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Journal Articles

Durable Responses and Survival in High Risk AML and MDS Patients Treated with an Allogeneic Leukemia-Derived Dendritic Cell Vaccine

Luca L.G. Janssen, MD, Theresia M. Westers, PhD, Jeroen Rovers, MD PhD, Peter Valk, PhD, Jacqueline Cloos, PhD, Tanja D. de Gruijl, PhD, Arjan A. Van de Loosdrecht, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1381.
https://doi.org/10.1182/blood-2019-127881
Published: 2019
Journal Articles

Immune Monitoring of Vaccine Quality and Persistence of Specific T Cell Responses in Five AML Patients Receiving Extended Dendritic Cell Vaccination Under Compassionate Use

Iris Bigalke, MD, Judith Eckl, PhD, Guri Solum, MSc, Kirsti Hønnåshagen, Msc, Lisbeth Skoge, MSc, Yngvar Fløisand, MD PhD, Dag Josefsen, MD PhD, Stein Sæbøe-Larssen, PhD, Christiane Geiger, PhD, Dolores Schendel, PhD, Gunnar Kvalheim, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2718.
https://doi.org/10.1182/blood-2018-99-114557
Published: 2018
Journal Articles

A Blood Dendritic Cell Vaccine for Acute Myeloid Leukemia Expands Anti-Tumour T Cell Responses at Remission

Derek NJ Hart, PhD FRCPA, FRACP, MB, Jennifer L Hsu, Christian E Bryant, Michael S Papadimitrious, Benjamin Kong, Robin E Gasiorowski, Daniel W Orellana, Helen McGuire, Barbara Fazekas de St Groth, Douglas E. Joshua, Phoebe Joy Ho, Stephen R Larsen, Harry J Iland, John Gibson, Georgina J Clark, Phillip D Fromm
Journal: Blood
Blood (2017) 130 (Supplement 1): 2648.
https://doi.org/10.1182/blood.V130.Suppl_1.2648.2648
Published: 2017
Journal Articles

Multimodality Targeting of Dendritic Cell Vaccination Combined with Immunomodulatory Drug and Immune Checkpoint Blockade Has Synergistically Induced a Marked Tumor Regression By Modulating Tumor Microenvironment in a Murine Myeloma Model

Manh-Cuong Vo, Hyun-Ju Lee, Sung-Hoon Jung, MD, Thangaraj Jaya Lakshmi, Hye-Sung Park, Tan-Huy Chu, Hyeoung-Joon Kim, Je-Jung Lee, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5453.
https://doi.org/10.1182/blood.V130.Suppl_1.5453.5453
Published: 2017
Journal Articles

Dendritic Cell Vaccination Combined with Pomalidomide and Dexamethasone Ameliorated Antitumor Immunity By Skewing Immuno-Suppressive Status Toward Immuno-Supportive Status in a Murine Myeloma Model

Sung-Hoon Jung, MD, Seoyun Yang, Hyun-Ju Lee, Manh-Cuong Vo, Thangaraj Jaya Lakshmi, Hye-Sung Park, Tan-Huy Chu, Hyeoung-Joon Kim, Je-Jung Lee, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5454.
https://doi.org/10.1182/blood.V130.Suppl_1.5454.5454
Published: 2017
Journal Articles

Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia

Clinical Trials & Observations
Sébastien Anguille, Ann L. Van de Velde, Evelien L. Smits, Viggo F. Van Tendeloo, Gunnar Juliusson, Nathalie Cools, Griet Nijs, Barbara Stein, Eva Lion, Ann Van Driessche, Irma Vandenbosch, Anke Verlinden, Alain P. Gadisseur, Wilfried A. Schroyens, Ludo Muylle, Katrien Vermeulen, Marie-Berthe Maes, Kathleen Deiteren, Ronald Malfait, Emma Gostick, Martin Lammens, Marie M. Couttenye, Philippe Jorens, Herman Goossens, David A. Price, Kristin Ladell, Yoshihiro Oka, Fumihiro Fujiki, Yusuke Oji, Haruo Sugiyama, Zwi N. Berneman
Journal: Blood
Blood (2017) 130 (15): 1713–1721.
https://doi.org/10.1182/blood-2017-04-780155
Published: 2017
Includes: Supplemental data
Journal Articles

