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Journal Articles

AXL/Mertk Inhibitor ONO-7475 Potently Synergizes with BCL2 Inhibitor ABT-199, Overcomes ABT-199 Resistance Mechanisms, and Kills FLT3 ITD AML Cells

Sean M Post, PhD, Huaxian Ma, MS, Vivian Ruvolo, Xiaorui Zhang, BS, Tomoko Yasuhiro, Kohei Tanaka, Ryohei Kozaki, Toshio Yoshizawa, PhD, Jorge E. Cortes, MD, Courtney D. DiNardo, MDMSc, Marina Y Konopleva, MD PhD, Steven M. Kornblau, MD, Joseph D. Khoury, MD, Michael Andreeff, MD PhD, Peter P. Ruvolo, PhD

Blood (2019) 134 (Supplement_1): 2550.

https://doi.org/10.1182/blood-2019-128626

Published: 2019

Journal Articles

Upregulation of Senescent/Exhausted Phenotype of CAR T Cells and Induction of Both Treg and Myeloid Suppressive Cells Correlate with Reduced Response to CAR T Cell Therapy in Relapsed/Refractory B Cell Malignancies

Katia Beider, Michal J Besser, PhD, Jacob Schachter, MD, Ania Hava Grushchenko-Polaq, Valeria Voevoda, Idit Wolf, Olga Ostrovsky, PhD, Elad Jacoby, MD, Avichai Shimoni, MD, Arnon Nagler, MD MSc

Blood (2019) 134 (Supplement_1): 3234.

https://doi.org/10.1182/blood-2019-128068

Published: 2019

Journal Articles

Aged Neutrophils in Sickle Cell Disease Impede Ischemic Repair

Derick Okwan-Duodu, MD PhD, David R. Archer, PhD, W Robert Taylor, MD PhD

Blood (2018) 132 (Supplement 1): 3688.

https://doi.org/10.1182/blood-2018-99-119384

Published: 2018

Journal Articles

Mertk Inhibition Promotes Anti-Leukemia Immunity By Reversing T Cell Suppression Via the PD-1 Axis

Alisa Lee-Sherick, MD, Kristen Jacobsen, PhD, Curtis J. Henry, PhD, Rebecca Parker, Xiaodong Wang, PhD, Stephen V Frye, PhD, H. Shelton Earp, MD, Deborah DeRyckere, PhD, Douglas K Graham, MD PhD

Blood (2018) 132 (Supplement 1): 4019.

https://doi.org/10.1182/blood-2018-99-119818

Published: 2018

Journal Articles

On Demand Recruitment of Macrophages Is Required for Erythroid Niche Formation during Stress Erythropoiesis in the Bone Marrow

Verena Petzer, MD, Piotr Tymoszuk, PhD, Felix Böhm, Markus Seifert, Sieghart Sopper, PhD, Christa Pfeifhofer-Obermair, PhD, Natascha Brigo, MSc, Dominik Wolf, MD, Günter Weiss, MD, Igor Theurl, MD PhD

Blood (2018) 132 (Supplement 1): 848.

https://doi.org/10.1182/blood-2018-99-116244

Published: 2018

Journal Articles

The Proto-Oncogene Mer Is a Novel Therapeutic Target in Mantle Cell Lymphoma

Cunzhen Shi, Xiaogan Wang, MD, Ning Ding, MD, Lingyan Ping, Yuqin Song, MD, Jun Zhu, BS

Blood (2017) 130 (Supplement 1): 5138.

https://doi.org/10.1182/blood.V130.Suppl_1.5138.5138

Published: 2017

Journal Articles

Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Myeloid Leukemia

Katherine A Minson, MD, Madeline G Huey, BA, Annie Qiu, Xiaodong Wang, PhD, Stephen V Frye, PhD, H. Shelton Earp, MD, Deborah DeRyckere, PhD, Douglas K Graham, MD PhD

Blood (2017) 130 (Supplement 1): 3823.

https://doi.org/10.1182/blood.V130.Suppl_1.3823.3823

Published: 2017

Journal Articles

Mertk Is a Therapeutic Target in Early T-Precursor Acute Lymphoblastic Leukemia

Ryan J Summers, MD, Katherine A Minson, MD, Stephen V Frye, PhD, Xiaodong Wang, PhD, H. Shelton Earp, III, MD, Deborah DeRyckere, PhD, Douglas K. Graham, MD PhD

Blood (2017) 130 (Supplement 1): 2536.

