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Christian P. Larsen
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Journal Articles

Rapamycin Rescues The Rapid Disappearance and Loss Of Phenotypic Integrity Of Autologous, Ex-Vivo Expanded Rhesus Macaque Natural Regulatory T Cells After Adoptive Transfer

Karnail Singh, Ph.D., Linda Stempora, Allan D Kirk, MD, PhD, Christian P Larsen, MD, DPhil, Bruce R Blazar, MD, Leslie S. Kean
Journal: Blood
Blood (2013) 122 (21): 895.
https://doi.org/10.1182/blood.V122.21.895.895
Published: 2013
Journal Articles

LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function

Natalie M. Reisman, Tamara L. Floyd, Maylene E. Wagener, Allan D. Kirk, Christian P. Larsen, Mandy L. Ford
Journal: Blood
Blood (2011) 118 (22): 5851–5861.
https://doi.org/10.1182/blood-2011-04-347252
Published: 2011
Includes: Supplemental data
Journal Articles

Sirolimus Inhibits Proliferation but Enhances Suppressive Activity of Rhesus Macaque Natural CD4 Regulatory T Cells

Karnail Singh, Ph.D., Natalia Kozyr, Ph.D., Linda Stempora, Allan D Kirk, MD, PhD, Christian P Larsen, MD, DPhil, Bruce R. Blazar, MD, Leslie S. Kean, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1008.
https://doi.org/10.1182/blood.V118.21.1008.1008
Published: 2011
Journal Articles

GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28 − CD8 + T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression

Weston P. Miller, Swetha Srinivasan, Angela Panoskaltsis-Mortari, Karnail Singh, Sharon Sen, Kelly Hamby, Taylor Deane, Linda Stempora, Jonathan Beus, Alexa Turner, Caleb Wheeler, Daniel C. Anderson, Prachi Sharma, Anapatricia Garcia, Elizabeth Strobert, Eric Elder, Ian Crocker, Timothy Crenshaw, M. Cecilia T. Penedo, Thea Ward, Mingqing Song, John Horan, Christian P. Larsen, Bruce R. Blazar, Leslie S. Kean
Journal: Blood
Blood (2010) 116 (24): 5403–5418.
https://doi.org/10.1182/blood-2010-06-289272
Published: 2010
Includes: Supplemental data
Journal Articles

Identification of a Costimulation Blockade Resistant Mechanism of Bone Marrow Allograft Rejection Induced by Infection with a Murine EBV Homologue.

Jonathan Beus, Kelly Hamby, Allan D Kirk, MD, PhD, Christian P Larsen, MD, DPhil, Samuel H Speck, PhD, Leslie Kean, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 1461.
https://doi.org/10.1182/blood.V116.21.1461.1461
Published: 2010
Journal Articles

Prevention of Acute GvHD During MHC Haploidentical BMT: Evaluating the Efficacy of T-Cell Costimulation Blockade Using a Novel Rhesus Macaque Transplant Model.

Weston Miller, Caleb E. Wheeler, MD, Angela Panoskaltsis-Mortari, PhD, Allan D Kirk, MD, PhD, Christian P Larsen, MD, PhD, Bruce R. Blazar, MD, Leslie S Kean, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 2455.
https://doi.org/10.1182/blood.V114.22.2455.2455
Published: 2009
Journal Articles

Prevention of Acute GvHD during Haplo-BMT: Evaluating the Efficacy of T-Cell Costimulation Blockade Using a Novel Rhesus Macaque Transplant Model

Weston Miller, IV, MD, Caleb E. Wheeler, MD, Angela Panoskaltsis- Mortari, PhD, Allan Kirk, MD/PhD, Christian P Larsen, MD/PhD, Bruce R Blazar, M.D., Leslie Kean, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 3522.
https://doi.org/10.1182/blood.V112.11.3522.3522
Published: 2008
Journal Articles

MHC-Matched Stem Cell Transplantation in Rhesus Macaques Using a Costimulation Blockade-Based Immunomodulation Platform.

Leslie S. Kean, MD, PhD, Kelly Hamby, Taylor Deane, Thomas C. Pearson, MD/PhD, Christian P. Larsen, MD/Phd
Journal: Blood
Blood (2007) 110 (11): 1189.
https://doi.org/10.1182/blood.V110.11.1189.1189
Published: 2007
Journal Articles

Role of CD28 in fatal autoimmune disorder in scurfy mice

Nagendra Singh, Phillip R. Chandler, Yoichi Seki, Babak Baban, Mayuko Takezaki, David J. Kahler, David H. Munn, Christian P. Larsen, Andrew L. Mellor, Makio Iwashima
Journal: Blood
Blood (2007) 110 (4): 1199–1206.
https://doi.org/10.1182/blood-2006-10-054585
Published: 2007
Includes: Supplemental data
Journal Articles

Apoptotic Cells Break Tolerance Induced by CD40-CD40L Blockade.

Jian-Ming Li, PhD, John W. Gorechlad, M.D., Cindy Giver, PH.D., Christian P. Larsen, Ph.D, M.D, Ned Waller, Ph.D, M.D
Journal: Blood
Blood (2006) 108 (11): 3221.
https://doi.org/10.1182/blood.V108.11.3221.3221
Published: 2006
Journal Articles

Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease

Leslie S. Kean, Elizabeth A. Manci, Jennifer Perry, Can Balkan, Shana Coley, David Holtzclaw, Andrew B. Adams, Christian P. Larsen, Lewis L. Hsu, David R. Archer
Journal: Blood
Blood (2003) 102 (13): 4582–4593.
https://doi.org/10.1182/blood-2003-03-0712
Published: 2003
Journal Articles

A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex–mismatched bone marrow transplantation

Leslie S. Kean, Megan M. Durham, Andrew B. Adams, Lewis L. Hsu, Jennifer R. Perry, Dirck Dillehay, Thomas C. Pearson, Edmund K. Waller, Christian P. Larsen, David R. Archer
Journal: Blood
Blood (2002) 99 (5): 1840–1849.
https://doi.org/10.1182/blood.V99.5.1840
Published: 2002