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Timothy P. Hughes, MD FRACP, FRCPA, MBBS, FAAHMS
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Journal Articles

Enhanced Natural Killer and Cytotoxic T Lymphocyte Responses, with Decreased Monocytic Myeloid Derived Suppressor Cells May Promote Treatment Free Remission in Chronic Myeloid Leukaemia Patients Following Tyrosine Kinase Inhibitor Cessation

Amy Hughes, PhD, Jade Clarson, B.Sc, Deborah L White, PhD FFSc (RCPA), David M. Ross, MBBS, PhD FRACP, FRCPA, Timothy P. Hughes, MD FRACP, FRCPA, MBBS, FAAHMS, Agnes S Yong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1122.
https://doi.org/10.1182/blood.V128.22.1122.1122
Published: 2016
Journal Articles

Novel Fusion Genes at CML Diagnosis Reveal a Complex Pattern of Genomic Rearrangements and Sequence Inversions Associated with the Philadelphia Chromosome in Patients with Early Blast Crisis

Justine E Marum, PhD, Paul PS Wang, PhD, Doris Stangl, PhD, David T. Yeung, BSc, MBBS, FRACP, FRCPA, Martin C. Mueller, Christian T. Dietz, PhD, Ieuan Walker, MSc, BSc, MBBS, Nathalie Nataren, BSc, Zoe Donaldson, BSc, Wendy T Parker, PhD, David M. Ross, MBBS, PhD FRACP, FRCPA, Hamish S Scott, BSc, PhD FFSc (RCPA), FAHMS, Timothy P. Hughes, MD FRACP, FRCPA, MBBS, FAAHMS, Andreas W Schreiber, PhD, Susan Branford, PhD FFSc (RCPA)
Journal: Blood
Blood (2016) 128 (22): 1219.
https://doi.org/10.1182/blood.V128.22.1219.1219
Published: 2016
Journal Articles

Expanded Phase 1 Study of ABL001, a Potent, Allosteric Inhibitor of BCR-ABL, Reveals Significant and Durable Responses in Patients with CML-Chronic Phase with Failure of Prior TKI Therapy

Timothy P. Hughes, MD FRACP, FRCPA, MBBS, FAAHMS, Yeow-Tee Goh, MBBS, MMed, Oliver G. Ottmann, MD, Hironobu Minami, MD PhD, Delphine Rea, MD PhD, Fabian Lang, MD, Michael J. Mauro, MD, Daniel J. DeAngelo, MD PhD, Moshe Talpaz, MD, Andreas Hochhaus, Prof. Dr., Massimo Breccia, MD, Jorge E. Cortes, MD, Michael C. Heinrich, MD, Jeroen Janssen, MD, Juan-Luis Steegmann, MD PhD, François-Xavier Mahon, MD PhD, Raina Duan, PhD, Varsha Iyer, David Hynds, MS, Gary J. Vanasse, MD, Dong-Wook Kim, MD PhD
Journal: Blood
Blood (2016) 128 (22): 625.
https://doi.org/10.1182/blood.V128.22.625.625
Published: 2016
Journal Articles

The ABCC6 Transporter Plays a Significant Role in the Efflux of Nilotinib and Dasatinib, and May Contribute to Tyrosine Kinase Inhibitor Resistance

Laura N Eadie, PhD, Jarrad M Goyne, BMedSc (Hons), Timothy P. Hughes, MD FRACP, FRCPA, MBBS, FAAHMS, Deborah L White, PhD FFSc (RCPA)
Journal: Blood
Blood (2016) 128 (22): 4237.
https://doi.org/10.1182/blood.V128.22.4237.4237
Published: 2016
Journal Articles

Patient-Reported Quality of Life before and after Stopping Treatment in the ENESTop Trial of Treatment-Free Remission for Patients with Chronic Myeloid Leukemia in Chronic Phase

François-Xavier Mahon, MD PhD, Carla Maria Boquimpani, Naoto Takahashi, MD PhD, Noam Benyamini, MD, Nelma Cristina D Clementino, MD, Vasily Shuvaev, MD, Sikander Ailawadhi, MD, Jeffrey H. Lipton, MD PhD, Anna G Turkina, Prof., MD, Elena Beatriz Moiraghi, MD, Franck-Emmanuel Nicolini, MD PhD, Jolanta Dengler, Tomasz Sacha, Dong-Wook Kim, MD PhD, Rafik Fellague-Chebra, MD MSc, Sandip Acharya, MSc, Patricia Brandt, Ari Gnanasakthy, MBA, MSc, Yu Jin, MS, Timothy P. Hughes, MD FRACP, FRCPA, MBBS, FAAHMS
Journal: Blood
Blood (2016) 128 (22): 1891.
https://doi.org/10.1182/blood.V128.22.1891.1891
Published: 2016
Journal Articles

Long-Term Follow-up of the Efficacy and Safety of Ponatinib in Philadelphia Chromosome-Positive Leukemia Patients with the T315I Mutation

Elias J. Jabbour, MD, Jorge E. Cortes, MD, Moshe Talpaz, MD, Michele Baccarani, MD, Michael J. Mauro, MD, Andreas Hochhaus, MD, Timothy P. Hughes, MD FRACP, FRCPA, MBBS, FAAHMS, Francois Guilhot, MD, Michael W. Deininger, MD PhD, Neil Shah, MD PhD, Dale L. Bixby, MD, Ian W. Flinn, MD PhD, Thomas O'Hare, PhD, Stephanie Lustgarten, PhD, Victor M. Rivera, PhD, Sergio Santillana, MD, Hagop M. Kantarjian, MD
Journal: Blood
Blood (2016) 128 (22): 3067.
https://doi.org/10.1182/blood.V128.22.3067.3067
Published: 2016
Journal Articles

Treatment-Free Remission in Patients with Chronic Myeloid Leukemia in Chronic Phase According to Reasons for Switching from Imatinib to Nilotinib: Subgroup Analysis from ENESTop

Timothy P. Hughes, MD FRACP, FRCPA, MBBS, FAAHMS, Carla Maria Boquimpani, Naoto Takahashi, MD PhD, Noam Benyamini, MD, Nelma Cristina D Clementino, MD, Vasily Shuvaev, MD, Sikander Ailawadhi, MD, Jeffrey H. Lipton, MD PhD, Anna G Turkina, Prof., MD, Elena Beatriz Moiraghi, MD, Franck E. Nicolini, MD PhD, Jolanta Dengler, Tomasz Sacha, Dong-Wook Kim, MD PhD, Rafik Fellague-Chebra, MD MSc, Sandip Acharya, MSc, Nancy Krunic, PhD, Yu Jin, MS, François-Xavier Mahon, MD PhD
Journal: Blood
Blood (2016) 128 (22): 792.
https://doi.org/10.1182/blood.V128.22.792.792
Published: 2016