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Journal Articles

Defective Platelet Thromboxane A2 Signaling and Serotonin Release in the Pathogenesis of Bleeding during Viral Infection

Roberto Aiolfi, PhD, Giovanni Sitia, Matteo Iannacone, Luca Guidotti, Zaverio M. Ruggeri, MD

Blood (2019) 134 (Supplement_1): 1074.

https://doi.org/10.1182/blood-2019-128940

Published: 2019

Journal Articles

Cardiac Myosin Acts Is a Potent Procoagulant in Vitro and In Vivo

Jevgenia Zilberman-Rudenko, Hiroshi Deguchi, MD PhD, Mohammed Hayat, Meenal Shukla, PhD, Jennifer Nagrampa Orje, Zihan Guo, Tine Wyseure, PhD, Laurent O Mosnier, Owen J T McCarty, PhD, Zaverio M. Ruggeri, MD, John H. Griffin, PhD

Blood (2019) 134 (Supplement_1): 3632.

https://doi.org/10.1182/blood-2019-129312

Published: 2019

Journal Articles

Sca-1 As a Marker of Stress-Induced Thrombopoiesis in Mice

Yosuke Morodomi, MD PhD, Roberto Aiolfi, PhD, Eric Won, MD, Sachiko Kanaji, MD PhD, Paul Schimmel, PhD, Zaverio M. Ruggeri, MD, Taisuke Kanaji, MD

Blood (2019) 134 (Supplement_1): 1068.

https://doi.org/10.1182/blood-2019-127446

Published: 2019

Journal Articles

A Novel Anti-Glycoprotein (GP) Iba-Targeting Chimeric Fibrinolytic Agent Demonstrates In Vivo Efficacy Against Human Platelet-Enriched Thrombi in Mice

Randolph Lyde, PhD, Hyunsook Ahn, Vincent Hayes, Sergei Zaistev, PhD, Shu-Wha Lin, PhD, Zaverio M. Ruggeri, MD, Renhao Li, PhD, Vladimir Muzykantov, Douglas B. Cines, MD, Mortimer Poncz, MD

Blood (2018) 132 (Supplement 1): 990.

https://doi.org/10.1182/blood-2018-99-115262

Published: 2018

Journal Articles

Identification of a VWFA1 Mutation Attenuating Thrombus Growth but Not Platelet Adhesion

Yunfeng Chen, PhD, James R. Roberts, Jennifer Nagrampa Orje, Yosuke Morodomi, MD PhD, Taisuke Kanaji, MD, Sachiko Kanaji, MD PhD, Zaverio M. Ruggeri, MD

Blood (2017) 130 (Supplement 1): 547.

https://doi.org/10.1182/blood.V130.Suppl_1.547.547

Published: 2017

Journal Articles

Expression of Functional Human Proteinase Activated Receptor (PAR)-1 on Mouse Platelets

Alessandro Zarpellon, PhD, Taisuke Kanaji, MD, Sachiko Kanaji, MD PhD, Yosuke Morodomi, MD PhD, Zaverio M. Ruggeri, MD

Blood (2017) 130 (Supplement 1): 451.

https://doi.org/10.1182/blood.V130.Suppl_1.451.451

Published: 2017

Journal Articles

Extracellular Tyrosyl-tRNA Synthetase Is a Potent Stimulator of Thrombocytopoiesis

Sachiko Kanaji, MD PhD, Taisuke Kanaji, MD PhD, My-Nuong Vo, PhD, Alessandro Zarpellon, PhD, Ryan Shapiro, Rajesh Belani, MD, Minh-Ha Do, PhD, Xiang-Lei Yang, PhD, Zaverio M. Ruggeri, MD, Paul Schimmel, PhD

Blood (2016) 128 (22): 1476.

https://doi.org/10.1182/blood.V128.22.1476.1476

Published: 2016

Journal Articles

Humanized Von Willebrand Factor-Glycoprotein Ibα Interaction in Mouse Models of Hemostasis and Thrombosis

Sachiko Kanaji, MD PhD, Jennifer N Orje, Yuichi Kamikubo, PhD, Taisuke Kanaji, MD PhD, Jeremy Mattson, Alessandro Zarpellon, PhD, Scot A. Fahs, Rashmi Sood, PhD, Sandra L Haberichter, PhD, Zaverio M. Ruggeri, MD, Robert R Montgomery, MD

Blood (2016) 128 (22): 558.

https://doi.org/10.1182/blood.V128.22.558.558

Published: 2016

Journal Articles

Platelet-Localized FXI Promotes a Glycoprotein Ib Alpha Dependent Feedback Loop in Arterial Hypertension and Vascular Inflammation

