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Wilbur A. Lam, MD
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Journal Articles

Monitoring the "Lifetime" of a Thrombus over Long Timescales By Leveraging a Novel Microvasculature-on-Chip Thrombosis Resolution Assay

Yongzhi Qiu, PhD, Yumiko Sakurai, MSc, Wilbur A. Lam, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 441.
https://doi.org/10.1182/blood-2019-128718
Published: 2019
Journal Articles

Stiff Erythrocyte Subpopulations Biomechanically Induce Endothelial Inflammation in Sickle Cell Disease

Christina Caruso, MD, Xiao Zhang, BS, Yumiko Sakurai, MSc, Wei Li, MD, Meredith E. Fay, BS, Marcus A. Carden, MD, David R. Myers, PhD, Robert G. Mannino, PhD, Clinton H. Joiner, MD PhD, Michael D. Graham, PhD, Wilbur A. Lam, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3560.
https://doi.org/10.1182/blood-2019-125408
Published: 2019
Journal Articles

Increased Platelet Force Is Associated with Decreased Bleeding Severity in Pediatric Immune Thrombocytopenia

Oluwamayokun T. Oshinowo, BS, Renee Copeland, BS, Christina Caruso, MD, Meredith E. Fay, BS, Traci Leong, PhD, Carolyn M. Bennett, MDMSc, Wilbur A. Lam, MD PhD, David R. Myers, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1096.
https://doi.org/10.1182/blood-2019-129573
Published: 2019
Journal Articles

A Comparative Medicine Study of Platelet Biophysics Among Hemostasis Models of Different Species

Renee Copeland, BS, Oluwamayokun T. Oshinowo, Yumiko Sakurai, MSc, Meredith Ellen Fay, BS, Brian G. Petrich, PhD, Benjamin Brainard, VMD, Dipl ACVAA, ACVECC, Wilbur A Lam, MD PhD, David R. Myers, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 869.
https://doi.org/10.1182/blood-2018-99-113107
Published: 2018
Journal Articles

Platelet Contraction Force As a Biophysical Biomarker for Bleeding Risk in Patients with Immune Thrombocytopenia

Oluwamayokun T. Oshinowo, Renee Copeland, BS, Carolyn M. Bennett, MD MSc, Wilbur A Lam, MD PhD, David R. Myers, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 517.
https://doi.org/10.1182/blood-2018-99-115292
Published: 2018
Journal Articles

Mitochondrial Uncoupling Prevents Procoagulant Platelet Formation Resulting in Decreased Thrombus Stability

Andaleb Kholmukhamedov, MD, Yumiko Sakurai, MSc, Elaissa L. Hardy, PhD, Wilbur A Lam, MD PhD, Shawn M. Jobe, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2421.
https://doi.org/10.1182/blood-2018-99-117004
Published: 2018
Journal Articles

Integrated Microfluidic Automated Particle Tracking Enables High-Throughput Cell Deformability Cytometry for Red Cell Disorders

Christina Caruso, MD, Puneeth Guruprasad, Robert G Mannino, PhD, Hanqing Zhang, PhD, Cassandra D Josephson, MD, John D Roback, MD PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1033.
https://doi.org/10.1182/blood-2018-99-118830
Published: 2018
Journal Articles

Real-Time Visualization of Shear-Dependent Erythrocyte Deformation into Schistocytes Using Single Micron Microfluidics

Julia Lins Arrighi Woodall, Meredith Ellen Fay, BS, Jordan Ciciliano, BS, PhD, Reza Abbaspour, BS, MS, Muhannad S Bakir, MS, PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1030.
https://doi.org/10.1182/blood-2018-99-120113
Published: 2018
Journal Articles

A Simple, Rapid, and Inexpensive Color-Based Hemoglobin Assay As a Robust Screening Test for Severe Anemia in Limited Resource Settings

Marina Perez-Plazola, Erika Tyburski, BS, Luke R. Smart, MD, Thad A. Howard, MS, Sophie Perier, BS MS, Russell E. Ware, MD PhD, Wilbur A Lam, MD PhD, Patrick T. McGann, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4724.
https://doi.org/10.1182/blood-2018-99-112898
Published: 2018
Journal Articles

A Microengineered Matrix to Decouple the Biophysical and Biochemical Mechanisms of Blood Cell Interactions with Thrombi and Vascular Wall Matrices

Jordan Ciciliano, BS, MS, Reza Abbaspour, Caroline Wu, Muhhanad Bakir, PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2016) 128 (22): 555.
https://doi.org/10.1182/blood.V128.22.555.555
Published: 2016
Journal Articles

