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Journal Articles

CLL Intraclonal Fractions Defined By Time Since Cell Birth/Division Promote a Leukemia-Supportive, Immune-Tolerant Microenvironment By Distinct Mechanisms

Shih-Shih Chen, PhD, Xiao J. Yan, MD PhD, Thomas M. Herndon, MD, Clare C. Sun, MD, Priyadarshini Ravichandran, Michael Ibrahim, Barbara Sherry, PhD, Adrian Wiestner, MD, Kanti R Rai, MD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 1836.

https://doi.org/10.1182/blood-2018-99-119843

Published: 2018

Journal Articles

IGHV Gene Replacement: A Potential Mechanism for Establishing Stereotypy in Certain Cases of Chronic Lymphocytic Leukemia

Sophia Yancopoulos, PhD, Wentian Li, PhD, Xiao J. Yan, MD PhD, Andreas Agathangelidis, PhD, Anastasia Hadzidimitriou, PhD, Frederic Davi, MD PhD, Richard Rosenquist, MD PhD, Paolo Ghia, MD PhD, Kostas Stamatopoulos, MD PhD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 1841.

https://doi.org/10.1182/blood-2018-99-119803

Published: 2018

Journal Articles

The RNA-Binding Protein Musashi 2 Is Upregulated in the Proliferative Fraction of CLL Clones, Particularly in U-CLL Patients, and Its Silencing Induces Programmed Cell Death

Florencia Palacios, PhD, Xiao J. Yan, MD PhD, Jacqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2016) 128 (22): 3216.

https://doi.org/10.1182/blood.V128.22.3216.3216

Published: 2016

Journal Articles

CLL Sera Drive Maturation of Normal Monocytes to M2-like Macrophages By Direct and Indirect Mechanisms

Sonia Marsilio, PhD, Barbara Sherry, PhD, Xiao J. Yan, MD PhD, Jacqueline C. Barrientos, MD, Steven L. Allen, MD, Jonathan E. Kolitz, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2014) 124 (21): 1970.

https://doi.org/10.1182/blood.V124.21.1970.1970

Published: 2014

Journal Articles

Lenalidomide Promotes The Expansion Of CD8 T Cells With An Effector Memory Phenotype In a Murine Xenograft Model Of Chronic Lymphocytic Leukemia

Rita Simone, PhD, Sonia Marsilio, PhD, Piers E.M. Patten, MD, PhD, Gerardo Ferrer, PhD, Shih-Shih Chen, Ph.D., Xiao J. Yan, MD, PhD, Stefano Vergani, Msc, Andrea Nicola Mazzarello, PhD, Jacqueline C. Barrientos, MD, Steven L. Allen, M.D., Jonathan E. Kolitz, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2013) 122 (21): 119.

https://doi.org/10.1182/blood.V122.21.119.119

Published: 2013

Journal Articles

Gene Expression Profiles Document That Recently- and Previously-Divided CLL Fractions Represent a Continuum but Suggest Differing Modes of Activation for These Fractions in U-CLL and M-CLL

Xiao J. Yan, MD, PhD, Wentian Li, Ph.D., Sophia Yancopoulos, PhD, Igor Dozmorov, PhD, Carlo Calissano, MD, Sonia Marsilio, PhD, Rajendra N Damle, PhD, Steven L. Allen, MD, Jonathan E. Kolitz, MD, Jacqueline C. Barrientos, MD, Kanti R. Rai, M.D., Nicholas Chiorazzi, MD

Blood (2012) 120 (21): 317.

https://doi.org/10.1182/blood.V120.21.317.317

Published: 2012

Journal Articles

Chronic Lymphocytic Leukemia Patients with IGHV Genes Carrying Only Silent Mutations Have A Longer Time From Diagnosis to Initial Therapy Than Patients Expressing B-Cell Receptors with No Somatic Mutations

Matthew Kaufman, MD, Xiao J. Yan, MD, PhD, Emanuela M. Ghia, PhD, Donna Neuberg, ScD, Laura Z. Rassenti, Ph.D., Kostas Stamatopoulos, MD, Paolo Ghia, MD, PhD, David G Oscier, MD, Frederic Davi, MD, PhD, Richard Rosenquist, MD, PhD, Chrysoula Belessi, MD, Zadie Davis, PhD, Andreas Agathangelidis, Neil Kay, MD, John C. Byrd, MD, Jennifer R Brown, MD, PhD, Kanti R. Rai, M.D., Thomas J. Kipps, M.D., Ph.D, Nicholas Chiorazzi, M.D.

