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Journal Articles

Results of the APG2575AU101 Study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax–exposed myeloid malignancies

Free
Tapan Kadia, Patricia Kropf, Michael Leahy, Chong Chyn Chua, Shaun Fleming, Caspian Oliai, John Kwan, Chun Yew Fong, Joshua Richmond, Paul Cannell, James Dugan, Maria Baer, Stephen Ting, Daniel Egan, Zi Chen, Qian Niu, Mingyu Li, Divya Mekala, Zhiyan Liang, Mohammad Ahmad, Yifan Zhai
Journal: Blood
Blood (2025) 146 (Supplement 1): 1641.
https://doi.org/10.1182/blood-2025-1641
Published: 2025
Journal Articles

Results of a registrational Phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with Relapsed/Refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) who had failed Bruton's tyrosine kinase inhibitors (BTKis)

Free
Keshu Zhou, Tingyu Wang, Ting Niu, Meifang Zheng, Jie Jin, Yang Liang, Rui Huang, Shuangnian Xu, Jianhua Qu, Guohui Cui, Fei Li, Yiming Luo, Ru Feng, Wenzheng Yu, Caixia Li, Zhiling Yan, Xin Zhou, Suijing Wu, Lihong Liu, Yinghua Geng, Jishi Wang, Sujun Gao, Jianfei Fu, Xiaoping Zhang, Chunyan Ji, Qianqian Xiang, Xiongpeng Zhu, Yajing Xu, Li'e Lin, Xiaoyu Zhu, Yuping Zhong, Hongling Peng, Ying Zhao, Hui Zeng, Zhao Wang, Rong Fu, Wenbin Qian, Yingmin Liang, Xiaobing Huang, Yajun Li, Min Yu, Zi Chen, Lei Wang, Lichuang Men, Zhiyan Liang, Shan Zeng, Baoer Lu, Yifan Zhai, Jianyong Li
Journal: Blood
Blood (2025) 146 (Supplement 1): 88.
https://doi.org/10.1182/blood-2025-88
Published: 2025
Journal Articles

Embryonic ectoderm development (EED) inhibitor APG-5918 overcomes immunomodulatory drug (IMiD) resistance as monotherapy and synergizes with IMiDs/cereblon E3 ligase modulators (CELMoDs) in preclinical models of multiple myeloma (MM)

Free
Yan Yin, Zhiyan Liang, Baisong Li, Zhou Yu, Daojie Liu, Shujie He, Dajun Yang, Yifan Zhai
Journal: Blood
Blood (2025) 146 (Supplement 1): 1528.
https://doi.org/10.1182/blood-2025-1528
Published: 2025
Journal Articles

Multitarget kinase inhibitor olverembatinib is active and synergizes with BTK inhibitor acalabrutinib in preclinical models of Mantle Cell Lymphoma

Free
Bo Peng, Zhiyan Liang, Yan Xiong, Bingxing Wu, Yanqiu Ji, Zhou Yu, Dajun Yang, Yifan Zhai
Journal: Blood
Blood (2025) 146 (Supplement 1): 6814.
https://doi.org/10.1182/blood-2025-6814
Published: 2025
Journal Articles

APG-2449, a Novel Focal Adhesion Kinase (FAK) Inhibitor, Exhibits Antileukemic Activity and Enhances Lisaftoclax (APG-2575)-Induced Apoptosis in Acute Myeloid Leukemia (AML)

Free
Zhou Yu, Zhiyan Liang, Xinyi Yao, Yanqiu Ji, Dajun Yang, Yifan Zhai
Journal: Blood
Blood (2024) 144 (Supplement 1): 4150.
https://doi.org/10.1182/blood-2024-202693
Published: 2024
Journal Articles

Lisaftoclax (APG-2575) Demonstrates Activity and Safety When Given with Accelerated Ramp-up and then Combined with Acalabrutinib or Rituximab in Patients (pts) with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Including Those with Prior Exposure to Venetoclax

Free
Matthew S. Davids, Sikander Ailawadhi, Asher A. Chanan-Khan, Boyd Mudenda, Larysa Nogaieva, Iryna Kryachok, Ganna Usenko, Vladimir Ivanov, Olena Kyselova, Tetiana Perekhrestenko, Ivan Muzhychuk, Alexander Myasnikov, Les Lukavetsky, Andrei Proydakov, Olga Uspenskaya, Elena Borisenkova, Paula Marlton, Tanya Siddiqi, Allison M. Winter, Tamila Lysa, Bulat Akhatovich Bakirov, Tommy Fu, Mingyu Li, Mohammad Ahmad, Zi Chen, Zhiyan Liang, Divya J. Mekala, Olena Karpenko, Iurii Osipov, Asit De, Hengbang Wang, Nashat Gabrail, Vinod Ganju, Tatiana Konstantinova, Olga Samoilova, Dajun Yang, Yifan Zhai
Journal: Blood
Blood (2024) 144 (Supplement 1): 4614.
https://doi.org/10.1182/blood-2024-207408
Published: 2024
Journal Articles

Embryonic Ectoderm Development (EED) Inhibitor APG-5918 Demonstrates Robust Antitumor Activity in Preclinical Models of T-Cell Lymphomas (TCLs)

Free
Zhiyan Liang, Yan Yin, Huanshan Guo, Baisong Li, Dajun Yang, Yifan Zhai
Journal: Blood
Blood (2024) 144 (Supplement 1): 1415.
https://doi.org/10.1182/blood-2024-202655
Published: 2024
Journal Articles

Olverembatinib (HQP1351) in Combination with Lisaftoclax Overcomes Venetoclax Resistance in Preclinical Model of Acute Myeloid Leukemia (AML)

Free
Yan Xiong, Zhiyan Liang, Ping Min, Bingxing Wu, Huidan Yu, Dajun Yang, Yifan Zhai
Journal: Blood
Blood (2024) 144 (Supplement 1): 5777.
https://doi.org/10.1182/blood-2024-202699
Published: 2024