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Journal Articles

MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells

Hao Gu, Chiqi Chen, Xiaoxin Hao, Ni Su, Dan Huang, Yejun Zou, Shu-Hai Lin, Xianjun Chen, Denghao Zheng, Ligen Liu, Zhuo Yu, Li Xie, Yaping Zhang, Xiaoxiao He, Xiaoyun Lai, Xiaocui Zhang, Guo-Qiang Chen, Yuzheng Zhao, Yi Yang, Joseph Loscalzo, Junke Zheng
Journal: Blood
Blood (2020) 136 (5): 553–571.
https://doi.org/10.1182/blood.2019003940
Published: 2020
Includes: Multimedia, Supplemental data
Journal Articles

Myelodysplastic Syndromes-Associated Gene Mutations Lead to Pseudohypoxia Condition and Epigenome Hyper-Methylation in Mouse Genetic Models

Asumi Yokota, PhD, Lulu Zhang, PhD, Jianhua Feng, Xiaomin Feng, MD PhD, Xiaomei Yan, MD PhD, Gang Huang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1696.
https://doi.org/10.1182/blood-2019-126799
Published: 2019
Journal Articles

Staurosporine Induces Caspase-Dependent Proteolysis of MEF2D-Fusion Protein and Cell Death Selective to MEF2D-Fusion-Positive ALL Cells

Naoyuki Tange, MD, Fumihiko Hayakawa, MD, PhD, Takahiko Yasuda, MD, PhD, Hideyuki Yamamoto, MD, Daiki Hirano, MD, PhD, Shinobu Tsuzuki, MD,PhD, Hitoshi Kiyoi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1349.
https://doi.org/10.1182/blood-2019-123602
Published: 2019
Journal Articles

Ibrutinib, Venetoclax Plus Obinutuzumab in Newly Diagnosed Mantle Cell Lymphoma Patients

Steven Le Gouill, MD PhD, Franck Morschhauser, MD, Kamal Bouabdallah, MD, Guillaume Cartron, Olivier Casasnovas, MD, Thomas Gastinne, MD, Patrice Chevallier, MD, Cédric Rossi, MD PhD, Emmanuelle Tchernonog, MD, Rory McCulloch, FRCPath, MRCP, MBBS, Charles Herbaux, MD, David Chiron, PhD, Mary Callanan, PhD, Simon Rule
Journal: Blood
Blood (2019) 134 (Supplement_1): 1530.
https://doi.org/10.1182/blood-2019-125681
Published: 2019
Journal Articles

Metabolomic Profile in Patients with Paroxysmal Nocturnal Hemoglobinuria

Patricia Eiko Yamakawa, MD, Ana Rita Da Fonseca, MD, Matheus Vescovi, MD PhD, Iara Baldim Rabelo Gomes, MD PhD, Ismael Dale Cotrim Guerreiro da Silva, MD PhD, Celso Arrais-Rodrigues, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2229.
https://doi.org/10.1182/blood-2019-126241
Published: 2019
Journal Articles

Separate Roles of Asparagine and Glutamine in Cytostatic Effect of L-Asparaginase - Stable Isotope Tracing Approach

Katerina Hlozkova, PhD, Alpesh Thakker, PhD, Natividad Alquézar-Artieda, Marketa Zaliova, MD PhD, Jan Trka, Prof., MD PhD, Daniel A Tennant, PhD, Julia Starkova, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2575.
https://doi.org/10.1182/blood-2019-127911
Published: 2019
Journal Articles

Glutamine Depletion By Addicted Myeloma Cells Inhibits Osteoblastic Differentiation of Bone Marrow Mesenchymal Stromal Cells Limiting Asparagine Availability: A Possible New Mechanism for Myeloma Bone Disease

Martina Chiu, PhD, Denise Toscani, PhD, Emanuela Vicario, PhD, Roberta Andreoli, PhD, Giuseppe Taurino, MS, Valentina Marchica, MS, Paola Storti, PhD, Massimiliano Bianchi, PhD, Ovidio Bussolati, MD PhD, Nicola Giuliani
Journal: Blood
Blood (2019) 134 (Supplement_1): 4339.
https://doi.org/10.1182/blood-2019-128034
Published: 2019
Journal Articles

