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Viviana Guadagnuolo, PhD
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Journal Articles

Ex-Vivo Drug Response Profiling for Precision Medicine Approaches in Acute Myeloid Leukemia with the Open Microwell Microfluidic Platform

Laura Rocchi, PhD, Andrea Faenza, PhD, Laura Rambelli, Viviana Guadagnuolo, PhD, Giovanni Marconi, MD, Giorgia Simonetti, PhD, Cristina Papayannidis, MD PhD, Antonella Padella, Nicola Pecorari, Luca Giulianelli, Dario Biscarini, Giovanni Martinelli, MD PhD, Roberto Guerrieri, PhD, Massimo Bocchi, PhD
Journal: Blood
Blood (2016) 128 (22): 1675.
https://doi.org/10.1182/blood.V128.22.1675.1675
Published: 2016
Journal Articles

Alterations of BRCA1 and PALB2 Define a Novel Class of Complex-Karyotype AML with a Very Bad Prognosis

Antonella Padella, Giorgia Simonetti, PhD, Marco Manfrini, PhD, Maria Chiara Fontana, Giovanni Marconi, MD, Anna Ferrari, PhD, Italo Faria do Valle, Marianna Garonzi, Cristina Papayannidis, MD PhD, Eugenia Franchini, Elisa Zuffa, PhD, Viviana Guadagnuolo, PhD, Samantha Bruno, Elena Tenti, Carmen Baldazzi, PhD, Emanuela Ottaviani, Nicoletta Testoni, Daniel Remondini, PhD, Massimo Delledonne, PhD, Giovanni Martinelli, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1677.
https://doi.org/10.1182/blood.V128.22.1677.1677
Published: 2016
Journal Articles

Chromothripsis in Acute Myeloid Leukemia Is Strongly Associated with Poor Prognosis and TP53 Alterations

Maria Chiara Fontana, Giovanni Marconi, MD, Jelena D. Milosevic Feenstra, PhD, Cristina Papayannidis, MD PhD, Marco Manfrini, PhD, Viviana Guadagnuolo, PhD, Giorgia Simonetti, PhD, Antonella Padella, Anna Ferrari, PhD, Eugenia Franchini, Andrea Ghelli Luserna di Rorà, Emanuela Ottaviani, Rossella De Tommaso, Samantha Bruno, Simona Soverini, Nicoletta Testoni, Stefania Paolini, Chiara Sartor, Sarah Parisi, MD, Elena Tenti, Robert Kralovics, Giovanni Martinelli
Journal: Blood
Blood (2016) 128 (22): 1678.
https://doi.org/10.1182/blood.V128.22.1678.1678
Published: 2016
Journal Articles

Alterations in Pathways Regulating Phosphatidil Inositol 3 Phosphate (PI3P) Produce Both Cell Proliferation and Therapy Resistance, and Define a Group of Patients with Poor Prognosis in Acute Myeloid Leukemia (AML)

Giovanni Marconi, MD, Cristina Papayannidis, MD PhD, Maria Chiara Fontana, Antonella Padella, Giorgia Simonetti, PhD, Marco Manfrini, PhD, Anna Ferrari, PhD, Eugenia Franchini, Stefania Paolini, MD, Sarah Parisi, MD, Chiara Sartor, Maria Chiara Abbenante, MD, Silvia Lo Monaco, Francesca Volpato, MD, Elena Tenti, Viviana Guadagnuolo, PhD, Margherita Perricone, PhD, Maria Teresa Bochicchio, Dr., Andrea Ghelli Luserna Di Rora, Carmen Baldazzi, PhD, Valentina Robustelli, Nicoletta Testoni, Simona Soverini, Emanuela Ottaviani, Giovanni Martinelli, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1679.
https://doi.org/10.1182/blood.V128.22.1679.1679
Published: 2016
Journal Articles

Aggressive Aneuploid Acute Myeloid Leukemia Is Dependent on Alterations of P53, Gain of APC and PLK1 and Loss of RAD50

