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Journal Articles

3D Modeling of Novel Transforming JAK Mutations in T-Cell Acute Lymphoblastic Leukemia Reveals Altered Pseudokinase-Kinase Domain Interactions That Result in Constitutive JAK Kinase Activity

Kirsten Canté-Barrett, PhD, Joost CM Uitdehaag, PhD, Jessica GCAM Buijs-Gladdines, Wilco K Smits, Rogier C Buijsman, PhD, Guido JR Zaman, PhD, Rob Pieters, MD PhD, Jules PP Meijerink, PhD
Journal: Blood
Blood (2015) 126 (23): 869.
https://doi.org/10.1182/blood.V126.23.869.869
Published: 2015
Journal Articles

Identification of Candidate Oncogenes and Chromosomal Breakpoint Sequencing By Targeted Locus Amplification in T-Cell Acute Lymphoblastic Leukemia

Eric M Vroegindeweij, PhD, Tim Lammens, PhD, Erik Splinter, PhD, Anne Uyttebroeck, Kirsten Canté-Barrett, PhD, Jessica GCAM Buijs-Gladdines, Wilco K Smits, Peter Vandenberghe, MD PhD, Max J van Min, PhD, Rob Pieters, MD PhD, Pieter Van Vlierberghe, PhD, Jules PP Meijerink, PhD
Journal: Blood
Blood (2015) 126 (23): 1409.
https://doi.org/10.1182/blood.V126.23.1409.1409
Published: 2015
Journal Articles

Constitutive Expression of MEF2C, LYL1, or LMO2 in CD34 + HSCs Blocks the in Vitro Differentiation before the T-Cell Commitment Point and Could be Oncogenic in Early T-Cell Progenitor ALL

Kirsten Canté-Barrett, PhD, Rui D Mendes, Wilco K Smits, Rob Pieters, MD PhD, Jules PP Meijerink, PhD
Journal: Blood
Blood (2015) 126 (23): 2423.
https://doi.org/10.1182/blood.V126.23.2423.2423
Published: 2015
Journal Articles

T-Cell Acute Lymphoblastic Leukemia Patients with Mutations in IL7Ra or Downstream RAS-MEK or PI3K-AKT Can be Collectively Targeted By Combination of RAS and AKT Inhibitors

Kirsten Canté-Barrett, PhD, Jill AP Spijkers-Hagelstein, Jessica GCAM Buijs-Gladdines, Wilco K Smits, Rogier C Buijsman, PhD, Guido JR Zaman, PhD, Rob Pieters, MD PhD, Jules PP Meijerink, PhD
Journal: Blood
Blood (2015) 126 (23): 445.
https://doi.org/10.1182/blood.V126.23.445.445
Published: 2015