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Toshio Yoshizawa, PhD
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Journal Articles

AXL/Mertk Inhibitor ONO-7475 Potently Synergizes with BCL2 Inhibitor ABT-199, Overcomes ABT-199 Resistance Mechanisms, and Kills FLT3 ITD AML Cells

Sean M Post, PhD, Huaxian Ma, MS, Vivian Ruvolo, Xiaorui Zhang, BS, Tomoko Yasuhiro, Kohei Tanaka, Ryohei Kozaki, Toshio Yoshizawa, PhD, Jorge E. Cortes, MD, Courtney D. DiNardo, MDMSc, Marina Y Konopleva, MD PhD, Steven M. Kornblau, MD, Joseph D. Khoury, MD, Michael Andreeff, MD PhD, Peter P. Ruvolo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2550.
https://doi.org/10.1182/blood-2019-128626
Published: 2019
Journal Articles

TAM Inhibitor ONO-7475 Combination with Sorafenib Is Effective Using in Vitro and In Vivo Models of FLT3 ITD Acute Myeloid Leukemia

Peter P. Ruvolo, PhD, Huaxian Ma, MS, Vivian Ruvolo, MS, Xiaorui Zhang, BS, Hong Mu, MD PhD, Tomoko Yasuhiro, Kohei Tanaka, Toshio Yoshizawa, PhD, Weiguo Zhang, MD PhD, Jorge E. Cortes, MD, Michael Andreeff, MD PhD, Sean M Post, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2642.
https://doi.org/10.1182/blood-2018-99-112211
Published: 2018
Journal Articles

AXL Inhibitor ONO-9330547 Suppresses PLK1 Gene and Protein Expression and Effectively Induces Growth Arrest and Apoptosis in FLT3 ITD Acute Myeloid Leukemia Cells

Peter Ruvolo, PhD, Huaxian Ma, BS, Vivian Ruvolo, MS, Hong Mu, MD PhD, Wendy Schober, Tomoko Yasuhiro, Toshio Yoshizawa, PhD, Miguel Gallardo, PhD, Xiaorui Zhang, BS, Joseph D Khoury, MD, Jorge Cortes, MD, Michael Andreeff, MD PhD, Sean M. Post, PhD
Journal: Blood
Blood (2016) 128 (22): 3939.
https://doi.org/10.1182/blood.V128.22.3939.3939
Published: 2016
Journal Articles

A Phase I Study Of The Oral Btk Inhibitor ONO-4059 In Patients With Relapsed/Refractory B-Cell Lymphoma

Simon Rule, MD, Nimish Shah, MD, Gilles Andre Salles, MD, PhD, Lionel Karlin, MD, Franck Morschhauser, MD, PhD, Louis Terriou, MD, Martin JS Dyer, MA, DPhil, FRCP, FRCPath, Claire Hutchinson, BMedSci, MRCP, FRCPath, Chris Fegan, MBBS, Guillaume Cartron, MD, PhD, Tomasz Knurowski, MD, James G Wright, PhD, Andrew J Saunders, MD, Hideyuki Honda, Bsc, Andrew Mazur, Toshio Yoshizawa, PhD, Kazuhito Kawabata, PhD, Joseph TP Birkett, PhD
Journal: Blood
Blood (2013) 122 (21): 4397.
https://doi.org/10.1182/blood.V122.21.4397.4397
Published: 2013
Journal Articles

A Phase I Study Of The Oral Btk Inhibitor ONO-4059 In Patients With Relapsed/Refractory and High Risk Chronic Lymphocytic Leukaemia (CLL)

Gilles Andre Salles, MD, PhD, Lionel Karlin, MD, Simon Rule, MD, Nimish Shah, MD, Franck Morschhauser, MD, PhD, Louis Terriou, MD, Martin JS Dyer, MA, DPhil, FRCP, FRCPath, Claire Hutchinson, BMedSci, MRCP, FRCPath, Chris Fegan, MBBS, Guillaume Cartron, MD, PhD, Tomasz Knurowski, MD, Andrew J Saunders, MD, James G Wright, PhD, Hideyuki Honda, Bsc, Andrew Mazur, Toshio Yoshizawa, PhD, Kazuhito Kawabata, PhD, Joseph TP Birkett, PhD
Journal: Blood
Blood (2013) 122 (21): 676.
https://doi.org/10.1182/blood.V122.21.676.676
Published: 2013
Journal Articles

ONO-4059, A Novel Bruton’s Tyrosine Kinase (Btk) Inhibitor: Synergistic Activity In Combination With Chemotherapy In a ABC-DLBCL Cell Line

Tomoko Yasuhiro, Toshio Yoshizawa, PhD, Joseph TP Birkett, PhD, Kazuhito Kawabata, PhD
Journal: Blood
Blood (2013) 122 (21): 5151.
https://doi.org/10.1182/blood.V122.21.5151.5151
Published: 2013
Journal Articles

Anti-Tumour Efficacy Study Of The Bruton’s Tyrosine Kinase (Btk) Inhibitor, ONO-4059, In Combination With The Glycoengineered Type II Anti-CD20 Monoclonal Antibody, Obinutuzumab (GA101) Demonstrates Superior In Vivo Efficacy Compared To ONO-4059 In Combination With Rituximab

Toshio Yoshizawa, PhD, Tomoko Yasuhiro, Joseph TP Birkett, PhD, Christian Klein, PhD, Kazuhito Kawabata, PhD
Journal: Blood
Blood (2013) 122 (21): 3069.
https://doi.org/10.1182/blood.V122.21.3069.3069
Published: 2013