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Yaron Pereg, PhD
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Journal Articles

The Selective Anti Leukemic Effect of BL-8040, a Peptidic CXCR4 Antagonist, Is Mediated By Induction of Leukemic Blast Mobilization, Differentiation and Apoptosis: Results of Correlative Studies from a Ph2a Trial in Acute Myeloid Leukemia

Gautam Borthakur, MD, Martin S. Tallman, MD, Yishai Ofran, MD, James M. Foran, MD, Geoffrey L Uy, MD, John F DiPersio, MD PhD, Arnon Nagler, Jacob M. Rowe, MD, Margaret M. Showel, MD, Jessica Altman, MD, Ahmed Al-Rawi, Rui-Yu Wang, MD PhD, Amnon Peled, PhD, Michal Abraham, PhD, Yaron Pereg, PhD, Abi Vainstein, MD, Galia Oberkovitz, PhD, Tzipi Lustig, DVM, Arnon Aharon, MD, Carlos E. Bueso-Ramos, MD PhD, Jorge E. Cortes, MD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2745.
https://doi.org/10.1182/blood.V128.22.2745.2745
Published: 2016
Journal Articles

The High Affinity CXCR4 Inhibitor, BL-8040, Induces Apoptosis of AML Blasts and Their Terminal Differentiation By Blocking AKT/ERK Survival Signals and Downregulating BCL-2, MCL-1 and Cyclin-D1 through Regulation of Mir-15a/16-1 Expression

Michal Abraham, PhD, Shiri Klein, Baruch Bulvik, Hanna Wald, Dvora Holam, Lola Weiss, Katia Beider, PhD, Orly Eizenberg, Ori Wald, MD PhD, Abraham Avigdor, MD, Ohad Benjamini, MD, Eithan Galun, MD, Arnon Nagler, Yaron Pereg, PhD, Amnon Peled, PhD
Journal: Blood
Blood (2016) 128 (22): 767.
https://doi.org/10.1182/blood.V128.22.767.767
Published: 2016
Journal Articles

The Peptidic CXCR4 Antagonist, BL-8040, Significantly Reduces Bone Marrow Immature Leukemia Progenitors By Inducing Differentiation, Apoptosis and Mobilization: Results of the Dose Escalation Clinical Trial in Acute Myeloid Leukemia

Gautam Borthakur, MD, Yishai Ofran, MD, Arnon Nagler, MD MSc, Jacob M. Rowe, MD, James M. Foran, MD, Geoffrey L. Uy, MD, John F. DiPersio, MD PhD, Jessica K. Altman, MD, Olga Frankfurt, MD, Martin S Tallman, MD, Amnon Peled, PhD, Yaron Pereg, PhD, Abi Vainstein, MD, Arnon Aharon, MD, Ahmed AlRawi, PhD, Teresa McQueen, Naveen Pemmaraju, MD, Carlos E. Bueso-Ramos, Jorge E. Cortes, MD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2546.
https://doi.org/10.1182/blood.V126.23.2546.2546
Published: 2015
Journal Articles

BL-8040, a Peptidic CXCR4 Antagonist, Induces Leukemia Cell Death and Specific Leukemia Cell Mobilization in Relapsed/Refractory Acute Myeloid Leukemia Patients in an Ongoing Phase IIa Clinical Trial

Gautam Borthakur, MD, Arnon Nagler, MD, Yishai Ofran, MD, Jacob M. Rowe, MD, Jessica K. Altman, MD, Olga Frankfurt, MD, Martin S. Tallman, MD, Irit Avivi, Amnon Peled, PhD, Yaron Pereg, PhD, Adam Foley-Comer, MD, Lena Russovsky, BS, Arnon Aharon, MD, Teresa McQueen, BS, Naveen Pemmaraju, MD, Carlos E. Bueso-Ramos, MD PhD, Jorge E. Cortes, MD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2014) 124 (21): 950.
https://doi.org/10.1182/blood.V124.21.950.950
Published: 2014