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Journal Articles

Sequential Infusion of Anti-CD22 and Anti-CD19 Chimeric Antigen Receptor T Cells for Adult Patients with Refractory/Relapsed B-Cell Acute Lymphoblastic Leukemia

Liang Huang, MD PhD, Na Wang, MD PhD, Chunrui Li, MD PhD, Yang Cao, MD PhD, Yi Xiao, MD PhD, Min Xiao, MD PhD, Yicheng Zhang, MD PhD, Tongcun Zhang, PhD, Jianfeng Zhou, MD PhD

Blood (2017) 130 (Supplement 1): 846.

https://doi.org/10.1182/blood.V130.Suppl_1.846.846

Published: 2017

Journal Articles

Whole Genome and Transcriptome Analysis of Waldenstrom's Cell Lines Show Preservation of Many Important Genomic Features of Primary Disease, and Identify a Non-L265P Mutation in MYD88

Zachary Hunter, PhD, Yang Cao, MD, Guang Yang, PhD, Xia Liu, MD, Jie Chen, PhD, Lian Xu, Nicholas Tsakmaklis, Jiaji Chen, Christopher J Patterson, MFA, Jorge J Castillo, MD, Steven P Treon, MD PhD

Blood (2015) 126 (23): 2665.

https://doi.org/10.1182/blood.V126.23.2665.2665

Published: 2015

Journal Articles

The Clonal Architecture of CXCR4mutations in Waldenstrom's Macroglobulinemia Shows Highly Variable Subclonal Distribution, and Multiple Mutations within Individual Patients Indicative of Targeted Genomic Instability

Blood (2015) 126 (23): 1486.

https://doi.org/10.1182/blood.V126.23.1486.1486

Published: 2015

Journal Articles

Highly Recurrent Copy Number Alterations and Insight Into The Origins Of 6q Deletions In Waldenström’s Macroglobulinemia Revealed By Whole Genome Sequencing

Zachary Hunter, Lian Xu, Guang Yang, PhD, Xia Liu, MD, Yang Cao, MD, Robert Manning, Christina K Tripsas, MA, Christopher Patterson, Steven Peter Treon, MD, MA, PhD

Blood (2013) 122 (21): 4254.

https://doi.org/10.1182/blood.V122.21.4254.4254

Published: 2013

Journal Articles

Somatic Activating Mutations In CXCR4 Are Common In Patients With Waldenstrom’s Macroglobulinemia, and Their Expression In WM Cells Promotes Resistance To Ibrutinib

Yang Cao, MD, Zachary Hunter, Xia Liu, MD, Lian Xu, Guang Yang, PhD, Christina K Tripsas, MA, Robert Manning, Christopher Patterson, Steven Peter Treon, MD, MA, PhD

Blood (2013) 122 (21): 4424.

https://doi.org/10.1182/blood.V122.21.4424.4424

Published: 2013

Journal Articles

Detection Of MYD88 L265P In Peripheral Blood Of Patients With Waldenström's Macroglobulinemia and IgM Monoclonal Gammopathy Of Undetermined Significance

Lian Xu, Zachary Hunter, Guang Yang, PhD, Yangsheng Zhou, MD, Xia Liu, MD, Yang Cao, MD, Robert Manning, Christopher Patterson, Christina K Tripsas, MA, Sandra Kanan, NP, Jiaji G Chen, Neil I Lindeman, MD, Steven Peter Treon, MD, MA, PhD

Blood (2013) 122 (21): 3024.

https://doi.org/10.1182/blood.V122.21.3024.3024

Published: 2013

Journal Articles

PI3K/AKT Pathway Is Activated By MYD88 L265P and Use Of PI3K-Delta Inhibitors Induces Robust Tumor Cell Killing In Waldenstrom’s Macroglobulinemia

Guang Yang, PhD, Xia Liu, MD, Yangsheng Zhou, MD, Lian Xu, Yang Cao, MD, Robert Manning, Christopher Patterson, Christina K Tripsas, MA, Zachary Hunter, Sara Buhrlage, Ph.D, Nathanael S Gray, PhD, Steven Peter Treon, MD, MA, PhD