Giorgia Simonetti, PhD, Antonella Padella, Marco Manfrini, PhD, Italo Faria do Valle, Cristina Papayannidis, MD PhD, Maria Chiara Fontana, Viviana Guadagnuolo, PhD, Carmen Baldazzi, PhD, Anna Ferrari, PhD, Samantha Bruno, Alberto Ferrarini, PhD, Simona Bernardi, PhD, Marianna Garonzi, Annalisa Astolfi, PhD, Giovanni Marconi, MD, Elisa Zuffa, PhD, Eugenia Franchini, Emanuela Ottaviani, Antonella Laginestra, Maddalena Raffini, Sara Bacilieri, Nicoletta Testoni, Massimo Delledonne, PhD, Torsten Haferlach, MD, Daniel Remondini, PhD, Giovanni Martinelli
Journal: Blood
Blood (2016) 128 (22): 1702.
https://doi.org/10.1182/blood.V128.22.1702.1702
Published: 2016
Journal Articles

The Genomic and Transcriptomic Landscape of Systemic Mastocytosis

Simona Soverini, Caterina De Benedittis, Michela Rondoni, Cristina Papayannidis, MD PhD, Elisa Ficarra, PhD, Giulia Paciello, Marco Manfrini, PhD, Manuela Mancini, Roberta Zanotti, MD, Luigi Scaffidi, Giorgina Specchia, MD, Francesco Albano, Serena Merante, MD, Chiara Elena, MD, Livio Pagano, Domenica Gangemi, Patrizia Tosi, Luana Bavaro, Maria Chiara Fontana, Viviana Guadagnuolo, PhD, Alberto Ferrarini, PhD, Elisa Zago, PhD, Michele Cavo, Massimo Delledonne, PhD, Peter Valent, MD, Giovanni Martinelli
Journal: Blood
Blood (2016) 128 (22): 3136.
https://doi.org/10.1182/blood.V128.22.3136.3136
Published: 2016
Journal Articles

Genome-Wide Molecular Portrait of Aggressive Systemic Mastocytosis and Mast Cell Leukemia Depicted By Whole Exome Sequencing and Copy Number Variation Analysis

Simona Soverini, PhD, Caterina De Benedittis, PhD, Manuela Mancini, PhD, Michela Rondoni, MD, Cristina Papayannidis, MD PhD, Antonella Padella, Giorgina Specchia, Pr, MD, Roberta Zanotti, MD, Livio Pagano, Viviana Guadagnuolo, PhD, Maria Chiara Fontana, Massimo Delledonne, PhD, Alberto Ferrarini, PhD, Italo Do Valle, Daniel Remondini, PhD, Gastone Castellani, Raffaele Calogero, Serena Merante, MD, Chiara Elena, MD, Peter Valent, MD, Michele Cavo, Giovanni Martinelli, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4085.
https://doi.org/10.1182/blood.V126.23.4085.4085
Published: 2015
Journal Articles

Gemtuzumab-Ozogamicin Containing Regimens As Induction Therapy Give the Highest Complete Remission Rate and the Longest Overall Survival Compared with Other Induction Regimens in Patients with Newly Diagnosed Acute Myeloid Leukemia

Cristina Papayannidis, MD PhD, Anna Candoni, MD, Michele Malagola, Giovanni Marconi, MD, Marco Manfrini, PhD, Giorgia Simonetti, PhD, Elisa Zuffa, PhD, Maria Chiara Abbenante, MD, Sarah Parisi, MD, Stefania Paolini, Chiara Sartor, Eugenia Franchini, Emanuela Ottaviani, Claudia Venturi, PhD, Maria Chiara Fontana, Antonella Padella, Viviana Guadagnuolo, PhD, Maria Teresa Bochicchio, Anna Ferrari, PhD, Simona Soverini, Nicoletta Testoni, Carmen Baldazzi, PhD, Renato Fanin, Domenico Russo, Michele Cavo, MD, Giovanni Martinelli, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2513.
https://doi.org/10.1182/blood.V126.23.2513.2513
Published: 2015
Journal Articles

