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Wai-Kin Chan
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Journal Articles

The asns inhibitor asx-173 potentiates l-asparaginase anticancer activity

Free
Victor Tatarskii, Wai-Kin Chan, Lin Tan, Alvina Khamidullina, Iqbal Mahmud, Marina Konopleva, John Weinstein, Roman Kombarov, Philip Lorenzi
Journal: Blood
Blood (2025) 146 (Supplement 1): 4327.
https://doi.org/10.1182/blood-2025-4327
Published: 2025
Journal Articles

The Glutaminase Activity of L-Asparaginase Mediates Suppression of Asns Upregulation

Free
Wai Kin Chan, PhD, Lin Tan, MS, Karine Harutyunyan, PhD, Di Du, PhD, Leona Martin, MS, Eric Yin, MS, Marina Y. Konopleva, MD PhD, John Weinstein, MD PhD, Philip L Lorenzi, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3959.
https://doi.org/10.1182/blood-2018-99-117818
Published: 2018
Journal Articles

Red Blood Cell-Encapsulation of L-Asparaginase Favorably Modulates Target Selectivity and Pharmacodynamics

Free
Philip L Lorenzi, PhD, Thomas D Horvath, PhD, Leona A Martin, M.S., Wai Kin Chan, PhD, Di Du, PhD, David H. Hawke, PhD, John N Weinstein, MD,PhD, Kenneth J Swart, PhD, Iman El-Hariry, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1266.
https://doi.org/10.1182/blood.V128.22.1266.1266
Published: 2016
Journal Articles

The glutaminase activity of l-asparaginase is not required for anticancer activity against ASNS-negative cells

Free
Wai Kin Chan, Philip L. Lorenzi, Andriy Anishkin, Preeti Purwaha, David M. Rogers, Sergei Sukharev, Susan B. Rempe, John N. Weinstein
Journal: Blood
Blood (2014) 123 (23): 3596–3606.
https://doi.org/10.1182/blood-2013-10-535112
Published: 2014
Includes: Supplemental data
Journal Articles

The Glutaminase Activity Of L-Asparaginase Is Not Required For Anticancer Activity Against Asns-Negative Cell Lines

Free
Philip L Lorenzi, Wai Kin Chan, Andriy Anishkin, Preeti Purwaha, David M Rogers, Sergei Sukharev, Susan B Rempe, John N Weinstein
Journal: Blood
Blood (2013) 122 (21): 4912.
https://doi.org/10.1182/blood.V122.21.4912.4912
Published: 2013