The Distinctive Metabolic Environment of the Bone Marrow Niche Drives Leukemia Chemoresistance

Nick van Gastel, PhD, Jessica B. Spinelli, PhD, Azeem Sharda, MS, Amir Schajnovitz, PhD, Ninib Baryawno, PhD, Catherine S Rhee, PhD, Toshihiko Oki, MD PhD, Eliane Grace, Heather J. Soled, Charles Vidoudez, PhD, Sunia A. Trauger, PhD, Marcia C. Haigis, PhD, David T. Scadden, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3725.
https://doi.org/10.1182/blood-2019-124789
Published: 2019
Journal Articles

Inhibition of De Novo Pyrimidine Nucleotide Synthesis By the Novel DHODH Inhibitor PTC299 Induces Differentiation and/or Death of AML Cells

Marla Weetall, PhD, Kensuke Kojima, MD PhD, Sujan Piya, PhD, Christopher Trotta, PhD, John Baird, PhD, Kylie O'Keefe, Bansri Furia, Gautam M. Borthakur, MD, Robert Spiegel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5152.
https://doi.org/10.1182/blood-2019-124569
Published: 2019
Journal Articles

Parsaclisib, a potent and highly selective PI3Kδ inhibitor, in patients with relapsed or refractory B-cell malignancies

Andres Forero-Torres, Radhakrishnan Ramchandren, Abdulraheem Yacoub, Michael S. Wertheim, William J. Edenfield, Paolo Caimi, Martin Gutierrez, Luke Akard, Carolina Escobar, Justin Call, Daniel Persky, Swaminathan Iyer, Douglas J. DeMarini, Li Zhou, Xuejun Chen, Fitzroy Dawkins, Tycel J. Phillips
Journal: Blood
Blood (2019) 133 (16): 1742–1752.
https://doi.org/10.1182/blood-2018-08-867499
Published: 2019
Includes: Supplemental data
Journal Articles

Increased Methylation of Deamidated Asparagines and Aspartates in Stored Red Blood Cells from Glucose 6-Phosphate Dehydrogenase-Deficient Blood Donors

Angelo D'Alessandro, PhD, Travis Nemkov, Julie Reisz, PhD, Monika Dzieciatkowska, PhD, Rachel Culp-Hill, BS, Davide Stefanoni, Tatsuro Yoshida, PhD, Andrew Dunham, PhD, Tamir Kanias, PhD, Larry J. DuMont, PhD MBA, Michael Paul Busch, MD PhD, Elan Z Eisenmesser, Kirk C Hansen, Xiaoyun Fu, PhD, Tiffany Thomas, PhD, Matthew Karafin, MD, Eldad A. Hod, MD, Richard O Francis, MD PhD, Steven L Spitalnik, PhD, James C. Zimring, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2543.
https://doi.org/10.1182/blood-2018-99-119262
Published: 2018
Journal Articles

N 6 -Methyladenosine Modification Regulates Cell Metabolism in Acute Myeloid Leukemia

Hengyou Weng, PhD, Huilin Huang, PhD, Huizhe Wu, Mingli Sun, Savanna Stanford, Sean Robinson, zhen-Hua Chen, Xi Qin, Xiaolan Deng, Xi Jiang, PhD, Ying Qing, Chao Shen, PhD, Rui Su, PhD, Minjie Wei, Jianjun Chen, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 880.
https://doi.org/10.1182/blood-2018-99-117455
Published: 2018
Journal Articles

Aspartate Beta-Hydroxylase (ASPH) As a Novel Therapeutic Target in Acute Myeloid Leukemia

Noa G. Holtzman, MD, Michael S. Lebowitz, PhD, Rima Koka, MD PhD, Maria R. Baer, MD, Kanam Malhotra, Steven A. Fuller, PhD, Amir Shahlaee, MD, Hossein A. Ghanbari, PhD, Soren M. Bentzen, PhD DMSc, Ashkan Emadi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5273.
https://doi.org/10.1182/blood-2018-99-110897
Published: 2018
Journal Articles

