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Journal Articles

AICAR Induces AMPK-Independent Cell Death in Adult T-Cell Leukemia/Lymphoma and Has Anti-Tumor Activity

Tomohiro Kozako, Akiyoshi Aikawa, Takeo Ohsugi, Shin-Ichiro Honda

Blood (2023) 142 (Supplement 1): 7146.

https://doi.org/10.1182/blood-2023-173246

Published: 2023

Journal Articles

Extracellular CD30 and ADAM10/17 Regulate Brentuximab Vedotin-Induced Cell Death in an Adult T-Cell Leukemia Cell Line

Keisuke Sato, Tomohiro Kozako, Akira Nakano, Kentaro Ogata, Hidetoshi Kamimura, Hidenori Sasaki, Yasushi Takamatsu, Shigeki Takemoto, Shin-Ichiro Honda

Blood (2023) 142 (Supplement 1): 5803.

https://doi.org/10.1182/blood-2023-173221

Published: 2023

Journal Articles

Induction of Apoptosis and Autophagy By Nampt Inhibition in Adult T-Cell Leukemia/Lymphoma and Leukemic Cell Lines

Tomohiro Kozako, PhD, Makoto Yoshimitsu, MD, PhD, Naomichi Arima, MD PhD, Keisuke Sato, MS, Moe Toyoshima, Shin-ichiro Honda, PhD, Shinji Soeda, PhD

Blood (2016) 128 (22): 2327.

https://doi.org/10.1182/blood.V128.22.2327.2327

Published: 2016

Journal Articles

Telmisartan, Angiotensin II Receptor Blocker, Induces Apoptosis and Autophagy in Adult T-Cell Leukemia Cells from Patients and Leukemia Cell Lines

Tomohiro Kozako, PhD, Makoto Yoshimitsu, MD PhD, Naomichi Arima, MD PhD, Shuhei Soeda, PhD, Shinya Hirata, MD PhD, Hiroaki Tanaka, PhD, Shin-ichiro Honda, PhD, Shinji Soeda, PhD

Blood (2015) 126 (23): 2055.

https://doi.org/10.1182/blood.V126.23.2055.2055

Published: 2015

Journal Articles

Immune Exhaustion and 2B4 Expression in Human T-Cell Lymphotropic Virus Type 1(HTLV-1) Infection

Ezinne Chioma Chibueze, MD, Yohann White, MD, PhD, Makoto Yoshimitsu, MD PhD, Tomohiro Kozako, PhD, Shinsuke Suzuki, MD, PhD, Kakushi Matsushita, MD, Kimiharu Uozumi, MD, PhD, Naomichi Arima, MD, PhD

Blood (2012) 120 (21): 4807.

https://doi.org/10.1182/blood.V120.21.4807.4807

Published: 2012

Journal Articles

CD70 Expression on HTLV-1 Infected T Cells of Carriers and ATL Patients and Its Clinical Significance

Izumi Masamoto, BSc, MSc, Sawako Horai, PhD, Tomohiro Kozako, PhD, Makoto Yoshimitsu, MD, Junko Niimoto, BSc, Yohann White, BMedSc, MBBS, Kimiharu Uozumi, MD, PhD, Shinsuke Suzuki, MD, PhD, Naomichi Arima, MD, PhD

Blood (2010) 116 (21): 1730.

https://doi.org/10.1182/blood.V116.21.1730.1730

Published: 2010

Journal Articles

Overexpression of SIRT1, a Longevity Gene-Encoded Protein, and Induction of Apoptosis by Its Inhibition In Adult T-Cell Leukemia Cells

Tomohiro Kozako, Makoto Yoshimitsu, MD, Yohann White, Akiyoshi Aikawa, Teruhisa Shoji, Shinichiro Honda, Hiroshi Shimeno, Shinji Soeda, Naomichi Arima

Blood (2010) 116 (21): 2768.

https://doi.org/10.1182/blood.V116.21.2768.2768

Published: 2010

Journal Articles

Target Epitopes of Human T Lymphotropic Virus 1 Recognized by Class I MHC-Restricted Cytotoxic T Lymphocytes in HAM/TSP Patients and Infected Patients with Autoimmune Disorders.

