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Journal Articles

Discovery of Unexpected Phospholipid-Binding Proteins in Antiphospholipid Syndrome Patients

Jacob H Rand, Xiao-Xuan Wu, Lucia R. Wolgast, Douglas M Taatjes, Stephen R Master

Blood (2023) 142 (Supplement 1): 5393.

https://doi.org/10.1182/blood-2023-182506

Published: 2023

Journal Articles

High Glycine Promotes Proliferation and Progression Though Increase of Glutathione Synthesis in Multiple Myeloma

Jiliang Xia, PhD, Jingyu Zhang, Bin Meng, Xuan Wu, Qian Lei, Yinghong Zhu, Yanjuan He, MD, Lugui Qiu, MD PhD, Wei Jia, PhD, Wen Zhou, PhD

Blood (2019) 134 (Supplement_1): 1791.

https://doi.org/10.1182/blood-2019-125452

Published: 2019

Journal Articles

Excess Serine from the Microenvironment Caused the Impaired Megakaryopoiesis and Thrombocytopia in Multiple Myeloma

Chunmei Kuang, Meijuan Xia, Gang An, MD, Cuicui Liu, Dan Wu, Pei Su, Jingyu Zhang, Jiliang Xia, PhD, Jiaojiao Guo, Xuan Wu, Wei Jia, PhD, Lugui Qiu, MD PhD, Wen Zhou, PhD, Jiaxi Zhou

Blood (2019) 134 (Supplement_1): 4331.

https://doi.org/10.1182/blood-2019-125289

Published: 2019

Journal Articles

NEK2 Promotes Bortezomib Resistance through Enhancing Autophagy By Upregulation of Beclin1 in Multiple Myeloma Cells

Jiliang Xia, PhD, Yanjuan He, MD, Bin Meng, Jingyu Zhang, Xuan Wu, Xiangling Feng, PhD, Chunmei Kuang, Jiaojiao Guo, Yinghong Zhu, Qian Lei, Yongjun Guan, Yi Shen, MD PhD, Lugui Qiu, MD PhD, Wen Zhou, PhD

Blood (2019) 134 (Supplement_1): 4332.

https://doi.org/10.1182/blood-2019-126617

Published: 2019

Journal Articles

Platelet-Derived Microvesicles Reverse the Lupus Anticoagulant Effect and Are More Potent then Synthetic Phospholipids in Supporting Thrombin Generation in Antiphospholipid Syndrome

Cuicui Bai, PhD, Saartje Bloemen, PhD, Xiao Xuan Wu, MD, Ruchika Goel, MD MPH, Sheshadri Narayanan, Bas De Laat, MD, PhD, Jacob H. Rand, MD PhD, Ljiljana V. Vasovic, MD

Blood (2018) 132 (Supplement 1): 3790.

https://doi.org/10.1182/blood-2018-99-113486

Published: 2018

Journal Articles

Potential Metabolite Markers of Multiple Myeloma

Jiliang Xia, PhD, Jingyu Zhang, Xuan Wu, ShiLian Chen, Jingchao Lin, Mingming Su, Jiaojiao Guo, Yongjun Guan, Minghua Wu, Lugui Qiu, MD, Fenghuang Zhan, MD, Wen Zhou, PhD

Blood (2018) 132 (Supplement 1): 3163.

https://doi.org/10.1182/blood-2018-99-115934

Published: 2018

Journal Articles

Antiphospholipid Syndrome (APS) Patient Plasmas Consistently Activate Complement: A Novel Approach to Detecting a Pathogenic Mechanism for APS

Jacob H. Rand, MD, Xiao-Xuan Wu, MD, Lucia R Wolgast, MD, Victor Lei, MSc, Edward M. Conway, MD PhD

Blood (2016) 128 (22): 719.

https://doi.org/10.1182/blood.V128.22.719.719

Published: 2016

Journal Articles

Inverted Erythrocyte Membranes Are a Novel Platform for Expressing Phosphatidylserine and Investigating the Antiphospholipid Syndrome

Saartje Bloemen, PhD, Xiao Xuan Wu, PhD, Bas De Laat, MD PhD, Jacob H. Rand, MD, Ljiljana V. Vasovic, MD

