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Journal Articles

Therapeutic Base Editing of Human Hematopoietic Stem Cells

Jing Zeng, MD, Yuxuan Wu, PhD, Chunyan Ren, PhD, Jasmine Bonanno, Anne H. Shen, Devlin Shea, Jason M Gehrke, PhD, John P Manis, MD, J. Keith Gehrke, Daniel E. Bauer, MD PhD

Blood (2019) 134 (Supplement_1): 612.

https://doi.org/10.1182/blood-2019-129173

Published: 2019

Journal Articles

Interactome Analysis of APOBEC3B in Multiple Myeloma

Yasuhiro Kazuma, MD, Kotaro Shirakawa, MD PhD, Anamaria Daniela Sarca, MD, Yoshihito Horisawa, MD, Hirofumi Fukuda, MD, Hiroyuki Matsui, MD, Hiroyuki Yamazaki, MD, Tadahiko Matsumoto, MD, Fumiko Tanabe, Ryo Morishita, PhD, Shinji Ito, PhD, Akifumi Takaori-Kondo, MD PhD

Blood (2019) 134 (Supplement_1): 1259.

https://doi.org/10.1182/blood-2019-126856

Published: 2019

Journal Articles

Combined Heterozygous Loss of Tet2 and Dnmt3a Along with Expression of Flt3 ITD/WT results in Acute Myeloid Leukemia Which Responds to a Combination of FLT3 Inhibitor, APE1 Inhibitor and Decitabine

Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Raghuveer Singh Mali, PhD, Zhigang Cai, PhD, Ruchi Pandey, PhD, Reuben Kapur, PhD

Blood (2019) 134 (Supplement_1): 3754.

https://doi.org/10.1182/blood-2019-131172

Published: 2019

Journal Articles

Universal' Fratricide-Resistant CAR T Cells Against T Cell Leukemia Generated By Coupled & Uncoupled Deamination Mediated Base Editing

Christos Georgiadis, PhD, Jane Rasaiyaah, PhD, Soragia Athina Gkazi, PhD, Roland Preece, Annie Etuk, PhD, Abraham Christi, Waseem Qasim, MBBS, PhD

Blood (2019) 134 (Supplement_1): 3219.

https://doi.org/10.1182/blood-2019-130057

Published: 2019

Journal Articles

Decitabine-Induced Early Platelet Response, a Predictor of Favorable Outcome during Hypomethylating Treatment of MDS, Is Associated with In Vivo Megakaryocytic Differentiation

Julia Stomper, Annette M. May, Tina E. Joeckel, Peter Bronsert, Martin Werner, Michael Lübbert

Blood (2019) 134 (Supplement_1): 4265.

https://doi.org/10.1182/blood-2019-128141

Published: 2019

Journal Articles

5-Fluorotroxacitabine Displays Potent Anti-Leukemic Effects and Circumvents Resistance to Ara-C

Aniket Bankar, MBBS, MD DM, Thirushi Piyumika Siriwardena, Biljana Rizoska, PhD, Christina Rydergård, BSc, Helen Kylefjord, BSc, Vilma Rraklli, PhD, Anders Eneroth, PhD, Pedro Pinho, PhD, Stefan Norin, MD PhD, Johan Bylund, PhD, Sara Moses, PhD, Richard Bethell, PhD, Simon Kavanagh, MBBS(Hons), FRACP, FRCPA, Xiaoming Wang, Rose Hurren, BSc, Mark D. Minden, MD PhD, Paul Targett-Adams, PhD BSc, Aaron D Schimmer, MD PhD, Mark Albertella, PhD

Blood (2018) 132 (Supplement 1): 3939.

https://doi.org/10.1182/blood-2018-99-114345

Published: 2018

Journal Articles

APOBEC3B Is Induced By Activation of DNA Repair Pathway and Modulates the Survival and Treatment Response in Human Multiple Myeloma

Lijie Xing, MD, Jiye Liu, PhD, Liang Lin, PhD, Shih-Feng Cho, MD PhD, Kenneth Wen, BS, Tengteng Yu, MD, Phillip Hsieh, Gang An, MD, Lugui Qiu, MD PhD, Nikhil Munshi, MD, Kenneth Anderson, MD, Yu-Tzu Tai, PhD

Blood (2018) 132 (Supplement 1): 407.

https://doi.org/10.1182/blood-2018-99-110317

Published: 2018

Journal Articles

The Therapeutic Response of Myelodsyplastic Syndromes to Azacytidine Is Independent of Endogenous Retroelement Modulation

Chrysoula Kordella, Anastasiya Kazachenka, Eleftheria Lamprianidou, Emmanouela Zoulia, George Vrachiolias, Menelaos Konstantinos Papoutselis, Zoe Bezirgiannidou, Emmanouil Spanoudakis, Christiana Georgiou, Urszula Eksmond, George Kassiotis, Ioannis Kotsianidis, PhD

Blood (2018) 132 (Supplement 1): 4349.