Jadenu Substituting Exjade in Beta Thalassemia Major (BTM) Patients with Iron Overload: Effect on Serum Ferritin Concentration, Liver Iron Content and Biochemical Profiles

Mohamed A Yassin, MBBS, MSc, Abdulqadir Nashwan, MSc, Nancy Kassem, BSC, Ashraf Tawfiq Soliman, MD PhD, Vincenzo De Sanctis, Ahmed A Adel, BSC, Radwa M Hussein, BSC, Ahmed Basha, BSC, Randa Al -Okka, BSC, Rula Ghasoub, BSC
Journal: Blood
Blood (2018) 132 (Supplement 1): 4905.
https://doi.org/10.1182/blood-2018-99-113998
Published: 2018
Journal Articles

Metabolic Profiling Identifies De Novo Nucleotide Synthesis As a Potential Metabolic Vulnerability for Targeted Therapy Against Mantle Cell Lymphoma

Yixin Yao, PhD, Yang Liu, PhD, Hui Guo, PhD, Makhdum Ahmed, MD PhD MPH, Shabnam Bhuiyan, MSc, Krystle Nomie, PhD, Liang Zhang, MD PhD, Michael Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2945.
https://doi.org/10.1182/blood-2018-99-112192
Published: 2018
Journal Articles

Bosutinib Vs Imatinib for Newly Diagnosed Chronic Myeloid Leukemia (CML) in the BFORE Trial: 18 Month Follow-up

Carlo Gambacorti-Passerini, MD, Michael W. Deininger, MD PhD, Michael J. Mauro, MD, Charles Chuah, MD, Dong-Wook Kim, MD PhD, Iryna Dyagil, MDPhD, Natalia Glushko, Dragana Milojkovic, MBBS, PhD, Philipp D. le Coutre, MD, Valentín García Gutiérrez, PhD, Rocco J. Crescenzo, DO, FACOI, Eric Leip, PhD, Nathalie Bardy-Bouxin, PhD, Andrea Hochhaus, Prof. Dr., Timothy H. Brümmendorf, Jorge E. Cortes, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 896.
https://doi.org/10.1182/blood.V130.Suppl_1.896.896
Published: 2017
Journal Articles

CPX-351 Population Pharmacokinetics in Patients with Hematologic Malignancies

Qi Wang, Kamalika Banerjee, Grygoriy Vasilinin, J.F. Marier, Jackie Gibbons
Journal: Blood
Blood (2017) 130 (Supplement 1): 5064.
https://doi.org/10.1182/blood.V130.Suppl_1.5064.5064
Published: 2017
Journal Articles

Untargeted Metabolomics Identifies Glutamine Metabolism As a Driver of Chemoresistance in Acute Myeloid Leukemia

Nick van Gastel, PhD, Amir Schajnovitz, PhD, Charles Vidoudez, PhD, Toshihiko Oki, MD PhD, Azeem Sharda, MS, Sunia A. Trauger, PhD, David T. Scadden, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2523.
https://doi.org/10.1182/blood.V130.Suppl_1.2523.2523
Published: 2017
Journal Articles

Factor VII Augusta (FVII G395D/G395N):Â a Compound Heterozygous Deletion Insertion and Missense Variant Manifesting As Moderate Bleeding Disorder

Afshin Ameri, MD, Rebecca S Parker, MD, Joetta H Smith, RN MSN
Journal: Blood
Blood (2017) 130 (Supplement 1): 2349.
https://doi.org/10.1182/blood.V130.Suppl_1.2349.2349
Published: 2017
Journal Articles

Cerebral Metabolic Alterations in Transgenic and Hemizygous Murine Models of Sickle Cell Disease

Craig A Branch, PhD MS, Min-Hui Cui, PhD, Seetharama Acharya, PhD, Caterina Minniti, MD, Sandra Suzuka, Henny Heisler Billett, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2228.
https://doi.org/10.1182/blood.V130.Suppl_1.2228.2228
Published: 2017