Blood (2015) 126 (23): 2315.

https://doi.org/10.1182/blood.V126.23.2315.2315

Published: 2015

Journal Articles

A Potential Antithrombotic Trick for an Old Drug: Quinine Inhibits the Binding of Antiphospholipid Antibody-β2-Glycoprotein I Immune Complexes to Phospholipid Bilayers in Vitro

Ervis Bezati, Xiao Xuan Wu, MD, Jacob H. Rand, MD

Blood (2012) 120 (21): 3423.

https://doi.org/10.1182/blood.V120.21.3423.3423

Published: 2012

Journal Articles

From Phenomenology to Mechanism: Resistance to Annexin A5 Anticoagulant Activity Identifies a Subset of Patients with Antiphospholipid Antibodies and Thrombosis

Lucia R Wolgast, MD, Xiao Xuan Wu, MD, Alan Arslan, MD, Jacob H. Rand, MD

Blood (2012) 120 (21): 631.

https://doi.org/10.1182/blood.V120.21.631.631

Published: 2012

Journal Articles

A Functional Assay for Annexin A5 Resistance Identifies a Thrombogenic Mechanism In a Subset of Patients with Antiphospholipid Antibodies

Lucia Wolgast, MD, Xiao Xuan Wu, MD, Jessica Niakan, MD, Alan Arslan, MD, Jacob Rand, MD

Blood (2010) 116 (21): 153.

https://doi.org/10.1182/blood.V116.21.153.153

Published: 2010

Journal Articles

Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug

Jacob H. Rand, Xiao-Xuan Wu, Anthony S. Quinn, Anthony W. Ashton, Pojen P. Chen, James J. Hathcock, Harry A. M. Andree, Douglas J. Taatjes

Blood (2010) 115 (11): 2292–2299.

https://doi.org/10.1182/blood-2009-04-213520

Published: 2010

Journal Articles

Hydroxychloroquine Protects the Annexin A5 Anticoagulant Shield from Disruption by Antiphospholipid Antibodies

Jacob Rand, MD, Xiao-Xuan Wu, MD, Anthony Ashton, PhD

Blood (2008) 112 (11): 404.

https://doi.org/10.1182/blood.V112.11.404.404

Published: 2008

Journal Articles

Resistance to Annexin A5 Anticoagulant Activity and Specificity for Anti-B2GPI Domain I Antibodies in Obstetric Antiphospholipid Syndrome

Beverley J Hunt, FRCP, FRCPath, MD, Xiao-Xuan Wu, MD, Bas de Laat, Alan A Arslan, MD, Kiran Parmar, MSc, Sarah Stuart-Smith, MD, Jacob H Rand, MD

Blood (2008) 112 (11): 3821.

https://doi.org/10.1182/blood.V112.11.3821.3821

Published: 2008

Journal Articles

Hydroxychloroquine directly reduces the binding of antiphospholipid antibody–β2-glycoprotein I complexes to phospholipid bilayers

Jacob H. Rand, Xiao-Xuan Wu, Anthony S. Quinn, Pojen P. Chen, James J. Hathcock, Douglas J. Taatjes

Blood (2008) 112 (5): 1687–1695.

https://doi.org/10.1182/blood-2008-03-144204

Published: 2008

Journal Articles

Correlation between antiphospholipid antibodies that recognize domain I of β2-glycoprotein I and a reduction in the anticoagulant activity of annexin A5

Bas de Laat, Xiao-Xuan Wu, Menno van Lummel, Ronald H. W. M. Derksen, Philip G. de Groot, Jacob H. Rand

Blood (2006) 109 (4): 1490–1494.

https://doi.org/10.1182/blood-2006-07-030148

Published: 2006

Journal Articles

Pathological Anti-β 2 -Glycoprotein I Antibodies Disrupt the Anticoagulant Activity of Annexin A5: A Possible Explanation for the Lupus Anticoagulant Paradox.

