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Journal Articles

Successful MPB Therapy Followed By Bortezomib Maintenance for Non-Transplant Eligible Patients with Newly Diagnosed Multiple Myeloma: Japanese Phase 2 Study - Broad-J Study

Michihide Tokuhira, MD, Naoki Takezako, MD PhD, Yoichi Imai, MD PhD, Tadao Ishida, MD, Tomonori Nakazato, MD PhD, Kinuko Mitani, MD, PhD, Tohru Ikuta, MDPhD, Morio Matsumoto, MD, Takayuki Ikezoe, MD, PhD, Jun Taguchi, MD PhD, Kensuke Usuki, MD PhD, Takeshi Shimomura, MD, Kenkou Chin, MD, Shunya Arai, MD PhD, Kazuma Ohyashiki, MD, Miho Nara, MD, Kenji Kishi, MD, Yoshiaki Kuroda, MD, Yuichi Nakamura, MD, Hisashi Wakita, MD PhD, Makoto Sasaki, MD PhD, Hirotoshi Kamata, MD, Yoshikazu Ichikawa, MD, Akihiko Yokoyama, MD, Kenshi Suzuki, Masahiro Kizaki, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5432.
https://doi.org/10.1182/blood.V130.Suppl_1.5432.5432
Published: 2017
Journal Articles

Molecular mechanisms underlying synergistic adhesion of sickle red blood cells by hypoxia and low nitric oxide bioavailability

Diana R. Gutsaeva, Pedro Montero-Huerta, James B. Parkerson, Shobha D. Yerigenahally, Tohru Ikuta, C. Alvin Head
Journal: Blood
Blood (2014) 123 (12): 1917–1926.
https://doi.org/10.1182/blood-2013-06-510180
Published: 2014
Includes: Supplemental data
Journal Articles

Inhibition of cell adhesion by anti–P-selectin aptamer: a new potential therapeutic agent for sickle cell disease

Diana R. Gutsaeva, James B. Parkerson, Shobha D. Yerigenahally, Jeffrey C. Kurz, Robert G. Schaub, Tohru Ikuta, C. Alvin Head
Journal: Blood
Blood (2011) 117 (2): 727–735.
https://doi.org/10.1182/blood-2010-05-285718
Published: 2011
Includes: Supplemental data
Journal Articles

Synergistic Enhancement of Sickle Red Blood Cell Adhesion to Endothelium by Hypoxia and Low Nitric Oxide Bioavailability

Diana Gutsaeva, James Parkerson, Shobha Yerigenahally, Tohru Ikuta, MD, PhD, C. Alvin Head
Journal: Blood
Blood (2010) 116 (21): 1637.
https://doi.org/10.1182/blood.V116.21.1637.1637
Published: 2010
Journal Articles

Hydroxyurea Induces Fetal Hemoglobin Expression by Activating cAMP Signaling Pathways In a cAMP- and cGMP-Dependent Manner; New Hypothesis to Account for a Role of Non-Erythroid Cells In Fetal Hemoglobin Induction

Tohru Ikuta, MD, PhD, Diana Gutsaeva, James Parkerson, Shobha Yerigenahally, C. Alvin Head
Journal: Blood
Blood (2010) 116 (21): 1622.
https://doi.org/10.1182/blood.V116.21.1622.1622
Published: 2010
Journal Articles

The Cyclic GMP-Dependent Pathway Is Involved in the Mechanisms of Action of Hydroxyurea.

Yusuke Suzuki, PhD, Lakiea Bailey, M.S., Abdullah Kutlar, M.D., Nicola Conran, Ph.D., Fernando F. Costa, M.D., Karin M. Gaensler, M.D., Tohru Ikuta, M.D., Ph.D.
Journal: Blood
Blood (2007) 110 (11): 2256.
https://doi.org/10.1182/blood.V110.11.2256.2256
Published: 2007
Journal Articles

Differential Modulation of the β-Like Globin Genes by KLFs Isolated with a γ-Globin CACCC Bait.

Paolo Moi, MD, Loredana Porcu, PhD, Maria G. Marini, PhD, Isadora Asunis, Maria G. Loi, PhD, Tohru Ikuta, MD, Antonio Cao, MD
Journal: Blood
Blood (2005) 106 (11): 3637.
https://doi.org/10.1182/blood.V106.11.3637.3637
Published: 2005
Journal Articles

Anti-Apoptotic Effect, Mediated by Elevated Intracellular Cyclic AMP Levels, in Neutrophils of Sickle Cell Disease Patients.

Nicola Conran, BSc, PhD, Carolina Lanaro, B.Sc, Fernanda G. Pereira, M.Sc, Tohru Ikuta, MD, PhD, Sara T.O. Saad, MD, PhD, Fernando F. Costa, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 2343.
https://doi.org/10.1182/blood.V106.11.2343.2343
Published: 2005
Journal Articles

Increased GM-CSF Levels in Sickle Cell Disease Are Associated with Increased Leukocyte Counts and Are Reversed by Hydroxyurea.

Nicola Conran, Ph.D, Tohru Ikuta, M.D., Ph.D., Sara T.O. Saad, M.D., PhD, Fernando F. Costa, M.D., Ph.D.
Journal: Blood
Blood (2004) 104 (11): 3573.
https://doi.org/10.1182/blood.V104.11.3573.3573
Published: 2004
Journal Articles

Alterations in Protein-DNA Interactions in the γ-Globin Gene Promoter in Response to Butyrate Therapy

Tohru Ikuta, Yuet Wai Kan, Paul S. Swerdlow, Douglas V. Faller, Susan P. Perrine
Journal: Blood
Blood (1998) 92 (8): 2924–2933.
https://doi.org/10.1182/blood.V92.8.2924
Published: 1998