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Journal Articles

Evaluation of a Blood Coagulation Factor IX Variant That Functions Independently of Factor VIII As an Alternative Treatment for Hemophilia A

Viola J.F. Strijbis, MSc, Ka Lei Cheung, Pavlina Konstantinova, PhD, Ying Poi Liu, PhD, Sander J van Deventer, MD PhD, Mettine H.A. Bos, PhD

Blood (2019) 134 (Supplement_1): 1110.

https://doi.org/10.1182/blood-2019-124120

Published: 2019

Journal Articles

Active Calpain Promotes Fibrin Clot Contraction By Strengthening the Coupling of Fibrin-Bound αIIbβ3 to the Platelet Cytoskeleton

Rustem I. Litvinov, Karen Pei Yi Fong, PhD BS, Oleg V. Kim, PhD, Kathleen I. Molnar, PhD, Paul C. Billings, PhD, Alex Sternisha, BS, James A. Wells, PhD, John W. Weisel, PhD, William F. DeGrado, PhD, Joel S. Bennett, MD

Blood (2018) 132 (Supplement 1): 1128.

https://doi.org/10.1182/blood-2018-99-113063

Published: 2018

Journal Articles

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

Blood (2016) 128 (22): 2474.

https://doi.org/10.1182/blood.V128.22.2474.2474

Published: 2016

Journal Articles

CD46 Is Amplified in High-Risk Myeloma with Gain of Chromosome 1q and Selectively Targeted By a Novel Anti-CD46 Antibody-Drug Conjugate

Daniel W. Sherbenou, MD PhD, Blake T. Aftab, PhD, Yang Su, PhD, Christopher R. Behrens, PhD, Arun P. Wiita, MD PhD, Aaron C. Logan, MD PhD, Diego Acosta-Alvear, PhD, Byron C. Hann, MD PhD, Peter Walter, PhD, Xiaobo Wu, MD, John P. Atkinson, MD, Jeffrey L. Wolf, MD, Thomas G. Martin, III, MD, Bin Liu, PhD

Blood (2016) 128 (22): 384.

https://doi.org/10.1182/blood.V128.22.384.384

Published: 2016

Journal Articles

Engineered Factor Xa Variants Retain Procoagulant Activity Independent of Direct Factor Xa-Inhibitors

Daniël Verhoef, Mark Schreuder, Ka Lei Cheung, Pieter H. Reitsma, Mettine H.A. Bos, PhD

Blood (2015) 126 (23): 126.

https://doi.org/10.1182/blood.V126.23.126.126

Published: 2015

Journal Articles

Chemical Mutagenesis Screen Identifies Novel Drug Resistant JAK2 Variants in V617FJAK2 Mediated MPN and Predict HSP90 Inhibitors As Possible Agents to Overcome Drug Resistance

Sivahari Prasad Gorantla, PhD, Detlef Bentrop, PhD, Nikolas Bubnoff, MD, Anna Lena Illert, MD, Robert Zeiser, MD, Justus Duyster, MD

Blood (2015) 126 (23): 3687.

https://doi.org/10.1182/blood.V126.23.3687.3687

Published: 2015

Journal Articles

Pre-Clinical Development of Adct-402, a Novel Pyrrolobenzodiazepine (PBD)-Based Antibody Drug Conjugate (ADC) Targeting CD19-Expressing B-Cell Malignancies

Francesca Zammarchi, PhD, David G. Williams, PhD, Lauren Adams, Karin Havenith, PhD, Simon Chivers, PhD, Francois D'Hooge, PhD, Philip W. Howard, PhD, John A. Hartley, PhD, Patrick H. van Berkel, PhD

Blood (2015) 126 (23): 1564.

https://doi.org/10.1182/blood.V126.23.1564.1564

Published: 2015

Journal Articles

Novel Structurally-Modified Allosteric Effectors of Hemoglobin Exhibit Superior Antisickling Properties

Osheiza Abdulmalik, DVM, MS, Tanvi Deshpande, MS, Mohini Ghatge, PhD, Yan Zhang, PhD, Jurgen Venitz, MDPhD, Apurvasena Parikh, PhD, Martin K. Safo, PhD

Blood (2014) 124 (21): 218.