Bas de Laat, PhD, Xiao-Xuan Wu, PhD, Menno van Lummel, Ronald H.W.M. Derksen, PhD, MD, Philip G. de Groot, PhD, Jacob H. Rand, PhD

Blood (2005) 106 (11): 135.

https://doi.org/10.1182/blood.V106.11.135.135

Published: 2005

Journal Articles

A Novel Flow Cytometric Annexin A5 Competition Assay for the Diagnosis of Antiphospholipid Syndrome.

Lisa Senzel, MD PhD, Xiao-Xuan Wu, MD, Jacob Rand, MD.

Blood (2004) 104 (11): 4042.

https://doi.org/10.1182/blood.V104.11.4042.4042

Published: 2004

Journal Articles

Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome

Jacob H. Rand, Xiao-Xuan Wu, Robert Lapinski, Waander L. van Heerde, Chris P. Reutelingsperger, Pojen P. Chen, Thomas L. Ortel

Blood (2004) 104 (9): 2783–2790.

https://doi.org/10.1182/blood-2004-01-0203

Published: 2004

Journal Articles

Antiphospholipid Antibodies Accelerate Plasma Coagulation by Inhibiting Annexin-V Binding to Phospholipids: A “Lupus Procoagulant” Phenomenon

Jacob H. Rand, Xiao-Xuan Wu, Harry A.M. Andree, J.B. Alexander Ross, Elena Rusinova, Mayra G. Gascon-Lema, Cesare Calandri, Peter C. Harpel

Blood (1998) 92 (5): 1652–1660.

https://doi.org/10.1182/blood.V92.5.1652

Published: 1998

NARROW

Discovery of Unexpected Phospholipid-Binding Proteins in Antiphospholipid Syndrome Patients

High Glycine Promotes Proliferation and Progression Though Increase of Glutathione Synthesis in Multiple Myeloma

Excess Serine from the Microenvironment Caused the Impaired Megakaryopoiesis and Thrombocytopia in Multiple Myeloma

NEK2 Promotes Bortezomib Resistance through Enhancing Autophagy By Upregulation of Beclin1 in Multiple Myeloma Cells

Platelet-Derived Microvesicles Reverse the Lupus Anticoagulant Effect and Are More Potent then Synthetic Phospholipids in Supporting Thrombin Generation in Antiphospholipid Syndrome

Potential Metabolite Markers of Multiple Myeloma

Antiphospholipid Syndrome (APS) Patient Plasmas Consistently Activate Complement: A Novel Approach to Detecting a Pathogenic Mechanism for APS

Inverted Erythrocyte Membranes Are a Novel Platform for Expressing Phosphatidylserine and Investigating the Antiphospholipid Syndrome

A Potential Antithrombotic Trick for an Old Drug: Quinine Inhibits the Binding of Antiphospholipid Antibody-β2-Glycoprotein I Immune Complexes to Phospholipid Bilayers in Vitro

From Phenomenology to Mechanism: Resistance to Annexin A5 Anticoagulant Activity Identifies a Subset of Patients with Antiphospholipid Antibodies and Thrombosis

A Functional Assay for Annexin A5 Resistance Identifies a Thrombogenic Mechanism In a Subset of Patients with Antiphospholipid Antibodies

Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug

Hydroxychloroquine Protects the Annexin A5 Anticoagulant Shield from Disruption by Antiphospholipid Antibodies

Resistance to Annexin A5 Anticoagulant Activity and Specificity for Anti-B2GPI Domain I Antibodies in Obstetric Antiphospholipid Syndrome

Hydroxychloroquine directly reduces the binding of antiphospholipid antibody–β2-glycoprotein I complexes to phospholipid bilayers

Correlation between antiphospholipid antibodies that recognize domain I of β2-glycoprotein I and a reduction in the anticoagulant activity of annexin A5

Pathological Anti-β 2 -Glycoprotein I Antibodies Disrupt the Anticoagulant Activity of Annexin A5: A Possible Explanation for the Lupus Anticoagulant Paradox.

A Novel Flow Cytometric Annexin A5 Competition Assay for the Diagnosis of Antiphospholipid Syndrome.

Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome

Antiphospholipid Antibodies Accelerate Plasma Coagulation by Inhibiting Annexin-V Binding to Phospholipids: A “Lupus Procoagulant” Phenomenon

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American Society of Hematology

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American Society of Hematology

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