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Journal Articles

Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms

Vasundhara Sharma, PhD, Lanzhu Yue, MD, Nathan P. Horvat, MDCandidate, Agni Christodoulidou, PhD, Afua Adutwumwa Akuffo, PhDCandidate, Mathew Beatty, PhD, Cem Murdun, MS, Julia Billington, PhDCandidate, William E Goodheart, MS, PhDCandidate, Eva Sahakian, PhD, Ling Zhang, MD, John J. Powers, BS, Narmin E. Amin, Que T. Lambert-Showers, Lancia Darville, PhD, Javier Pinilla Ibarz, MD PhD, Gary W. Reuther, Jennifer Lee, PhD, Xiaozhang Zheng, PhD, Pui Yee Ng, PhD, Mathew W. Martin, PhD, Gary C. Marshall, PhD, John M. Koomen, PhD, Ross L. Levine, MD, Amit Verma, MBBS, H. Leighton Grimes, PhD, Eduardo Sotomayor, MD, Zonghong Shao, MD, Kenneth Wright, PhD, Pearlie K. Epling-Burnette
Journal: Blood
Blood (2019) 134 (Supplement_1): 474.
https://doi.org/10.1182/blood-2019-127235
Published: 2019
Journal Articles

Development of Exosome-Capturing Antibody-Conjugated Nucleic Acid Medicines Targeting Multiple Myeloma Cells

Emi Soma, Yuki Toda, PhD, Shigekuni Hosogi, MD PhD, Asako Yamayoshi, PhD, Eishi Ashihara, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3365.
https://doi.org/10.1182/blood-2019-121995
Published: 2019
Journal Articles

Inhibitory Effect of a Novel DNA Aptamer with Artificial Nucleic Bases for Von Willebrand Factor A1 Domain on Platelet Thrombosis Formation

Kazuya Sakai, MD, Hideo Yagi, MD, Masaki Hayakawa, MD, Tatsuhiko Someya, PhD, Kaori Harada, PhD, Masanori Matsumoto, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2522.
https://doi.org/10.1182/blood-2018-99-113948
Published: 2018
Journal Articles

Recurrent Mutations in EGR2 Direct Specific Epigenetic Reconfiguration in Chronic Lymphocytic Leukemia

Christoph Weigel, PhD, Yassen Assenov, Charles Imbusch, Qi Wang, Renée Beekman, Brian Giacopelli, BS, Yue-zhong Wu, MSc, David Brocks, Weichenhan Dieter, Popanda Odilia, Peter Schmezer, Benedikt Brors, Daniel Mertens, Karsten Rippe, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD, Jennifer A. Woyach, MD, James S. Blachly, MD, Elias Campo, Thorsten Zenz, MD, John C. Byrd, MD, José I. Martin-Subero, PhD, Christoph Plass, Christopher C. Oakes
Journal: Blood
Blood (2018) 132 (Supplement 1): 650.
https://doi.org/10.1182/blood-2018-99-119070
Published: 2018
Journal Articles

RAB31-Mediated Endosomal Trafficking Is Defective in RUNX1 Haplodeficiency

Gauthami S. Jalagadugula, PhD, Guangfen Mao, MD, Lawrence E. Goldfinger, PhD, Jeremy Wurtzel, MS, Michele P. Lambert, MD, Angara Koneti Rao, MBBS
Journal: Blood
Blood (2018) 132 (Supplement 1): 519.
https://doi.org/10.1182/blood-2018-99-118312
Published: 2018
Journal Articles

Small-Molecule Targeting of Musashi RNA-Binding Activity in Acute Myeloid Leukemia

Gerard Minuesa Dinares, PhD, Steven K. Albanese, BS, Arthur Chow, BA, Alexandra Schurer, BS, Sun Mi Park, PhD, Christina Z. Rotsides, PhD, James Taggart, BS, Andrea Rizzi, BS, Levi N. Naden, PhD, Timothy Chou, BS, Saroj Gourkanti, BA, Daniel Cappel, PhD, Maria C. Passarelli, BS, Lauren Fairchild, PhD, Carolina Adura, PhD, Joseph Fraser Glickman, MSPH, PhD, Jessica Schulman, Christopher Famulare, MS, Minal Patel, BA, Joseph K. Eibl, PhD, Gregory M. Ross, PhD, Derek Tan, PhD, Christina Leslie, PhD, Thijs Beuming, PhD, Yehuda Goldgur, PhD, John D. Chodera, PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 428.
https://doi.org/10.1182/blood-2018-99-118745
Published: 2018
Journal Articles

