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Journal Articles

Rare Germline Mutations in Complement Regulatory Genes Make the Antiphospholipid Syndrome Catastrophic

Shruti Chaturvedi, MBBS, MS, Evan M Braunstein, MD PhD, Xuan Yuan, MD MSc, Hang Chen, Ravi Kumar Alluri, PhD, Michael B. Streiff, MD, Michelle Petri, MD MPH, Mark Crowther, MD MSc, FRCPC, Keith R McCrae, MD, Robert A. Brodsky, MD

Blood (2019) 134 (Supplement_1): 4.

https://doi.org/10.1182/blood-2019-129115

Published: 2019

Journal Articles

A Phase 2 Open-Label Study of Danicopan (ACH-0144471) in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have an Inadequate Response to Eculizumab Monotherapy

Austin Kulasekararaj, MBBS MDMRCP FRCPath, Antonio M. Risitano, MD PhD, Jaroslaw P. Maciejewski, MD PhD, Rosario Notaro, MD, Peter Browett, BMedSci, MBChB, FRACP, FRCPA, Jong-Wook Lee, MD, Mingjun Huang, PhD, Michael Geffner, MD, Robert A. Brodsky, MD

Blood (2019) 134 (Supplement_1): 3514.

https://doi.org/10.1182/blood-2019-124748

Published: 2019

Journal Articles

Mechanistic Evaluation of Efficacy Using Biomarkers of the Oral, Small Molecule Factor D Inhibitor, Danicopan (ACH-4471), in Untreated Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

Antonio M. Risitano, MD PhD, Jong Wook Lee, MD PhD, Rosario Notaro, MD, Robert A. Brodsky, MD, Austin Kulasekararaj, MBBS MDMRCP FRCPath, Jaroslaw P. Maciejewski, MD PhD, Mingjun Huang, PhD, Michael Geffner, MD, Peter Browett, BMedSci, MBChB, FRACP, FRCPA

Blood (2019) 134 (Supplement_1): 2226.

https://doi.org/10.1182/blood-2019-124837

Published: 2019

Journal Articles

Comparative Evaluation of Complement Factor D, C3, and C5 Inhibitors on Serum Bactericidal Activity Against Neisseria Meningitidis Isolates

Yongsen Zhao, Dharaben Patel, MS, Jane A Thanassi, BS, Mingjun Huang, PhD, Steven D Podos, PhD

Blood (2019) 134 (Supplement_1): 5763.

https://doi.org/10.1182/blood-2019-132253

Published: 2019

Journal Articles

An Alternative Pathway Specific Flow Cytometric Assay to Detect Complement Activation in Atypical Hemolytic Uremic Syndrome (aHUS)

Jia Yu, Xuan Yuan, MD MSc, Kang Zhou, Daniel White, Samuel A. Merrill, MD PhD, Robert A. Brodsky, MD

Blood (2018) 132 (Supplement 1): 3748.

https://doi.org/10.1182/blood-2018-99-119445

Published: 2018

Journal Articles

Current Status and Optimal Management of Eculizumab Poor-Responders Due to C5 Polymorphisms

Yasutaka Ueda, MD PhD, Hiroyuki Takamori, MD, Jun-Ho Jang, MD PhD, Chezi Ganzel, MD, Saskia Langemeijer, MD PhD, Makiko Osato, MS, Petra Muus, MD PhD, Jong-Wook Lee, MD PhD, Jun-Ichi Nishimura, MD PhD, Yuzuru Kanakura, MD PhD

Blood (2018) 132 (Supplement 1): 2323.

https://doi.org/10.1182/blood-2018-99-111230

Published: 2018

Journal Articles

In Vitro Combination Studies of ACH-4471 with Eculizumab to Assess a Potential "Switch" Treatment Approach for Paroxysmal Nocturnal Hemoglobinuria

Dharaben Patel, MS, Jane A Thanassi, BS, Guangwei Yang, PhD, Xuan Yuan, MD MSc, Robert A. Brodsky, MD, Mingjun Huang, PhD, Steven D Podos, PhD

Blood (2017) 130 (Supplement 1): 2198.

https://doi.org/10.1182/blood.V130.Suppl_1.2198.2198

Published: 2017

Journal Articles

Eculizumab treatment and impaired opsonophagocytic killing of meningococci by whole blood from immunized adults

Monica Konar, Dan M. Granoff

Blood (2017) 130 (7): 891–899.

https://doi.org/10.1182/blood-2017-05-781450

Published: 2017

Includes: Supplemental data

Journal Articles

Effect of Complement Inhibition By Anti-C5 (Eculizumab) or a Small Molecule Inhibitor of Factor D (ACH-4471) on Survival of Meningococci in Blood from Vaccinated Adults