https://doi.org/10.1182/blood.V130.Suppl_1.2536.2536

Published: 2017

Journal Articles

Integrated Phosphoproteomic and N-Glycoproteomic Landscape of Cutaneous T-Cell Lymphoma Reveals Distinctive Pathogenetic Insights and Therapeutic Vulnerabilities

John Simon Van Arnam, MD MS, Delphine C. M. Rolland, PharmD, PhD, Kojo S. J. Elenitoba-Johnson, MD, Megan S. Lim, MDPhD, Özlem Önder, PhD, Nathanael G. Bailey, MD, David Bahler, MD

Blood (2017) 130 (Supplement 1): 2763.

https://doi.org/10.1182/blood.V130.Suppl_1.2763.2763

Published: 2017

Journal Articles

Multiple Myeloma Cancer Stem Cells: Immunophenotypic and Functional Characterization, Gene Expression Profiling and Therapeutic Targets

Mariana Bleker de Oliveira, BSc, Paola Marino Dantonio, BSc, Veruska Lia Fook Alves, PhD, Rodrigo Carlini Fernando, BSc, Daniela Teixeira, MSc, Alexandre Basso, PhD, Mihoko Yamamoto, MD PhD, Gisele W. B. Colleoni, MD PhD

Blood (2016) 128 (22): 4434.

https://doi.org/10.1182/blood.V128.22.4434.4434

Published: 2016

Journal Articles

MAF Induces Inflammatory Mediators Involved in the Pathogenesis of Primary Myelofibrosis

Samantha Ruberti, BSc, Elisa Bianchi, PhD, Tiziana Fanelli, MSc, Sebastiano Rontauroli, BSc, Valentina Pennucci, PhD, Giuditta Corbizzi Fattori, BSc, Carmela Mannarelli, MSc, PhD, Ruggiero Norfo, PhD, Chiara Rossi, BSc, Roberta Zini, PhD, Simona Salati, PhD, Zelia Prudente, PhD, Enrico Tagliafico, MDPhD, Paola Guglielmelli, MD PhD, Alessandro M. Vannucchi, MD, Rossella Manfredini, PhDBSc

Blood (2016) 128 (22): 3132.

https://doi.org/10.1182/blood.V128.22.3132.3132

Published: 2016

Journal Articles

Identifying Functional Differences Between Protein S and Gas-6 in Pancreatic Cancer

Cosette Zacarias, Vijaya Satish Sekhar Pilli, PhD, William E. Plautz, A'drianne Wells, Rinku Majumder, PhD

Blood (2016) 128 (22): 2571.

https://doi.org/10.1182/blood.V128.22.2571.2571

Published: 2016

Journal Articles

Cultured Human Macrophages As a Model for Central Macrophages in Erythroblastic Islands

Esther Heideveld, MSc, Maartje van Den Biggelaar, PhD, Floris P. van Alphen, BSc, Marieke Von Lindern, PhD, Emile van den Akker, PhD

Blood (2016) 128 (22): 1248.

https://doi.org/10.1182/blood.V128.22.1248.1248

Published: 2016

Journal Articles

MerTK Receptor Tyrosine Kinase Inhibition As a Potential Strategy to Augment Immune-Mediated Clearance of Acute Myeloid Leukemia

Lauren Shelby Page, BS, Xiaodong Wang, PhD, H. Shelton Earp, III, MD, Stephen Frye, PhD, Craig T Jordan, PhD, Alisa B. Lee-Sherick, MD

Blood (2016) 128 (22): 4044.

https://doi.org/10.1182/blood.V128.22.4044.4044

Published: 2016

Journal Articles

Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Leukemia

Katherine A Minson, MD, Madeline G Huey, BS, Amanda A Hill, Irene Perez, Xiaodong Wang, PhD, Stephen Frye, PhD, H. Shelton Earp, III, MD, Deborah DeRyckere, PhD, Douglas K. Graham, MD PhD

Blood (2016) 128 (22): 2819.

https://doi.org/10.1182/blood.V128.22.2819.2819

Published: 2016

Journal Articles

Flippases and Scramblases at Plasma Membranes that Regulate Phosphatidylserine Exposure

Shigekazu Nagata, PhD

Blood (2015) 126 (23): SCI-31.

https://doi.org/10.1182/blood.V126.23.SCI-31.SCI-31

Published: 2015

Journal Articles

Melphalan Affects Genes Critical for Myeloma Survival, Homing, and Response to Cytokines and Chemokines

