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Journal Articles

Interim Analysis of a Phase II Study of the Glutaminase Inhibitor Telaglenastat (CB-839) in Combination with Azacitidine in Advanced Myelodysplastic Syndrome (MDS)

Veronica A Guerra, MD, Jan A. Burger, MD PhD, Gautam M. Borthakur, MD, Elias Jabbour, MD, Naveen Pemmaraju, MD, Tapan M. Kadia, MD, Guillermo Garcia-Manero, MD, Hagop M. Kantarjian, MD, Marina Y Konopleva, MD PhD, Courtney D. DiNardo, MD MSc

Blood (2019) 134 (Supplement_1): 567.

https://doi.org/10.1182/blood-2019-125970

Published: 2019

Journal Articles

Integrated Systems Level Examination of Proteasome Inhibitor Stress Recovery in Myeloma Cells Reveals Druggable Vulnerabilities Linked to Multiple Metabolic Processes

Paula Saavedra-Garcia, PhD, Hibah A Al-Sadah, MSc, Lucy Penfold, PhD, Xiaobei Xiong, MRes, Elena Lopez-Jimenez, PhD, Katarzyna Parzych, PhD, Valentina S Caputo, Kevin Blighe, PhD, Martin F. Kaiser, Paolo Piazza, PhD, Vesela Encheva, PhD, Ambrosius P Snijders, PhD, Hector C Keun, DPhil, Diego Oyarzun, PhD, Denise Thiel, MSc, Zijing Liu, PhD, Mauricio Barahona, PhD, Holger W Auner, MD PhD

Blood (2019) 134 (Supplement_1): 1818.

https://doi.org/10.1182/blood-2019-121549

Published: 2019

Journal Articles

Identify AMPK-Mediated Autophagy and Oxphos As a Novel Metabolic Vulnerability for Targeted Therapy in Mantle Cell Lymphoma

Yixin Yao, PhD, Yang Liu, MD, Hui Zhang, Angela Leeming, Joseph Mitchell McIntosh, Preetesh Jain, MBBS,MDDM,PhD, Liang Zhang, MD PhD, Krystle Nomie, PhD, Michael L. Wang, MD

Blood (2019) 134 (Supplement_1): 1506.

https://doi.org/10.1182/blood-2019-126738

Published: 2019

Journal Articles

Loss of ZBTB7A Enhances Glycolysis and Beta Oxidation in Myeloid Leukemia

Enric Redondo Monte, MSc, BSc, Anja Wilding, MSc, Georg Leubolt, MSc, Paul Kerbs, MSc, Johannes Bagnoli, Wolfgang Hiddemann, MD PhD, Wolfgang Enard, PhD, Sebastian Theurich, MD, Philipp A. Greif, MD PD

Blood (2019) 134 (Supplement_1): 1453.

https://doi.org/10.1182/blood-2019-128378

Published: 2019

Journal Articles

Metabolomic Profile in Patients with Paroxysmal Nocturnal Hemoglobinuria

Patricia Eiko Yamakawa, MD, Ana Rita Da Fonseca, MD, Matheus Vescovi, MD PhD, Iara Baldim Rabelo Gomes, MD PhD, Ismael Dale Cotrim Guerreiro da Silva, MD PhD, Celso Arrais-Rodrigues, MD PhD

Blood (2019) 134 (Supplement_1): 2229.

https://doi.org/10.1182/blood-2019-126241

Published: 2019

Journal Articles

Separate Roles of Asparagine and Glutamine in Cytostatic Effect of L-Asparaginase - Stable Isotope Tracing Approach

Katerina Hlozkova, PhD, Alpesh Thakker, PhD, Natividad Alquézar-Artieda, Marketa Zaliova, MD PhD, Jan Trka, Prof., MD PhD, Daniel A Tennant, PhD, Julia Starkova, PhD

Blood (2019) 134 (Supplement_1): 2575.

https://doi.org/10.1182/blood-2019-127911

Published: 2019

Journal Articles

Characterization of Immune Cells Producing Regulatory Cytokines That Mediate Engraftment in Sickle Cell Disease Patients after Haploidentical Peripheral Blood Stem Cell Transplantation

Berline Francis, Arunakumar Gangaplara, PhD, Deepali K Bhat, PhD, J. Philip McCoy, PhD, Courtney D. Fitzhugh, MD

Blood (2019) 134 (Supplement_1): 803.

https://doi.org/10.1182/blood-2019-130711

Published: 2019

Journal Articles

Glutamine Depletion By Addicted Myeloma Cells Inhibits Osteoblastic Differentiation of Bone Marrow Mesenchymal Stromal Cells Limiting Asparagine Availability: A Possible New Mechanism for Myeloma Bone Disease

Martina Chiu, PhD, Denise Toscani, PhD, Emanuela Vicario, PhD, Roberta Andreoli, PhD, Giuseppe Taurino, MS, Valentina Marchica, MS, Paola Storti, PhD, Massimiliano Bianchi, PhD, Ovidio Bussolati, MD PhD, Nicola Giuliani

