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Linda Stempora
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Journal Articles

CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire

Yvonne Suessmuth, Rithun Mukherjee, Benjamin Watkins, Divya T. Koura, Knut Finstermeier, Cindy Desmarais, Linda Stempora, John T. Horan, Amelia Langston, Muna Qayed, Hanna J. Khoury, Audrey Grizzle, Jennifer A. Cheeseman, Jason A. Conger, Jennifer Robertson, Aneesah Garrett, Allan D. Kirk, Edmund K. Waller, Bruce R. Blazar, Aneesh K. Mehta, Harlan S. Robins, Leslie S. Kean
Journal: Blood
Blood (2015) 125 (25): 3835–3850.
https://doi.org/10.1182/blood-2015-03-631853
Published: 2015
Includes: Supplemental data
Journal Articles

Defining the Primate T Cell Transcriptome during Graft Versus Host Disease: New Data Implicating the Hedgehog and Aurora Kinase Pathways in Pathogenesis and Prevention

Scott N. Furlan, MD, Benjamin Watkins, MD, Ryan P Flynn, Swetha Ramakrishnan, Karnail Singh, PhD, Cynthia R. Giver, PhD, Kelly Hanby, Linda Stempora, Aneesah P. Garrett, Carly GK Ziegler, Gregory Tharp, Steven Bosinger, Bruce R. Blazar, MD, Edmund K. Waller, MD PhD, Leslie S. Kean, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2432.
https://doi.org/10.1182/blood.V124.21.2432.2432
Published: 2014
Journal Articles

Rapamycin Rescues The Rapid Disappearance and Loss Of Phenotypic Integrity Of Autologous, Ex-Vivo Expanded Rhesus Macaque Natural Regulatory T Cells After Adoptive Transfer

Karnail Singh, Ph.D., Linda Stempora, Allan D Kirk, MD, PhD, Christian P Larsen, MD, DPhil, Bruce R Blazar, MD, Leslie S. Kean
Journal: Blood
Blood (2013) 122 (21): 895.
https://doi.org/10.1182/blood.V122.21.895.895
Published: 2013
Journal Articles

Defining the Primate GvHD Transcriptome: Network Analysis Identifies the Key Pathways Responsible for GvHD Pathogenesis and the Mechanisms of Partial GvHD Control with Sirolimus

Natalia Kozyr, Ph.D., Carly GK Ziegler, Swetha Ramakrishnan, Aneesah Polnett, Kelly Hamby, Taylor Deane, Linda Stempora, Bruce R. Blazar, MD, Leslie S. Kean, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1888.
https://doi.org/10.1182/blood.V120.21.1888.1888
Published: 2012
Journal Articles

Synergistic Control of Acute GvHD: Effectively Down-Regulating T Cell Proliferation and Cytotoxicity with Combined mTOR Inhibition and CD28:CD80/86 Costimulation Blockade.

Natalia Kozyr, Ph.D., Swetha Ramakrishnan, Aneesah Polnett, Kelly Hamby, Divya Tiwari, MD, Taylor Deane, Linda Stempora, Joe Jenkins, Elizabeth Strobert, Anapatricia Garcia, DVM, PhD, Prachi Sharma, Cynthia Courtney, Angela Panoskaltsis-Mortari, Cynthia R. Giver, PhD, Edmund K. Waller, MD, PhD, Bruce R. Blazar, MD, Leslie S. Kean, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2998.
https://doi.org/10.1182/blood.V120.21.2998.2998
Published: 2012
Journal Articles

Significant mobilization of both conventional and regulatory T cells with AMD3100

Leslie S. Kean, Sharon Sen, Olusegun Onabajo, Karnail Singh, Jennifer Robertson, Linda Stempora, Aylin C. Bonifacino, Mark E. Metzger, Daniel E. L. Promislow, Joseph J. Mattapallil, Robert E. Donahue
Journal: Blood
Blood (2011) 118 (25): 6580–6590.
https://doi.org/10.1182/blood-2011-06-359331
Published: 2011
Includes: Supplemental data
Journal Articles

Sirolimus Inhibits Proliferation but Enhances Suppressive Activity of Rhesus Macaque Natural CD4 Regulatory T Cells

Karnail Singh, Ph.D., Natalia Kozyr, Ph.D., Linda Stempora, Allan D Kirk, MD, PhD, Christian P Larsen, MD, DPhil, Bruce R. Blazar, MD, Leslie S. Kean, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1008.
https://doi.org/10.1182/blood.V118.21.1008.1008
Published: 2011
Journal Articles

GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28 − CD8 + T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression

Weston P. Miller, Swetha Srinivasan, Angela Panoskaltsis-Mortari, Karnail Singh, Sharon Sen, Kelly Hamby, Taylor Deane, Linda Stempora, Jonathan Beus, Alexa Turner, Caleb Wheeler, Daniel C. Anderson, Prachi Sharma, Anapatricia Garcia, Elizabeth Strobert, Eric Elder, Ian Crocker, Timothy Crenshaw, M. Cecilia T. Penedo, Thea Ward, Mingqing Song, John Horan, Christian P. Larsen, Bruce R. Blazar, Leslie S. Kean
Journal: Blood
Blood (2010) 116 (24): 5403–5418.
https://doi.org/10.1182/blood-2010-06-289272
Published: 2010
Includes: Supplemental data
Journal Articles

Sirolimus and GvHD Control: the Rhesus Macaque GvHD Model Reveals That Sirolimus Preferentially Inhibits T Cell Proliferation While Permitting Breakthrough T cell Activation After MHC-Mismatched Hematopoietic Stem Cell Transplantation

Karnail Singh, Swetha Srinivasan, Angela Panoskaltsis-Mortari, PhD, Sharon Sen, Kelly Hamby, Taylor Deane, Linda Stempora, Frank Leopardi, John Shires, Jonathan Beus, Benjamin Byrd, Bruce R. Blazar, MD, Leslie Kean, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 2549.
https://doi.org/10.1182/blood.V116.21.2549.2549
Published: 2010
Journal Articles

GvHD After Haploidentical Transplant: A Novel, MHC-Defined Rhesus Macaque Model Identifies CD28-Negative CD8+ T Cells as a Reservoir of Breakthrough T Cell Proliferation During Costimulation Blockade and Sirolimus-Based Immunosuppression

Swetha Srinivasan, Weston P. Miller IV, MD, Angela Panoskalltsis-Mortari, Sharon Sen, Kelly Hamby, Taylor Deane, Linda Stempora, Karnail Singh, Jonathan Beus, Bruce R. Blazar, MD, Leslie Kean, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 2550.
https://doi.org/10.1182/blood.V116.21.2550.2550
Published: 2010