A Blood Dendritic Cell Vaccine for Acute Myeloid Leukemia

Jennifer Hsu, PhD, Christian Bryant, Phillip Fromm, PhD, Michael Papadimitrious, Daniel Orellana, Hayley Suen, Shihong Yang, Claire Weatherburn, Robin Gasiorowski, Harry J Iland, MBBS FRACP FRCPA, Ross D Brown, Douglas E Joshua, Phoebe Joy Ho, MBBS, DPhil, John Gibson, Georgina Clark, Derek NJ Hart
Journal: Blood
Blood (2016) 128 (22): 5221.
https://doi.org/10.1182/blood.V128.22.5221.5221
Published: 2016
Journal Articles

Induction of Antigen-Specific T-Cell Responses through Dendritic Cell Vaccination in AML: Results of a Phase I/II Trial and Ex Vivo Enhancement By Checkpoint Blockade

Felix S. Lichtenegger, MD, Katrin Deiser, PhD, Maurine Rothe, Frauke M. Schnorfeil, PhD, Christina Krupka, PhD, Christian Augsberger, Thomas Köhnke, MD, Veit L. Bücklein, MD, Torben Altmann, MD, Andreas Moosmann, Monika Brüggemann, MD PhD, Mirjam H.M. Heemskerk, PhD, Georg Wittmann, MD, Beate Wagner, MD, Wolfgang Hiddemann, MD, Iris Bigalke, PhD, Gunnar Kvalheim, MD PhD, Marion Subklewe, MD
Journal: Blood
Blood (2016) 128 (22): 764.
https://doi.org/10.1182/blood.V128.22.764.764
Published: 2016
Journal Articles

Next-Generation Dendritic Cell Vaccination in Postremission Therapy of AML: Results of a Clinical Phase I Trial

Katrin Deiser, Felix S. Lichtenegger, Frauke Schnorfeil, Thomas Koehnke, Torben Altmann, Veit Buecklein, Andreas Moosmann, Monika Brueggemann, Beate Wagner, Wolfgang Hiddemann, Iris Bigalke, Gunnar Kvalheim, Marion S. Subklewe, MD
Journal: Blood
Blood (2015) 126 (23): 3805.
https://doi.org/10.1182/blood.V126.23.3805.3805
Published: 2015
Journal Articles

Dendritic Cell Vaccine Treatment for B-Cell Non-Hodgkin Lymphoma: Clinical Trial in Progress

Yi Lin, MDPhD, Thomas Atwell, MD, Adam Weisbrod, MD, Mary Maas, Adam S. Armstrong, Michael Deeds, Peggy A Bulur, Michael Gustafson, PhD, Zhe (Jenny) Zhang, PhD, Stefan Cordes, MD PhD, Luis F. Porrata, MD, Svetomir N. Markovic, MD, PhD, Patrick B. Johnston, MD PhD, Ivana N. Micallef, MD, David J. Inwards, MD, Joseph P. Colgan, MD, Stephen M. Ansell, MD PhD, Dennis A. Gastineau, MD, Allan B Dietz, PhD, Thomas E. Witzig, MD
Journal: Blood
Blood (2014) 124 (21): 4474.
https://doi.org/10.1182/blood.V124.21.4474.4474
Published: 2014
Journal Articles

Identification of Minor Histocompatibility Antigens Based on the 1000 Genomes Project for Application in Therapeutic Dendritic Cell Vaccination

Rimke Oostvogels, MD, Henk M. Lokhorst, MDPhD, Maureen van Elk, Kelly van den Oudenalder, Eric Spierings, PhD, Monique C. Minnema, MDPhD, Tuna Mutis, MDPhD, Robbert Spaapen, PhD
Journal: Blood
Blood (2014) 124 (21): 2418.
https://doi.org/10.1182/blood.V124.21.2418.2418
Published: 2014
Journal Articles

The Cancer/Testis Antigens of SSX4, MAGE-A3, and CTAG2 Are Attractive Targets for Cancer Immunotherapy in Korean Patients with Multiple Myeloma

Nu-Ri Choi, Sung-Hoon Jung, Hyun-Ju Lee, Manh-Cuong Vo, My-Dung Hoang, Hyeoung-Joon Kim, MD PhD, Je-Jung Lee, MD PhD
Journal: Blood
Blood (2014) 124 (21): 5757.
https://doi.org/10.1182/blood.V124.21.5757.5757
Published: 2014
Journal Articles

Dendritic Cell Vaccination in Acute Leukemia Patients Induces Reduction of Myeloid-Derived Suppressor Cells : Immunological Analysis of a Pilot Study

Masahiro Ogasawara, MD PhD, Shuichi Ota, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1113.
https://doi.org/10.1182/blood.V124.21.1113.1113
Published: 2014
Journal Articles

