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Thorsten M Schlaeger
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Journal Articles

Generation of Functional iPSC-Derived CAR-T Cells for Cancer Immunotherapy Via G9a/GLP Inhibition

Free
Ran Jing, Marcelo Falchetti, Tianxiao Han, Mohamad Najia, Luca Hensch, Eleanor Meader, Martin Kononov, Stephanie Wang, Caroline Kubaczka, Edroaldo Lummertz Da Rocha, Robert Grant Rowe, Thorsten M. Schlaeger, Marcela Maus, Trista E. North, Leonard I. Zon, George Q. Daley
Journal: Blood
Blood (2024) 144 (Supplement 1): 2043.
https://doi.org/10.1182/blood-2024-208634
Published: 2024
Journal Articles

Transcription Factor Programming of Human iPSC-Derived Sinusoidal Vascular Endothelial Cells Enhances Co-Cultured Hematopoietic Stem and Progenitor Cell Transplantation

Free
Tianxiao Han, Rajesh D. Gunage, Ran Jing, Olivia Stockard, Alexandra F. Corbin, Luca Hensch, Yang Tang, Kenny Chen, Song Yang, Yi Zhou, George Q. Daley, Thorsten M. Schlaeger, Leonard I. Zon
Journal: Blood
Blood (2024) 144 (Supplement 1): 820.
https://doi.org/10.1182/blood-2024-208453
Published: 2024
Journal Articles

Exposure of hiPSC-Derived Mature Megakaryocytes to Vincristine Boosts Platelet Biogenesis in Vitro

Free
Yasuo Harada, Emiri Nakamura, Trevor Bingham, Leonard I. Zon, George Q. Daley, Andrew Frelinger, Koji Eto, Thorsten M. Schlaeger
Journal: Blood
Blood (2023) 142 (Supplement 1): 1292.
https://doi.org/10.1182/blood-2023-185254
Published: 2023
Journal Articles

In Vivo Reprogramming of Adult Liver Sinusoidal Vascular Endothelial Cells into a Hematopoietic Stem and Progenitor Cell Niche

Free
Tianxiao Han, Rajesh D. Gunage, Ran Jing, Alexandra F. Corbin, Kenny Zhi Ming Chen, Yang Tang, Olivia Stockard, Song Yang, Yi Zhou, George Q. Daley, Thorsten M. Schlaeger, Leonard I. Zon
Journal: Blood
Blood (2023) 142 (Supplement 1): 4071.
https://doi.org/10.1182/blood-2023-180300
Published: 2023
Journal Articles

Blood Flow Directs Yap/Taz-Mediated Transcriptional Regulation of Self-Renewal Programs to Control Developmental HSPC Expansion By Mechanical Stimulation of Piezo1

Free
Wade W Sugden, Zachary LeBlanc, Mayuri Tanaka-Yano, Ran Jing, Maria Gonzalez di Tillio, Mohamad Najia, Yang Tang, Elizabeth Molnar, Stephan George, Brittney Love, Caroline Kubaczka, Nan Liu, Nah-Young Shin, Thorsten M. Schlaeger, Edroaldo Lummertz da Rocha, Alan B. Cantor, Stuart H Orkin, Robert Grant Rowe, Wolfram Goessling, George Q. Daley, Trista E. North
Journal: Blood
Blood (2023) 142 (Supplement 1): 1309.
https://doi.org/10.1182/blood-2023-190416
Published: 2023
Journal Articles

Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium

Free
Il Ho Jang, Yi-Fen Lu, Long Zhao, Pamela L. Wenzel, Tsutomu Kume, Sumon M. Datta, Natasha Arora, Jordi Guiu, Mounia Lagha, Peter G. Kim, Eun Kyoung Do, Jae Ho Kim, Thorsten M. Schlaeger, Leonard I. Zon, Anna Bigas, Caroline E. Burns, George Q. Daley
Journal: Blood
Blood (2015) 125 (9): 1418–1426.
https://doi.org/10.1182/blood-2014-04-568170
Published: 2015
Includes: Supplemental data
Journal Articles

Modeling Diamond Blackfan Anemia in Vivo Using Human Induced Pluripotent Stem Cells

