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Journal Articles

Mitophagy Plays a Key Role in the Anti-Leukemic Activity of Autophagy Inhibitors Under Hypoxia in Acute Myeloid Leukemia

Hannah R.S. Fay, BS, Kaitlyn M. Dykstra, PhD, Matthew Johnson, Tara L. Cronin, BA, Linda Lutgen-Dunckley, Brandon L. Martens, BS, Joseph R. Moberg, BS, Monica L. Guzman, PhD, Eunice S. Wang, MD

Blood (2019) 134 (Supplement_1): 1278.

https://doi.org/10.1182/blood-2019-127024

Published: 2019

Journal Articles

Inhibition of TLR4 Signaling Affects Mitochondrial Fitness Overcoming Bortezomib Resistance in Myeloma Plasma Cells

Cesarina Giallongo, PhD, Daniele Tibullo, PhD, Giuseppina Camiolo, Fabrizio Puglisi, Daniela Cambria, Alessandro Barbato, Nunziatina Laura Parrinello, PhD, Alessandra Romano, MD PhD, Concetta Conticello, MD, Angela Amorini, PhD, Giovanni Li Volti, MD PhD, Giuseppe Lazzarino, Giuseppe A. Palumbo, MD PhD, Francesco Di Raimondo, MD

Blood (2019) 134 (Supplement_1): 3073.

https://doi.org/10.1182/blood-2019-129812

Published: 2019

Journal Articles

PKR-like Endoplasmic Reticulum Kinase Mediates Apoptosis Induced By Pharmacological AMP-Activated Protein Kinase Activation in Acute Myeloid Leukemia

Laury Poulain, PhD, Adrien Grenier, MD PhD, Johanna Mondesir, MD, Arnaud Jacquel, PhD, Claudie Bosc, Lucille Stuani, PhD, Rudy Birsen, MD, Sarah Mouche, Justine Decroocq, MD, Fetta Mazed, PhD, Benoit Viollet, PhD, Patrick Auberger, PhD, Pierre Sujobert, MD PhD, Didier Bouscary, MD PhD, Jean-Emmanuel Sarry, PhD, Jerome Tamburini, MD PhD

Blood (2019) 134 (Supplement_1): 2552.

https://doi.org/10.1182/blood-2019-123364

Published: 2019

Journal Articles

A Phase Ib/II Study of the BCL-2 Inhibitor Venetoclax in Combination with Standard Intensive AML Induction/Consolidation Therapy with FLAG-IDA in Patients with Newly Diagnosed or Relapsed/Refractory AML

Iman Aboudalle, MD, Marina Y Konopleva, MD PhD, Tapan M. Kadia, MD, Kiran Naqvi, MDMPH, Kenneth Vaughan, RN, Mehmet Kurt, RN, Antonio Cavazos, Sherry A. Pierce, BSN, BA, Koichi Takahashi, MD, Lucia Masarova, MD, Musa E. Yilmaz, MD, Elias Jabbour, MD, Guillermo Garcia-Manero, MD, Steven M. Kornblau, MD, Farhad Ravandi, MD, Jorge Cortes, MD, Hagop M. Kantarjian, MD, Courtney D. DiNardo, MD MSc

Blood (2019) 134 (Supplement_1): 176.

https://doi.org/10.1182/blood-2019-121780

Published: 2019

Journal Articles

The Long Noncoding RNA BALR2 Controls Novel Transcriptional Circuits Involved in Chemotherapy Sensitivity of Pediatric Acute Myeloid Leukemia (AML) Blasts

Valeria Bisio, PhD, Maddalena Benetton, Elena Porcù, PhD, Matteo Bordi, PhD, Carlo Zanon, PhD, Giulia Borella, Ambra Da Ros, Giuseppe Germano, PhD, Sabrina Manni, PhD, Claudia Tregnago, PhD, Silvia Campello, PhD, Dinesh S. Rao, MD PhD, Franco Locatelli, MD PhD, Martina Pigazzi, PhD

Blood (2019) 134 (Supplement_1): 2734.

https://doi.org/10.1182/blood-2019-128152

Published: 2019

Journal Articles

Anti-Apoptotic BCL-2 Family Members Confer Resistance to Calicheamicin-Based Antibody-Drug Conjugate Therapy of Acute Leukemia

