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Journal Articles

Evaluation of Minnelide As a Potential Therapeutic Agent for Preventing the Relapse of AML

Pooja Roy, MBBS, Bhuwan Giri, MD, Vanessa Tonin Garrido, PhD, Dujon Brandon Edwards, Justin M. Watts, MD, Sulagna Banerjee, PhD, Vikas Dudeja, PhD, Sundaram Ramakrishnan, PhD, Ashok Saluja, PhD

Blood (2019) 134 (Supplement_1): 5159.

https://doi.org/10.1182/blood-2019-123567

Published: 2019

Journal Articles

The Immunomodulatory Effect of Triptolide on Mesenchymal Stem Cells in Vitro

Haiping He, MD PhD, Atsuko Takahashi, MT., Yuki Yamamoto, MT, Akiko Hori, Yuta Miharu, MT, Kazuaki Yokoyama, MD PhD, Miwako Narita, MD PhD, Fumitaka Nagamura, MD PhD, Arinobu Tojo, MD PhD, Tonghua Yang, MD PhD, Tokiko Nagamura-Inoue, MD PhD

Blood (2019) 134 (Supplement_1): 5011.

https://doi.org/10.1182/blood-2019-125046

Published: 2019

Journal Articles

Foxo 3a Signaling Mediates Apoptosis in Lymphoma Cells By the Diterpenoid Lactone Andrographolide (Andro), the Active Component of Andrographis Paniculata

Shuo Yang, Bo Ding, Fei Ying, Jana Svetlichnaya, Austin Tom, Sheila Prachand, Yanzhuang Wang, Leo I Gordon, MD FACP

Blood (2015) 126 (23): 2760.

https://doi.org/10.1182/blood.V126.23.2760.2760

Published: 2015

Journal Articles

Cotylenin Α, a Fusicoccane Diterpene Glycoside with a Complex Sugar Moiety, and Vincristine Synergistically Inhibit the Growth of Myeloma Cell in Vitro and in Vivo

Tsutomu Takahashi, MD PhD, Yoshio Honma, PhD, Koshi Kawakami, MDPhD, Junji Suzumiya

Blood (2014) 124 (21): 5721.

https://doi.org/10.1182/blood.V124.21.5721.5721

Published: 2014

Journal Articles

Molecular Mechanisms Underlying the Synergism of Erib and Hht in Treating t(8;21) AML with C-KIT mutations

Bing Chen, MD, PhD, Xin-Jie Chen, Sai-Juan Chen, MD, PhD

Blood (2014) 124 (21): 2332.

https://doi.org/10.1182/blood.V124.21.2332.2332

Published: 2014

Journal Articles

Low-dose Triptolide could enhance the Idarubicin-induced apoptosis in KG1α cells through down-regulation of MDR1 and NF-κb

Bing Xu, MD, Jiahong Tang, MD, Feili Chen, M.D., Yanyan Li, MD, Huijuan Dong, MD, Yuejian Liu, M.D., Shuyun Zhou, MD, PhD

Blood (2013) 122 (21): 4922.

https://doi.org/10.1182/blood.V122.21.4922.4922

Published: 2013

Journal Articles

Oridonin Upregulates All- Trans Retinoic Acid Receptor Alpha and Induces Differentiation Of NB4 Cells Though NF-Kb Pathway

Hua Yan, Yang Cao, Wei Wei, Nan Zhang, Ying-Li Wu, Guo-Qiang Chen, Sr., PhD

Blood (2013) 122 (21): 2909.

https://doi.org/10.1182/blood.V122.21.2909.2909

Published: 2013

Journal Articles

Cflar Genetic Variant Resulting In Alternate Splicing Determines Isoform Specific Production Of H -Cflar Protein and Is Predictive Of Cellular Cytoxicity Of Triptolide In Hapmap Lymphoblast and AML Cell Lines

Lata Chauhan, PhD, Brooke Fridley, Feldberg Tanya, Taraswi Mitra Ghosh, Neha Bhise, Jatinder Lamba, PhD

Blood (2013) 122 (21): 1287.

https://doi.org/10.1182/blood.V122.21.1287.1287

Published: 2013

Journal Articles

Low-dose Triptolide in combination with Idarubicin could induce apoptosis in leukemia stem and progenitor cells via affecting the intrinsic and extrinsic factors

Bing Xu, MD, Yuejian Liu, M.D., Feili Chen, M.D., Rongwei Li, MD, Shiyun Wang, M.D., Huijuan Dong, MD, Weiguang Wang, M.D. PhD

Blood (2013) 122 (21): 5410.

https://doi.org/10.1182/blood.V122.21.5410.5410

Published: 2013

Journal Articles

The Diterpenoid Lactone Andrographolide Induces Reactive Oxygen Species (ROS) Dependent Apoptosis in ATRA Sensitive and Resistant APL Cell Lines.