Blood (2019) 134 (Supplement_1): 4339.

https://doi.org/10.1182/blood-2019-128034

Published: 2019

Journal Articles

The Distinctive Metabolic Environment of the Bone Marrow Niche Drives Leukemia Chemoresistance

Nick van Gastel, PhD, Jessica B. Spinelli, PhD, Azeem Sharda, MS, Amir Schajnovitz, PhD, Ninib Baryawno, PhD, Catherine S Rhee, PhD, Toshihiko Oki, MD PhD, Eliane Grace, Heather J. Soled, Charles Vidoudez, PhD, Sunia A. Trauger, PhD, Marcia C. Haigis, PhD, David T. Scadden, MD

Blood (2019) 134 (Supplement_1): 3725.

https://doi.org/10.1182/blood-2019-124789

Published: 2019

Journal Articles

CXCR4 Blockade By BL-8040 in T Cell Acute Lymphoblastic Leukemia Decreases Mitochondrial Mass and Induces Non-Apoptotic Cell Death

Jun Xia, PhD, Stephanie Sun, Matthew RM Jotte, Geoffrey L. Uy, MD, Osnat Bohana-Kashtan, PhD, Ella Sorani, PhD, Abi Vainstein, Amnon Peled, PhD, Daniel C. Link, MD

Blood (2019) 134 (Supplement_1): 2745.

https://doi.org/10.1182/blood-2019-128881

Published: 2019

Journal Articles

Trial in Progress: Phase I Dose-Escalation and Dose-Expansion Trial of a Novel Glutaminase Inhibitor (CB-839 HCl) in Combination with Carfilzomib and Dexamethasone in Relapsed and/or Refractory Multiple Myeloma

Wilson I Gonsalves, MD, Srinivas Devarakonda, MD, Rachid Baz, MD, Natalia Neparidze, MD, Alex A Adjei, MD PhD, Charles Kunos, MD, Shaji K. Kumar, MD

Blood (2019) 134 (Supplement_1): 3160.

https://doi.org/10.1182/blood-2019-123399

Published: 2019

Journal Articles

STAT3 Plays a Critical Role in Mitochondrial Function and Survival of Primary AML Cells

Maria L Amaya, MD PhD, Anagha Inguva, BSc, Courtney L Jones, PhD, Anna Krug, BS, Shanshan Pei, PhD, Phillip Reigan, PhD, Craig T Jordan, PhD

Blood (2019) 134 (Supplement_1): 1275.

https://doi.org/10.1182/blood-2019-127669

Published: 2019

Journal Articles

Integrated Genome Wide Association Study (GWAS) Identifies SNPs Associated with Outcome in Pediatric AML

Abdelrahman H Elsayed, MSc, Huiyun Wu, PhD, Xueyuan Cao, PhD, Soheil Meshinchi, MD PhD, Raul Ribeiro, MD, Jeffrey Rubnitz, MD PhD, Stanley Pounds, PhD, Jatinder K Lamba, PhD

Blood (2018) 132 (Supplement 1): 2758.

https://doi.org/10.1182/blood-2018-99-120367

Published: 2018

Journal Articles

NSD2 Mutations in Pediatric ALL Leads to a Distinct Gene Expression Profile and Epigenetic Landscape That Is Cell Context Specific

Joanna Pierro, DO, Jason Saliba, PhD, Nikki Ann Evensen, PhD BS, William L. Carroll, MD, Gunjan Sethia, MS, Shella Saint Fleur-Lominy, MD PhD

Blood (2018) 132 (Supplement 1): 3905.

https://doi.org/10.1182/blood-2018-99-118535

Published: 2018

Journal Articles

N 6 -Methyladenosine Modification Regulates Cell Metabolism in Acute Myeloid Leukemia

Hengyou Weng, PhD, Huilin Huang, PhD, Huizhe Wu, Mingli Sun, Savanna Stanford, Sean Robinson, zhen-Hua Chen, Xi Qin, Xiaolan Deng, Xi Jiang, PhD, Ying Qing, Chao Shen, PhD, Rui Su, PhD, Minjie Wei, Jianjun Chen, PhD

Blood (2018) 132 (Supplement 1): 880.

https://doi.org/10.1182/blood-2018-99-117455

Published: 2018

Journal Articles

Disruption of NOTCH1-MYC-CD44 Axis Targets Leukemia Initiating Cells (LIC) in T-ALL

Sujan Piya, PhD, Seemana Bhattacharya, PhD, Hong Mu, MD PhD, Vivian Ruvolo, MS, Natalia Baran, PhDMD, Teresa McQueen, MS, R. Eric Davis, MD, Yimin Qian, PhD, Kanak Raina, PhD, M. James You, MD PhD, Marina Y. Konopleva, MD PhD, Hagop M. Kantarjian, MD, Michael Andreeff, MD PhD, Gautam Borthakur, MD

Blood (2018) 132 (Supplement 1): 890.

https://doi.org/10.1182/blood-2018-99-115692

Published: 2018

Journal Articles

Myeloma-Induced Alterations of Glutamine Metabolism Impair Bone Microenvironment Niche in Multiple Myeloma Patients

