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Journal Articles

Phosphatidylinositol-3,4-Bisphosphate-Akt Signaling Pathway Promotes Platelet Activation

Jasna Marjanovic, Brad Rumancik, Luke Weber, Felix Wangmang, Dane Fickes, Dmitri Postnov, Dung Nguyen, Yoon Lee, Richard Ngo-Lam, Monita Wilson

Blood (2018) 132 (Supplement 1): 1131.

https://doi.org/10.1182/blood-2018-99-115066

Published: 2018

Journal Articles

Development and Scale-up of a Novel GMP Method for Enrichment and Expansion of Terminally Differentiated Adaptive Natural Killer Cells (FATE-NK100) with Enhanced Anti-Tumor Function

Frank Cichocki, PhD, Bahram Valamehr, PhD MBA, Dhifaf Sarhan, PhD, Bin Zhang, Sarah Cooley, MD, Michael R. Verneris, MD, Bruce R. Blazar, MD, Ryan Bjordahl, PhD, Betsy Rezner, BS, Paul Rogers, PhD, Chad Green, David H McKenna, MD, Daniel Shoemaker, PhD, Scott Wolchko, MS, Jeffrey S. Miller, MD

Blood (2016) 128 (22): 1225.

https://doi.org/10.1182/blood.V128.22.1225.1225

Published: 2016

Journal Articles

All -Trans-Retinoic Acid (ATRA) Combined with Lithium As Treatment of Relapsed Non-Progranulocytic AML: Therapeutic Targeting Inhibition of the Glycogen Synthase Kinase 3-Beta (GSK3) Enzyme

Paolo Caimi, MD, Kalpana Gupta, PhD, Tammy Stefan, Brenda Cooper, MD, Basem M. William, MD, Erica L Campagnaro, MD, Richard J. Creger, Pharm D, Donna Kane, BSN, Stanton L. Gerson, Hillard M. Lazarus, MD, Marcos de Lima, MD, David N. Wald, MD PhD

Blood (2014) 124 (21): 5299.

https://doi.org/10.1182/blood.V124.21.5299.5299

Published: 2014

Journal Articles

Small Molecule Activators Of AMPK Block The Glycogen Production Required For Transformation Of Myeloid Leukemia Cells

Haymanti Bhanot, PhD, Mamatha M. Reddy, PhD, Atsushi Nonami, MD, PhD, Ellen L. Weisberg, PhD, Kelly Xing, Sabrina K. Salgia, John M. Asara, PhD, Richard M. Stone, MD, James D. Griffin, MD, Martin Sattler, PhD

Blood (2013) 122 (21): 1479.

https://doi.org/10.1182/blood.V122.21.1479.1479

Published: 2013

Journal Articles

Phosphorylation Of GSK3β Is Associated With Inferior Survival In Acute Myeloid Leukemia and Is An Indicator Of AKT Activation In AML Blasts and Bone Marrow Mesenchymal Stem Cells

Peter P. Ruvolo, PhD, Rui-yu Wang, MD, PhD, Vivian R Ruvolo, MA, Rodrigo Jacamo, PhD, Teresa McQueen, BS, Gautam Borthakur, MD, Yihua Qiu, MD, Kevin R. Coombes, PhD, Nianxiang Zhang, Elizabeth J Shpall, MD, Richard E Champlin, MD, Ramiro Garzon, MD, Guido Marcucci, MD, Carlo M. Croce, MD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Steven M. Kornblau, MD

Blood (2013) 122 (21): 2551.

https://doi.org/10.1182/blood.V122.21.2551.2551

Published: 2013

Journal Articles

BCR-ABL Transformation Requires Glycogen Synthase 1 (GYS1) Expression for Cell Growth and Increased Glycogen Production

Mamatha M. Reddy, PhD, Anagha Deshpande, PhD, Atsushi Nonami, MD, PhD, Ellen L. Weisberg, PhD, Tirumala K. Chowdary, PhD, James D. Griffin, MD, Martin Sattler, PhD

