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Journal Articles

Molecular Interaction Site on Procoagulant Skeletal Muscle Myosin for Factor Xa-Dependent Prothrombin Activation

Hiroshi Deguchi, MD PhD, Zihan Guo, Mohammed Hayat, Elsa Pflimlin, Weijun Shen, John H. Griffin, PhD

Blood (2019) 134 (Supplement_1): 3622.

https://doi.org/10.1182/blood-2019-129161

Published: 2019

Journal Articles

Cardiac Myosin Acts Is a Potent Procoagulant in Vitro and In Vivo

Jevgenia Zilberman-Rudenko, Hiroshi Deguchi, MD PhD, Mohammed Hayat, Meenal Shukla, PhD, Jennifer Nagrampa Orje, Zihan Guo, Tine Wyseure, PhD, Laurent O Mosnier, Owen J T McCarty, PhD, Zaverio M. Ruggeri, MD, John H. Griffin, PhD

Blood (2019) 134 (Supplement_1): 3632.

https://doi.org/10.1182/blood-2019-129312

Published: 2019

Journal Articles

Regulation of Coagulation by Polyphosphate

Nicola J. Mutch, BSc, PhD

Blood (2019) 134 (Supplement_1): SCI-18.

https://doi.org/10.1182/blood-2019-121062

Published: 2019

Journal Articles

Super factor Va, an Engineered Factor V Molecule, Effectively Reduces Bleeding and Acute Coagulopathy in Mouse Models of Trauma and Shock

Bilgimol Chumappumkal Joseph, PhD, Laurent O Mosnier, Annette von Drygalski, MD PharmD

Blood (2019) 134 (Supplement_1): 1101.

https://doi.org/10.1182/blood-2019-124433

Published: 2019

Journal Articles

BFPI: A Minimal Prothrombinase Inhibitor from the Saliva of Simulium Vittatum

Jeremy P. Wood, PhD, Xiao H. Song, Alan E. Mast, MDPhD

Blood (2018) 132 (Supplement 1): 1163.

https://doi.org/10.1182/blood-2018-99-118666

Published: 2018

Journal Articles

Prothrombinase Inhibition By Tfpiα Requires Three Distinct Interactions with Factors Va and X

Jeremy P. Wood, PhD, Alan E. Mast, MDPhD

Blood (2017) 130 (Supplement 1): 1060.

https://doi.org/10.1182/blood.V130.Suppl_1.1060.1060

Published: 2017

Journal Articles

A Single Cleavage Reaction in the Proteolytic Activation of Factor V to the Cofactor Is Rate-Limiting in a Step That Is Selectively Dependent on Anion Binding Exosite 2 of Thrombin

Harlan N Bradford, BA, Sriram Krishnaswamy, PhD

Blood (2017) 130 (Supplement 1): 3649.

https://doi.org/10.1182/blood.V130.Suppl_1.3649.3649

Published: 2017

Journal Articles

Targeting Factor Xa Expression in Platelets As a Potential Gene Therapy Strategy for Hemophilia with Inhibitors

Dawei Wang, Xiaohu Shao, Guowei Zhang, PhD, Shuxian Yao, Xielai Zhou, Jianhua Mao, PhD, Zhugang Wang, Zhu Chen, Saijuan Chen

Blood (2016) 128 (22): 1171.

https://doi.org/10.1182/blood.V128.22.1171.1171

Published: 2016

Journal Articles

Escalating Single Doses of PF-05230907 (Recombinant Factor Xa Variant FXa I16L ) Are Safe and Demonstrate Hemostatic Pharmacology in Healthy Volunteers

Steven Arkin, MD, Fei Hua, PhD, Constantino Kantaridis, MD, Gang Li, PhD, Dana Parsons-Rich, MPH, MPA, Debra D Pittman

Blood (2016) 128 (22): 3781.

https://doi.org/10.1182/blood.V128.22.3781.3781

Published: 2016

Journal Articles

Rivaroxaban Prophylaxis in Severe Congenital Protein C Deficiency

Gabriel Salinas Cisneros, MD, Ziad Khatib, MD

Blood (2016) 128 (22): 4945.

https://doi.org/10.1182/blood.V128.22.4945.4945

Published: 2016

Journal Articles

Structural Basis for the Procofactor to Cofactor Transition in Human Factor V

Shekhar Kumar, PhD, Wei Deng, PhD, Steven Stayrook, PhD, Renhao Li, PhD, Rodney M. Camire, PhD, Sriram Krishnaswamy, PhD

Blood (2016) 128 (22): 253.

https://doi.org/10.1182/blood.V128.22.253.253

Published: 2016

Journal Articles

PDI Inhibition Blocks Thrombin Generation in Humans By Interfering with Platelet Factor V Activation

Jack D Stopa, PhD, Donna S. Neuberg, ScD, Maneka Puligandla, MS, Bruce Furie, MD, Robert C. Flaumenhaft, MD PhD, Jeffrey I. Zwicker, MD

Blood (2016) 128 (22): 2628.

https://doi.org/10.1182/blood.V128.22.2628.2628

Published: 2016

Journal Articles

Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va

Hiroshi Deguchi, Ranjeet K. Sinha, Patrizia Marchese, Zaverio M. Ruggeri, Jevgenia Zilberman-Rudenko, Owen J. T. McCarty, Mitchell J. Cohen, John H. Griffin

Blood (2016) 128 (14): 1870–1878.

