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Journal Articles

Therapeutic Candidate Alpn-101, a Dual ICOS/CD28 Antagonist, Potently Suppresses Human/NSG Mouse Xenograft Graft Vs. Host Disease (GvHD) in a Dose Ranging Study and Reduces Disease Activity in a Mouse Model of Hemophagocytic Lymphohistiocytosis (HLH)

Stacey R. Dillon, PhD, Katherine E. Lewis, PhD, Katherine Verbist, PhD, Paige Tedrick, PhD, Sabrin Albeituni, PhD, Ryan Swanson, B.S., Lawrence S. Evans, B.S., Steven D Levin, PhD, Mark W. Rixon, PhD, Stanford L. Peng, MD, PhD, Kim E. Nichols, MD, Kristine M. Swiderek, PhD

Blood (2018) 132 (Supplement 1): 2037.

https://doi.org/10.1182/blood-2018-99-110001

Published: 2018

Journal Articles

Novel Variant Ig Domain (vIgD) Proteins Generated Via Directed Evolution of Igsf Domains Have Therapeutic Efficacy in Animal Models of Graft Versus Host Disease

Steven D Levin, PhD, Lawrence S. Evans, Erika Rickel, Martin F. Wolfson, Stacey R. Dillon, PhD, Michael G. Kornacker, PhD, Ryan Swanson, Stanford L. Peng, MDPhD

Blood (2017) 130 (Supplement 1): 1892.

https://doi.org/10.1182/blood.V130.Suppl_1.1892.1892

Published: 2017

Journal Articles

Pure Red Cell Aplasia - a New Manifestation of CTLA4 Mutation

Ingunn Dybedal, MDPhD, Anna Mari Lone, PhD, Hanne Sørmo Sorte, MSc, Lorant Farkas, MD PhD, Jürgen Rolke, MD, Robert Brudevold, MD, Asbjørg Stray-Pedersen, MD PhD, Kjetil Tasken, MD PhD

Blood (2015) 126 (23): 2225.

https://doi.org/10.1182/blood.V126.23.2225.2225

Published: 2015

Journal Articles

T-Cell Transcriptome Analysis Reveals the Mechanisms Controlling Synergy Between Costimulation Blockade and mTOR Inhibition during Graft Versus Host Disease Prevention

Scott N. Furlan, MD, Benjamin Watkins, MD, Kelly Hanby, Aneesah P. Garrett, Angela Panoskaltsis-Mortari, PhD, Bruce R. Blazar, MD, Leslie S. Kean

Blood (2014) 124 (21): 3824.

https://doi.org/10.1182/blood.V124.21.3824.3824

Published: 2014

Journal Articles

Synergistic Control of Acute GvHD: Effectively Down-Regulating T Cell Proliferation and Cytotoxicity with Combined mTOR Inhibition and CD28:CD80/86 Costimulation Blockade.

Natalia Kozyr, Ph.D., Swetha Ramakrishnan, Aneesah Polnett, Kelly Hamby, Divya Tiwari, MD, Taylor Deane, Linda Stempora, Joe Jenkins, Elizabeth Strobert, Anapatricia Garcia, DVM, PhD, Prachi Sharma, Cynthia Courtney, Angela Panoskaltsis-Mortari, Cynthia R. Giver, PhD, Edmund K. Waller, MD, PhD, Bruce R. Blazar, MD, Leslie S. Kean, MD, PhD

Blood (2012) 120 (21): 2998.

https://doi.org/10.1182/blood.V120.21.2998.2998

Published: 2012

Journal Articles

Sirolimus Inhibits Proliferation but Enhances Suppressive Activity of Rhesus Macaque Natural CD4 Regulatory T Cells

Karnail Singh, Ph.D., Natalia Kozyr, Ph.D., Linda Stempora, Allan D Kirk, MD, PhD, Christian P Larsen, MD, DPhil, Bruce R. Blazar, MD, Leslie S. Kean, MD, PhD

Blood (2011) 118 (21): 1008.

https://doi.org/10.1182/blood.V118.21.1008.1008

Published: 2011

Journal Articles

Towards Clinically Feasible Co-Stimulatory Blockade for Tolerance Induction: Transient Treatment with CTLA4-Ig, Anti-CD48 and FTY720 Enables Durable Engraftment of T Cell Depleted BM Allografts Following Non-Myeloablative Conditioning.

Esther Bachar-Lustig, PhD, Dalit Tchorsh-Yutsis, PhD, Eran Ophir, MSc, Yael Zlotnikov Klionsky, MSc, Noga Or-Geva, BSc, Yair Reisner, PhD

Blood (2010) 116 (21): 3726.

https://doi.org/10.1182/blood.V116.21.3726.3726

Published: 2010

NARROW

Therapeutic Candidate Alpn-101, a Dual ICOS/CD28 Antagonist, Potently Suppresses Human/NSG Mouse Xenograft Graft Vs. Host Disease (GvHD) in a Dose Ranging Study and Reduces Disease Activity in a Mouse Model of Hemophagocytic Lymphohistiocytosis (HLH)

Novel Variant Ig Domain (vIgD) Proteins Generated Via Directed Evolution of Igsf Domains Have Therapeutic Efficacy in Animal Models of Graft Versus Host Disease

Pure Red Cell Aplasia - a New Manifestation of CTLA4 Mutation

T-Cell Transcriptome Analysis Reveals the Mechanisms Controlling Synergy Between Costimulation Blockade and mTOR Inhibition during Graft Versus Host Disease Prevention

Synergistic Control of Acute GvHD: Effectively Down-Regulating T Cell Proliferation and Cytotoxicity with Combined mTOR Inhibition and CD28:CD80/86 Costimulation Blockade.

Sirolimus Inhibits Proliferation but Enhances Suppressive Activity of Rhesus Macaque Natural CD4 Regulatory T Cells

Towards Clinically Feasible Co-Stimulatory Blockade for Tolerance Induction: Transient Treatment with CTLA4-Ig, Anti-CD48 and FTY720 Enables Durable Engraftment of T Cell Depleted BM Allografts Following Non-Myeloablative Conditioning.

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ASH Publications

American Society of Hematology

Therapeutic Candidate Alpn-101, a Dual ICOS/CD28 Antagonist, Potently Suppresses Human/NSG Mouse Xenograft Graft Vs. Host Disease (GvHD) in a Dose Ranging Study and Reduces Disease Activity in a Mouse Model of Hemophagocytic Lymphohistiocytosis (HLH)

Novel Variant Ig Domain (vIgD) Proteins Generated Via Directed Evolution of Igsf Domains Have Therapeutic Efficacy in Animal Models of Graft Versus Host Disease

Pure Red Cell Aplasia - a New Manifestation of CTLA4 Mutation

T-Cell Transcriptome Analysis Reveals the Mechanisms Controlling Synergy Between Costimulation Blockade and mTOR Inhibition during Graft Versus Host Disease Prevention

Synergistic Control of Acute GvHD: Effectively Down-Regulating T Cell Proliferation and Cytotoxicity with Combined mTOR Inhibition and CD28:CD80/86 Costimulation Blockade.

Sirolimus Inhibits Proliferation but Enhances Suppressive Activity of Rhesus Macaque Natural CD4 Regulatory T Cells

Towards Clinically Feasible Co-Stimulatory Blockade for Tolerance Induction: Transient Treatment with CTLA4-Ig, Anti-CD48 and FTY720 Enables Durable Engraftment of T Cell Depleted BM Allografts Following Non-Myeloablative Conditioning.

Email alerts

ASH Publications

American Society of Hematology

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