https://doi.org/10.1182/blood.V124.21.218.218

Published: 2014

Journal Articles

High Density Lipoprotein and Apolipoprotein A-I Bind Von Willebrand Factor and Prevent Its Self-Association Into Thick Fibers

Dominic W. Chung, PhD, Ying Zheng, Junmei Chen, PhD, Minhua Ling, Ph.D., Xiaoyun Fu, PhD, José A. López

Blood (2013) 122 (21): 194.

https://doi.org/10.1182/blood.V122.21.194.194

Published: 2013

Journal Articles

PLX3397 Is An Investigational Selective FLT3 Inhibitor That Retains Activity Against the Clinically-Relevant FLT3-ITD/F691L “Gatekeeper” Mutation in Vitro

Catherine C. Smith, MD, Alexander E Perl, MD, Elisabeth Lasater, PhD, Chao Zhang, PhD, Grace R Jeschke, Lauren E. Damon, Martin Carroll, MD, Neil P. Shah, MD, PhD

Blood (2011) 118 (21): 764.

https://doi.org/10.1182/blood.V118.21.764.764

Published: 2011

Journal Articles

Kinase Domain Mutations in JAK2V617F Confer Resistance to the Novel JAK2 Inhibitor Ruxolitinib

Anagha Deshpande, PhD, Mamatha M. Reddy, PhD, Georg Schade, Arghya Ray, Ph.D, Tirumala K. Chowdary, PhD, James D. Griffin, MD, Martin Sattler, PhD

Blood (2011) 118 (21): 125.

https://doi.org/10.1182/blood.V118.21.125.125

Published: 2011

Journal Articles

Structural and Mutational Analysis of Canonical Loop Residues In Protease Nexin 2 Involved In Factor XIa and Trypsin Inhibition.

Duraiswamy Navaneetham, Dipali Sinha, Peter N. Walsh, MD, PhD

Blood (2010) 116 (21): 1147.

https://doi.org/10.1182/blood.V116.21.1147.1147

Published: 2010

Journal Articles

EspP, An Extracellular Serine Protease From Enterohemorrhagic E. Coli , Induces Coagulopathy In Human Whole Blood and Plasma

Kevin H.M. Kuo, MD, Shekeb Khan, MSc, Elena Brnjac, MLT, Emil F. Pai, Dr.rer.nat, Alden E. Chesney, MD

Blood (2010) 116 (21): 4416.

https://doi.org/10.1182/blood.V116.21.4416.4416

Published: 2010

Journal Articles

Increasing Hydrophobicity and Disulfide Bridging Between A1 and C2 Subunits Improves Factor VIII Stability.

Hironao Wakabayashi, MD, PhD, Amy E Griffiths, MS, Philip Fay, PhD

Blood (2009) 114 (22): 3176.

https://doi.org/10.1182/blood.V114.22.3176.3176

Published: 2009

Journal Articles

Crystal structure of protein Z–dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X

Zhenquan Wei, Yahui Yan, Robin W. Carrell, Aiwu Zhou

Blood (2009) 114 (17): 3662–3667.

https://doi.org/10.1182/blood-2009-04-210021

Published: 2009

Includes: Supplemental data

Journal Articles

A Unified Mechanism of Tyrosine Kinase Regulation by the Gatekeeper Residue.

Mohammad Azam, PhD, Markus Seeliger, PhD, Nathanael S. Gray, PhD, John Kuriyan, PhD, George Q. Daley, MD, PhD

Blood (2007) 110 (11): 223.

https://doi.org/10.1182/blood.V110.11.223.223

Published: 2007

Journal Articles

Factor XI Homodimer Formation Is Mediated by Electrostatic (Lys331 with Glu287) and Hydrophobic (Ile290 with Leu284 and Tyr329 with Tyr329) Interactions in the Apple 4 Domain and Is Essential for Normal Proteolytic Activation of Factor XI by Factor XIIa, Thrombin and Factor XIa.

