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Journal Articles

Plasma Proteomic Profile Associated with Platelet Dysfunction after Trauma

Alexander E St. John, MD, Yi Wang, PhD, Junmei Chen, PhD, Warren Osborn, Xu Wang, MD, Esther Lim, BS, Dominic W. Chung, PhD, Susan Stern, MD, Nathan White, MD, Xiaoyun Fu, PhD, Jose A. Lopez, MDBS

Blood (2020) 136 (Supplement 1): 9–10.

https://doi.org/10.1182/blood-2020-141361

Published: 2020

Journal Articles

Human Platelets Stored at Room Temperature Demonstrate Diminished Resistance to Oxidative Stress Compared to Those Stored at 4°C

Xiaoyun Fu, PhD, Warren Osborn, Yu Shen, Yi Wang, PhD, Jeffrey Miles, Lydia Fang, M.S., Barbara Osborne, RN, Junmei Chen, PhD, José A. López, MDBS, Moritz Stolla, MD

Blood (2020) 136 (Supplement 1): 24.

https://doi.org/10.1182/blood-2020-143190

Published: 2020

Journal Articles

Targeted Proteomics Reveals That the Dominant Mechanism of Gpibα Loss during Platelet Storage Depends on Temperature of Storage

Moritz Stolla, MD, Yi Wang, PhD, Jeffrey Miles, Barbara Osborne, RN, Yu Shen, Lydia Fang, M.S., Shawn Lawrence Bailey, BS, Warren Osborn, Junmei Chen, PhD, Jose A. Lopez, MDBS, Xiaoyun Fu, PhD

Blood (2020) 136 (Supplement 1): 31–32.

https://doi.org/10.1182/blood-2020-143077

Published: 2020

Journal Articles

Differential Metabolomics and Lipidomics of Hypoxic/Hypocapnic Long-Term Stored Red Cells Associate with Improved 24-Hour Recovery after Transfusion

Tatsuro Yoshida, PhD, Angelo D'Alessandro, PhD, Xiaoyun Fu, PhD, Travis Nemkov, PhD, Davide Stefanoni, Michael Dioguardi, BS, Neeta Rugg, Shawnagay Nestheide, BS, William Iselin, BA, Andrew Dunham, PhD, James C. Zimring, MD PhD, Jose A Cancelas, MD

Blood (2019) 134 (Supplement_1): 4994.

https://doi.org/10.1182/blood-2019-125961

Published: 2019

Journal Articles

Increased Methylation of Deamidated Asparagines and Aspartates in Stored Red Blood Cells from Glucose 6-Phosphate Dehydrogenase-Deficient Blood Donors

Blood (2018) 132 (Supplement 1): 2543.

https://doi.org/10.1182/blood-2018-99-119262

Published: 2018

Journal Articles

Effect of Intravenous and Oral N-Acetylcysteine Treatment in a Patient with Sickle Cell Disease at Disease Baseline

Hasan Tahsin Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Warren Osborn, Jennie Le, BS, Minhua Ling, PhD, Sophie Schmitter, BS, Sarah Ruuska, MPH, Dominic W. Chung, PhD, Barbara A Konkle, José A. López, MD

Blood (2018) 132 (Supplement 1): 4911.

https://doi.org/10.1182/blood-2018-99-117087

Published: 2018

Journal Articles

Effects of Oral N -Acetylcysteine on Oxidative Stress in Patients with Sickle Cell Disease

Blood (2017) 130 (Supplement 1): 2244.

https://doi.org/10.1182/blood.V130.Suppl_1.2244.2244

Published: 2017

Journal Articles

Effects of N-Acetylcysteine Infusion in Patients with Sickle Cell Disease during Vaso-Occlusive Crises

Hasan Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Melissa Dominguez, MA, Jennie Le, BS, Minhua Ling, PhD, Sophie Schmitter, BS, Sarah Ruuska, MPH, Dominic W. Chung, PhD, Jose A. Lopez, MD, Barbara Konkle, MD

Blood (2017) 130 (Supplement 1): 2238.

https://doi.org/10.1182/blood.V130.Suppl_1.2238.2238

Published: 2017

Journal Articles

A Quantitative Assay of In Vivo Cleavage of Von Willebrand Factor By ADAMTS13 Reveals Excessive Cleavage in Type 2B Von Willebrand Disease and Diminished Cleavage in Thrombotic Thrombocytopenic Purpura