The Inhibition of Checkpoint Kinase 1 As a Promising Strategy to Increase the Effectiveness of Different Treatments in Acute Lymphoblastic Leukemia

Andrea Ghelli Luserna Di Rora, Ilaria Iacobucci, PhD, Enrica Imbrogno, Enrico Derenzini, MD, Anna Ferrari, PhD, Viviana Guadagnuolo, PhD, Valentina Robustelli, Simona Soverini, Cristina Papayannidis, MD PhD, Maria Chiara Abbenante, MD, Michele Cavo, MD, Giovanni Martinelli, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2478.
https://doi.org/10.1182/blood.V126.23.2478.2478
Published: 2015
Journal Articles

Genomic-Wide Analysis By High Resolution SNP Array Identifies Novel Genomic Alteration in Acute Myeloid Leukemia

Maria Chiara Fontana, Viviana Guadagnuolo, PhD, Cristina Papayannidis, MD PhD, Giorgia Simonetti, PhD, Antonella Padella, Anna Ferrari, PhD, Marco Manfrini, PhD, Italo Faria do Valle, Barbara Santacroce, Margherita Perricone, Giovanni Marconi, MD, Emanuela Ottaviani, Jelena D. Milosevic Feenstra, PhD, Doris Chen, PhD, Nicole C.C. Them, Simona Soverini, Daniel Remondini, PhD, Gerardo Musuraca, Michele Cavo, MD, Robert Kralovics, PhD, Giovanni Martinelli
Journal: Blood
Blood (2015) 126 (23): 2600.
https://doi.org/10.1182/blood.V126.23.2600.2600
Published: 2015
Journal Articles

Two or More Chemotherapy Consolidation Courses, Followed By Autologous Bone Marrow Transplantation, and MRD Negativity, Give Long Term Overall Survival in Acute Myeloid Leukemia Patients

Giovanni Marconi, MD, Cristina Papayannidis, MD PhD, Federico Mosna, Michele Gottardi, Giorgia Simonetti, PhD, Simona Soverini, Antonio Curti, MD PhD, Elisa Zuffa, PhD, Maria Chiara Abbenante, MD, Sarah Parisi, MD, Stefania Paolini, MD, Chiara Sartor, Eugenia Franchini, Emanuela Ottaviani, Claudia Venturi, PhD, Maria Chiara Fontana, Antonella Padella, Viviana Guadagnuolo, PhD, Maria Teresa Bochicchio, Anna Ferrari, PhD, Nicoletta Testoni, Carmen Baldazzi, PhD, Marco Manfrini, PhD, Debora Capelli, MD, Piero Galieni, Andrea Piccin, MD, Giuseppe Visani, MD, Francesco Rodeghiero, Cristina Tecchio, Filippo Gherlinzoni, MD, Michele Cavo, Giovanni Martinelli, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3198.
https://doi.org/10.1182/blood.V126.23.3198.3198
Published: 2015
Journal Articles

Novel Genomic Patterns of Metabolic Remodeling in Acute Myeloid Leukemia

Giorgia Simonetti, PhD, Antonella Padella, Ítalo Faria do Valle, Gabriele Fontanarosa, Elisa Zago, PhD, Marianna Garonzi, Cristina Papayannidis, MD PhD, Maria Chiara Abbenante, MD, Giovanni Marconi, MD, Viviana Guadagnuolo, PhD, Maria Chiara Fontana, Samantha Bruno, Anna Ferrari, PhD, Elisa Zuffa, PhD, Eugenia Franchini, Annalisa Astolfi, PhD, Elisa Dan, Barbara Sinigaglia, Ilaria Iacobucci, PhD, Simona Soverini, Michele Cavo, MD, Emanuela Ottaviani, Alberto Ferrarini, PhD, Massimo Delledonne, PhD, Daniel Remondini, PhD, Giovanni Martinelli, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3837.
https://doi.org/10.1182/blood.V126.23.3837.3837
Published: 2015
Journal Articles