Shuo Yang, PhD, Jessica K. Altman, MD, Sheila Prachand, MS, Austin Tom, BS, Bo Ding, BS, Brent Wu, Leonidas C. Platanias, MD, PhD, Leo I. Gordon, MD

Blood (2012) 120 (21): 2446.

https://doi.org/10.1182/blood.V120.21.2446.2446

Published: 2012

Journal Articles

MAPK Expression Profile in AML cells ex Vivo changes with Differentiation Induced by 1,25-Dihydroxyvitamin D3 and Its Analogs PRI-1906 and PRI-2191

Xiangwen Chen-Deutsch, Ph.D., George P. Studzinski, M.D., Ph.D., Jonathan Harrison, MD

Blood (2011) 118 (21): 5009.

https://doi.org/10.1182/blood.V118.21.5009.5009

Published: 2011

Journal Articles

Preclinical Development of Triptolide Derivative MRx102 as a Therapeutic Agent for Acute Myeloid Leukemia

John M. Fidler, Ph.D., Jinhua An, Ph.D., John H. Musser, Ph.D., Duncan H. Mak, M.S., Bing Carter, Ph.D., Michael Andreeff, MD, PhD

Blood (2010) 116 (21): 3271.

https://doi.org/10.1182/blood.V116.21.3271.3271

Published: 2010

Journal Articles

Oridonin, An Ent-Kaurane Diterpenoid, Shows Antileukemic Effect and Enhances the Effect of Indarubicin on Human T-Cell Leukemia Cell Line

Kangni Wu, Yanmin Zhao, Haowen Xiao, Lifei Zhang, Lizhen Liu, Yingjia Wang, Xiaohong Yu, He Huang, MD, PhD

Blood (2010) 116 (21): 4933.

https://doi.org/10.1182/blood.V116.21.4933.4933

Published: 2010

Journal Articles

Triptolide Exerts a Cytotoxic Effect on Human Acute Myeloid Leukemia Cell Lines

Jennifer M.H. McCormack, MD, Tanya Feldberg, Jatinder Lamba, PhD

Blood (2010) 116 (21): 4352.

https://doi.org/10.1182/blood.V116.21.4352.4352

Published: 2010

Journal Articles

Mitochondrial-Mediated Apoptosis in Lymphoma by the Diterpenoid Lactone Andrographolide (Andro), the Active Component of Andrographolis Paniculata.

Shuo Yang, PhD, Andrew M Evens, DO, MSc, Savita Bhalla, PhD, Sheila Prachand, M.S., Amareshwar Singh, PhD, Leo I. Gordon, MD

Blood (2009) 114 (22): 2710.

https://doi.org/10.1182/blood.V114.22.2710.2710

Published: 2009

Journal Articles

Identification of crassin acetate as a new immunosuppressant triggering heme oxygenase-1 expression in dendritic cells

Hironori Matsushima, Hiroaki Tanaka, Norikatsu Mizumoto, Akira Takashima

Blood (2009) 114 (1): 64–73.

https://doi.org/10.1182/blood-2009-02-204297

Published: 2009

Includes: Supplemental data

Journal Articles

Pharicin a, a Novel Natural Compound That Induces Mitotic Arrest and Catastrophe of Cancer Cells by Perturbing Microtubule Dynamics and the Spindle Checkpoint

Guo-Qiang Chen, Wei Dai, Han-Zhang Xu, Dao Li

Blood (2008) 112 (11): 4723.

https://doi.org/10.1182/blood.V112.11.4723.4723

Published: 2008

Journal Articles

Pharicin B, a Novel Diterpenoid, Stabilizes Retinoic Acid Receptor-α Protein and Induces Differentiation of AML Cells in the Presence of Physiological Doses of ATRA.