Monica Konar, PhD, Eduardo Lujan, Dan Granoff, MD

Blood (2016) 128 (22): 2429.

https://doi.org/10.1182/blood.V128.22.2429.2429

Published: 2016

Journal Articles

Evaluation of Bacteria-Mediated Potential "Bystander" Hemolysis of PNH RED CELLS I n Vitro : NO Evidence of Significant Complement Classical or Lectin Pathway-Mediated Hemolysis Induced by Microorganisms

Xuan Yuan, MD MSc, Guangwei Yang, PhD, Jane A Thanassi, Manuel D Galvan, PhD, Steven D Podos, PhD, Mingjun Huang, PhD, Robert A. Brodsky, MD

Blood (2016) 128 (22): 2431.

https://doi.org/10.1182/blood.V128.22.2431.2431

Published: 2016

Journal Articles

Small Molecule Factor D Inhibitors Block Complement Activation in Paroxysmal Nocturnal Hemoglobinuria and Atypical Hemolytic Uremic Syndrome

Eleni Gavriilaki, MD, Jane A Thanassi, BS, Guangwei Yang, Xuan Yuan, MD MSc, Mngjun Huang, Robert A. Brodsky, MD

Blood (2015) 126 (23): 275.

https://doi.org/10.1182/blood.V126.23.275.275

Published: 2015

Journal Articles

Novel Small-Molecule Inhibitors Targeting Complement Factor D for Therapy of Paroxysmal Nocturnal Hemoglobinuria

B. Paul Morgan, PhD, Jane Thanassi, Steven Podos, PhD, Avinash Phadke, PhD, Venkat Gadhachanda, PhD, Godwin Pais, PhD, Akihiro Hashimoto, PhD, Qiuping Wang, PhD, Dawei Chen, PhD, Xiangzhu Wang, PhD, Atul Agarwal, PhD, Milind Deshpande, PhD, Yongqing Huang, PhD, Jason Wiles, PhD, Mingjun Huang, PhD

Blood (2014) 124 (21): 4817.

https://doi.org/10.1182/blood.V124.21.4817.4817

Published: 2014

Journal Articles

Preclinical Evaluation of Orally Bioavailable Small-Molecule Inhibitors of Complement Factor D As a Potential Treatment for Paroxysmal Nocturnal Hemoglobinuria

Jason Wiles, PhD, Steven Podos, PhD, Jane Thanassi, Avinash Phadke, PhD, Venkat Gadhachanda, PhD, Godwin Pais, PhD, Akihiro Hashimoto, PhD, Qiuping Wang, PhD, Dawei Chen, PhD, Xiangzhu Wang, PhD, Atul Agarwal, PhD, Jose Rivera, Michael Elliot, Christopher Marlor, Jay Zhang, Milind Deshpande, PhD, Mingjun Huang, PhD, Yongqing Huang, PhD

Blood (2014) 124 (21): 4819.

https://doi.org/10.1182/blood.V124.21.4819.4819

Published: 2014

Journal Articles

Von Willebrand Factor Is a Cofactor in Complement Regulation

Shuju Feng, PhD, Michael H. Kroll, MD, Vahid Afshar-Kharghan, MD

Blood (2014) 124 (21): 109.

https://doi.org/10.1182/blood.V124.21.109.109

Published: 2014

Journal Articles

Activation Of Autophagy By Bone Marrow Adipocytes Protects Myeloma Cells From Chemotherapy-Induced Apoptosis

Jing Yang, PhD, Jingda Xu, PhD, Zhiqiang Liu, PhD, Jin He, Huan Liu, Pei Lin, MD, Robert Z. Orlowski, M.D., Ph.D, Larry W. Kwak, MD, PhD, Qing Yi, MD, PhD

Blood (2013) 122 (21): 1915.

https://doi.org/10.1182/blood.V122.21.1915.1915

Published: 2013

Journal Articles

The Supportive Role Of Mesenchymal Stem Cells On Normal Hematopoietic Stem Cells Is Impaired In Leukemic Bone Marrow

Meiguang Lin, Ph.D, Yakun Pang, Yawei Zheng, Xin Gu, Feng-chun Yang, M.D., Ph.D., Weiping Yuan, Ph.D, Tao Cheng, M.D

Blood (2013) 122 (21): 1214.

https://doi.org/10.1182/blood.V122.21.1214.1214

Published: 2013

Journal Articles

The role of complement component 3 (C3) in differentiation of myeloid-derived suppressor cells