Blood (2013) 122 (21): 4255.

https://doi.org/10.1182/blood.V122.21.4255.4255

Published: 2013

Journal Articles

A Prospective Multicenter Study Of The Bruton’s Tyrosine Kinase Inhibitor Ibrutinib In Patients With Relapsed Or Refractory Waldenstrom’s Macroglobulinemia

Steven Peter Treon, MD, MA, PhD, Christina K Tripsas, MA, Guang Yang, PhD, Yang Cao, MD, Lian Xu, Zachary Hunter, Steven J Cropper, Patrick Mostyn, Kirsten Meid, MPH, Diane Warren, Christopher Patterson, Gaurav Varma, MSPH, Jacob P. Laubach, MD, Claudia E. Paba-Prada, MD, Janet Kunsman, NP, Irene M. Ghobrial, MD, Sandra Kanan, NP, Ranjana H. Advani, MD, Maria Lia Palomba, MD

Blood (2013) 122 (21): 251.

https://doi.org/10.1182/blood.V122.21.251.251

Published: 2013

Journal Articles

Whole Genome Sequencing Identifies Recurring Somatic Mutations in the C-Terminal Domain of CXCR4, Including a Gain of Function Mutation in Waldenstrom's Macroglobinemia.

Yang Cao, MD, Lian Xu, Xia Liu, MD, Yangsheng Zhou, MD, Guang Yang, MD, Christopher J Patterson, Steven Peter Treon, MD, MA, PhD, Zachary Hunter

Blood (2012) 120 (21): 2715.

https://doi.org/10.1182/blood.V120.21.2715.2715

Published: 2012

Journal Articles

MYD88 L265P Promotes Survival of Waldenstrom's Macroglobulinemia Cells by Activation of Bruton's Tyrosine Kinase

Guang Yang, MD, Yangsheng Zhou, MD, Xia Liu, MD, Lian Xu, Yang Cao, MD, Christopher J Patterson, Yu-Tzu Tai, PhD, Kenneth C. Anderson, Zachary Hunter, Steven P. Treon, M.D., Ph.D.

Blood (2012) 120 (21): 897.

https://doi.org/10.1182/blood.V120.21.897.897

Published: 2012

Journal Articles

A Somatic Variant in MYD88 (L265P) Revealed by Whole Genome Sequencing Differentiates Lymphoplasmacytic Lymphoma From Marginal Zone Lymphomas

Lian Xu, Aliyah R. Sohani, MD, Luca Arcaini, MD, Zachary Hunter, Guang Yang, PhD, Yangsheng Zhou, MD, Xia Liu, MD, Yang Cao, MD, Robert Manning, Christopher J Patterson, Leukothea Ioakimidis, Christina Tripsas, Geraldine S. Pinkus, MD, Nancy Lee Harris, MD, Scott J. Rodig, MD, PhD, Steven Treon, MD, PhD

Blood (2011) 118 (21): 261.

https://doi.org/10.1182/blood.V118.21.261.261

Published: 2011

Journal Articles

MicroRNA-21 and −155 Are Induced by a Widely Expressed Mutation in MyD88 (L265P) in Waldenstrom's Macroglobulinemia,

Yang Cao, MD, Zachary Hunter, Yangsheng Zhou, MD, Xia Liu, MD, Guang Yang, PhD, Lian Xu, Christopher Patterson, Steven P Treon, MD, PhD

Blood (2011) 118 (21): 3957.

https://doi.org/10.1182/blood.V118.21.3957.3957

Published: 2011

Journal Articles

Aberrant Expression of Oct-2, Spi-B, and Id2/Id1 Is Associated with Repression of Plasma Cell Differentiation in Waldenström's Macroglobulinemia

Yangsheng Zhou, MD, Xia Liu, MD, Lian Xu, Guang Yang, PhD, Yang Cao, MD, Zachary Hunter, Steven P Treon, MD, PhD

Blood (2011) 118 (21): 86.

https://doi.org/10.1182/blood.V118.21.86.86

Published: 2011

Journal Articles

Whole-Genome Sequencing Results From 30 Patients with Waldenstrom's Macroglobulinemia