Kinetic Catalytic Inhibition and Cell-Based Analysis, Not Just Target Binding, Are Required to Assess Kinase Selectivity of Covalent Inhibitors: Comparable BTK vs TEC Selectivity Profile for Ibrutinib and Acalabrutinib

Melissa Hopper, MS, Tarikere Gururaja, PhD, Taisei Kinoshita, PhD, James P. Dean, Ronald Hill, PhD, Ann Mongan, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3498.
https://doi.org/10.1182/blood-2018-99-110849
Published: 2018
Journal Articles

Disruption of a GATA1-binding motif upstream of XG / PBDX abolishes Xg a expression and resolves the Xg blood group system

Brief Report
Mattias Möller, Yan Quan Lee, Karina Vidovic, Sven Kjellström, Linda Björkman, Jill R. Storry, Martin L. Olsson
Journal: Blood
Blood (2018) 132 (3): 334–338.
https://doi.org/10.1182/blood-2018-03-842542
Published: 2018
Includes: Supplemental data
Journal Articles

Defective Rab1b Related Megakaryocytic ER-to-Golgi Transport in RUNX1 Haplodeficiency

Gauthami S. Jalagadugula, PhD, Lawrence E. Goldfinger, PhD, Guangfen Mao, MD, Angara Koneti Rao, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2333.
https://doi.org/10.1182/blood.V130.Suppl_1.2333.2333
Published: 2017
Journal Articles

Targeted Inhibition of STAT/TET1 Axis As a Potent Therapeutic Strategy for Acute Myeloid Leukemia

Xi Jiang, PhD, Chao Hu, Kyle Ferchen, Ji Nie, Xiaolong Cui, Chih-Hong Chen, PhD, Liting Cheng, Zhixiang Zuo, PhD, William Seibel, PhD, Chunjiang He, PhD, Yixuan Tang, Jennifer R Skibbe, Mark Wunderlich, MS, William C Reinhold, Lei Dong, PhD, Chao Shen, PhD, Stephen Arnovitz, Bryan Ulrich, Jiuwei Lu, PhD, Hengyou Weng, PhD, Rui Su, PhD, Huilin Huang, PhD, Yungui Wang, PhD, Chenying Li, MD, Xi Qin, James C. Mulloy, PhD, Yi Zheng, PhD, Jiajie Diao, PhD, Jie Jin, Chong Li, PhD, Paul P Liu, MD, Chuan He, PhD, Yuan Chen, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 857.
https://doi.org/10.1182/blood.V130.Suppl_1.857.857
Published: 2017
Journal Articles

A Protective Role of DNA Repair Genes Against Acute Graft Versus Host Disease in Children

Patricia Huezo-Diaz, Chakradhara RS Uppugunduri, PhD, Mohamed Aziz Rezgui, MsC, Anuj Tyagi, PhD, Vid Mlakar, PhD, Laurence Lesne, MSc, Tiago Nava, MD, Yves Theoret, PhD, Yves Chalandon, MD PhD, Robbert Bredius, PhD MD, Jean-Hugues Dalle, MD PhD, Peter Bader, MD PhD, Christina Peters, MD, Henrique Bittencourt, MD PhD, Maja Krajinovic, MD PhD, Marc Ansari, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 749.
https://doi.org/10.1182/blood.V130.Suppl_1.749.749
Published: 2017
Journal Articles

Histone Deacetylase Inhibitors Abolish HBZ Protein Expression and Induce Cell Death in HTLV-1 Related Adult T-Cell Leukemia-Lymphoma

Ngoc L Toomey, BS, Juan Carlos Ramos, MD BS
Journal: Blood
Blood (2017) 130 (Supplement 1): 4012.
https://doi.org/10.1182/blood.V130.Suppl_1.4012.4012
Published: 2017
Journal Articles