Blood (2011) 118 (21): 288.

https://doi.org/10.1182/blood.V118.21.288.288

Published: 2011

Journal Articles

Gene Set Enrichment Analysis of Ki-67 high CLL Clones Suggests Complex Interactions of B-Cell Receptor Signaling and Normal Cell Interactions in the Disease

Xiao J. Yan, MD, PhD, Daniel Kalenscher, Erin Boyle, Sophia Yancopoulos, PhD, Rajendra N Damle, PhD, Aarti Damle, Houman Khalili, Annette Lee, PhD, Wentian Li, Ph.D., Igor Dozmorov, MD, PhD, Matthew Kaufman, M.D., Peter Gregersen, MD, Steven L. Allen, M.D., Jonathan E. Kolitz, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, M.D.

Blood (2011) 118 (21): 2833.

https://doi.org/10.1182/blood.V118.21.2833.2833

Published: 2011

Journal Articles

Targeted Oligonucleotide Array Assessment of Genomic Copy Number Alterations for Risk Stratification in Chronic Lymphocytic Leukemia

Jane Houldsworth, PhD, Asha Guttapalli, MS, Xiao J. Yan, MD, PhD, Charles Ma, PhD, Weiyi Chen, PhD, Sujata Patil, PhD, Kanti R Rai, MD, Nicholas Chiorazzi, M.D.

Blood (2011) 118 (21): 1773.

https://doi.org/10.1182/blood.V118.21.1773.1773

Published: 2011

Journal Articles

Combining Expression of Hypervariably Expressed Genes with IGHV Mutation Status Is a More Robust Prognostic Indicator Than Mutation Status Alone in Chronic Lymphocytic Leukemia

Blood (2011) 118 (21): 1774.

https://doi.org/10.1182/blood.V118.21.1774.1774

Published: 2011

Journal Articles

Th-17/IL-17 Axis in Chronic Lymphocytic Leukemia.

Preetesh Jain, MBBS, MD, DM, Xiao J. Yan, MD, PhD, Mohammad Javdan, PhD, Pui Yan Chiu, MS, Rajendra N Damle, PhD, Tarush Kothari, MD, Steven L Allen, Matthew Kaufman, MD, Jonathan E. Kolitz, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD, Barbara Sherry, PhD

Blood (2009) 114 (22): 2357.

https://doi.org/10.1182/blood.V114.22.2357.2357

Published: 2009

Journal Articles

Autologous Human T Cells and Allogeneic Antigen-Presenting Cells Permit Effective Adoptive Transfer of B-CLL Cells Into Immune Deficient Mice.

Davide Bagnara, PhD, Matthew Kaufman, MD, Carlo Calissano, MD, Sonia Marsilio, PhD, Philip Chum, Xiao J. Yan, MD, PhD, Peter K Gregersen, MD, Annette Lee, PhD, Kanti R Rai, MD, Nicholas Chiorazzi, MD

Blood (2009) 114 (22): 2326.

https://doi.org/10.1182/blood.V114.22.2326.2326

Published: 2009

Journal Articles

Multi-Parameter Phenotypic Analysis of Members of Chronic Lymphocytic Leukemia Clones Identifies Distinct Proliferative and Resting/Re-Entry Compartments with Discrete Gene Expression Profiles.

Carlo Calissano, MD, Rajendra N Damle, PhD, Xiao J. Yan, MD, PhD, Wentian Li, PhD, Sonia Marsilio, PhD, Jonathan E. Kolitz, MD, Matthew S. Kaufman, MD, Steven L Allen, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2009) 114 (22): 668.

https://doi.org/10.1182/blood.V114.22.668.668

Published: 2009

Journal Articles

A Human Hematopoietic Environment and Autologous T-Cell Growth Support Proliferation of Chronic Lymphocytic Leukemia B Cells in Immune-Deficient Mice

Davide Bagnara, Matthew Kaufman, Xiao J. Yan, MD, PhD, Kanti Rai, Nicholas Chiorazzi, MD

Blood (2008) 112 (11): 26.

https://doi.org/10.1182/blood.V112.11.26.26

Published: 2008

Journal Articles

Elevated Levels of IL-17, MIP-1 β, MIG and ITAC in B-Cell Chronic Lymphocytic Leukemia: Correlation with Prognostic Markers.