Cost Analysis of Immunotherapy Using Dendritic Cells for Acute Myeloid Leukemia Patients

Ann L. Van de Velde, Sébastien Anguille, Philippe Beutels, PhD, Suzy Dom, Ingrid Cornille, Griet Nijs, Viggo F Van Tendeloo, Evelien L. Smits, Anke Verlinden, Alain P. Gadisseur, Wilfried A Schroyens, Zwi N Berneman, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1322.
https://doi.org/10.1182/blood.V124.21.1322.1322
Published: 2014
Journal Articles

Clinical and Immunological Response Following hTERT/Survivin mRNA-Loaded Dendritic Cell Vaccination Combined With Ex-Vivo Expanded T Cell Transfer In Melanoma Patients

Gunnar Kvalheim, MD, PhD, Iris Bigalke, MD, Siri Torhaug, MD, Marianne Lundby, Camilla Mollat, Else-Marit Inderberg Suso, PhD, Arne Kolstad, MD, PhD, Gustav Gaudernack, PhD, Anne-Marie Rasmussen, PhD, Steinar Aamdal, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4487.
https://doi.org/10.1182/blood.V122.21.4487.4487
Published: 2013
Journal Articles

Improving Efficacy of Dendritic Cell Vaccination in AML: Optimization of the DC Generation Protocol and Maximization of T Cell Responses by Immune Checkpoint Blockade

Felix S Lichtenegger, MD, Barbara Beck, PhD, Christiane Geiger, PhD, Dieter Munker, Miriam Schlueter, Rika Draenert, MD, Frauke Schnorfeil, PhD, Gunnar Kvalheim, MD, PhD, Wolfgang Hiddemann, M.D., Dolores J Schendel, PhD, Marion Subklewe, MD
Journal: Blood
Blood (2013) 122 (21): 3492.
https://doi.org/10.1182/blood.V122.21.3492.3492
Published: 2013
Journal Articles

Immunomodulatory Drugs Restore Effector Cell Immune Functions In Myeloma Patients With Low Disease Burden After Autologous Stem Cell Transplantation

Karel Fostier, MD, Jurgen Corthals, Carlo Heirman, Joeri L. Aerts, PhD, Kris Thielemans, MD, PhD, Rik Schots, MD, PhD, Brenda De Keersmaecker, PhD
Journal: Blood
Blood (2013) 122 (21): 3214.
https://doi.org/10.1182/blood.V122.21.3214.3214
Published: 2013
Journal Articles

Improved Vaccine Design For Adoptive Immunotherapy In Hematological Malignancies Through Chemically Modified Minor Histocompatibility Antigen Epitopes

Rimke Oostvogels, MD, Rieuwert Hoppes, Henk Lokhorst, Robbert M Spaapen, PhD, Huib Ovaa, PhD, Tuna Mutis, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 5435.
https://doi.org/10.1182/blood.V122.21.5435.5435
Published: 2013
Journal Articles

Clinical and Immunological Results Of a Phase I/IIa Study Of Allogeneic Dendritic Cell (DC) Vaccination, An “off The shelf” Treatment To Prevent Or Delay Relapse In Elderly Patients With Acute Myeloid Leukemia

Arjan A van de Loosdrecht, MD, PhD, Sandra van Wetering, PhD, Saskia Santegoeds, Satwinder Kaur Singh, PhD, Malika Koppes, Anthony Hall, MD, Ada M. Kruisbeek, PhD, Tanja D. de Gruijl, PhD., Gert J. Ossenkoppele, MD PhD
Journal: Blood
Blood (2013) 122 (21): 2651.
https://doi.org/10.1182/blood.V122.21.2651.2651
Published: 2013
Journal Articles

Prevention Of Relapse In Acute Myeloid Leukemia By Dendritic Cell Vaccination: Report on a Phase II Study With 29 Patients

Zwi N. Berneman, MD, PhD, FRCP, Ann Van de Velde, MD, Sébastien Anguille, MD, Yannick Willemen, MD, Wilfried A. Schroyens, MD, PhD, Alain P. Gadisseur, MD, PhD, Inge Vrelust, MD, Griet Nijs, MT, Barbara Stein, MSc, Nathalie Cools, PhD, Ronald Malfait, MD, Marie-Berthe Maes, PharmD, PhD, Katrien Vermeulen, PhD, Viggo F. Van Tendeloo, PhD, Evelien L. Smits, PhD
Journal: Blood
Blood (2013) 122 (21): 236.
https://doi.org/10.1182/blood.V122.21.236.236
Published: 2013