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Yiguo Hu, PhD
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Journal Articles

Functional Mapping of Multiple Myeloma Kinome Using a Small Molecule Inhibitor Library

Eugen Dhimolea, PhD, Emily King, Michal Sheffer, PhD, Yiguo Hu, PhD, Subhashis Sarkar, PhD, Megan Murnane, Megan A. Bariteau, B.Sc., Blake T. Aftab, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3642.
https://doi.org/10.1182/blood.V124.21.3642.3642
Published: 2014
Journal Articles

Temporal Dynamics of Tumor-Microenvironment Interaction and Treatment Responses Revealed through Time-Lapse Compartment-Specific Bioluminescence Imaging: Translational implications

Eugen Dhimolea, PhD, Emily King, Efstathios Kastritis, MD, Douglas W. McMillin, PhD, Jake E. Delmore, B.Sc., Joseph M. Negri, B.Sc., Hannah M. Jacobs, B.Sc., Catriona A. Hayes, MD, Michal Sheffer, PhD, Yiguo Hu, PhD, Subhashis Sarkar, PhD, Richard W.J. Groen, PhD, Megan A. Bariteau, B.Sc., Blake T. Aftab, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2014) 124 (21): 276.
https://doi.org/10.1182/blood.V124.21.276.276
Published: 2014
Journal Articles

Genome-Scale Crispr-Cas9 Knockout Studies Reveal Mutifactorial and Functionally Overlapping Mechanisms of Myeloma Cell Resistance to Proteasome Inhibition

Michal Sheffer, PhD, Yiguo Hu, PhD, Ophir Shalem, PhD, Neville Sanjana, PhD, Eugen Dhimolea, PhD, Subhashis Sarkar, PhD, Megan A. Bariteau, B.Sc., Blake T. Aftab, PhD, Richard W.J. Groen, PhD, Feng Zhang, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2014) 124 (21): 273.
https://doi.org/10.1182/blood.V124.21.273.273
Published: 2014
Journal Articles

Bone Marrow Microenvironment Regulates Alternative Splicing Events in Myeloma Cells through Downregulation of RNA Binding Protein Fox2

Weihua Song, MD, Chaolin Zhang, PhD, Yiguo Hu, PhD, Maria Gkotzamanidou, MD PhD, Parantu Shah, Weisong Shan, MDPhD, Guang Yang, PhD, Yi Li, Adam Sperling, MD PhD, Naim Rashid, PhD, Mehmet Kemal Samur, PhD, Samir B. Amin, MBBS, Yu-Tzu Tai, Teru Hideshima, MDPhD, Giovanni Parmigiani, PhD, Florence Magrangeas, PhD, Stephane Minvielle, PhD, Hervé Avet-Loiseau, MD PhD, Kenneth C. Anderson, Cheng Li, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2014) 124 (21): 4714.
https://doi.org/10.1182/blood.V124.21.4714.4714
Published: 2014
Journal Articles

Bone Marrow Microenvironment Affects The Pathogenesis Of Multiple Myeloma Through Downregulation Of Alternative Splicing Factor Fox2 In Myeloma Cells

Weihua Song, MD, Chaolin Zhang, PhD, Yiguo Hu, PhD, Maria Gkotzamanidou, MD, Parantu Shah, PhD, Weisong Shan, MD PhD, Guang Yang, PhD, Samir B. Amin, MBBS, Yu-Tzu Tai, PhD, Yi Li, PhD, Adam Sperling, MD, PhD, Naim Rashid, PhD, Florence Magrangeas, PhD, Stephane Minvielle, PhD, Hervé Avet-Loiseau, MD, PhD, Kenneth C. Anderson, MD, Cheng Li, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2013) 122 (21): 3085.
https://doi.org/10.1182/blood.V122.21.3085.3085
Published: 2013
Journal Articles

A Novel Small Molecule Inhibitor Of Deubiquitylating Enzyme USP14 and UCHL5 Induces Apoptosis In Myeloma Cells and Overcomes Bortezomib Resistance

Ze Tian, Ph.D, Padraig D'Arcy, Ph.D, Xin Wang, Ph.D, Arghya Ray, Yu-Tzu Tai, PhD, Yiguo Hu, PhD, Ruben Carrasco, MD, PhD, Deepika Das, Ph.D, Paul Richardson, MD, Stig Linder, MD, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2013) 122 (21): 1923.
https://doi.org/10.1182/blood.V122.21.1923.1923
Published: 2013
Journal Articles

CRM1 Blockade by Novel Inhibitors of Nuclear Export (SINEs) Inhibits Multiple Myeloma Cell Growth, Osteoclastogenesis, and Myeloma-Induced Osteolysis