Xiaoyun Fu, PhD, Mallory N. Pahl, Yi Wang, PhD, Barbara A. Konkle, MD, Junmei Chen, PhD, Jose A Lopez, MD

Blood (2016) 128 (22): 2532.

https://doi.org/10.1182/blood.V128.22.2532.2532

Published: 2016

Journal Articles

A Pilot Study of High-Dose N-Acetylcysteine Infusion in Patients with Sickle Cell Disease

Hasan Tahsin Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Shelby A Cate, BS, Jennie Le, BS, Minhua Ling, PhD, Colette Norby, MS, Dominic W Chung, PhD, Barbara A. Konkle, MD, Jose A. Lopez, MD

Blood (2016) 128 (22): 1299.

https://doi.org/10.1182/blood.V128.22.1299.1299

Published: 2016

Journal Articles

Potential Mechanisms for Enhanced Activity of Von Willebrand Factor in Patients with Sickle Cell Disease

Junmei Chen, PhD, Tahsin Özpolat, MD, Yi Wang, PhD, Colette Norby, MS, Minhua Ling, PhD, Dominic W Chung, PhD, Barbara Konkle, MD, Xiaoyun Fu, PhD, Jose A. Lopez, MD

Blood (2016) 128 (22): 3716.

https://doi.org/10.1182/blood.V128.22.3716.3716

Published: 2016

Journal Articles

Bioactive Lipids Are Generated to Micromolar Levels during RBC Storage, Even in Leukoreduced Units

Xiaoyun Fu, PhD, Jacob R. Felcyn, BS, James C. Zimring, MD PhD

Blood (2015) 126 (23): 2344.

https://doi.org/10.1182/blood.V126.23.2344.2344

Published: 2015

Journal Articles

N-Acetylcysteine Treatment in Two Patients with Relapsed Thrombotic Thrombocytopenic Purpura Increased ADAMTS13 Activity, Free Thiol Concentration in Plasma, and Inhibited Platelet Activation

Junmei Chen, PhD, Tahsin Özpolat, MD, Colette Norby, MS, Jennie Le, BS, Minhua Ling, PhD, Shelby A Cate, BS, Dominic W Chung, PhD, Xiaoyun Fu, PhD, Barbara Konkle, MD, Jose A. Lopez, MD

Blood (2015) 126 (23): 239.

https://doi.org/10.1182/blood.V126.23.239.239

Published: 2015

Journal Articles

Effect of N-Acetyl-L-Cysteine on Cysteine Redox Status in Patients with Thrombotic Thrombocytopenic Purpura: Protein Disulfide Bound Cysteine As a Biomarker of Oxidative Stress

Xiaoyun Fu, PhD, Shelby A Cate, BS, Junmei Chen, PhD, Tahsin Özpolat, MD, Colette Norby, MS, Barbara A Konkle, MD, Jose A. Lopez, MD

Blood (2015) 126 (23): 1044.

https://doi.org/10.1182/blood.V126.23.1044.1044

Published: 2015

Journal Articles

Effects of N-Acetylcysteine in Patients with Sickle Cell Disease

Tahsin Özpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Shelby A Cate, BS, Jennie Le, BS, Colette Norby, MS, Barbara A. Konkle, MD, Jose A. Lopez, MD

Blood (2014) 124 (21): 4173.

https://doi.org/10.1182/blood.V124.21.4173.4173

Published: 2014

Journal Articles

Quantitative Analysis of Small Molecular Weight Thiols and Disulfides in Blood from a Sickle Cell Disease Patient Infused with N-Acetyl-L-Cysteine

Shelby A Cate, BS, Tahsin Ozpolat, MD, Junmei Chen, PhD, Colette Norby, MS, Barbara A. Konkle, MD, Jose A. Lopez, MD, Xiaoyun Fu, PhD

Blood (2014) 124 (21): 2662.

https://doi.org/10.1182/blood.V124.21.2662.2662

Published: 2014

Journal Articles

Piperlongumine Blocks JAK2-STAT3 Pathway to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species

Hengjie Yuan, MD PhD, Katie Houck, BS, Ye Tian, MD PhD, Zhou Zhou, MDPhD, Mingzhao Zhu, Vimal Patel, Uddalak Bharadwaj, PhD, David John Tweardy, MD, Daniel Romo, PhD, Xiaoyun Fu, PhD, Yanjun Zhang, PhD, Jianning Zhang, MD PhD, Jing-fei Dong, MD PhD

