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Xavier Jirau Serrano
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Journal Articles

The ATM Inhibitor KU60019 Synergizes the Antineoplastic Effect of Romidepsin in Mantle Cell Lymphoma (MCL)

Luigi Scotto, PhD, Xavier Jirau-Serrano, BS, Kelly Zullo, MS, Michael Mangone, PhD, Jennifer E Amengual, MD, Changchun Deng, MD PhD, Owen A. O'Connor, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3703.
https://doi.org/10.1182/blood.V126.23.3703.3703
Published: 2015
Journal Articles

The Investigational Aurora A Kinase Inhibitor Alisertib Exhibits Broad Activity in Preclinical Models of T-Cell Lymphoma and Is Highly Synergistic with Romidepsin

Kelly Zullo, MS, Yige Guo, PhD, Laurence Cooke, B.A., Xavier Jirau Serrano, BS, Michael Mangone, PhD, Luigi Scotto, PhD, Jennifer E. Amengual, MD, Daruka Mahadevan, MD PhD, Owen A. O'Connor, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4493.
https://doi.org/10.1182/blood.V124.21.4493.4493
Published: 2014
Journal Articles

Complementary Targeting of PI3K and the Proteasome Causes Potent Inhibition of mTORC1 and NF-Kappab in Models of B- and T-Cell Lymphoma

Changchun Deng, MD PhD, Mark Lipstein, B.S., Xavier Jirau Serrano, Michael Mangone, PhD, Luigi Scotto, PhD, Owen A O'Connor, MD, PhD, Peter Sportelli, Hari P. Miskin, MS, Srikant Viswanadha, PhD
Journal: Blood
Blood (2014) 124 (21): 1770.
https://doi.org/10.1182/blood.V124.21.1770.1770
Published: 2014
Journal Articles

The HDACi Romidepsin Markedly Synergizes With Inhibition Of ATM By KU60019 In Mantle Cell Lymphoma

Luigi Scotto, PhD, Kelly Zullo, BS, Xavier Jirau Serrano, BS, Laura K Fogli, MS, Owen A. O'Connor, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3066.
https://doi.org/10.1182/blood.V122.21.3066.3066
Published: 2013
Journal Articles

Dual Targeting With The Selective Histone Deacetylase (HDAC) 6 Inhibitor, ACY-1215, and Bortezomib (BOR) Leads To Marked Disruption Of Protein Degradation Pathways and Apoptosis In Preclinical Models Of Lymphoma

Jennifer E. Amengual, MD, Paul M Johannet, Xavier Jirau-Serrano, BS, Kelly Zullo, BS, Daniela Hoehn, MD, PhD, Govind Bhagat, MD, Maximilian Lombardo, B.S., Luigi Scotto, PhD, Simon S Jones, PhD, Owen A. O'Connor, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 648.
https://doi.org/10.1182/blood.V122.21.648.648
Published: 2013
Journal Articles

Novel Imaging Modalities in Innovative Xenograft Mouse Models of T-Cell Lymphoma Confirm Marked Synergy of Romidepsin and Pralatrexate.

Salvia Jain, MD, Xavier Jirau-Serrano, BS, Carmine F Palermo, BS, Luigi Scotto, PhD, Kenneth P Olive, PhD, Govind Bhagat, MD, Serge Cremers, PhD, Jennifer E Amengual, MD, Owen A. O'Connor, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2758.
https://doi.org/10.1182/blood.V120.21.2758.2758
Published: 2012