Colin D. Godwin, MDMPhil, Olivia M. Bates, BA, Sae Rin Jean, PhD, George S. Laszlo, PhD, Eliotte E. Garling, BA, Mary E. Beddoe, BS, Michael H. Cardone, PhD, Roland B. Walter, MD PhD MS

Blood (2019) 134 (Supplement_1): 2561.

https://doi.org/10.1182/blood-2019-126110

Published: 2019

Journal Articles

Transcriptomic and Metabolomic Profiling Identifies Calcium-Dependent Signaling Mechanisms As a Novel and Exploitable Target to Overcome Anti-CD20 Resistance in Non-Hodgkin Lymphoma (NHL)

Ravi Dashnamoorthy, PhD, Saheli Sarkar, PhD, Afshin Beheshti, PhD, Maisarah Mokhtar, B.S, Tali Konry, PhD, Michael Levin, PhD, Andrew M. Evens, DO, MSc

Blood (2019) 134 (Supplement_1): 1511.

https://doi.org/10.1182/blood-2019-126539

Published: 2019

Journal Articles

Dynamic BH3 Profiling Predicts for Clinical Response to Lenalidomide Plus Chemotherapy in Relapsed Acute Myeloid Leukemia

Jacqueline S Garcia, MD, Shruti Bhatt, PhD, Geoffrey Fell, PhD, Traci M. Blonquist, MS, Jack Taw, David Iberri, MD, Anthony Letai, MD PhD, Bruno C. Medeiros, MD

Blood (2018) 132 (Supplement 1): 4058.

https://doi.org/10.1182/blood-2018-99-117428

Published: 2018

Journal Articles

Targeting Autophagy Kinase ULK1 Can Reverse Bcl2 Inhibitor (ABT-199) Induced Autophagy to Overcome Acquired Resistance in Acute Myeloid Leukemia

Seemana Bhattacharya, PhD, Sujan Piya, PhD, Qi Zhang, PhD, Natalia Baran, PhD MD, Teresa McQueen, MS, R. Eric Davis, MD, Nicholas Cosford, PhD, Marina Y. Konopleva, MD PhD, Michael Andreeff, MD PhD, Gautam Borthakur, MD

Blood (2018) 132 (Supplement 1): 3934.

https://doi.org/10.1182/blood-2018-99-114817

Published: 2018

Journal Articles

Apoptotic Blocks in Primary Non-Hodgkin B-Cell Lymphomas Identified By BH3 Profiling

Nathalie A Johnson, MD PhD, Claudia M Wever, PhD, Dominique Geoffrion, BSc, Ghassemian Artin, MD, Brailovski Eugene, Pierre Sesques, MD, Jeremy A. Ryan, SM, Liliana Stoica, Josee Hebert, MD, Tina Petrogiannis-Haliotis, MD PhD, Svetlana Dmitrienko, MD PhD, Frenkiel Saul, MD, German Ott, MD, Annette Staiger, Christian Steidl, MD, David W. Scott, PhD MD, FRACP, FRCPA, Koren Kathleen Mann, PhD, Anthony Letai, MD PhD

Blood (2018) 132 (Supplement 1): 4126.

https://doi.org/10.1182/blood-2018-99-118225

Published: 2018

Journal Articles

Fatal Dysfunction and Fragmentation of Thrombin-Stimulated Platelets

Oleg V. Kim, PhD, Tatiana A. Nevzorova, PhD, Elmira R. Mordakhanova, Izabella A. Andrianova, Giang Le Minh, Mark S. Alber, PhD, Olga Vagin, PhD, Rustem I. Litvinov, MD PhD, John W. Weisel, PhD

Blood (2018) 132 (Supplement 1): 521.

https://doi.org/10.1182/blood-2018-99-112703

Published: 2018

Journal Articles

Mitochondrial Uncoupling Prevents Procoagulant Platelet Formation Resulting in Decreased Thrombus Stability

Andaleb Kholmukhamedov, MD, Yumiko Sakurai, MSc, Elaissa L. Hardy, PhD, Wilbur A Lam, MD PhD, Shawn M. Jobe, MD PhD

Blood (2018) 132 (Supplement 1): 2421.