RNA Sequencing Reveals Novel and Rare Fusion Transcripts in Acute Myeloid Leukemia

Antonella Padella, Giorgia Simonetti, PhD, Giulia Paciello, Anna Ferrari, PhD, Elisa Zago, PhD, Carmen Baldazzi, PhD, Viviana Guadagnuolo, PhD, Cristina Papayannidis, MD PhD, Valentina Robustelli, Enrica Imbrogno, Nicoletta Testoni, Gerardo Musuraca, Simona Soverini, Massimo Delledonne, PhD, Ilaria Iacobucci, PhD, Clelia Tiziana Storlazzi, PhD, Elisa Ficarra, PhD, Giovanni Martinelli
Journal: Blood
Blood (2015) 126 (23): 3627.
https://doi.org/10.1182/blood.V126.23.3627.3627
Published: 2015
Journal Articles

A Specific Pattern of Somatic Mutations Associates with Poor Prognosis Aneuploid Acute Myeloid Leukemia: Results from the European NGS-PTL Consortium

Giorgia Simonetti, PhD, Antonella Padella, Ítalo Faria do Valle, Marco Manfrini, PhD, Cristina Papayannidis, MD PhD, Carmen Baldazzi, PhD, Maria Chiara Fontana, Viviana Guadagnuolo, PhD, Anna Ferrari, PhD, Elisa Zago, PhD, Marianna Garonzi, Simona Bernardi, Emanuela Ottaviani, Annalisa Astolfi, PhD, Maria Chiara Abbenante, MD, Giovanni Marconi, MD, Simona Soverini, Michele Cavo, MD, Nicoletta Testoni, Alberto Ferrarini, PhD, Massimo Delledonne, PhD, Torsten Haferlach, Daniel Remondini, PhD, Ilaria Iacobucci, PhD, Giovanni Martinelli
Journal: Blood
Blood (2015) 126 (23): 3840.
https://doi.org/10.1182/blood.V126.23.3840.3840
Published: 2015
Journal Articles

Leukemia Associated TP53 Mutations in AML Patients ARE Strongly Associated with Complex Karyotype and Poor Outcome

Anna Ferrari, PhD, Cristina Papayannidis, Carmen Baldazzi, PhD, Ilaria Iacobucci, Stefania Paolini, Antonella Padella, Viviana Guadagnuolo, PhD, Margherita Perricone, Valentina Robustelli, Claudia Venturi, Maria Chiara Abbenante, Sarah Parisi, Chiara Sartor, Francesca Volpato, Nicoletta Testoni, BSc, Giorgia Simonetti, PhD, Emanuela Ottaviani, Giovanni Martinelli, MD
Journal: Blood
Blood (2014) 124 (21): 2379.
https://doi.org/10.1182/blood.V124.21.2379.2379
Published: 2014
Journal Articles

Next-Generation Sequencing Analysis Revealed That BCL11B Chromosomal Translocation Cooperates with Point Mutations in the Pathogenesis of Acute Myeloid Leukemia

Antonella Padella, Giorgia Simonetti, PhD, Viviana Guadagnuolo, PhD, Emanuela Ottaviani, Anna Ferrari, PhD, Elisa Zago, PhD, Francesca Griggio, Marianna Garonzi, Giulia Paciello, Simona Bernardi, Carmen Baldazzi, PhD, Cristina Papayannidis, MD PhD, Maria Chiara Abbenante, Francesca Volpato, Raffaele Calogero, PhD, Nicoletta Testoni, PhD, Elisa Ficarra, Alberto Ferrarini, PhD, Massimo Delledonne, PhD, Ilaria Iacobucci, PhD, Giovanni Martinelli, MD
Journal: Blood
Blood (2014) 124 (21): 2352.
https://doi.org/10.1182/blood.V124.21.2352.2352
Published: 2014
Journal Articles

Dissecting the Molecular Mechanisms of Aneuploidy in Acute Myeloid Leukemia By Next Generation Sequencing

