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Xiaomei Yan, MD PhD
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Journal Articles

RUNX1 Mutation Leads to Megakaryocyte-Primed Hematopoietic Stem Cell Expansion and Familial Platelet Disorder

Chen Wang, MD, Weinan Wang, BS, Lei Huang, PhD, Yoshihiro Hayashi, MD PhD, Xiongwei Cai, PhD, Xiaomei Yan, MD PhD, Gang Huang, PhD, Yi Zheng, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-140769
Published: 2020
Journal Articles

Myelodysplastic Syndromes-Associated Gene Mutations Lead to Pseudohypoxia Condition and Epigenome Hyper-Methylation in Mouse Genetic Models

Asumi Yokota, PhD, Lulu Zhang, PhD, Jianhua Feng, Xiaomin Feng, MD PhD, Xiaomei Yan, MD PhD, Gang Huang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1696.
https://doi.org/10.1182/blood-2019-126799
Published: 2019
Journal Articles

Inducible Correction of a RUNX1 Mutation of Human AML Causes a Switch of AML to B-ALL

Chen Wang, PhDcandidate, Yoshihiro Hayashi, MD PhD, Xiongwei Cai, PhD, Xiaomei Yan, MD PhD, Gang Huang, PhD, Yi Zheng, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1325.
https://doi.org/10.1182/blood-2018-99-116919
Published: 2018
Journal Articles

Myc Regulates the Development and Anti-Tumor Immunity of Natural Killer Cells

Yuting Tang, MD PhD, Xiaomei Yan, MD PhD, Di Zhan, PhD, Lijun Wen, MS, Rui Huang, MD PhD, Yue Zhang, MD PhD, Yoshihiro Hayashi, MD PhD, Qianfei Wang, PhD, Jianfeng Zhou, MD PhD, Gang Huang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1113.
https://doi.org/10.1182/blood-2018-99-114180
Published: 2018
Journal Articles

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

Asumi Yokota, PhD, Lulu Zhang, PhD, Xiaomei Yan, MD PhD, Xiaomin Feng, MD PhD, Lijun Wen, MS, George Freudiger, Maria Rife, Ally Woeste, Yoshihiro Hayashi, MD PhD, Gang Huang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1311.
https://doi.org/10.1182/blood-2018-99-112529
Published: 2018
Journal Articles

Downregulation of SETD2-H3K36me3 Tumor Suppression Axis Promotes MLL Leukemia through Activation of DOT1L-H3K79me2 Axis

Jiachen Bu, Aili Chen, PhD, Yunzhu Dong, PhD, Fuhong He, PhD, Xiaomei Yan, MD PhD, Yile Zhou, Di Zhan, Yoshihiro Hayashi, MD PhD, Qianfei Wang, PhD, Gang Huang, PhD
Journal: Blood
Blood (2016) 128 (22): 435.
https://doi.org/10.1182/blood.V128.22.435.435
Published: 2016
Journal Articles

SETD2, a H3K36 Lysine Methyltransferase, Is Essential for Adult Normal Hematopoiesis and Leukemia Stem Cells

Yile Zhou, Yunzhu Dong, Jiachen Bu, Xiaomei Yan, MD PhD, Yoshihiro Hayashi, MD PhD, Qianfei Wang, PhD, Jie Jin, MD PhD, Gang Huang, PhD
Journal: Blood
Blood (2016) 128 (22): 1055.
https://doi.org/10.1182/blood.V128.22.1055.1055
Published: 2016
Journal Articles

EPO Signaling Triggers Erythrocytosis By Expanding Erythrocytes and Also Subsets of Macrophages

Yoshihiro Hayashi, MD PhD, Jieyu Wang, MD, Zefeng Xu, MD, Xiaomei Yan, MD PhD, Yue Zhang, MD, Theodosia A Kalfa, MD PhD, Zhijian Xiao, MD, Gang Huang, PhD
Journal: Blood
Blood (2016) 128 (22): 542.
https://doi.org/10.1182/blood.V128.22.542.542
Published: 2016
Journal Articles

Two Novel Knock-in and Knock-out of Setd2 Alleles Cooperate with Mll-Af9 Knock-in Allele to Accelerate Leukemia Development

Yunzhu Dong, Yoshihiro Hayashi, MD PhD, Xiaomei Yan, MD PhD, Feng Xue, PhD, Wei Chen, PhD, Gang Huang, PhD
Journal: Blood
Blood (2015) 126 (23): 555.
https://doi.org/10.1182/blood.V126.23.555.555
Published: 2015
Journal Articles

Activation of HIF-2a-EPO Axis in Kidney or Liver Is Sufficient to Drive Erythrocytosis in a Novel Inducible HIF-2a Transgenic Mouse Model

Jieyu Wang, MD, Yoshihiro Hayashi, MD PhD, Zefeng Xu, MD, Lingyun Wu, MD PhD, Xiaomei Yan, MD PhD, Theodosia A. Kalfa, MD PhD, Zhijian Xiao, MD, Gang Huang, PhD
Journal: Blood
Blood (2015) 126 (23): 931.
https://doi.org/10.1182/blood.V126.23.931.931
Published: 2015
Journal Articles

HIF-1a Pathway, As a Signal Funnel for Genetic, Epigenetic, and Metabolic Aberrations, Is Sufficient and Essential for MDS Development

Yoshihiro Hayashi, MD PhD, Yue Zhang, MD, Xiaomei Yan, MD PhD, Kwangmin Choi, PhD, Goro Sashida, MD PhD, Yunzhu Dong, Zefeng Xu, MD, Lingyun Wu, MD PhD, Aili Chen, PhD, Xiujuan Sun, MD, Andre Olsson, PhD, Hironori Harada, MD PhD, Lee-Yung Shih, MD, William Tse, MD FACP, James Bridges, PhD, David P Witte, MD, Qianfei Wang, Michael A. Caligiuri, MD, H. Leighton Grimes, PhD, Stephen D. Nimer, MD, Zhijian Xiao, MD, Gang Huang, PhD
Journal: Blood
Blood (2015) 126 (23): 303.
https://doi.org/10.1182/blood.V126.23.303.303
Published: 2015
Journal Articles

RUNX1/CBFβ Dosage Is Critical for MLL Leukemias Development

Xiaomei Yan, MD PhD, Yoshihiro Hayashi, MD PhD, Xinghui Zhao, PhD, Aili Chen, PhD, Yue Zhang, MD, Fuhong He, Yunzhu Dong, Yalan Rao, PhD, Bo Li, Rajeana Conway, Alba Maiques-Díaz, Nuomin Huang, Shannon E Elf, Johannes Zuber, MD, Zhijian Xiao, MD, William Tse, Daniel G. Tenen, MD, Qianfei Wang, Wei Chen, James C. Mulloy, PhD, Stephen D Nimer, MD, Gang Huang, PhD
Journal: Blood
Blood (2014) 124 (21): 2187.
https://doi.org/10.1182/blood.V124.21.2187.2187
Published: 2014
Journal Articles

Novel Myelodysplastic Syndromes-like Mouse Models By Cooperating Genetic/Epigenetic Mutations Reveal the Critical Role of HIF-1α for Disease Development

Yoshihiro Hayashi, MD PhD, Yue Zhang, MD, Xiaomei Yan, MD PhD, Goro Sashida, MD PhD, Zefeng Xu, MD, Yunzhu Dong, Hironori Harada, MD PhD, Zhijian Xiao, MD, Gang Huang, PhD
Journal: Blood
Blood (2014) 124 (21): 362.
https://doi.org/10.1182/blood.V124.21.362.362
Published: 2014