https://doi.org/10.1182/blood-2018-99-117004

Published: 2018

Journal Articles

Combination of Momelotinib and Citarinostat Show Strong Synergistic Effect in Lymphoid Cell Lines Co-Targeting JAK2/STAT3 and HDAC6

Maria Cosenza, MS, Monica Civallero, PhD, Stefano Sacchi, MD, Samantha Pozzi, MD

Blood (2018) 132 (Supplement 1): 3506.

https://doi.org/10.1182/blood-2018-99-116468

Published: 2018

Journal Articles

Inhibition of WIP1 Phosphatase in Multiple Myeloma Overcomes Bortezomib Resistance and Promotes Cell Death Via ER Stress-Induced Apoptotic JNK/c-Jun Signaling and Downregulation of Inhibitors of Apoptosis Proteins (IAPs)

Katia Beider, Evgenia Rosenberg, Valeria Voevoda, Hanna Bitner, Yaarit Sirovsky, Hila Magen, MD, Olga Ostrovsky, PhD, Avichai Shimoni, MD, Michael Milyavsky, PhD, Amnon Peled, Arnon Nagler, MD

Blood (2018) 132 (Supplement 1): 1366.

https://doi.org/10.1182/blood-2018-99-114652

Published: 2018

Journal Articles

The Pharmacological Blockade of Phosphodiesterase IV Potentiates the Anti-Tumor Effects of Arsenic Trioxide (ATO) in Acute Myelogenous Leukemia Cells through Multiple Signaling Pathways

Laura Mazzera, PhD, Manuela Abeltino, PhD, Antonio Bonati, MD, Paolo Lunghi, PhD

Blood (2017) 130 (Supplement 1): 2520.

https://doi.org/10.1182/blood.V130.Suppl_1.2520.2520

Published: 2017

Journal Articles

Understanding Apoptotic Blocks in "Double Hit" and Other Non-Hodgkin Lymphomas By BH3 Profiling

Claudia M Wever, PhD, Dominique Geoffrion, BSc, Pierre Sesques, MD, Liliana Stoica, Josee Hebert, MD, Jeremy Ryan, Anthony Letai, MD PhD, Nathalie A Johnson, MDPhD

Blood (2017) 130 (Supplement 1): 1471.

https://doi.org/10.1182/blood.V130.Suppl_1.1471.1471

Published: 2017

Journal Articles

Abbv-621 Is a Novel and Potent TRAIL Receptor Agonist Fusion Protein That Induces Apoptosis Alone and in Combination with Navitoclax and Venetoclax in Hematological Tumors

Stephen Kenneth Tahir, PhD, Morey L Smith, MS, Larry R Solomon, PhD, Haichao Zhang, PhD, John C Xue, MD, Yu Xiao, MS, Dong Cheng, MS, Greg Buchanan, PhD, Susan Morgan-Lappe, PhD, Darren C. Phillips, PhD

Blood (2017) 130 (Supplement 1): 2812.

https://doi.org/10.1182/blood.V130.Suppl_1.2812.2812

Published: 2017

Journal Articles

Preclinical Evaluation of the First in Class BMI1 Inhibitor PTC-028 Confirms Potent Efficacy to Target BMI1-Addiction in Multiple Myeloma

Arnold Bolomsky, PhD, Roy Heusschen, PhD, Kathrin Stangelberger, MSc, Muller Joséphine, Marla Weetall, PhD, Art Branstrom, PhD, Niklas Zojer, MD, Jo Caers, MD, Heinz Ludwig, MD

Blood (2017) 130 (Supplement 1): 1804.

https://doi.org/10.1182/blood.V130.Suppl_1.1804.1804

Published: 2017

Journal Articles

Maternal Embryonic Leucine Zipper Kinase (MELK) Drives a High-Risk Gene Network and Represents an Attractive Novel Drug Target in Multiple Myeloma

Arnold Bolomsky, PhD, Roy Heusschen, PhD, Karin Schlangen, PhD, Kathrin Schönfelder, MSc, Joséphine Muller, MSc, Wolfgang Schreiner, PhD, Niklas Zojer, MD, Jo Caers, Heinz Ludwig, MD

Blood (2016) 128 (22): 309.