Free
Sergei Doulatov, PhD, Linda T Vo, Elizabeth R Macari, PhD, Stephanie S Chou, Manav Gupta, Michelle Godfrey, Katherine McGrath, Thorsten M Schlaeger, PhD, Leonard I. Zon, MD, George Q. Daley, MD PhD
Journal: Blood
Blood (2014) 124 (21): 359.
https://doi.org/10.1182/blood.V124.21.359.359
Published: 2014
Journal Articles

Epoxyeicosatrienoic Acids Regulate Hematopoietic Stem/Progenitor Cell Fate Decision During Stress Response and Embryonic Hematopoiesis

Free
Pulin Li, Emily K Pugach, Elizabeth B Riley, Dipak Panigrahy, M.D., Garrett C Heffner, PhD, Teresa V. Bowman, PhD, Owen J. Tamplin, PhD, Shannon McKinney-Freeman, PhD, Thorsten M Schlaeger, PhD, George Q. Daley, MD, PhD, Darryl C Zeldin, M.D., Leonard I. Zon, MD
Journal: Blood
Blood (2011) 118 (21): 860.
https://doi.org/10.1182/blood.V118.21.860.860
Published: 2011
Journal Articles

Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage

Free
Asmin Tulpule, M. William Lensch, Justine D. Miller, Karyn Austin, Alan D'Andrea, Thorsten M. Schlaeger, Akiko Shimamura, George Q. Daley
Journal: Blood
Blood (2010) 115 (17): 3453–3462.
https://doi.org/10.1182/blood-2009-10-246694
Published: 2010
Includes: Supplemental data
Journal Articles

ABC-Me (ABCB10) Is Required for Erythroid Development in the Mouse Embryo and Is Protective against Mitochondrial Oxidative Stress

Free
Brigham B Hyde, Alvaro A Elorza, PhD, Hanna K Mikkola, MD/PhD, Thorsten M Schlaeger, PhD, Orian S Shirihai, MD/PhD
Journal: Blood
Blood (2008) 112 (11): 529.
https://doi.org/10.1182/blood.V112.11.529.529
Published: 2008
Journal Articles

Targeted Disruption of the Mouse Mitoferrin (Slc25A37) Mitochondrial Solute Carrier Results in Defective Primitive and Definitive Erythropoiesis.

Free
Barry H. Paw, MD, PhD, Babette Gwynn, M.S., Nathaniel B. Langer, B.A., George C. Shaw, B.A., Amy J. Lambert, B.S., Leah A. Boyer, B.A., Liangtao Li, M.D., Jens Stolte, Raymond F. Robledo, Ph.D., Kenneth E. Sahr, Ph.D., Thorsten M. Schlaeger, Ph.D., Matthias W. Hentze, M.D., Martina U. Muckenthaler, Ph.D., Jerry Kaplan, Ph.D., Luanne L. Peters, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 265.
https://doi.org/10.1182/blood.V108.11.265.265
Published: 2006
Journal Articles

Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1) –dependent window during hematopoietic stem-cell development

Free
Brief Report
Thorsten M. Schlaeger, Hanna K. A. Mikkola, Christos Gekas, Hildur B. Helgadottir, Stuart H. Orkin
Journal: Blood
Blood (2005) 105 (10): 3871–3874.
https://doi.org/10.1182/blood-2004-11-4467
Published: 2005
Journal Articles

Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo

Free
Hanna K. A. Mikkola, Yuko Fujiwara, Thorsten M. Schlaeger, David Traver, Stuart H. Orkin
Journal: Blood
Blood (2003) 101 (2): 508–516.
https://doi.org/10.1182/blood-2002-06-1699
Published: 2003
Journal Articles

Role of SCL/Tal-1, GATA, and Ets transcription factor binding sites for the regulation of Flk-1 expression during murine vascular development

Free
Andreas Kappel, Thorsten M. Schlaeger, Ingo Flamme, Stuart H. Orkin, Werner Risau, Georg Breier
Journal: Blood
Blood (2000) 96 (9): 3078–3085.
https://doi.org/10.1182/blood.V96.9.3078
Published: 2000