Blood (2015) 126 (23): 2192.

https://doi.org/10.1182/blood.V126.23.2192.2192

Published: 2015

Journal Articles

Distinct Mechanism of Anti-Hemophilic FVIII Activation By Nascent FXa in the Tissue Factor-FVIIa Coagulation Initiation Complex Resistant to FXa-Directed Inhibition

Yuichi Kamikubo, PhD, Grazia Loredana Mendolicchio, MD PhD, Antonella Zampolli, PhD, Patrizia Marchese, PhD, Andrew J. Gale, PhD, Sriram Krishnaswamy, PhD, Andras Gruber, MD, Lars Christian Petersen, Wolfram Ruf, MD, Zaverio M Ruggeri, MD

Blood (2014) 124 (21): 2803.

https://doi.org/10.1182/blood.V124.21.2803.2803

Published: 2014

Journal Articles

A Crucial Role for Caspase 1 in Thrombo-Inflammatory Microparticle Release

Andrea S Rothmeier, PhD, Patrizia Marchese, PhD, Christian Furlan-Freguia, PhD, Brian G. Petrich, PhD, Mark H. Ginsberg, MD, Zaverio M Ruggeri, MD, Wolfram Ruf, MD

Blood (2014) 124 (21): 2806.

https://doi.org/10.1182/blood.V124.21.2806.2806

Published: 2014

Journal Articles

Platelet Aggregation and Fibrin Deposition: The Yin and Yang of Thrombin Activity Regulation By Platelet Glycoprotein Ibα

Alessandro Zarpellon, PhD, Patrizia Marchese, PhD, Antonella Zampolli, Dr. Biol., Grazia Loredana Mendolicchio, MD PhD, Zaverio M. Ruggeri, MD

Blood (2014) 124 (21): 114.

https://doi.org/10.1182/blood.V124.21.114.114

Published: 2014

Journal Articles

Apolipoprotein Α-IV Is a Novel Ligand of Platelet αIIbβ3 Integrin and an Endogenous Thrombosis Inhibitor: Measurement of Single-Molecular Interactions By Biomembrane Force Probe

Blood (2014) 124 (21): 92.

https://doi.org/10.1182/blood.V124.21.92.92

Published: 2014

Journal Articles

Variable Reduction Of Thrombus Formation In The Blood Of Patients Treated With Oral Factor Xa and Thrombin Inhibitors: Pathophysiologic and Therapeutic Implications

Grazia Loredana Mendolicchio, MD, PhD, Patrizia Marchese, PhD, Corrado Lodigiani, MD, PhD, Anna Colombo, BsD, Matteo Ferrari, MD, Marco Scardino, MD, Guido Grappiolo, MD, Lidia Rota, MD, Zaverio M Ruggeri, MD

Blood (2013) 122 (21): 1144.

https://doi.org/10.1182/blood.V122.21.1144.1144

Published: 2013

Journal Articles

GPIbα As a Selective Bidirectional Modulator Of α-Thrombin Prothrombotic Functions Influencing Fibrin Deposition and PAR-Dependent Platelet Activation

Alessandro Zarpellon, PhD, Antonella Zampolli, PhD, Patrizia Marchese, PhD, James R. Roberts, Grazia Loredana Mendolicchio, MD, PhD, Zaverio M Ruggeri, MD

Blood (2013) 122 (21): 32.

https://doi.org/10.1182/blood.V122.21.32.32

Published: 2013

Journal Articles

Binding of Erythrocyte ICAM–4 to the Platelet Activated Integrin α IIb β 3 leads to a Direct Erythrocyte-Platelet Adhesion Under Venous Flow Shear Rate

Vivian Xiaoyan Du, Philip G de Groot, PhD, Richard van Wijk, PhD, Zaverio M. Ruggeri, MD, PhD, Bas De Laat, PhD

Blood (2012) 120 (21): 105.

https://doi.org/10.1182/blood.V120.21.105.105

Published: 2012

Journal Articles

Thrombosis and Inflammation Are Coupled by a Common Thioredoxin Reductase Pathway Downstream of the P2×7 Receptor.