Leveraging the Contractile Force of Platelets for Targeted Factor VIII Delivery in Hemophilia with Inhibitors

Caroline E. Hansen, BS, David R Myers, PhD, Yumiko Sakurai, MSc, Wallace Hunter Baldwin, BS, Shannon L. Meeks, MD, L. Andrew Lyon, PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2016) 128 (22): 81.
https://doi.org/10.1182/blood.V128.22.81.81
Published: 2016
Journal Articles

Engineering a "Self-Healing" Hydrogel-Based Microvasculature-on-a-Chip for Investigating the Effects of Cellular and Biomolecular Interactions on Endothelial Permeability in Sickle Cell Disease

Yongzhi Qiu, PhD, Byungwook Ahn, PhD, Yumiko Sakurai, MSc, Caroline Hansen, BS, Clinton H. Joiner, MD PhD, Solomon Fiifi Ofori-Acquah, PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2015) 126 (23): 240.
https://doi.org/10.1182/blood.V126.23.240.240
Published: 2015
Journal Articles

Clot Contraction-Mediated Erythrocyte Packing Is Significantly Altered in Sickle Cell Disease

Hunter Strauss, David R Myers, PhD, Margo Renee Rollins, MD, John W. Weisel, PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2015) 126 (23): 215.
https://doi.org/10.1182/blood.V126.23.215.215
Published: 2015
Journal Articles

Characterizing Cellular Interactions Contributing to Vaso-Occlusion in Patients with Sickle Cell Disease Utilizing a Novel Endothelialized Microfluidic Device

Margo Renee Rollins, MD, Byungwook Ahn, PhD, Yumiko Sakurai, MSc, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3381.
https://doi.org/10.1182/blood.V126.23.3381.3381
Published: 2015
Journal Articles

Improving Lentiviral Transduction Efficiency with Microfluidic Systems

Reginald Tran, BS, David R Myers, PhD, Jordan E Shields, MS, Byungwook Ahn, PhD, Yongzhi Qiu, PhD, Caroline Hansen, BS, Yumiko Sakurai, MSc, Robert Moot, BS, H. Trent Spencer, PhD, Christopher B Doering, PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4415.
https://doi.org/10.1182/blood.V126.23.4415.4415
Published: 2015
Journal Articles

Vessel Geometry Interacts with Red Blood Cell Stiffness to Promote Endothelial Dysfunction in Sickle Cell Disease

Yichen Wang, Robert G Mannino, BS, David R Myers, PhD, Wei Li, Clinton H. Joiner, MD PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2015) 126 (23): 965.
https://doi.org/10.1182/blood.V126.23.965.965
Published: 2015
Journal Articles

Engineering a Valve-Regulated Endothelialized Microfluidic Device As an " in Vitro " Bleeding Time for Assessing Global Hemostasis

Yumiko Sakurai, MSc, Elaissa T. Hardy, PhD, Byungwook Ahn, PhD, Shannon L. Meeks, MD, W. Hunter Baldwin, BS, Shawn M Jobe, MD PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3485.
https://doi.org/10.1182/blood.V126.23.3485.3485
Published: 2015
Journal Articles

Commonly Used Clinical Intravenous Fluid Formulations Differentially Affect Sickle Red Blood Cell Stiffness and Transit Time

Marcus A Carden, MD, Meredith Ellen Fay, BS, Yumiko Sakurai, MSc, Robert G Mannino, BS, Jordan Ciciliano, BS, Reginald Tran, BS, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2164.
https://doi.org/10.1182/blood.V126.23.2164.2164
Published: 2015
Journal Articles

Vascular Geometry and Flow Profile Mediate Pathological Cell-Cell Interactions in Sickle Cell Disease As Measured with "Do-It-Yourself" "Endothelial-Ized" Microfluidics

Robert Mannino, BS, David R Myers, PhD, Byungwook Ahn, PhD, Hope Gole, PhD, Yichen Wang, Angela Lin, Robert Guldberg, PhD, Don Giddens, PhD, Lucas Timmins, PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2014) 124 (21): 454.
https://doi.org/10.1182/blood.V124.21.454.454
Published: 2014
Journal Articles

Investigating Platelet Interactions in Sickle Cell Disease Using a Novel Multi-Shear "Endothelialized" Microfluidic System

Margo Renee Rollins, MD, Byungwook Ahn, PhD, Yumiko Sakurai, MSc, Jordan C Ciciliano, BS, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4155.
https://doi.org/10.1182/blood.V124.21.4155.4155
Published: 2014