Zachary Hunter, Lian Xu, Yangsheng Zhou, MD, Guang Yang, PhD, Xia Liu, MD, Yang Cao, MD, Christina Hanzis, Patricia Sheehy, NP, Robert Manning, Christopher J Patterson, Jason M Laramie, PhD, Donald A Skifter, PhD, Stephen E Lincoln, PhD, Steven P Treon, MD, PhD

Blood (2011) 118 (21): 434.

https://doi.org/10.1182/blood.V118.21.434.434

Published: 2011

Journal Articles

Whole Genome Sequencing Reveals a Widely Expressed Mutation (MYD88 L265P) with Oncogenic Activity in Waldenstrom's Macroglobulinemia

Steven P Treon, MD, PhD, Lian Xu, Yangsheng Zhou, MD, Xia Liu, MD, Guang Yang, PhD, Yang Cao, MD, Christina Hanzis, Patricia Sheehy, NP, Robert Manning, Christopher J Patterson, Jason M Laramie, PhD, Donald A Skifter, PhD, Stephen E Lincoln, PhD, Zachary Hunter

Blood (2011) 118 (21): 300.

https://doi.org/10.1182/blood.V118.21.300.300

Published: 2011

Journal Articles

Disruption of MYD88 Pathway Signaling Leads to Loss of Constitutive IRAK1, NF-κβ and JAK/STAT Signaling and Induces Apoptosis of Cells Expressing the MYD88 L265P Mutation in Waldenstrom's Macroglobulinemia

Guang Yang, PhD, Yangsheng Zhou, MD, Xia Liu, MD, Yang Cao, MD, Zachary Hunter, Steven P Treon, MD, PhD

Blood (2011) 118 (21): 597.

https://doi.org/10.1182/blood.V118.21.597.597

Published: 2011

Journal Articles

Involvement of Lipogenic Pathway In 5-Azacytidine-Induced Cytotoxicity In Waldenstrom's Macroglobulinemia

Lian Xu, Christopher Patterson, Jenny Sun, MD, Guang Yang, MD, Yangsheng Zhou, MD, Zachary Hunter, Bryan Ciccarelli, Robert Manning, Xia Liu, MD, Yang Cao, MD, Hsiuyi Tseng, Leukothea Ioakimidis, Christina Hanzis, Steven P. Treon, MD, PhD

Blood (2010) 116 (21): 2991.

https://doi.org/10.1182/blood.V116.21.2991.2991

Published: 2010

Journal Articles

The Rituximab and IVIG Related IgM Flare In Waldenstrom's Macroglobulinemia Is Associated with Monocytic Activation of Fcgriia Signaling, and Triggering of IL-6 Release by the PI3K/AKT and MAPK Pathways

Guang Yang, MD, Lian Xu, Zachary Hunter, Xia Liu, MD, Yang Cao, MD, Jingrui Jiang, Hsiuyi Tseng, Yangsheng Zhou, MD, Leukothea Ioakimidis, Christina Hanzis, Patricia Sheehy, NP, Christopher Patterson, Steven P. Treon, MD, PhD

Blood (2010) 116 (21): 2870.

https://doi.org/10.1182/blood.V116.21.2870.2870

Published: 2010

Journal Articles

Aberrant Expression of Regulatory miRNAs and Transcripts for IRS-PI3K Growth and Survival Signaling In Waldenstrom's Macroglobulinemia

Zachary Hunter, Yang Cao, MD, Megan Lewicki, Jenny Sun, MD, Hsiuyi Tseng, Christina Hanzis, Philip Brodsky, Robert Manning, Lian Xu, Guang Yang, MD, Yangsheng Zhou, MD, Xia Liu, MD, Jingrui Jiang, Christopher Patterson, Steven P. Treon, MD, PhD

Blood (2010) 116 (21): 1912.

https://doi.org/10.1182/blood.V116.21.1912.1912

Published: 2010

Journal Articles

Survival Outcomes of Hematopoietic Stem Cell Transplantation (HSCT) and Imatinib in the Treatment of Chronic Myeloid Leukemia Treatment in China: a Meta-Analysis.