Giorgia Simonetti, PhD, Antonella Padella, Anna Ferrari, PhD, Viviana Guadagnuolo, PhD, Elisa Zago, PhD, Francesca Griggio, Marianna Garonzi, Simona Bernardi, Cristina Papayannidis, MD PhD, Stefania Paolini, Francesca Volpato, Emanuela Ottaviani, Margherita Bodini, Laura Riva, PhD, Serena Formica, Annalisa Astolfi, PhD, Carmen Baldazzi, PhD, Elisa Dan, Barbara Sinigaglia, Ilaria Iacobucci, PhD, Nicoletta Testoni, BSc, Daniel Remondini, PhD, Pier Giuseppe Pelicci, Raffaele Calogero, PhD, Alberto Ferrarini, PhD, Massimo Delledonne, PhD, Giovanni Martinelli, MD
Journal: Blood
Blood (2014) 124 (21): 1028.
https://doi.org/10.1182/blood.V124.21.1028.1028
Published: 2014
Journal Articles

SIRPB1 Is a Strong Predictor Biomarker of Response to 5-Azacitidine Therapy in MDS and AML Patients

Viviana Guadagnuolo, PhD, Cristina Papayannidis, Ilaria Iacobucci, Antonella Padella, Giorgia Simonetti, Stefania Paolini, Mariachiara Abbenante, Sarah Parisi, Francesca Volpato, Chiara Sartor, Maria Chiara Fontana, Emanuela Ottaviani, Anna Ferrari, PhD, Nicoletta Testoni, BSc, Carmen Baldazzi, PhD, Massimo Delledonne, Carla Filì, MD, Michele Malagola, Federica Cattina, Simona Bernardi, Domenico Russo, MD PhD, Giovanni Martinelli, MD
Journal: Blood
Blood (2014) 124 (21): 1030.
https://doi.org/10.1182/blood.V124.21.1030.1030
Published: 2014
Journal Articles

Inactivation of the SETD2 Tumor Suppressor Gene in Mast Cell Leukemia

Simona Soverini, PhD, Caterina De Benedittis, Michela Rondoni, MD, Manuela Mancini, PhD, Cristina Papayannidis, MD PhD, Viviana Guadagnuolo, PhD, Elisa Leo, PhD, Luca Zazzeroni, Raffaele Calogero, PhD, Elisa Zago, Anna Scandola, Marianna Garonzi, Alberto Ferrarini, Paolo Savini, MD, Oliviero Quercia, Livio Pagano, MD, Roberta Zanotti, MD, Omar Perbellini, MD, Giorgina Specchia, Serena Merante, Chiara Elena, MD, Domenica Gangemi, Giovanni Poletti, MD, Massimo Delledonne, PhD, Sabine Cerny-Reiterer, Dr., Michele Cavo, MD, Peter Valent, MD, Giovanni Martinelli
Journal: Blood
Blood (2014) 124 (21): 1881.
https://doi.org/10.1182/blood.V124.21.1881.1881
Published: 2014
Journal Articles

Very Poor Outcome and Chemoresistance of Acute Myeloid Leukemia Patients with TP53 Mutations: Correlation with Complex Karyotype and Clinical Outcome

Cristina Papayannidis, MD PhD, Anna Ferrari, PhD, Stefania Paolini, Carmen Baldazzi, PhD, Chiara Sartor, Abbenante maria Chiara, Giovanni Marconi, Sarah Parisi, Francesca Volpato, Ilaria Iacobucci, PhD, Antonella Padella, Viviana Guadagnuolo, PhD, Margherita Perricone, Valentina Robustelli, Claudia Venturi, PhD, Giorgia Simonetti, PhD, Alberto Conficoni, Katia Mancuso, MD, Beatrice Zannetti, Emanuela Ottaviani, Elisa Zuffa, PhD, Eugenia Franchini, Nicoletta Testoni, BSc, Michele Cavo, MD, Giovanni Martinelli
Journal: Blood
Blood (2014) 124 (21): 484.
https://doi.org/10.1182/blood.V124.21.484.484
Published: 2014