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Journal Articles

Epigenetic Modulation Enhances the Therapeutic Potential of All-Trans Retinoic Acid in Acute Myeloid Leukemia

Lukasz Szymanski, Rafal Skopek, Malgorzata Palusinska, Karolina Maslinska-Gromadka, Leszek Kraj, Tino Schenk, Arthur Zelent
Journal: Blood
Blood (2023) 142 (Supplement 1): 7141.
https://doi.org/10.1182/blood-2023-174217
Published: 2023
Journal Articles

Inhibition of the PI3K/AKT/mTOR Pathway Leads to Down-Regulation of c-Myc and Overcomes Resistance to ATRA in Acute Myeloid Leukemia

Ronan T. Swords, MDPhDFRCPI FRCPath, Tino Schenk, PhD, Sven Stengel, PhD, Veronica Sylvina Gil, PhD, Kevin R. Petrie, PhD, Aymee Perez, PhD, Rodriguez Ana, Justin M. Watts, MD, Fernando Vargas, MD, Roy Elias, Arthur Zelent, PhD
Journal: Blood
Blood (2015) 126 (23): 1363.
https://doi.org/10.1182/blood.V126.23.1363.1363
Published: 2015
Journal Articles

In Acute Myeloid Leukemia (AML), Targeting the Histone Methyltransferase EZH2 Promotes Differentiation, Impairs Clonogenic Survival and Augments the Anti-Leukemic Effects of the Retinoid, All-Trans-Retinoic Acid (ATRA)

Ronan T. Swords, MDPhDFRCPI FRCPath, Aymee Perez, PhD, Ana Rodriguez, Justin M. Watts, MD, Tino Schenk, PhD, Fernando Vargas, MD, Roy Elias, Arthur Zelent, PhD
Journal: Blood
Blood (2015) 126 (23): 3786.
https://doi.org/10.1182/blood.V126.23.3786.3786
Published: 2015
Journal Articles

Loss Of H3K27 Trimethylation (H3K27me3) Associates With a Multi Drug Resistance Phenotype In Acute Myeloid Leukemia (AML)

Stefanie Göllner, PhD, Tino Schenk, PhD, Sven Stengel, PhD, Christian Rohde, PhD, Tim Sauer, MD, Arthur Zelent, PhD, Sigal Tavor, MD, Friedrich Stölzel, MD, Gerhard Ehninger, MD, Gabriele Köhler, MD, Wolfgang E. Berdel, MD, Christian Thiede, MD, Carsten Müller-Tidow, MD
Journal: Blood
Blood (2013) 122 (21): 1253.
https://doi.org/10.1182/blood.V122.21.1253.1253
Published: 2013
Journal Articles

Loss of EZH2 and Aberrant DNA Methylation Account for PKC412 Drug Resistance in the FLT3-ITD Positive Acute Myeloid Leukemia (AML) Cell Line MV4-11,

Stefanie Göllner, PhD, Tino Schenk, PhD, Christian Rohde, PhD, Arthur Zelent, PhD, Friedrich Stölzel, MD, Christian Thiede, MD, Wolfgang E. Berdel, Carsten Müller-Tidow, MD
Journal: Blood
Blood (2011) 118 (21): 3468.
https://doi.org/10.1182/blood.V118.21.3468.3468
Published: 2011
Journal Articles

Histone H3 Methylation Mediates All- Trans -Retinoic Acid Responsiveness in Acute Myeloid Leukemia

Tino Schenk, PhD, Stefanie Göllner, PhD, Weihsu Claire Chen, PhD, Louise Howell, BSc, Liqing Jin, MD, Katja Hebestreit, Hans-Ulrich Klein, PhD, Alan K Burnett, MD, Ken I. Mills, PhD, FRCPath, Laurence Marton, MD, Robert Casero, Jr., PhD, Patrick Woster, PhD, Martin Dugas, MD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD, Carsten Müller-Tidow, MD, Kevin Petrie, PhD, Arthur Zelent, PhD
Journal: Blood
Blood (2011) 118 (21): 224.
https://doi.org/10.1182/blood.V118.21.224.224
Published: 2011
Journal Articles

Modulation of Histone H3K4 and H3K27 Methylation Levels Via Pharmacological Inhibition of LSD1 and Degradation of the EZH2-Containing Polycomb Repressive Complex 2 Stimulates ATRA-Mediated Differentiation of AML Cells.

Kevin R. Petrie, PhD, Tino Schenk, PhD, Manuel Boix Chornet, PhD, Louise Howell, John E Dick, PhD, Victor E Marquez, PhD, Laurence J Marton, MD, Patrick M Woster, PhD, Robert A Casero, Jr., PhD, Arthur Zelent, PhD
Journal: Blood
Blood (2009) 114 (22): 1046.
https://doi.org/10.1182/blood.V114.22.1046.1046
Published: 2009
Journal Articles

Non-Cycling Cells From Acute Myeloid Leukemia Patients Harbor the FLT3-ITD Mutation and Are Insensitive to TKI258, a Potent FLT3-Directed Inhibitor, in Vitro .

Caroline L Alvares, Tino Schenk, Sanna Hulkki, Toon Min, Gowri Vijayaraghavan, Yeung Jenny, David Gonzalez, Eric So, Mel Greaves, Ian Titley, Kerol Bartolovic, Gareth Morgan
Journal: Blood
Blood (2009) 114 (22): 479.
https://doi.org/10.1182/blood.V114.22.479.479
Published: 2009