Ching-Chuan Hsieh, Hong-Shiue Chou, Horng-Ren Yang, Feng Lin, Sumantha Bhatt, Jie Qin, Lianfu Wang, John J. Fung, Shiguang Qian, Lina Lu

Blood (2013) 121 (10): 1760–1768.

https://doi.org/10.1182/blood-2012-06-440214

Published: 2013

Includes: Supplemental data

Journal Articles

Bone Marrow-Derived Adipocytes Promote Differentiation, Proliferation and Survival of Acute Monoblastic Leukemia Cells

Linhua Jin, PhD, Yoko Tabe, MD, PhD, Marina Konopleva, MD, PhD, Michael Andreeff, M.D., Ph.D., Akimichi Ohsaka, MD, PhD, Takashi Miida, MD, PhD

Blood (2011) 118 (21): 1501.

https://doi.org/10.1182/blood.V118.21.1501.1501

Published: 2011

Journal Articles

Efficient osteoclast differentiation requires local complement activation

Zhidan Tu, Hong Bu, James E. Dennis, Feng Lin

Blood (2010) 116 (22): 4456–4463.

https://doi.org/10.1182/blood-2010-01-263590

Published: 2010

Journal Articles

Vascular endothelial growth factor-D transgenic mice show enhanced blood capillary density, improved postischemic muscle regeneration, and increased susceptibility to tumor formation

Anna-Mari Kärkkäinen, Antti Kotimaa, Jenni Huusko, Ivana Kholova, Suvi Elina Heinonen, Anna Stefanska, Marike Hinke Dijkstra, Hanna Purhonen, Eveliina Hämäläinen, Petri Ilmari Mäkinen, Mikko Petri Turunen, Seppo Ylä-Herttuala

Blood (2009) 113 (18): 4468–4475.

https://doi.org/10.1182/blood-2008-07-171108

Published: 2009

NARROW

Rare Germline Mutations in Complement Regulatory Genes Make the Antiphospholipid Syndrome Catastrophic

A Phase 2 Open-Label Study of Danicopan (ACH-0144471) in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have an Inadequate Response to Eculizumab Monotherapy

Mechanistic Evaluation of Efficacy Using Biomarkers of the Oral, Small Molecule Factor D Inhibitor, Danicopan (ACH-4471), in Untreated Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

Comparative Evaluation of Complement Factor D, C3, and C5 Inhibitors on Serum Bactericidal Activity Against Neisseria Meningitidis Isolates

An Alternative Pathway Specific Flow Cytometric Assay to Detect Complement Activation in Atypical Hemolytic Uremic Syndrome (aHUS)

Current Status and Optimal Management of Eculizumab Poor-Responders Due to C5 Polymorphisms

In Vitro Combination Studies of ACH-4471 with Eculizumab to Assess a Potential "Switch" Treatment Approach for Paroxysmal Nocturnal Hemoglobinuria

Eculizumab treatment and impaired opsonophagocytic killing of meningococci by whole blood from immunized adults

Effect of Complement Inhibition By Anti-C5 (Eculizumab) or a Small Molecule Inhibitor of Factor D (ACH-4471) on Survival of Meningococci in Blood from Vaccinated Adults

Evaluation of Bacteria-Mediated Potential "Bystander" Hemolysis of PNH RED CELLS I n Vitro : NO Evidence of Significant Complement Classical or Lectin Pathway-Mediated Hemolysis Induced by Microorganisms

Small Molecule Factor D Inhibitors Block Complement Activation in Paroxysmal Nocturnal Hemoglobinuria and Atypical Hemolytic Uremic Syndrome

Novel Small-Molecule Inhibitors Targeting Complement Factor D for Therapy of Paroxysmal Nocturnal Hemoglobinuria

Preclinical Evaluation of Orally Bioavailable Small-Molecule Inhibitors of Complement Factor D As a Potential Treatment for Paroxysmal Nocturnal Hemoglobinuria

Von Willebrand Factor Is a Cofactor in Complement Regulation

Activation Of Autophagy By Bone Marrow Adipocytes Protects Myeloma Cells From Chemotherapy-Induced Apoptosis

The Supportive Role Of Mesenchymal Stem Cells On Normal Hematopoietic Stem Cells Is Impaired In Leukemic Bone Marrow

The role of complement component 3 (C3) in differentiation of myeloid-derived suppressor cells

Bone Marrow-Derived Adipocytes Promote Differentiation, Proliferation and Survival of Acute Monoblastic Leukemia Cells

Efficient osteoclast differentiation requires local complement activation

Vascular endothelial growth factor-D transgenic mice show enhanced blood capillary density, improved postischemic muscle regeneration, and increased susceptibility to tumor formation

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American Society of Hematology

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ASH Publications

American Society of Hematology

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