Blood (2012) 120 (21): 1673.

https://doi.org/10.1182/blood.V120.21.1673.1673

Published: 2012

Journal Articles

Treatment with β-Catenin Antagonist BC2059 Exerts Single Agent Efficacy and Exerts Improved Activity with Tyrosine Kinase Inhibitor (TKI) or Pan-Histone Deacetylase (HDAC) Inhibitor Against Human CML and Myeloproliferative Neoplasm (MPN) Progenitor Cells

Warren Fiskus, PhD, Jacqueline Smith, MS, Uma Mudunuru, MS, Stacey Hembruff, MS, Ruben Reyes, MD, Sunil Abhyankar, MD, Joseph McGuirk, DO, Omar S. Aljitawi, MD, Siddhartha Ganguly, MD, Stephen K. Horrigan, PhD, Sunil Sharma, MD, Kapil N. Bhalla, MD

Blood (2011) 118 (21): 65.

https://doi.org/10.1182/blood.V118.21.65.65

Published: 2011

Journal Articles

GSK3β Signaling Regulates the Motility of Hematopoietic Progenitors Via Prune.

Kfir Lapid, MSc, Gabriele D‘Uva, MSc, Alexander Kalinkovich, MD, PhD, Aya Ludin, DMD, MSc, Karin Golan, MSc, Tomer Itkin, MSc, Massimo Zollo, PhD, Tsvee Lapidot, PhD

Blood (2010) 116 (21): 1553.

https://doi.org/10.1182/blood.V116.21.1553.1553

Published: 2010

Journal Articles

Deregulated Activity and Localization of Glycogen Synthase Kinase 3β In Chronic Myeloid Leukemia Progenitors: Role In Leukemia Maintenance and Targeted Therapy.

Addolorata ML Coluccia, PhD, Simone De Leo, Emanuela de Luca, BSc, Giovanni Reddiconto, MD, Ilaria Palamà, BSc, Sara Redaelli, PhD, Serena De Matteis, Carlo Gambacorti-Passerini, MD, Luciana Dini, Prof, Michele Maffia, Prof

Blood (2010) 116 (21): 1216.

https://doi.org/10.1182/blood.V116.21.1216.1216

Published: 2010

Journal Articles

Ligand of scavenger receptor class A indirectly induces maturation of human blood dendritic cells via production of tumor necrosis factor-α

Jun-O Jin, Hae-Young Park, Qi Xu, Joo-In Park, Tatyana Zvyagintseva, Valentin A. Stonik, Jong-Young Kwak

Blood (2009) 113 (23): 5839–5847.

https://doi.org/10.1182/blood-2008-10-184796

Published: 2009

Includes: Supplemental data

Journal Articles

Epigenetic Regulation of the WNT Canonical Pathway in Mantle Cell Lymphoma.

Anthea C Peters, MD, MSc, Randy Chung, MD, Charles S Wong, Leah C Young, PhD, Tony Reiman, MD, Raymond Lai, MD, PhD

Blood (2008) 112 (11): 3340.

https://doi.org/10.1182/blood.V112.11.3340.3340

Published: 2008

Journal Articles

AT7519, a Novel Small Molecule Multi-Cyclin Dependent Kinase Inhibitor, Induces Apoptosis in Multiple Myeloma VIA GSK3β

Loredana Santo, MD, Sonia Vallet, M.D., Teru Hideshima, M.D., Ph.D., Diana Cirstea, MD, Samantha Pozzi, MD, Nileshwari Vaghela, Hiroshi Ikeda, MD, PhD, Yutaka Okawa, MD, Gullu Gorgun, PhD, Giulia Perrone, MD, Elisabetta Calabrese, MD, Matthew S Squires, Marco Ladetto, MD, Nikhil C. Munshi, MD, Mario Boccadoro, Kenneth C. Anderson, MD, Noopur Raje, MD

Blood (2008) 112 (11): 251.

https://doi.org/10.1182/blood.V112.11.251.251

Published: 2008

Journal Articles

PI-103, a Dual Inhibitor of Class IA Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin, Has Cytotoxic Activity in T-Cell Acute Lymphoblastic Leukemia Cells: A New Therapeutic Strategy in T-Cell Acute Lymphoblastic Leukemia.