https://doi.org/10.1182/blood-2016-03-707679

Published: 2016

Includes: Supplemental data

Journal Articles

Engineered Factor Xa Variants Retain Procoagulant Activity Independent of Direct Factor Xa-Inhibitors

Daniël Verhoef, Mark Schreuder, Ka Lei Cheung, Pieter H. Reitsma, Mettine H.A. Bos, PhD

Blood (2015) 126 (23): 126.

https://doi.org/10.1182/blood.V126.23.126.126

Published: 2015

Journal Articles

The X-Ray Structure of a Variant of Human Factor V Provides Structural Insights into the Procofactor Activation Paradox

Shekhar Kumar, PhD, Steven Stayrook, PhD, Rodney M. Camire, PhD, Sriram Krishnaswamy, PhD

Blood (2015) 126 (23): 121.

https://doi.org/10.1182/blood.V126.23.121.121

Published: 2015

Journal Articles

Assembly of Prothrombinase on Endothelial Cells: Receptor-Mediated or Phospholipid-Driven?

Mikhail Galkin, PhD, Harlan Bradford, BA, Sriram Krishnaswamy, PhD

Blood (2015) 126 (23): 2267.

https://doi.org/10.1182/blood.V126.23.2267.2267

Published: 2015

Journal Articles

A Quantitative Systems Pharmacology Model for the Coagulation Network Describes Biomarker Changes Observed in a Clinical Study with FXa Variant and Predicts Age-Associated Biomarker Variations

Satyaprakash Nayak, PhD, Dooyoung Lee, PhD, Steven Arkin, MD, Steven W. Martin, PhD, Anne C. Heatherington, PhD, William S. Denney, PhD, Paolo Vicini, PhD, Fei Hua, PhD

Blood (2015) 126 (23): 3502.

https://doi.org/10.1182/blood.V126.23.3502.3502

Published: 2015

Journal Articles

TFPIα Has Reduced Ability to Inhibit FV Leiden

Jeremy P. Wood, PhD, Lisa Baumann Kreuziger, MD, Rodney M. Camire, PhD, Alan E. Mast, MD PhD

Blood (2015) 126 (23): 423.

https://doi.org/10.1182/blood.V126.23.423.423

Published: 2015

Journal Articles

Exome Genotyping Links Venous Thrombosis Risk with the Skeletal Muscle Myosin Gene Cluster and Leads to Discovery of New Family of Procoagulant Factors

Hiroshi Deguchi, MD PhD, Ranjeet Kumar Sinha, PhD MSc, Darlene J. Elias, MD, John H. Griffin, PhD

Blood (2015) 126 (23): 763.

https://doi.org/10.1182/blood.V126.23.763.763

Published: 2015

Journal Articles

Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data

Hiroshi Deguchi, Yajnavalka Banerjee, Sunia Trauger, Gary Siuzdak, Ewa Kalisiak, José A. Fernández, Linh Hoang, Minerva Tran, Subramanian Yegneswaran, Darlene J. Elias, John H. Griffin

Blood (2015) 126 (13): 1595–1600.

https://doi.org/10.1182/blood-2015-03-636761

Published: 2015

Includes: Supplemental data

NARROW

Molecular Interaction Site on Procoagulant Skeletal Muscle Myosin for Factor Xa-Dependent Prothrombin Activation

Cardiac Myosin Acts Is a Potent Procoagulant in Vitro and In Vivo

Regulation of Coagulation by Polyphosphate

Super factor Va, an Engineered Factor V Molecule, Effectively Reduces Bleeding and Acute Coagulopathy in Mouse Models of Trauma and Shock

BFPI: A Minimal Prothrombinase Inhibitor from the Saliva of Simulium Vittatum

Prothrombinase Inhibition By Tfpiα Requires Three Distinct Interactions with Factors Va and X

A Single Cleavage Reaction in the Proteolytic Activation of Factor V to the Cofactor Is Rate-Limiting in a Step That Is Selectively Dependent on Anion Binding Exosite 2 of Thrombin

Targeting Factor Xa Expression in Platelets As a Potential Gene Therapy Strategy for Hemophilia with Inhibitors

Escalating Single Doses of PF-05230907 (Recombinant Factor Xa Variant FXa I16L ) Are Safe and Demonstrate Hemostatic Pharmacology in Healthy Volunteers

Rivaroxaban Prophylaxis in Severe Congenital Protein C Deficiency

Structural Basis for the Procofactor to Cofactor Transition in Human Factor V

PDI Inhibition Blocks Thrombin Generation in Humans By Interfering with Platelet Factor V Activation

Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va

Engineered Factor Xa Variants Retain Procoagulant Activity Independent of Direct Factor Xa-Inhibitors

The X-Ray Structure of a Variant of Human Factor V Provides Structural Insights into the Procofactor Activation Paradox

Assembly of Prothrombinase on Endothelial Cells: Receptor-Mediated or Phospholipid-Driven?

A Quantitative Systems Pharmacology Model for the Coagulation Network Describes Biomarker Changes Observed in a Clinical Study with FXa Variant and Predicts Age-Associated Biomarker Variations

TFPIα Has Reduced Ability to Inhibit FV Leiden

Exome Genotyping Links Venous Thrombosis Risk with the Skeletal Muscle Myosin Gene Cluster and Leads to Discovery of New Family of Procoagulant Factors

Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data

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American Society of Hematology

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ASH Publications

American Society of Hematology

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