Wenman Wu, MD, PhD, Dipali Sinha, PhD, James D. Lear, PhD, Paul C. Billings, PhD, Peter N. Walsh, MD, PhD

Blood (2007) 110 (11): 2706.

https://doi.org/10.1182/blood.V110.11.2706.2706

Published: 2007

Journal Articles

Expression of a Two Chain Gamma-Glutamyl Carboxylase: Importance of Disulfide Bond Formation and Transmembrane Domain Interactions.

Jian-Kie Tie, PhD, Mei-Yan Zheng, B.S., Darrel W. Stafford, Ph.D, David L. Straight, Ph.D

Blood (2006) 108 (11): 1694.

https://doi.org/10.1182/blood.V108.11.1694.1694

Published: 2006

Journal Articles

Two Virus Reduction Steps Are Inherent in the Manufacturing Process of Berinert P, a C1-Esterase-Inhibitor Concentrate.

Albrecht Groener, Thomas Nowak, Wolfram Schäfer

Blood (2005) 106 (11): 4170.

https://doi.org/10.1182/blood.V106.11.4170.4170

Published: 2005

Journal Articles

Evidence for an Inhibitor-Blocking Antibody in an "Acquired Hemophiliac".

Robert Litwiller, Rajiv Pruthi, MD, David Fass, PhD

Blood (2005) 106 (11): 3209.

https://doi.org/10.1182/blood.V106.11.3209.3209

Published: 2005

NARROW

Evaluation of a Blood Coagulation Factor IX Variant That Functions Independently of Factor VIII As an Alternative Treatment for Hemophilia A

Active Calpain Promotes Fibrin Clot Contraction By Strengthening the Coupling of Fibrin-Bound αIIbβ3 to the Platelet Cytoskeleton

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

CD46 Is Amplified in High-Risk Myeloma with Gain of Chromosome 1q and Selectively Targeted By a Novel Anti-CD46 Antibody-Drug Conjugate

Engineered Factor Xa Variants Retain Procoagulant Activity Independent of Direct Factor Xa-Inhibitors

Chemical Mutagenesis Screen Identifies Novel Drug Resistant JAK2 Variants in V617FJAK2 Mediated MPN and Predict HSP90 Inhibitors As Possible Agents to Overcome Drug Resistance

Pre-Clinical Development of Adct-402, a Novel Pyrrolobenzodiazepine (PBD)-Based Antibody Drug Conjugate (ADC) Targeting CD19-Expressing B-Cell Malignancies

Novel Structurally-Modified Allosteric Effectors of Hemoglobin Exhibit Superior Antisickling Properties

High Density Lipoprotein and Apolipoprotein A-I Bind Von Willebrand Factor and Prevent Its Self-Association Into Thick Fibers

PLX3397 Is An Investigational Selective FLT3 Inhibitor That Retains Activity Against the Clinically-Relevant FLT3-ITD/F691L “Gatekeeper” Mutation in Vitro

Kinase Domain Mutations in JAK2V617F Confer Resistance to the Novel JAK2 Inhibitor Ruxolitinib

Structural and Mutational Analysis of Canonical Loop Residues In Protease Nexin 2 Involved In Factor XIa and Trypsin Inhibition.

EspP, An Extracellular Serine Protease From Enterohemorrhagic E. Coli , Induces Coagulopathy In Human Whole Blood and Plasma

Increasing Hydrophobicity and Disulfide Bridging Between A1 and C2 Subunits Improves Factor VIII Stability.

Crystal structure of protein Z–dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X

A Unified Mechanism of Tyrosine Kinase Regulation by the Gatekeeper Residue.

Factor XI Homodimer Formation Is Mediated by Electrostatic (Lys331 with Glu287) and Hydrophobic (Ile290 with Leu284 and Tyr329 with Tyr329) Interactions in the Apple 4 Domain and Is Essential for Normal Proteolytic Activation of Factor XI by Factor XIIa, Thrombin and Factor XIa.

Expression of a Two Chain Gamma-Glutamyl Carboxylase: Importance of Disulfide Bond Formation and Transmembrane Domain Interactions.

Two Virus Reduction Steps Are Inherent in the Manufacturing Process of Berinert P, a C1-Esterase-Inhibitor Concentrate.

Evidence for an Inhibitor-Blocking Antibody in an "Acquired Hemophiliac".

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American Society of Hematology

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ASH Publications

American Society of Hematology

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