Francesca Chiarini, BS, Federica Fala, PhD, Francesca Ricci, BS, PierLuigi Tazzari, MD, Annalisa Astolfi, PhD, Andrea Pession, MD, PhD, James McCubrey, PhD, Alberto M. Martelli, MD

Blood (2008) 112 (11): 1921.

https://doi.org/10.1182/blood.V112.11.1921.1921

Published: 2008

Journal Articles

GSK3β is a negative regulator of platelet function and thrombosis

Dongjun Li, Shelley August, Donna S. Woulfe

Blood (2008) 111 (7): 3522–3530.

https://doi.org/10.1182/blood-2007-09-111518

Published: 2008

Includes: Supplemental data

Journal Articles

Missplicing of Glycogen Synthase Kinase 3β: A Potential Mechanism of Blast Crisis Chronic Myeloid Leukemia Stem Cell Generation.

Annelie Abrahamsson, MS, Ifat Geron, MS, Jason Gotlib, MD MS, Kim-Hien Dao, DO PhD, Francis Giles, MD, Isabel Newton, MD PhD, Edward Kavalerchik, MD, Jeffrey Durocher, PhD, Remi Creusot, PhD, Mobin Karimi, PhD, Carol Jones, PhD, James Zehnder, PhD, Armand Keating, MD, Robert Negrin, MD, Irving L. Weissman, MD, Catriona H.M. Jamieson, MD PhD

Blood (2007) 110 (11): 775.

https://doi.org/10.1182/blood.V110.11.775.775

Published: 2007

Journal Articles

GSK-3β Negatively Regulates Megakaryocyte and Platelet Production in an In Vitro Human Bone Marrow Mononuclear Cell-Derived Differentiation System.

Yumiko Matsubara, PhD, Mitsuru Murata, MD, Hidenori Suzuki, PhD, Kenji Yokoyama, MD, Hiroaki Ishihara, PhD, Yoshiyuki Morishima, PhD, Toshiro Shibano, PhD, Yasuo Ikeda, MD

Blood (2007) 110 (11): 4036.

https://doi.org/10.1182/blood.V110.11.4036.4036

Published: 2007

Journal Articles

Glycogen Synthase Kinase-3β Regulates Ex-Vivo Expansion and Engraftment of Umbilical Cord Blood Hematopoietic Stem Cells through the Activation of Wnt Signaling.

Alla Dolnikov, PhD, Tiffany Holmes, MSc, Tracey A. O’Brien, MBChB,FRACP,MHL,BSc

Blood (2006) 108 (11): 340.

https://doi.org/10.1182/blood.V108.11.340.340

Published: 2006

Journal Articles

ERBB Signaling Promotes BCR-Abl Expression and Modulates Multiple Signaling Pathways as Assessed by High-Throughput, Reverse Phase Protein Array.

Laura D. Nelson, PhD, Doris R. Siwak, PhD, Yiling Lu, PhD, Claudia Miller, MS, Joya Chandra, PhD, Dennis P.M. Hughes, MD, PhD

Blood (2006) 108 (11): 4349.

https://doi.org/10.1182/blood.V108.11.4349.4349

Published: 2006

Journal Articles

PECAM-1 Inhibits Signaling Pathways That Amplify Platelet Aggregation.

Cunji Gao, MD, PhD, Peter J. Newman, Ph.D

Blood (2006) 108 (11): 1505.

https://doi.org/10.1182/blood.V108.11.1505.1505

Published: 2006

Journal Articles

Aberrant Regulation of Wnt/Beta-Catenin Pathway Mediators in Chronic Myelogenous Leukemia Stem Cells.