https://doi.org/10.1182/blood-2018-99-114446

Published: 2018

Journal Articles

Critical Role for Apobec and Its Interacting Partners in Mediating Mutations and Cell Growth in Multiple Myeloma (MM)

Srikanth Talluri, PhD, Mehmet Kemal Samur, PhD, Jialan Shi, MD PhD, Rao Prabhala, PhD, Hervé Avet-Loiseau, MD PhD, Masood A. Shammas, PhD, Nikhil Munshi, MD

Blood (2018) 132 (Supplement 1): 4462.

https://doi.org/10.1182/blood-2018-99-118441

Published: 2018

Journal Articles

Intraclonal Diversification Occurs in Chronic Lymphocytic Leukemia Expressing B Cell Receptors Belonging to the IGHV4 Gene Family

Blood (2018) 132 (Supplement 1): 944.

https://doi.org/10.1182/blood-2018-99-112423

Published: 2018

Journal Articles

Protides of 5-Fluorotroxacitabine Display Potent Anti-Proliferative Properties and Circumvent Deoxycytidine Kinase-Mediated Resistance Associated with Cytotoxic Cytidine Analogues; A Novel Approach for Acute Myeloid Leukemia

Pedro Pinho, PhD, Helen Kylefjord, BSc, Vilma Rraklli, PhD, Christina Rydergård, BSc, Biljana Rizoska, PhD, Anders Eneroth, PhD, Johan Bylund, PhD, Sara Moses, PhD, Stefan Norin, MD PhD, Richard Bethell, PhD, Aniket Bankar, MBBS, MD DM, Thirushi Piyumika Siriwardena, Mark D. Minden, MD PhD, Aaron D Schimmer, MD PhD, Mark Albertella, PhD, Paul Targett-Adams, PhD BSc

Blood (2018) 132 (Supplement 1): 3497.

https://doi.org/10.1182/blood-2018-99-114440

Published: 2018

Journal Articles

Biological and Prognostic Impact of Apobec-Induced Mutations in the Spectrum of Plasma Cell Dyscrasias

Blood (2017) 130 (Supplement 1): 1771.

https://doi.org/10.1182/blood.V130.Suppl_1.1771.1771

Published: 2017

Journal Articles

A Small Molecule RAD51 Inhibitor Preferentially Affects Cells Expressing High Cytidine Deaminase Activity

Kevin Mills, PhD, Amber Cyr, Tyler Maclay, Melinda Day, Muneer G Hasham, PhD, Andre Khalil

Blood (2017) 130 (Supplement 1): 4627.

https://doi.org/10.1182/blood.V130.Suppl_1.4627.4627

Published: 2017

Journal Articles

Altered Enhancer Activity Represses CEBPE Expression in MLL -Rearranged Leukemia

Xianwen Yang, Yuk Man Lam, Wing Chi Lui, Ray K. Ng, PhD

Blood (2017) 130 (Supplement 1): 1207.

https://doi.org/10.1182/blood.V130.Suppl_1.1207.1207

Published: 2017

Journal Articles

Apobec Family of Proteins Mediate Genomic Changes in Multiple Myeloma By Inducing DNA Damage and C>T Mutations

Srikanth Talluri, PhD, Mehmet Kemal Samur, PhD, Leutz Buon, Puru Nanjappa, Rao Prabhala, PhD, Masood A. Shammas, PhD, Nikhil Munshi, MD

Blood (2017) 130 (Supplement 1): 4334.

https://doi.org/10.1182/blood.V130.Suppl_1.4334.4334

Published: 2017

Journal Articles

Pilot Use of a Novel DNA Methytransferase -1 (DNMT1) Flow Cytometric Pharmacodynamic Assay to Evaluate Response to Low-Dose Azacitidine Therapy for Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapse after Allogeneic Hematopoietic Cell Transplantation

Najla H El Jurdi, MD, Masumi Ueda, MD MA, BA, Philip Woost, PhD, Hillard M Lazarus, MD, Paolo Caimi, MD, Brenda W. Cooper, MD, Richard Creger, PhD, Jane A. Little, MD, Linda Baer, MSN, NP-C, AOCNP, Lauren Brister, MSN, NP-C, AOCNP, Ehsan Malek, MD, Leland Metheny, MD, Folashade Otegbeye, MBBChir, MPH, Ben K. Tomlinson, MD, Basem M. William, MRCP,MD, James Jacobberger, PhD, Marcos De Lima, MD

Blood (2017) 130 (Supplement 1): 5503.

https://doi.org/10.1182/blood.V130.Suppl_1.5503.5503

Published: 2017

Journal Articles

Leveraging Increased Nucleoside Kinase Activity to Selectively Deplete Mitochondrial DNA (mtDNA), Impair Oxidative Phosphorylation, and Target AML Cells

Sanduni U. Liyanage, Hon. B. Sc., Rose Hurren, Veronique Voisin, Wang Xiaoming, Gaëlle Bridon, Changjiang Xu, Neil MacLean, Thirushi Siriwardena, Aisha Shamas-Din, PhD, Shrivani Sriskanthadevan, Mark D. Minden, MD PhD, Gary D Bader, Rebecca Laposa, Aaron D. Schimmer, MD PhD