Denise Toscani, PhD, Martina Chiu, PhD, Giuseppe Taurino, MS, Emanuela Vicario, MS, Valentina Marchica, MS, Fabrizio Accardi, MD, Anna Benedetta Dalla Palma, MD, Paola Storti, PhD, Gaetano Donofrio, PhD, Franco Aversa, MD, Ovidio Bussolati, MD PhD, Nicola Giuliani, MD PhD

Blood (2018) 132 (Supplement 1): 4481.

https://doi.org/10.1182/blood-2018-99-111337

Published: 2018

Journal Articles

Concomitant BRAF Mutation in Hairy Cell Leukemia and Papillary Thyroid Cancer

Shehab Mohamed, MD, Mohamed A Yassin, MBBS, MSc, Abdulqadir Jeprel Nashwan, BSN, MSN, RN, CBT-HMS, Halima El Omri, Firyal Ibrahim, MB, CHB, PhD, Susana El akiki, PhD

Blood (2018) 132 (Supplement 1): 5140.

https://doi.org/10.1182/blood-2018-99-116084

Published: 2018

Journal Articles

The Glutaminase Activity of L-Asparaginase Mediates Suppression of Asns Upregulation

Wai Kin Chan, PhD, Lin Tan, MS, Karine Harutyunyan, PhD, Di Du, PhD, Leona Martin, MS, Eric Yin, MS, Marina Y. Konopleva, MD PhD, John Weinstein, MD PhD, Philip L Lorenzi, PhD

Blood (2018) 132 (Supplement 1): 3959.

https://doi.org/10.1182/blood-2018-99-117818

Published: 2018

Journal Articles

Glutamine Catabolism Maintains MCL-1 Expression in Glucose-Deprived Multiple Myeloma

Changyong Wei, PhD BS, Richa Bajpai, PhD, Alisha D Hunter, MS, Darius Mahboubi, MS, Mala Shanmugam, PhD

Blood (2017) 130 (Supplement 1): 3076.

https://doi.org/10.1182/blood.V130.Suppl_1.3076.3076

Published: 2017

NARROW

Interim Analysis of a Phase II Study of the Glutaminase Inhibitor Telaglenastat (CB-839) in Combination with Azacitidine in Advanced Myelodysplastic Syndrome (MDS)

Integrated Systems Level Examination of Proteasome Inhibitor Stress Recovery in Myeloma Cells Reveals Druggable Vulnerabilities Linked to Multiple Metabolic Processes

Identify AMPK-Mediated Autophagy and Oxphos As a Novel Metabolic Vulnerability for Targeted Therapy in Mantle Cell Lymphoma

Loss of ZBTB7A Enhances Glycolysis and Beta Oxidation in Myeloid Leukemia

Metabolomic Profile in Patients with Paroxysmal Nocturnal Hemoglobinuria

Separate Roles of Asparagine and Glutamine in Cytostatic Effect of L-Asparaginase - Stable Isotope Tracing Approach

Characterization of Immune Cells Producing Regulatory Cytokines That Mediate Engraftment in Sickle Cell Disease Patients after Haploidentical Peripheral Blood Stem Cell Transplantation

Glutamine Depletion By Addicted Myeloma Cells Inhibits Osteoblastic Differentiation of Bone Marrow Mesenchymal Stromal Cells Limiting Asparagine Availability: A Possible New Mechanism for Myeloma Bone Disease

The Distinctive Metabolic Environment of the Bone Marrow Niche Drives Leukemia Chemoresistance

CXCR4 Blockade By BL-8040 in T Cell Acute Lymphoblastic Leukemia Decreases Mitochondrial Mass and Induces Non-Apoptotic Cell Death

Trial in Progress: Phase I Dose-Escalation and Dose-Expansion Trial of a Novel Glutaminase Inhibitor (CB-839 HCl) in Combination with Carfilzomib and Dexamethasone in Relapsed and/or Refractory Multiple Myeloma

STAT3 Plays a Critical Role in Mitochondrial Function and Survival of Primary AML Cells

Integrated Genome Wide Association Study (GWAS) Identifies SNPs Associated with Outcome in Pediatric AML

NSD2 Mutations in Pediatric ALL Leads to a Distinct Gene Expression Profile and Epigenetic Landscape That Is Cell Context Specific

N 6 -Methyladenosine Modification Regulates Cell Metabolism in Acute Myeloid Leukemia

Disruption of NOTCH1-MYC-CD44 Axis Targets Leukemia Initiating Cells (LIC) in T-ALL

Myeloma-Induced Alterations of Glutamine Metabolism Impair Bone Microenvironment Niche in Multiple Myeloma Patients

Concomitant BRAF Mutation in Hairy Cell Leukemia and Papillary Thyroid Cancer

The Glutaminase Activity of L-Asparaginase Mediates Suppression of Asns Upregulation

Glutamine Catabolism Maintains MCL-1 Expression in Glucose-Deprived Multiple Myeloma

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American Society of Hematology

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ASH Publications

American Society of Hematology

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