Xiaojun Huang, MD, PhD, Zhixiang Shen, MD, PhD, Zi Chen, Yang Cao, MD, Ph.D., Xiaoping Xu, MD, Ph.D., Qiang Wang, Ph.D., Samara Mendes de Costa, Henry Dummett, Jie Chen, MD, Ph.D.

Blood (2009) 114 (22): 2497.

https://doi.org/10.1182/blood.V114.22.2497.2497

Published: 2009

NARROW

Sequential Infusion of Anti-CD22 and Anti-CD19 Chimeric Antigen Receptor T Cells for Adult Patients with Refractory/Relapsed B-Cell Acute Lymphoblastic Leukemia

Whole Genome and Transcriptome Analysis of Waldenstrom's Cell Lines Show Preservation of Many Important Genomic Features of Primary Disease, and Identify a Non-L265P Mutation in MYD88

The Clonal Architecture of CXCR4mutations in Waldenstrom's Macroglobulinemia Shows Highly Variable Subclonal Distribution, and Multiple Mutations within Individual Patients Indicative of Targeted Genomic Instability

Highly Recurrent Copy Number Alterations and Insight Into The Origins Of 6q Deletions In Waldenström’s Macroglobulinemia Revealed By Whole Genome Sequencing

Somatic Activating Mutations In CXCR4 Are Common In Patients With Waldenstrom’s Macroglobulinemia, and Their Expression In WM Cells Promotes Resistance To Ibrutinib

Detection Of MYD88 L265P In Peripheral Blood Of Patients With Waldenström's Macroglobulinemia and IgM Monoclonal Gammopathy Of Undetermined Significance

PI3K/AKT Pathway Is Activated By MYD88 L265P and Use Of PI3K-Delta Inhibitors Induces Robust Tumor Cell Killing In Waldenstrom’s Macroglobulinemia

A Prospective Multicenter Study Of The Bruton’s Tyrosine Kinase Inhibitor Ibrutinib In Patients With Relapsed Or Refractory Waldenstrom’s Macroglobulinemia

Whole Genome Sequencing Identifies Recurring Somatic Mutations in the C-Terminal Domain of CXCR4, Including a Gain of Function Mutation in Waldenstrom's Macroglobinemia.

MYD88 L265P Promotes Survival of Waldenstrom's Macroglobulinemia Cells by Activation of Bruton's Tyrosine Kinase

A Somatic Variant in MYD88 (L265P) Revealed by Whole Genome Sequencing Differentiates Lymphoplasmacytic Lymphoma From Marginal Zone Lymphomas

MicroRNA-21 and −155 Are Induced by a Widely Expressed Mutation in MyD88 (L265P) in Waldenstrom's Macroglobulinemia,

Aberrant Expression of Oct-2, Spi-B, and Id2/Id1 Is Associated with Repression of Plasma Cell Differentiation in Waldenström's Macroglobulinemia

Whole-Genome Sequencing Results From 30 Patients with Waldenstrom's Macroglobulinemia

Whole Genome Sequencing Reveals a Widely Expressed Mutation (MYD88 L265P) with Oncogenic Activity in Waldenstrom's Macroglobulinemia

Disruption of MYD88 Pathway Signaling Leads to Loss of Constitutive IRAK1, NF-κβ and JAK/STAT Signaling and Induces Apoptosis of Cells Expressing the MYD88 L265P Mutation in Waldenstrom's Macroglobulinemia

Involvement of Lipogenic Pathway In 5-Azacytidine-Induced Cytotoxicity In Waldenstrom's Macroglobulinemia

The Rituximab and IVIG Related IgM Flare In Waldenstrom's Macroglobulinemia Is Associated with Monocytic Activation of Fcgriia Signaling, and Triggering of IL-6 Release by the PI3K/AKT and MAPK Pathways

Aberrant Expression of Regulatory miRNAs and Transcripts for IRS-PI3K Growth and Survival Signaling In Waldenstrom's Macroglobulinemia

Survival Outcomes of Hematopoietic Stem Cell Transplantation (HSCT) and Imatinib in the Treatment of Chronic Myeloid Leukemia Treatment in China: a Meta-Analysis.

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American Society of Hematology

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American Society of Hematology

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