Tomohiro Kozako, PhD, Masaki Akimoto, MD, PhD, Yohann White, MD, Shingo Toji, Kakushi Matsushita, MD, PhD, Ryuji Kubota, MD, PhD, Shuji Izumo, MD, PhD, Shinsuke Suzuki, MD, PhD, Kimiharu Uozumi, MD, Hiroshi Shimeno, PhD, Shinji Soeda, PhD, Naomichi Arima, MD, PhD

Blood (2009) 114 (22): 2660.

https://doi.org/10.1182/blood.V114.22.2660.2660

Published: 2009

Journal Articles

SIRT1, a Longevity Gene Encoded Protein, Regulates Apoptosis of Adult T-Cell Leukemia Cells and Its Inhibition by Sirtinol Induces Apoptosis.

Tomohiro Kozako, PhD, Teruhisa Shoji, Akiyoshi Aikawa, Satoru Hayashida, Yukako Kuramoto, PhD, Rie Mononagare, Shinichiro Honda, PhD, Hiroshi Shimeno, PhD, Shinji Soeda, PhD, Makoto Yoshimitsu, MD, Yohann White, MD, Naomichi Arima, MD, PhD

Blood (2009) 114 (22): 3684.

https://doi.org/10.1182/blood.V114.22.3684.3684

Published: 2009

Journal Articles

Increased Frequency of HTLV-1 Tax Specific CD8+ Regulatory T-Cells in HTLV-1 Infected Individuals.

Yohann White, MBBS, BMedSc, Makoto Yoshimitsu, MD, Tomohiro Kozako, PhD, Kakushi Matsushita, MD, PhD, Kimiharu Uozumi, MD, Shinsuke Suzuki, MD, PhD, Hiroki Kofune, BSc, Naomichi Arima, MD, PhD

Blood (2009) 114 (22): 3676.

https://doi.org/10.1182/blood.V114.22.3676.3676

Published: 2009

Journal Articles

Efficient Induction of HTLV-1-Specific CTL Response by HTLV-1/HBc Chimeric Particle without Adjuvant as a Prophylactic for HTLV-1- Associated T-Cell Leukemia

Tomohiro Kozako, PhD, Katsuhiko Fukada, PhD, Shinya Hirata, MD, PhD, Michiko Harao, MD, PhD, Yasuharu Nishimura, MD, PhD, Youichiro Kino, PhD, Yohann White, MD, Naomichi Arima, MD, PhD

Blood (2008) 112 (11): 84.

https://doi.org/10.1182/blood.V112.11.84.84

Published: 2008

Journal Articles

Immunological Function against Human T-Lymphotrophic Virus Type I in Carriers with Collagen Diseases and HAM/TSP.

Tomohiro Kozako, PhD, Makoto Yoshimitsu, MD, Masaki Akimoto, MD, PhD, Kakushi Matsushita, MD, PhD, Yohann White, MD, Shingo Toji, Shuji Izumo, MD, PhD, Shunro Sonoda, MD, PhD, Naomichi Arima, MD, PhD

Blood (2008) 112 (11): 1470.

https://doi.org/10.1182/blood.V112.11.1470.1470

Published: 2008

Journal Articles

CTL Exhaustion in Persistent HTLV-1 Infection and ATLL Is Restored through PD-1/PD-L1 Pathway.

Tomohiro Kozako, PhD, Makoto Yoshimitsu, MD, Hiroshi Fujiwara, MD, PhD, Izumi Masamoto, MS, Sawako Horai, PhD, Masaki Akimoto, MD, PhD, Yukio Suruga, MD, PhD, Hideaki Kawada, MD, Heiichiro Hamada, MD, Noriko Aoki, MD, Shinsuke Suzuki, MD, PhD, Kakushi Matsushita, MD, PhD, Kimiharu Uozumi, MD, PhD, Chuwa Tei, MD, PhD, Naomichi Arima, MD, PhD

Blood (2007) 110 (11): 511.

https://doi.org/10.1182/blood.V110.11.511.511

Published: 2007

Journal Articles

The Frequency, Diversity, and Function of Human T-Cell Leukemia Virus Type 1-Specific CD8+ T-Cell Is Reduced in Adult T-Cell Leukemia Patients.

Tomohiro Kozako, PhD, Masaki Akimoto, MD, Izumi Masamoto, Makoto Yoshimitsu, MD, Kakushi Matsushita, MD, PhD, Shinsuke Suzuki, MD, PhD, Kimiharu Uozumi, MD, PhD, Naomichi Arima, MD, PhD

Blood (2006) 108 (11): 1264.

https://doi.org/10.1182/blood.V108.11.1264.1264

Published: 2006

Journal Articles

The Clinical Significance of Programmed Death1 Ligand-1 Expression on Leukemia Cells in Adult T Cell Leukemia Patients.