Shmuel Yaccoby, Joshua Epstein, DSc, Pingping Qu, PhD, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Christoph Heuck, MD, Faith E Davies, MD, Alan Mitchell, Antje Hoering, PhD, John Crowley, PhD, Bart Barlogie, MD PhD, Gareth J Morgan, MDPhD

Blood (2015) 126 (23): 1808.

https://doi.org/10.1182/blood.V126.23.1808.1808

Published: 2015

Journal Articles

UNC2025, a Small Molecule MerTK and Flt3 Tyrosine Kinase Inhibitor, Decreases Disease Burden, Prolongs Survival, and Promotes Sensitivity to Chemotherapy in Xenograft Models of Acute Leukemia

Deborah DeRyckere, PhD, Alisa B. Lee-Sherick, MD, Amanda A. Hill, Lauren Page, BS, Xiaodong Wang, PhD, Stephen V. Frye, PhD, H. Shelton Earp, MD, Douglas K. Graham, MD PhD

Blood (2014) 124 (21): 998.

https://doi.org/10.1182/blood.V124.21.998.998

Published: 2014

Journal Articles

MRX2843, a Novel Dual MerTK-FLT3 Inhibitor with Activity Against Resistance-Conferring FLT3 Mutations in Acute Myeloid Leukemia

Katherine A Minson, MD, Catherine C Smith, MD, Alisa B. Lee-Sherick, MD, Deborah DeRyckere, PhD, Elisabeth Lasater, PhD, Amanda A. Hill, Xiaodong Wang, PhD, Stephen V. Frye, PhD, H. Shelton Earp, MD, Neil P. Shah, MD PhD, Douglas K. Graham, MD PhD

Blood (2014) 124 (21): 3757.

https://doi.org/10.1182/blood.V124.21.3757.3757

Published: 2014

Journal Articles

MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands

Satoshi Toda, Katsumori Segawa, Shigekazu Nagata

Blood (2014) 123 (25): 3963–3971.

https://doi.org/10.1182/blood-2014-01-547976

Published: 2014

Includes: Multimedia, Supplemental data

NARROW

AXL/Mertk Inhibitor ONO-7475 Potently Synergizes with BCL2 Inhibitor ABT-199, Overcomes ABT-199 Resistance Mechanisms, and Kills FLT3 ITD AML Cells

Upregulation of Senescent/Exhausted Phenotype of CAR T Cells and Induction of Both Treg and Myeloid Suppressive Cells Correlate with Reduced Response to CAR T Cell Therapy in Relapsed/Refractory B Cell Malignancies

Aged Neutrophils in Sickle Cell Disease Impede Ischemic Repair

Mertk Inhibition Promotes Anti-Leukemia Immunity By Reversing T Cell Suppression Via the PD-1 Axis

On Demand Recruitment of Macrophages Is Required for Erythroid Niche Formation during Stress Erythropoiesis in the Bone Marrow

The Proto-Oncogene Mer Is a Novel Therapeutic Target in Mantle Cell Lymphoma

Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Myeloid Leukemia

Mertk Is a Therapeutic Target in Early T-Precursor Acute Lymphoblastic Leukemia

Integrated Phosphoproteomic and N-Glycoproteomic Landscape of Cutaneous T-Cell Lymphoma Reveals Distinctive Pathogenetic Insights and Therapeutic Vulnerabilities

Multiple Myeloma Cancer Stem Cells: Immunophenotypic and Functional Characterization, Gene Expression Profiling and Therapeutic Targets

MAF Induces Inflammatory Mediators Involved in the Pathogenesis of Primary Myelofibrosis

Identifying Functional Differences Between Protein S and Gas-6 in Pancreatic Cancer

Cultured Human Macrophages As a Model for Central Macrophages in Erythroblastic Islands

MerTK Receptor Tyrosine Kinase Inhibition As a Potential Strategy to Augment Immune-Mediated Clearance of Acute Myeloid Leukemia

Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Leukemia

Flippases and Scramblases at Plasma Membranes that Regulate Phosphatidylserine Exposure

Melphalan Affects Genes Critical for Myeloma Survival, Homing, and Response to Cytokines and Chemokines

UNC2025, a Small Molecule MerTK and Flt3 Tyrosine Kinase Inhibitor, Decreases Disease Burden, Prolongs Survival, and Promotes Sensitivity to Chemotherapy in Xenograft Models of Acute Leukemia

MRX2843, a Novel Dual MerTK-FLT3 Inhibitor with Activity Against Resistance-Conferring FLT3 Mutations in Acute Myeloid Leukemia

MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands

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American Society of Hematology

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American Society of Hematology

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