Guo-Qiang Chen, Zhi-Min Gu, Mei-Yi Zhou, Ying-Li Wu, Ying Huang

Blood (2008) 112 (11): 1601.

https://doi.org/10.1182/blood.V112.11.1601.1601

Published: 2008

Journal Articles

Adenanthin Upregulates c/ebp β Expression with Induction of Differentiation of the ATRA-Sensitive and -Resistant leukemic Cells.

Ying-Li Wu, Chuan-Xu Liu, Guo-Qiang Chen

Blood (2008) 112 (11): 1602.

https://doi.org/10.1182/blood.V112.11.1602.1602

Published: 2008

Journal Articles

The Diterpenoid Lactone Andrographolide (ANDRO) Stimulates Autophagy and Induces Reactive Oxygen Species (ROS)-Dependent Apoptosis in Lymphoma Cell Lines

Shuo Yang, PhD, Andrew M. Evens, DO, MS, Sheila Prachand, MS, Leo I. Gordon, MD

Blood (2008) 112 (11): 4991.

https://doi.org/10.1182/blood.V112.11.4991.4991

Published: 2008

NARROW

Evaluation of Minnelide As a Potential Therapeutic Agent for Preventing the Relapse of AML

The Immunomodulatory Effect of Triptolide on Mesenchymal Stem Cells in Vitro

Foxo 3a Signaling Mediates Apoptosis in Lymphoma Cells By the Diterpenoid Lactone Andrographolide (Andro), the Active Component of Andrographis Paniculata

Cotylenin Α, a Fusicoccane Diterpene Glycoside with a Complex Sugar Moiety, and Vincristine Synergistically Inhibit the Growth of Myeloma Cell in Vitro and in Vivo

Molecular Mechanisms Underlying the Synergism of Erib and Hht in Treating t(8;21) AML with C-KIT mutations

Low-dose Triptolide could enhance the Idarubicin-induced apoptosis in KG1α cells through down-regulation of MDR1 and NF-κb

Oridonin Upregulates All- Trans Retinoic Acid Receptor Alpha and Induces Differentiation Of NB4 Cells Though NF-Kb Pathway

Cflar Genetic Variant Resulting In Alternate Splicing Determines Isoform Specific Production Of H -Cflar Protein and Is Predictive Of Cellular Cytoxicity Of Triptolide In Hapmap Lymphoblast and AML Cell Lines

Low-dose Triptolide in combination with Idarubicin could induce apoptosis in leukemia stem and progenitor cells via affecting the intrinsic and extrinsic factors

The Diterpenoid Lactone Andrographolide Induces Reactive Oxygen Species (ROS) Dependent Apoptosis in ATRA Sensitive and Resistant APL Cell Lines.

MAPK Expression Profile in AML cells ex Vivo changes with Differentiation Induced by 1,25-Dihydroxyvitamin D3 and Its Analogs PRI-1906 and PRI-2191

Preclinical Development of Triptolide Derivative MRx102 as a Therapeutic Agent for Acute Myeloid Leukemia

Oridonin, An Ent-Kaurane Diterpenoid, Shows Antileukemic Effect and Enhances the Effect of Indarubicin on Human T-Cell Leukemia Cell Line

Triptolide Exerts a Cytotoxic Effect on Human Acute Myeloid Leukemia Cell Lines

Mitochondrial-Mediated Apoptosis in Lymphoma by the Diterpenoid Lactone Andrographolide (Andro), the Active Component of Andrographolis Paniculata.

Identification of crassin acetate as a new immunosuppressant triggering heme oxygenase-1 expression in dendritic cells

Pharicin a, a Novel Natural Compound That Induces Mitotic Arrest and Catastrophe of Cancer Cells by Perturbing Microtubule Dynamics and the Spindle Checkpoint

Pharicin B, a Novel Diterpenoid, Stabilizes Retinoic Acid Receptor-α Protein and Induces Differentiation of AML Cells in the Presence of Physiological Doses of ATRA.

Adenanthin Upregulates c/ebp β Expression with Induction of Differentiation of the ATRA-Sensitive and -Resistant leukemic Cells.

The Diterpenoid Lactone Andrographolide (ANDRO) Stimulates Autophagy and Induces Reactive Oxygen Species (ROS)-Dependent Apoptosis in Lymphoma Cell Lines

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American Society of Hematology

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ASH Publications

American Society of Hematology

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