Makoto Yoshimitsu, MD, Tomohiro Kozako, PhD, Hiroshi Fujiwara, MD, PhD, Naomichi Arima, MD, Chuwa Tei, MD

Blood (2006) 108 (11): 4425.

https://doi.org/10.1182/blood.V108.11.4425.4425

Published: 2006

Journal Articles

Graft vs. HTLV-I Virus Effect Can Be Induced Independently of Graft vs. Leukemia Effect in Patients with Adult T-Cell Leukemia Who Received Allogeneic Hematopoietic Stem Cell Transplantation.

Hiroshi Fujiwara, MD, PhD, Makoto Yoshimitsu, MD, Atsuo Ozaki, MD, Tomohiro Kozako, Ph.D, Naomichi Arima, MD.Ph.D, Chuwa Tei, MD.Ph.D

Blood (2006) 108 (11): 2903.

https://doi.org/10.1182/blood.V108.11.2903.2903

Published: 2006

Journal Articles

Anti-HTLV-I Tax-Protein-Specific CTL Is Not Necessarily Resposible for Graft-v.s.-ATL Effect in Allogeneic SCT for Patients with Adult T-Cell Leukemia/Lymphoma.

Hiroshi Fujiwara, MD, PhD, Izumi Masamoto, Tomohiro Kozako, PhD, Hideaki Kawada, MD, Makoto Yoshimitsu, MD, Noriko Aoki, MD, Atsuo Ozaki, MD, Heiichiro Hamada, MD, Kakushi Matsushita, MDPhD, Naomichi Arima, MD, PhD, Chuwa Tei, MDPh.D

Blood (2005) 106 (11): 5353.

https://doi.org/10.1182/blood.V106.11.5353.5353

Published: 2005

NARROW

AICAR Induces AMPK-Independent Cell Death in Adult T-Cell Leukemia/Lymphoma and Has Anti-Tumor Activity

Extracellular CD30 and ADAM10/17 Regulate Brentuximab Vedotin-Induced Cell Death in an Adult T-Cell Leukemia Cell Line

Induction of Apoptosis and Autophagy By Nampt Inhibition in Adult T-Cell Leukemia/Lymphoma and Leukemic Cell Lines

Telmisartan, Angiotensin II Receptor Blocker, Induces Apoptosis and Autophagy in Adult T-Cell Leukemia Cells from Patients and Leukemia Cell Lines

Immune Exhaustion and 2B4 Expression in Human T-Cell Lymphotropic Virus Type 1(HTLV-1) Infection

CD70 Expression on HTLV-1 Infected T Cells of Carriers and ATL Patients and Its Clinical Significance

Overexpression of SIRT1, a Longevity Gene-Encoded Protein, and Induction of Apoptosis by Its Inhibition In Adult T-Cell Leukemia Cells

Target Epitopes of Human T Lymphotropic Virus 1 Recognized by Class I MHC-Restricted Cytotoxic T Lymphocytes in HAM/TSP Patients and Infected Patients with Autoimmune Disorders.

SIRT1, a Longevity Gene Encoded Protein, Regulates Apoptosis of Adult T-Cell Leukemia Cells and Its Inhibition by Sirtinol Induces Apoptosis.

Increased Frequency of HTLV-1 Tax Specific CD8+ Regulatory T-Cells in HTLV-1 Infected Individuals.

Efficient Induction of HTLV-1-Specific CTL Response by HTLV-1/HBc Chimeric Particle without Adjuvant as a Prophylactic for HTLV-1- Associated T-Cell Leukemia

Immunological Function against Human T-Lymphotrophic Virus Type I in Carriers with Collagen Diseases and HAM/TSP.

CTL Exhaustion in Persistent HTLV-1 Infection and ATLL Is Restored through PD-1/PD-L1 Pathway.

The Frequency, Diversity, and Function of Human T-Cell Leukemia Virus Type 1-Specific CD8+ T-Cell Is Reduced in Adult T-Cell Leukemia Patients.

The Clinical Significance of Programmed Death1 Ligand-1 Expression on Leukemia Cells in Adult T Cell Leukemia Patients.

Graft vs. HTLV-I Virus Effect Can Be Induced Independently of Graft vs. Leukemia Effect in Patients with Adult T-Cell Leukemia Who Received Allogeneic Hematopoietic Stem Cell Transplantation.

Anti-HTLV-I Tax-Protein-Specific CTL Is Not Necessarily Resposible for Graft-v.s.-ATL Effect in Allogeneic SCT for Patients with Adult T-Cell Leukemia/Lymphoma.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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