Xiao J. Yan, MD, PhD, Michael Centola, PhD, Igor Dozmorov, PhD, Rajendra N. Damle, PhD, Steven L. Allen, MD, Kanti R. Rai, BArbara Sherry, PhD, Nicholas Chiorazzi, MD

Blood (2006) 108 (11): 2788.

https://doi.org/10.1182/blood.V108.11.2788.2788

Published: 2006

Journal Articles

The BCRs Expressed by Leukemia Cells from TCL1 Transgenic Mice Resemble Those of Unmutated B-CLL.

Xiao J. Yan, MD, PhD, Emilia Albesiano, PhD, Gloria Telusma, BS, Nicola Zanesi, Carlo M. Croce, MD., Nicholas Chiorazzi, MD.

Blood (2005) 106 (11): 49.

https://doi.org/10.1182/blood.V106.11.49.49

Published: 2005

Journal Articles

Is Elevated Serum IL-10 in B-CLL Associated with IL-10 Promoter Polymorphisms?.

Charles C. Chu, PhD, Stephanie T. Reese, MS, Leslie O. Goodwin, PhD, Dorothy Guzowski, PhD, Alamelu Chandrasekaran, PhD, Craig Gawel, BA, Wentian Li, PhD, Peter K. Gregersen, MD, Xiao J. Yan, MD, PhD, Barbara Sherry, PhD, Michael Centola, PhD, Steven L. Allen, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2005) 106 (11): 1198.

https://doi.org/10.1182/blood.V106.11.1198.1198

Published: 2005

NARROW

CLL Intraclonal Fractions Defined By Time Since Cell Birth/Division Promote a Leukemia-Supportive, Immune-Tolerant Microenvironment By Distinct Mechanisms

IGHV Gene Replacement: A Potential Mechanism for Establishing Stereotypy in Certain Cases of Chronic Lymphocytic Leukemia

The RNA-Binding Protein Musashi 2 Is Upregulated in the Proliferative Fraction of CLL Clones, Particularly in U-CLL Patients, and Its Silencing Induces Programmed Cell Death

CLL Sera Drive Maturation of Normal Monocytes to M2-like Macrophages By Direct and Indirect Mechanisms

Lenalidomide Promotes The Expansion Of CD8 T Cells With An Effector Memory Phenotype In a Murine Xenograft Model Of Chronic Lymphocytic Leukemia

Gene Expression Profiles Document That Recently- and Previously-Divided CLL Fractions Represent a Continuum but Suggest Differing Modes of Activation for These Fractions in U-CLL and M-CLL

Chronic Lymphocytic Leukemia Patients with IGHV Genes Carrying Only Silent Mutations Have A Longer Time From Diagnosis to Initial Therapy Than Patients Expressing B-Cell Receptors with No Somatic Mutations

Gene Set Enrichment Analysis of Ki-67 high CLL Clones Suggests Complex Interactions of B-Cell Receptor Signaling and Normal Cell Interactions in the Disease

Targeted Oligonucleotide Array Assessment of Genomic Copy Number Alterations for Risk Stratification in Chronic Lymphocytic Leukemia

Combining Expression of Hypervariably Expressed Genes with IGHV Mutation Status Is a More Robust Prognostic Indicator Than Mutation Status Alone in Chronic Lymphocytic Leukemia

Th-17/IL-17 Axis in Chronic Lymphocytic Leukemia.

Autologous Human T Cells and Allogeneic Antigen-Presenting Cells Permit Effective Adoptive Transfer of B-CLL Cells Into Immune Deficient Mice.

Multi-Parameter Phenotypic Analysis of Members of Chronic Lymphocytic Leukemia Clones Identifies Distinct Proliferative and Resting/Re-Entry Compartments with Discrete Gene Expression Profiles.

A Human Hematopoietic Environment and Autologous T-Cell Growth Support Proliferation of Chronic Lymphocytic Leukemia B Cells in Immune-Deficient Mice

Elevated Levels of IL-17, MIP-1 β, MIG and ITAC in B-Cell Chronic Lymphocytic Leukemia: Correlation with Prognostic Markers.

The BCRs Expressed by Leukemia Cells from TCL1 Transgenic Mice Resemble Those of Unmutated B-CLL.

Is Elevated Serum IL-10 in B-CLL Associated with IL-10 Promoter Polymorphisms?.

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American Society of Hematology

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American Society of Hematology

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