Blood (2014) 124 (21): 2755.

https://doi.org/10.1182/blood.V124.21.2755.2755

Published: 2014

Journal Articles

Oxidation Of Von Willebrand Factor and ADAMTS13 In Patients With Sickle Cell Disease

Junmei Chen, PhD, Yi Wang, PhD, Tahsin Ozpolat, MD, Colette Norby, MS, Xiaoyun Fu, PhD, José A López

Blood (2013) 122 (21): 2304.

https://doi.org/10.1182/blood.V122.21.2304.2304

Published: 2013

Journal Articles

Coagulopathy In Trauma Patients Is Accompanied By Oxidation Of a Methionine Residue In The αC Domain Of Fibrinogen and Abnormal Fibrin Polymerization

Nathan J White, MD, Yi Wang, Ph.D., Patrick Burney, Xiaoyun Fu, PhD, José A López, Jim Pfaendtner, PhD, Dominic Chung

Blood (2013) 122 (21): 1097.

https://doi.org/10.1182/blood.V122.21.1097.1097

Published: 2013

Journal Articles

High Density Lipoprotein and Apolipoprotein A-I Bind Von Willebrand Factor and Prevent Its Self-Association Into Thick Fibers

Dominic W. Chung, PhD, Ying Zheng, Junmei Chen, PhD, Minhua Ling, Ph.D., Xiaoyun Fu, PhD, José A. López

Blood (2013) 122 (21): 194.

https://doi.org/10.1182/blood.V122.21.194.194

Published: 2013

NARROW

Plasma Proteomic Profile Associated with Platelet Dysfunction after Trauma

Human Platelets Stored at Room Temperature Demonstrate Diminished Resistance to Oxidative Stress Compared to Those Stored at 4°C

Targeted Proteomics Reveals That the Dominant Mechanism of Gpibα Loss during Platelet Storage Depends on Temperature of Storage

Differential Metabolomics and Lipidomics of Hypoxic/Hypocapnic Long-Term Stored Red Cells Associate with Improved 24-Hour Recovery after Transfusion

Increased Methylation of Deamidated Asparagines and Aspartates in Stored Red Blood Cells from Glucose 6-Phosphate Dehydrogenase-Deficient Blood Donors

Effect of Intravenous and Oral N-Acetylcysteine Treatment in a Patient with Sickle Cell Disease at Disease Baseline

Effects of Oral N -Acetylcysteine on Oxidative Stress in Patients with Sickle Cell Disease

Effects of N-Acetylcysteine Infusion in Patients with Sickle Cell Disease during Vaso-Occlusive Crises

A Quantitative Assay of In Vivo Cleavage of Von Willebrand Factor By ADAMTS13 Reveals Excessive Cleavage in Type 2B Von Willebrand Disease and Diminished Cleavage in Thrombotic Thrombocytopenic Purpura

A Pilot Study of High-Dose N-Acetylcysteine Infusion in Patients with Sickle Cell Disease

Potential Mechanisms for Enhanced Activity of Von Willebrand Factor in Patients with Sickle Cell Disease

Bioactive Lipids Are Generated to Micromolar Levels during RBC Storage, Even in Leukoreduced Units

N-Acetylcysteine Treatment in Two Patients with Relapsed Thrombotic Thrombocytopenic Purpura Increased ADAMTS13 Activity, Free Thiol Concentration in Plasma, and Inhibited Platelet Activation

Effect of N-Acetyl-L-Cysteine on Cysteine Redox Status in Patients with Thrombotic Thrombocytopenic Purpura: Protein Disulfide Bound Cysteine As a Biomarker of Oxidative Stress

Effects of N-Acetylcysteine in Patients with Sickle Cell Disease

Quantitative Analysis of Small Molecular Weight Thiols and Disulfides in Blood from a Sickle Cell Disease Patient Infused with N-Acetyl-L-Cysteine

Piperlongumine Blocks JAK2-STAT3 Pathway to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species

Oxidation Of Von Willebrand Factor and ADAMTS13 In Patients With Sickle Cell Disease

Coagulopathy In Trauma Patients Is Accompanied By Oxidation Of a Methionine Residue In The αC Domain Of Fibrinogen and Abnormal Fibrin Polymerization

High Density Lipoprotein and Apolipoprotein A-I Bind Von Willebrand Factor and Prevent Its Self-Association Into Thick Fibers

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American Society of Hematology

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American Society of Hematology

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