Yu-Tzu Tai, PhD, Yosef Landesman, PhD, Chirag Acharya, M.D., Mike Y Zhong, B.S., Yolanda Calle, PhD, Michele Cea, MD, Yiguo Hu, PhD, Antonia Cagnetta, MD, Daniel Tannenbaum, B.S., Michelle Chen, Aditya Munshi, William Senapedis, PhD, Jean-Richard Saint-Martin, BS, Trinayan Kashyap, Haoqiang Ying, Dilara McCauley, PhD, Sharon Shacham, PhD MBA, Michael Kauffman, MD, PhD, Yumei Gu, Ph.D., Lizi Wu, PhD, Stephen Schey, MD, Andrew L. Kung, MD, PhD, Nikhil C. Munshi, MD, Paul G. Richardson, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2012) 120 (21): 326.
https://doi.org/10.1182/blood.V120.21.326.326
Published: 2012
Journal Articles

Alternate Splicing Factor Fox2 Affects Growth and Survival of Multiple Myeloma Cells

Weihua Song, MD, Yiguo Hu, PhD, Guang Yang, PhD, Parantu K Shah, PhD, Weisong Shan, MD PhD, Yu-Tzu Tai, PhD, Yi Li, PhD, Stephane Minvielle, PhD, Hervé Avet-Loiseau, MD, PhD, Kenneth C. Anderson, MD, Cheng Li, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2011) 118 (21): 1810.
https://doi.org/10.1182/blood.V118.21.1810.1810
Published: 2011
Journal Articles

Dual Inhibition of Canonical and Non-Canonical NF-KB Pathway Demonstrates Significant Anti-Tumor Activities in Multiple Myeloma (MM)

Claire Fabre, MD, PhD, Naoya Mimura, MD, PhD, Kathryn Bobb, MS, Gullu Gorgun, PhD, Diana D. Cirstea, MD, Yiguo Hu, PhD, Jiro Minami, MD, PhD, Hiroto Ohguchi, MD, PhD, Jie Zhang, PhD, Jeffrey Meshulam, BS, Constantine S. Mitsiades, MD, PhD, Paul G. Richardson, MD, Teru Hideshima, MD, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2011) 118 (21): 2902.
https://doi.org/10.1182/blood.V118.21.2902.2902
Published: 2011
Journal Articles

Immunomodulatory Effects of Histone Deacetylase 6 Inhibition in Suppressor Immune Cells in Multiple Myeloma

Gullu Gorgun, PhD, Teru Hideshima, MD, PhD, Noopur S. Raje, MD, Naoya Mimura, MD, PhD, James E. Bradner, MD, Diana Cirstea, MD, Loredana Santo, MD, Yu-Tzu Tai, PhD, Michael Sellitto, Yiguo Hu, PhD, Claire Fabre, MD, PhD, Hiroto Ohguchi, MD, PhD, Jiro Minami, MD, PhD, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2011) 118 (21): 128.
https://doi.org/10.1182/blood.V118.21.128.128
Published: 2011
Journal Articles

Blockade of XBP1 Splicing by Inhibition of IRE1α Is a Promising Therapeutic Option in Multiple Myeloma

Naoya Mimura, MD, PhD, Mariateresa Fulciniti, PhD, Gullu Gorgun, PhD, Yu-Tzu Tai, PhD, Diana D. Cirstea, MD, Loredana Santo, MD, Yiguo Hu, PhD, Claire Fabre, MD, PhD, Jiro Minami, MD, PhD, Hiroto Ohguchi, MD, PhD, Tanyel Kiziltepe, Hiroshi Ikeda, MD, PhD, Yutaka Kawano, MD, PhD, Martina Blumenthal, Victor Tam, Nathalie L. Kertesz, Mark Hokenson, Qingping Zeng, John B. Patterson, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2011) 118 (21): 133.
https://doi.org/10.1182/blood.V118.21.133.133
Published: 2011
Journal Articles

AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor with Potent Activity Against Aurora Kinase and STAT3 In Combination with Lenalidomide Results In Synergistic Anti-Myeloma Activity

Loredana Santo, MD, Teru Hideshima, MD, PhD, Diana Cirstea, MD, Madhavi L Bandi, PhD, Erik A Nelson, PhD, Hiroshi Ikeda, MD, Sonia Vallet, MD, Samantha Pozzi, MD, Kishan Patel, Gullu Gorgun, PhD, Naoya Mimura, MD, Claire Fabre, MD, Yiguo Hu, PhD, Dharminder Chauhan, PhD, Matthew S Squires, PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Noopur Raje, MD
Journal: Blood
Blood (2010) 116 (21): 2994.
https://doi.org/10.1182/blood.V116.21.2994.2994
Published: 2010