Blood (2016) 128 (22): 1573.

https://doi.org/10.1182/blood.V128.22.1573.1573

Published: 2016

Journal Articles

Expression of Poly [ADP-Ribose] Polymerase 1 (PARP-1) and Uridine-Cytidine Kinase (UCK) 1 and 2 in Myelodysplastic Syndrome

Panagiotis Theodorou Diamantopoulos, Panagiotis Zervakis, Maria Sofotasiou, Konstantinos Zervakis, Argiris Symeonidis, MD PhD, Kodandreopoulou Elina, Galanopoulos Athanassios, Pappa Vassiliki, MD PhD, Kotsianidis Ioannis, Christopoulou Georgia, Papadopoulou Vasiliki, Mantzourani Marina, MD PhD, Nora-Athina Viniou, MD PhD

Blood (2016) 128 (22): 3183.

https://doi.org/10.1182/blood.V128.22.3183.3183

Published: 2016

Journal Articles

The Anti-HIV-1 Cytidine Deaminase APOBEC3G Is a Cellular Site-Specific RNA Editing Enzyme

Bora E. Baysal, MD PhD, Santosh Patnaik, MD PhD, Robert T Taggart, PhD, Shraddha Sharma, PhD

Blood (2016) 128 (22): 547.

https://doi.org/10.1182/blood.V128.22.547.547

Published: 2016

Journal Articles

Resistance to Azacitidine Is Determined at Cellular Level By Lower Expression of Nucleoside Metabolizing Enzymes

Erico Masala, Ana Belén Valencia, Alessandro Sanna, MD, Alice Brogi, Laila Zaroili, Valeria Santini, MD

Blood (2016) 128 (22): 5129.

https://doi.org/10.1182/blood.V128.22.5129.5129

Published: 2016

NARROW

Therapeutic Base Editing of Human Hematopoietic Stem Cells

Interactome Analysis of APOBEC3B in Multiple Myeloma

Combined Heterozygous Loss of Tet2 and Dnmt3a Along with Expression of Flt3 ITD/WT results in Acute Myeloid Leukemia Which Responds to a Combination of FLT3 Inhibitor, APE1 Inhibitor and Decitabine

Universal' Fratricide-Resistant CAR T Cells Against T Cell Leukemia Generated By Coupled & Uncoupled Deamination Mediated Base Editing

Decitabine-Induced Early Platelet Response, a Predictor of Favorable Outcome during Hypomethylating Treatment of MDS, Is Associated with In Vivo Megakaryocytic Differentiation

5-Fluorotroxacitabine Displays Potent Anti-Leukemic Effects and Circumvents Resistance to Ara-C

APOBEC3B Is Induced By Activation of DNA Repair Pathway and Modulates the Survival and Treatment Response in Human Multiple Myeloma

The Therapeutic Response of Myelodsyplastic Syndromes to Azacytidine Is Independent of Endogenous Retroelement Modulation

Critical Role for Apobec and Its Interacting Partners in Mediating Mutations and Cell Growth in Multiple Myeloma (MM)

Intraclonal Diversification Occurs in Chronic Lymphocytic Leukemia Expressing B Cell Receptors Belonging to the IGHV4 Gene Family

Protides of 5-Fluorotroxacitabine Display Potent Anti-Proliferative Properties and Circumvent Deoxycytidine Kinase-Mediated Resistance Associated with Cytotoxic Cytidine Analogues; A Novel Approach for Acute Myeloid Leukemia

Biological and Prognostic Impact of Apobec-Induced Mutations in the Spectrum of Plasma Cell Dyscrasias

A Small Molecule RAD51 Inhibitor Preferentially Affects Cells Expressing High Cytidine Deaminase Activity

Altered Enhancer Activity Represses CEBPE Expression in MLL -Rearranged Leukemia

Apobec Family of Proteins Mediate Genomic Changes in Multiple Myeloma By Inducing DNA Damage and C>T Mutations

Pilot Use of a Novel DNA Methytransferase -1 (DNMT1) Flow Cytometric Pharmacodynamic Assay to Evaluate Response to Low-Dose Azacitidine Therapy for Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapse after Allogeneic Hematopoietic Cell Transplantation

Leveraging Increased Nucleoside Kinase Activity to Selectively Deplete Mitochondrial DNA (mtDNA), Impair Oxidative Phosphorylation, and Target AML Cells

Expression of Poly [ADP-Ribose] Polymerase 1 (PARP-1) and Uridine-Cytidine Kinase (UCK) 1 and 2 in Myelodysplastic Syndrome

The Anti-HIV-1 Cytidine Deaminase APOBEC3G Is a Cellular Site-Specific RNA Editing Enzyme

Resistance to Azacitidine Is Determined at Cellular Level By Lower Expression of Nucleoside Metabolizing Enzymes

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American Society of Hematology

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American Society of Hematology

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