Annelie Abrahamsson, MS, Ifat Geron, MS, Jason Gotlib, MD MS, Jeffrey Durocher, PhD, Remi Creusot, PhD, Edward Kavalerchik, MD, Daniel Goff, BS, C.G. Fathman, MD, Stanley L. Lilleberg, PhD, Francis Giles, MD, Irving Weissman, MD, Catriona Jamieson, MD, PhD

Blood (2006) 108 (11): 2135.

https://doi.org/10.1182/blood.V108.11.2135.2135

Published: 2006

NARROW

Phosphatidylinositol-3,4-Bisphosphate-Akt Signaling Pathway Promotes Platelet Activation

Development and Scale-up of a Novel GMP Method for Enrichment and Expansion of Terminally Differentiated Adaptive Natural Killer Cells (FATE-NK100) with Enhanced Anti-Tumor Function

All -Trans-Retinoic Acid (ATRA) Combined with Lithium As Treatment of Relapsed Non-Progranulocytic AML: Therapeutic Targeting Inhibition of the Glycogen Synthase Kinase 3-Beta (GSK3) Enzyme

Small Molecule Activators Of AMPK Block The Glycogen Production Required For Transformation Of Myeloid Leukemia Cells

Phosphorylation Of GSK3β Is Associated With Inferior Survival In Acute Myeloid Leukemia and Is An Indicator Of AKT Activation In AML Blasts and Bone Marrow Mesenchymal Stem Cells

BCR-ABL Transformation Requires Glycogen Synthase 1 (GYS1) Expression for Cell Growth and Increased Glycogen Production

Treatment with β-Catenin Antagonist BC2059 Exerts Single Agent Efficacy and Exerts Improved Activity with Tyrosine Kinase Inhibitor (TKI) or Pan-Histone Deacetylase (HDAC) Inhibitor Against Human CML and Myeloproliferative Neoplasm (MPN) Progenitor Cells

GSK3β Signaling Regulates the Motility of Hematopoietic Progenitors Via Prune.

Deregulated Activity and Localization of Glycogen Synthase Kinase 3β In Chronic Myeloid Leukemia Progenitors: Role In Leukemia Maintenance and Targeted Therapy.

Ligand of scavenger receptor class A indirectly induces maturation of human blood dendritic cells via production of tumor necrosis factor-α

Epigenetic Regulation of the WNT Canonical Pathway in Mantle Cell Lymphoma.

AT7519, a Novel Small Molecule Multi-Cyclin Dependent Kinase Inhibitor, Induces Apoptosis in Multiple Myeloma VIA GSK3β

PI-103, a Dual Inhibitor of Class IA Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin, Has Cytotoxic Activity in T-Cell Acute Lymphoblastic Leukemia Cells: A New Therapeutic Strategy in T-Cell Acute Lymphoblastic Leukemia.

GSK3β is a negative regulator of platelet function and thrombosis

Missplicing of Glycogen Synthase Kinase 3β: A Potential Mechanism of Blast Crisis Chronic Myeloid Leukemia Stem Cell Generation.

GSK-3β Negatively Regulates Megakaryocyte and Platelet Production in an In Vitro Human Bone Marrow Mononuclear Cell-Derived Differentiation System.

Glycogen Synthase Kinase-3β Regulates Ex-Vivo Expansion and Engraftment of Umbilical Cord Blood Hematopoietic Stem Cells through the Activation of Wnt Signaling.

ERBB Signaling Promotes BCR-Abl Expression and Modulates Multiple Signaling Pathways as Assessed by High-Throughput, Reverse Phase Protein Array.

PECAM-1 Inhibits Signaling Pathways That Amplify Platelet Aggregation.

Aberrant Regulation of Wnt/Beta-Catenin Pathway Mediators in Chronic Myelogenous Leukemia Stem Cells.

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American Society of Hematology

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American Society of Hematology

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