https://doi.org/10.1182/blood.V128.22.309.309

Published: 2016

Journal Articles

Synergistic Anti-Tumor Efficacy of BET Inhibitors JQ1 and Otx-015 in Combination with Dasatinib in Preclinical Models of T-Cell Lymphomas

Sara Rizzitano, Alessandra Cavanè, Marco Piazzoni, Antonio Vendramin, Silvia Gimondi, Giulia Biancon, Sofia Cannara Malan, Anna Dodero, Paolo Corradini, Cristiana Carniti

Blood (2016) 128 (22): 3967.

https://doi.org/10.1182/blood.V128.22.3967.3967

Published: 2016

NARROW

Mitophagy Plays a Key Role in the Anti-Leukemic Activity of Autophagy Inhibitors Under Hypoxia in Acute Myeloid Leukemia

Inhibition of TLR4 Signaling Affects Mitochondrial Fitness Overcoming Bortezomib Resistance in Myeloma Plasma Cells

PKR-like Endoplasmic Reticulum Kinase Mediates Apoptosis Induced By Pharmacological AMP-Activated Protein Kinase Activation in Acute Myeloid Leukemia

A Phase Ib/II Study of the BCL-2 Inhibitor Venetoclax in Combination with Standard Intensive AML Induction/Consolidation Therapy with FLAG-IDA in Patients with Newly Diagnosed or Relapsed/Refractory AML

The Long Noncoding RNA BALR2 Controls Novel Transcriptional Circuits Involved in Chemotherapy Sensitivity of Pediatric Acute Myeloid Leukemia (AML) Blasts

Anti-Apoptotic BCL-2 Family Members Confer Resistance to Calicheamicin-Based Antibody-Drug Conjugate Therapy of Acute Leukemia

Transcriptomic and Metabolomic Profiling Identifies Calcium-Dependent Signaling Mechanisms As a Novel and Exploitable Target to Overcome Anti-CD20 Resistance in Non-Hodgkin Lymphoma (NHL)

Dynamic BH3 Profiling Predicts for Clinical Response to Lenalidomide Plus Chemotherapy in Relapsed Acute Myeloid Leukemia

Targeting Autophagy Kinase ULK1 Can Reverse Bcl2 Inhibitor (ABT-199) Induced Autophagy to Overcome Acquired Resistance in Acute Myeloid Leukemia

Apoptotic Blocks in Primary Non-Hodgkin B-Cell Lymphomas Identified By BH3 Profiling

Fatal Dysfunction and Fragmentation of Thrombin-Stimulated Platelets

Mitochondrial Uncoupling Prevents Procoagulant Platelet Formation Resulting in Decreased Thrombus Stability

Combination of Momelotinib and Citarinostat Show Strong Synergistic Effect in Lymphoid Cell Lines Co-Targeting JAK2/STAT3 and HDAC6

Inhibition of WIP1 Phosphatase in Multiple Myeloma Overcomes Bortezomib Resistance and Promotes Cell Death Via ER Stress-Induced Apoptotic JNK/c-Jun Signaling and Downregulation of Inhibitors of Apoptosis Proteins (IAPs)

The Pharmacological Blockade of Phosphodiesterase IV Potentiates the Anti-Tumor Effects of Arsenic Trioxide (ATO) in Acute Myelogenous Leukemia Cells through Multiple Signaling Pathways

Understanding Apoptotic Blocks in "Double Hit" and Other Non-Hodgkin Lymphomas By BH3 Profiling

Abbv-621 Is a Novel and Potent TRAIL Receptor Agonist Fusion Protein That Induces Apoptosis Alone and in Combination with Navitoclax and Venetoclax in Hematological Tumors

Preclinical Evaluation of the First in Class BMI1 Inhibitor PTC-028 Confirms Potent Efficacy to Target BMI1-Addiction in Multiple Myeloma

Maternal Embryonic Leucine Zipper Kinase (MELK) Drives a High-Risk Gene Network and Represents an Attractive Novel Drug Target in Multiple Myeloma

Synergistic Anti-Tumor Efficacy of BET Inhibitors JQ1 and Otx-015 in Combination with Dasatinib in Preclinical Models of T-Cell Lymphomas

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American Society of Hematology

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American Society of Hematology

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