Ph.D., Thomas Friess, Ph.D., Christian Klein, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 229.
https://doi.org/10.1182/blood.V108.11.229.229
Published: 2006