Andrea S Rothmeier, Ph.D., Christian Furlan-Freguia, Ph.D., Brian G. Petrich, PhD, Patrizia Marchese, PhD, Zaverio M. Ruggeri, MD, PhD, Mark H. Ginsberg, M.D., Wolfram Ruf, MD

Blood (2012) 120 (21): 2218.

https://doi.org/10.1182/blood.V120.21.2218.2218

Published: 2012

Journal Articles

Effect of New Direct Oral Anticoagulants on Ex Vivo Platelet and Fibrin Thrombus Formation in Blood Flowing Over Fibrillar Type I Collagen

Grazia Loredana Mendolicchio, MD, PhD, Corrado Lodigiani, MD, Monica Bacci, Marco Scardino, MD, Carlo Ferrari Matteo, MD, Grappiolo Guido, MD, Lidia Rota, MD, Zaverio M. Ruggeri, MD

Blood (2011) 118 (21): 2318.

https://doi.org/10.1182/blood.V118.21.2318.2318

Published: 2011

Journal Articles

Distinct Roles of the Extrinsic and the Intrinsic Coagulation Pathways In Different Murine Thrombosis Models,

Antonella Zampolli, PhD, Patrizia Marchese, PhD, Andras Gruber, MD, Wolfram Ruf, MD, Zaverio M. Ruggeri, MD

Blood (2011) 118 (21): 3278.

https://doi.org/10.1182/blood.V118.21.3278.3278

Published: 2011

Journal Articles

Structural and Functional Evidence on the Role of Sulfated Tyrosine Residues In Glycoprotein Ib Binding to α-Thrombin Exosites

Alessandro Zarpellon, PhD, Reha Celikel, Richard McClintock, James R. Roberts, G. Loredana Mendolicchio, MD, PhD, Hua Jing, PhD, Kottayil I Varughese, PhD, Zaverio M. Ruggeri, MD

Blood (2010) 116 (21): 326.

https://doi.org/10.1182/blood.V116.21.326.326

Published: 2010

NARROW

Defective Platelet Thromboxane A2 Signaling and Serotonin Release in the Pathogenesis of Bleeding during Viral Infection

Cardiac Myosin Acts Is a Potent Procoagulant in Vitro and In Vivo

Sca-1 As a Marker of Stress-Induced Thrombopoiesis in Mice

A Novel Anti-Glycoprotein (GP) Iba-Targeting Chimeric Fibrinolytic Agent Demonstrates In Vivo Efficacy Against Human Platelet-Enriched Thrombi in Mice

Identification of a VWFA1 Mutation Attenuating Thrombus Growth but Not Platelet Adhesion

Expression of Functional Human Proteinase Activated Receptor (PAR)-1 on Mouse Platelets

Extracellular Tyrosyl-tRNA Synthetase Is a Potent Stimulator of Thrombocytopoiesis

Humanized Von Willebrand Factor-Glycoprotein Ibα Interaction in Mouse Models of Hemostasis and Thrombosis

Platelet-Localized FXI Promotes a Glycoprotein Ib Alpha Dependent Feedback Loop in Arterial Hypertension and Vascular Inflammation

Distinct Mechanism of Anti-Hemophilic FVIII Activation By Nascent FXa in the Tissue Factor-FVIIa Coagulation Initiation Complex Resistant to FXa-Directed Inhibition

A Crucial Role for Caspase 1 in Thrombo-Inflammatory Microparticle Release

Platelet Aggregation and Fibrin Deposition: The Yin and Yang of Thrombin Activity Regulation By Platelet Glycoprotein Ibα

Apolipoprotein Α-IV Is a Novel Ligand of Platelet αIIbβ3 Integrin and an Endogenous Thrombosis Inhibitor: Measurement of Single-Molecular Interactions By Biomembrane Force Probe

Variable Reduction Of Thrombus Formation In The Blood Of Patients Treated With Oral Factor Xa and Thrombin Inhibitors: Pathophysiologic and Therapeutic Implications

GPIbα As a Selective Bidirectional Modulator Of α-Thrombin Prothrombotic Functions Influencing Fibrin Deposition and PAR-Dependent Platelet Activation

Binding of Erythrocyte ICAM–4 to the Platelet Activated Integrin α IIb β 3 leads to a Direct Erythrocyte-Platelet Adhesion Under Venous Flow Shear Rate

Thrombosis and Inflammation Are Coupled by a Common Thioredoxin Reductase Pathway Downstream of the P2×7 Receptor.

Effect of New Direct Oral Anticoagulants on Ex Vivo Platelet and Fibrin Thrombus Formation in Blood Flowing Over Fibrillar Type I Collagen

Distinct Roles of the Extrinsic and the Intrinsic Coagulation Pathways In Different Murine Thrombosis Models,

Structural and Functional Evidence on the Role of Sulfated Tyrosine Residues In Glycoprotein Ib Binding to α-Thrombin Exosites

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American Society of Hematology

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American Society of Hematology

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