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Trinayan Kashyap, MS
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Journal Articles

Synergistic Anti-Tumor Effect of KPT-8602, a Second Generation Selective Inhibitor of Nuclear Export (SINE) Compound, and Panobinostat, a Pan-Histone Deacetylase (HDAC) Inhibitor in Multiple Myeloma

Christian Argueta, PhD, Hua Chang, PhD, Trinayan Kashyap, MS, Sivan Elloul, PhD, Sharon Friedlander, PhD, Margaret S. Lee, PhD, Michael Kauffman, MD PhD, Sharon Shacham, PhD MBA, William Senapedis, PhD, Erkan Baloglu, PhD MBA
Journal: Blood
Blood (2016) 128 (22): 3298.
https://doi.org/10.1182/blood.V128.22.3298.3298
Published: 2016
Journal Articles

Combination Therapy with Bortezomib or Carfilzomib and Selinexor Induces Nuclear Localization of Ikbα and Overcomes Acquired Proteasome Inhibitor Resistance in Human Multiple Myeloma

Joel G Turner, PhD, Trinayan Kashyap, MS, Jana L Dawson, BS, Juan A Gomez, BS, Alexis Bauer, BS, Steven Grant, MD, Yun Dai, PhD, Kenneth H. Shain, MD PhD, Mark B Meads, PhD, Yosef Landesman, PhD, Daniel M Sullivan, MD
Journal: Blood
Blood (2016) 128 (22): 3299.
https://doi.org/10.1182/blood.V128.22.3299.3299
Published: 2016
Journal Articles

Clinical Dosing Regimen of Selinexor Maintains Normal Immune Homeostasis and T Cell Effector Function in Mice: Implications for Combination with Immunotherapy

Paul M Tyler, Mariah M Servos, Boris Klebanov, Trinayan Kashyap, MS, Sharon Shacham, PhD MBA, Yosef Landesman, PhD, Michael Dougan, Stephanie K Dougan
Journal: Blood
Blood (2016) 128 (22): 2525.
https://doi.org/10.1182/blood.V128.22.2525.2525
Published: 2016
Journal Articles

Combination of Selinexor and the Proteasome Inhibitor, Bortezomib Shows Synergistic Cytotoxicity in Diffuse Large B-Cells Lymphoma Cells In Vitro and In Vivo

Trinayan Kashyap, MS, Irfana Muqbil, Amro Aboukameel, Boris Klebanov, MA, MS, Ramzi Mohammad, PhD, Asfar Sohail Azmi, PhD, William Senapedis, PhD, Sharon Shacham, PhD MBA, Michael Kauffman, MD PhD, Yosef Landesman, PhD
Journal: Blood
Blood (2016) 128 (22): 4131.
https://doi.org/10.1182/blood.V128.22.4131.4131
Published: 2016
Journal Articles

Combination of Selective Inhibitor of Nuclear Export (SINE) Compounds, Selinexor and KPT-8602, with Venetoclax (ABT-199) Displays Enhanced Activity in Leukemia and Large Cell Lymphoma

Melissa A. Fischer, PhD, Sharon Friedlander, PhD, Leah Hogdal, PhD, Pia Arrate, Hua Chang, PhD, Trinayan Kashyap, MS, Christian Argueta, PhD, Boris Klebanov, MA, MS, William Senapedis, PhD, Erkan Baloglu, PhD MBA, Margaret S. Lee, PhD, Sharon Shacham, PhD MBA, Michael R. Savona, MD
Journal: Blood
Blood (2016) 128 (22): 3949.
https://doi.org/10.1182/blood.V128.22.3949.3949
Published: 2016
Journal Articles

Efficacy of Selinexor Is Dependent on IκB-α Expression and NF-Kb Deactivation in Multiple Myeloma Cells

Trinayan Kashyap, MS, Boris Klebanov, MA, MS, Christian Argueta, PhD, Margaret S. Lee, PhD, Sharon Shacham, PhD MBA, Michael Kauffman, MD PhD, Yosef Landesman, PhD, William Senapedis, PhD
Journal: Blood
Blood (2016) 128 (22): 5660.
https://doi.org/10.1182/blood.V128.22.5660.5660
Published: 2016
Journal Articles

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) Compound, Shows Synergistic Anti-Tumor Activity in Combination with Dexamethasone Characterized By Specific Pattern of Gene Expression in Multiple Myeloma (MM)

Trinayan Kashyap, MS, Boris Klebanov, MA, MS, Margaret S. Lee, PhD, Yosef Landesman, PhD
Journal: Blood
Blood (2015) 126 (23): 3683.
https://doi.org/10.1182/blood.V126.23.3683.3683
Published: 2015
Journal Articles

Combination Therapy of Selinexor with Bortezomib or Carfilzomib Overcomes Drug Resistance to Proteasome Inhibitors (PI) in Human Multiple Myeloma

Daniel M Sullivan, MD, Trinayan Kashyap, MS, Jana L Dawson, BS, Yosef Landesman, PhD, Steven Grant, MD, Kenneth H. Shain, MD PhD, Yun Dai, PhD, Michael Kauffman, MD PhD, Sharon Shacham, Joel G Turner, PhD
Journal: Blood
Blood (2015) 126 (23): 3048.
https://doi.org/10.1182/blood.V126.23.3048.3048
Published: 2015