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Journal Articles

The Safety of Novel Drugs Targeting Factor XI and XII in Human Clinical Trials:a Systematic Review

Gillian E Mair, Sven Reid Olson, MD, Joseph J Shatzel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4966.
https://doi.org/10.1182/blood-2019-130823
Published: 2019
Journal Articles

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

Harry Roger Buller, MD PhD, Claudette Bethune, PhD, Sanjay Bhanot, MDPhD, David Gailani, MD, Brett P. Monia, PhD, Gary E. Raskob, PhD, Annelise Segers, Peter Verhamme, MD PhD, Jeffrey I. Weitz, MDFRCPC
Journal: Blood
Blood (2014) 124 (21): LBA-1.
https://doi.org/10.1182/blood.V124.21.LBA-1.LBA-1
Published: 2014
Journal Articles

Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys

Husam S. Younis, Jeff Crosby, Jung-Im Huh, Hong Soo Lee, Soyub Rime, Brett Monia, Scott P. Henry
Journal: Blood
Blood (2012) 119 (10): 2401–2408.
https://doi.org/10.1182/blood-2011-10-387134
Published: 2012
Journal Articles

Thrombin Supports Colitis and Colitis-Associated Cancer Pathogenesis

Brian K. Turpin, DO, Whitney M Miller, Eric S. Mullins, MD, Jay L. Degen, PhD, Matthew J. Flick, PhD, Brett P. Monia, PhD, Robert MacLeod, Ph.D., Alexey S Revenko, PhD, Joseph S. Palumbo, MD
Journal: Blood
Blood (2011) 118 (21): 2237.
https://doi.org/10.1182/blood.V118.21.2237.2237
Published: 2011
Journal Articles

Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk

Hong Zhang, Ester C. Löwenberg, Jeffrey R. Crosby, A. Robert MacLeod, Chenguang Zhao, Dacao Gao, Chris Black, Alexey S. Revenko, Joost C. M. Meijers, Erik S. Stroes, Marcel Levi, Brett P. Monia
Journal: Blood
Blood (2010) 116 (22): 4684–4692.
https://doi.org/10.1182/blood-2010-04-277798
Published: 2010
Includes: Multimedia, Supplemental data
Journal Articles

Combination of FXI Antisense Oligonucleotide and Plavix® Treatment Results in Enhanced Antithrombotic Activity without Increased Risk of Bleeding in Mouse Models of Thrombosis.

Dacao Gao, Jeff Crosby, PhD, Robert MacLeod, PhD, Gourab Bhattacharjee, PhD, Ester C Lowenberg, MD, Marcel Levi, MD, PhD, Prof., Brett P. Monia, PhD
Journal: Blood
Blood (2009) 114 (22): 4173.
https://doi.org/10.1182/blood.V114.22.4173.4173
Published: 2009
Journal Articles

Antithrombotic Effects of a FXI Antisense Oligonucleotide in Mice

Hong Zhang, MD, Chenguang Zhao, Jeff Crosby, Curt Mazur, Susan M. Freier, Andy Watt, Andy Siwkowski, Dacao Gao, Chris Black, Brett P. Monia
Journal: Blood
Blood (2008) 112 (11): 3076.
https://doi.org/10.1182/blood.V112.11.3076.3076
Published: 2008
Journal Articles

Reversibility in Mice of FXI Antisense-Induced Anticoagulation by Administration of FXI Protein Concentrate or a Sense Oligonucleotide.

Chenguang Zhao, Brett P. Monia, PhD, Andy Siwkowski, Jeff Crosby, Hong Zhang
Journal: Blood
Blood (2008) 112 (11): 1904.
https://doi.org/10.1182/blood.V112.11.1904.1904
Published: 2008