Extracellular Protein Disulfide Isomerase Regulates Vitronectin during the Initiation of Thrombus Formation

Chao Fang, PhD, Sheryl R. Bowley, PhD, Barbara C. Furie, PhD, Bruce Furie, MD
Journal: Blood
Blood (2016) 128 (22): 15.
https://doi.org/10.1182/blood.V128.22.15.15
Published: 2016
Journal Articles

PCTP (Phosphatidylcholine Transfer Protein) is Regulated By RUNX1 in Platelets/Megakaryocytes and is Associated with Adverse Cardiovascular Events

Natthapol Songdej, MD MPH, Guangfen Mao, MD, Deepak Voora, MD, Lawrence E. Goldfinger, PhD, Fabiola Del Carpio-Cano, Rachel Myers, Angara Koneti Rao, MBBS
Journal: Blood
Blood (2016) 128 (22): 365.
https://doi.org/10.1182/blood.V128.22.365.365
Published: 2016
Journal Articles

Nucleolin Controls Ribosome Biogenesis through Its RNA-Binding Properties

Julia Fremerey, PhD, Pavel Morozov, PhD, Cindy Meyer, PhD, Aitor Garzia, PhD, Marianna Teplova, PhD, Thomas Tuschl, PhD, Arndt Borkhardt, MD
Journal: Blood
Blood (2016) 128 (22): 5056.
https://doi.org/10.1182/blood.V128.22.5056.5056
Published: 2016
Journal Articles

Functional rs4693608 SNP is Located into Strong Hpse Gene Intron Enhancer and Thereby Influences to the Ability of Nuclear Proteins Binding and Activity of This Enhancer in Broad Number of Hematological Cell Lines and ALL/AML Primary Samples

Olga Ostrovsky, PhD, Ania Hava Grushchenko Polaq, Katia Beider, PhD, Rita Mayorov, Avichai Shimoni, MD, Israel Vlodavsky, PhD, Arnon Nagler
Journal: Blood
Blood (2016) 128 (22): 3934.
https://doi.org/10.1182/blood.V128.22.3934.3934
Published: 2016
Journal Articles

Allele-specific DNA methylation reinforces PEAR1 enhancer activity

Benedetta Izzi, Mariaelena Pistoni, Katrien Cludts, Pinar Akkor, Diether Lambrechts, Catherine Verfaillie, Peter Verhamme, Kathleen Freson, Marc F. Hoylaerts
Journal: Blood
Blood (2016) 128 (7): 1003–1012.
https://doi.org/10.1182/blood-2015-11-682153
Published: 2016
Includes: Supplemental data
Journal Articles

BRAF V600E Induces ABCB1/P-Glycoprotein Expression and Drug Resistance in B-Cells Via AP-1 Activation

Yo-Ting Tsai, MS, Gerard Lozanski, MD, Amy M. Lehman, MAS, Ellen Sass, Erin K. Hertlein, PhD, Santosh Salunke, Ching-Shih Chen, PhD, Michael R. Grever, MD, John C. Byrd, MD, David M. Lucas, PhD
Journal: Blood
Blood (2015) 126 (23): 2477.
https://doi.org/10.1182/blood.V126.23.2477.2477
Published: 2015
Journal Articles

Acute Monocytic Leukemia Associated Antigen MLAA-34 up-Regulates JAK2/STAT3 Expression and JAK2/STAT3 Enhances MLAA-34 Activation in a Positive Feedback Loop

Bo Lei, Ju Bai, Wanggang Zhang, Aili He, Yinxia Chen, Pengyu Zhang, Lu Qian, Fuling Zhou
Journal: Blood
Blood (2015) 126 (23): 1393.
https://doi.org/10.1182/blood.V126.23.1393.1393
Published: 2015
Journal Articles

Transcription Factor RUNX1 Regulates Pctp (Phosphatidylcholine Transfer Protein) in Platelets: A Potential Role in Regulating Platelet Function

Natthapol Songdej, MD MPH, Guangfen Mao, MD, Lawrence E. Goldfinger, PhD, Angara Koneti Rao, MD
Journal: Blood
Blood (2015) 126 (23): 2247.
https://doi.org/10.1182/blood.V126.23.2247.2247
Published: 2015