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Journal Articles

Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey M Matthews, PhD, Dennis Buckley, Joseline Raja, Quinlan L Sievers, PhD, Olga Dashevsky, PhD, Haley Poarch, Huihui Tang, PhD, Megan Bariteau, BSc, Michal Sheffer, PhD, Sondra L. Downey-Kopyscinski, PhD, Paul Hengeveld, Brian Glassner, PhD, Eugen Dhimolea, PhD, Christopher J. Ott, PhD, Tinghu Zhang, PhD, Nicholas P Kwiatkowski, PhD, Jacob P. Laubach, MD, Robert L. Schlossman, MD, Paul G. Richardson, MD, Aedin Culhane, PhD, Richard W.J. Groen, PhD, Eric Fischer, Benjamin L. Ebert, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, PhD, Daniel Auclair, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, James Bradner, MD, Nathanael Gray, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 318.
https://doi.org/10.1182/blood-2019-130549
Published: 2019
Journal Articles

NPM-ALK Upregulates Jab1/Csn5 through STAT3 Activation in Anaplastic Large Cell Lymphoma: A Novel Function of NPM-ALK That Contributes to PD1/PD-L1 Immune Checkpoint Regulation

Elias Drakos, MD PhD Prof., Konstantina Stathopoulou, MSc., Lingxiao Li, PhD, Daniel Bilbao, Vasiliki Leventaki, Pedro Farrajota Neves Da Silva, MD, Vasileios Atsaves, PhD, Anders Österborg, MD PhD, L. Jeffrey Medeiros, MD, Francisco Vega, MD PhD, Jonathan H. Schatz, MD, Francois Claret, PhD, George Z. Rassidakis, MD PhD Prof.
Journal: Blood
Blood (2019) 134 (Supplement_1): 2796.
https://doi.org/10.1182/blood-2019-130457
Published: 2019
Journal Articles

CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias

Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Dennis Buckley, Olga Dashevsky, PhD, Sondra L. Downey-Kopyscinski, PhD, Huihui Tang, PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Brian Glassner, PhD, Megan Bariteau, BSc, Jeffrey Sorrell, BA, Johanna B Bruggenthies, Quinlan Sievers, BA, Haley Poarch, Nicholas P Kwiatkowski, PhD, Tinghu Zhang, PhD, Jacob Laubach, MD, Robert L. Schlossman, MD, Paul Richardson, Aedin Culhane, PhD, Richard WJ Groen, PhD, Eric S. Fischer, PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, Daniel Auclair, PhD, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, Benjamin L. Ebert, MDPhD, James Bradner, MD, Nathanae Gray, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1367.
https://doi.org/10.1182/blood-2018-99-116232
Published: 2018
Journal Articles

Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophages

Zhongbin Deng, Ruggero Pardi, William Cheadle, Xiaoyu Xiang, Shuangyin Zhang, Spandan V. Shah, William Grizzle, Donald Miller, John Mountz, Huang-Ge Zhang
Journal: Blood
Blood (2011) 117 (18): 4796–4804.
https://doi.org/10.1182/blood-2010-10-314526
Published: 2011
Includes: Supplemental data
Journal Articles

Phosphoinositides and Other Glycerophospholipids Interact with Protein C Inhibitor (PCI) and Modify Its Activity towards Activated Protein C (APC).

Felix Wahlmüller, Margareta Furtmüller, Barbora Sokolikova, Bernd R Binder, Margarethe Geiger
Journal: Blood
Blood (2009) 114 (22): 2122.
https://doi.org/10.1182/blood.V114.22.2122.2122
Published: 2009
Journal Articles

The Jab1/COP9 signalosome subcomplex is a downstream mediator of Bcr-Abl kinase activity and facilitates cell-cycle progression

Kiichiro Tomoda, Jun-ya Kato, Eiji Tatsumi, Takayuki Takahashi, Yoshinobu Matsuo, Noriko Yoneda-Kato
Journal: Blood
Blood (2005) 105 (2): 775–783.
https://doi.org/10.1182/blood-2004-04-1242
Published: 2005
Journal Articles

Akt/PKB Activation-Induced Cytoplasmic Mislocalization of p27Kip1 Protein Is Mediated by Jab1 Shuttling in Human Myeloid Leukemia Cells.

Yoo-Hong Min, M.D., Ph.D., Ju In Eom, Ae Jin Choi, Jee Young Lee, Jin Seok Kim, M.D., Seung Tae Lee, M.D., June-Won Cheong, M.D.
Journal: Blood
Blood (2004) 104 (11): 4461.
https://doi.org/10.1182/blood.V104.11.4461.4461
Published: 2004